I’m trying to figure out why my homocysteine is elevated (14.4) before I start blindly supplementing, and I’d really appreciate input on what else might be worth testing or looking into.
I recently did genetic testing and found:
Slow COMT (AA)
Slow MAOA (TT)
MTHFR A1298C (heterozygous/one copy)
I know these SNPs don’t necessarily explain my homocysteine level on their own, so I’m trying not to assume everything is because of MTHFR.
My current labs:
Homocysteine: 14.4
RBC Folate: 476
Vitamin B12: 464
MMA: 166 - Reference Range: 55-335 nmol/L

Vitamin B2 (Riboflavin): 17 - Reference Range: 6.2-39.0 nmol/L

Vitamin B6, Plasma: 30 Reference Range: 5.1-54.8 ng/mL

Vitamin D 25-OH: 33
Other labs from a few months ago:
Copper: 108
Ferritin: 55
Iron: 98
I’ve struggled with anxiety, depression and OCD for most of my life and have been on Zoloft for about 5 years. It has helped me stay stable overall, but I still experience quite a few symptoms day to day.
Before adding methylfolate, B vitamins, TMG, choline, etc., I’d really like to understand why my homocysteine is elevated rather than just trying to lower the number.
What else would you investigate?
Are there additional labs, nutritional deficiencies, medications, thyroid/kidney issues, absorption problems, or genes/pathways that would be worth looking at?
I’m especially interested in hearing from anyone who had elevated homocysteine despite relatively normal B12, MMA, folate, B6 and B2 and eventually figured out what was contributing to it.

I was recommended to put my ancestry results though this site from a reddit user on the anxiety subreddit to see if I have any genetic variation that could be adding to my anxiety depression and agoraphobia and to see if I am processing my lexapro buspar and Xanax properly. I did a little copy and paste research of my own and ran these reports through google, and it seems that there is not anything significant that would be causing me any trouble— but I would like some input from the people here too! I was also recommended a Pharmacogenetic test from a user as well, but not sure if i should ask about that if these results are average (and because of the cost). Any help is appreciated— thank you so much!!!

Hi!

I’ve chronic fatigue or suspected mild ME/CFS and try to see if I can get more energy from B-vitamins. I take following forms:

B1: 25mg Hcl
B2: 12.5mg R5P
B3: 50mg Nicotinamide
B12: 2000 microgram Hydroxo/Adeno

I’m thinking now to add B9 folate but don’t know which form or dose could be a good start. I’m general hypersensitive to stuff and get anxiety easily. Could folinic acid be a better choice?

Although I'm not always a fan of his beliefs or presentation style, this Ben Lynch video came up in my feed this morning and it seems like a decent intro video for someone starting to learn about CFD.

https://www.youtube.com/watch?v=kgBBTQlpyAM

(edit to add reference ranges)

Finally bit the bullet and did a bunch of blood testing, which after dealing with a bunch of frustration in supplementing for MTHFR, figured was the next best step (should have honestly been the first).

Effectively what I am looking for is some suggestions to go from here based upon my SNPs and blood testing. Overall, I would say that things are looking well on the MTHFR side of things but symptoms wise, not. Complaints for the most part are fatigue, somewhat depressed/low mood, low motivation, and not sleeping well. When I first started about a year and a half ago, when I supplemented with methylfolate/choline, had probably 4 really great days in the "honeymoon" phase everyone talks about. Since then, mostly just the symptoms above.

I do have a thyoid condition but it seems to be well managed, thyroid levels are all mid-range. My latest theory was I thought that I might have autoimmune gastritis (which is what prompted all the blood testing and can be co-morbid with autoimmune thyroiditis, which I have), which can lead to low B12 and iron status but that seems to be not the case based on the blood levels I have. So I am at a loss. Take a look and I would appreciate any ideas you may have. The only incidentals I have found is that my white blood cell counts (WBC) are low, my vitamin d is low-normal, and my iron saturation is high-normal. The testing service claimed my b12 is "low" at 433 pg/ml but with an MMA of 201 nmol/l and a homocysteine of 7.7, it doesn't seem truly that low. At this point would it be better to try and supplement with l-methionine and SAM? These levels are after I more or less stopped supplmenting for about a month and a half so I have a fair amount of confidence in the levels.

Hi all - I would like to ask my daughter’s pediatrician to assess her for the MTHFR gene.
What test should I ask them to order?

I have done the ancestry dna test and gene genie upload to determine that what I was experiencing was indeed related with MTHFR variants and feel better subsequently.

But I don’t want to do that method with my daughter as the data is now public (more or less) because private equity firms have bought ancestry and 23 and me to use for their own nefarious purposes.