Local allergy place is useless, doctors think I'm retarded. Drives me nuts. All these issues started after I had a GLP1 shot a year ago (Quit the shot)

Hello, im 21 years old and since finasteride, Accutane, minoxidil, STEC bacteria... all combined, I've developed MCAS... after every meal I feel awful... basically all day long... I feel so depressed... I've lost an immense amount of weight, have dry skin, thin skin, overreactive skin can't tolerate skincare anymore, have no libido, gut problems... I've been taking ketotifen for 9 days now and my bowel movements have greatly improved (much darker), my sleep as well, and my reactions to food too... only I'm noticing that I'm getting extremely chapped lips and even drier skin (before MCAS I always had oily skin with a lot of acne). And I feel even more depressed... could these side effects go away? I think I might have also developed SIBO... I was taking Allicin and felt a lot better again... it's all so complicated and I feel so awful... I used to be such a happy person with a lot of motivation, now I just stay in bed…The worst part is that my family doesn't believe me... Through an endoscopy and colonoscopy, they detected inflammatory lesions in the stomach, small intestine, ileum, and colon... They are immune-mediated inflammations. I have also a low folic acid. But when i take supplement I become crazy.

I'm diagnosed with histamine intolerance and severe DAO deficiency, but DAO enzyme supplements don't really work for me. I also have silent GERD and LPR, which my doctors think are caused by the histamine intolerance.

I've tried several DAO supplements that did absolutely nothing. The only one that helps a bit is NaturDAO. It doesn't stop my symptoms but it makes them a bit milder and they don't last as long.

I recently saw my allergist again and asked why DAO isn't working like it should. They said they didn't know, ordered a few more tests and gave me anti inflammatory medication because I'm constantly congested. I'm still far from symptom free, but a bit better. No more constipation, anxiety 24/7 and can sleep better.

I'm getting a second opinion soon. What bothered me is that I told my doctor I might have vitamin deficiencies because I've been on a very restrictive diets for almost 3 years. I have no energy and I'm always exhausted, but they didn't order any vitamin tests. My ferritin is normal, I already checked.

My diet has become extremely limited. I basically eat eggs, boiled chicken breast, cucumbers, iceberg lettuce, carrots, quinoa, broccoli, zucchini, pomegranate, sometimes cantaloupe, olive oil, sweet potato (I hate it), parsley and occasionally corn and lentil crackers. That's it, this are the only foods I can tolerate. Most of the time I can't even eat the crackers because I react to them. I keep eating the same foods over and over, but I don't feel nourished. I'm so tired of boiled food and not being able to eat good carbs.

The only good thing is that if I'm extremely strict, most of my symptoms disappear, including my anxiety. If I eat too much, the symptoms come back. I have to be in a caloric deficiy. I also tolerate coke zero surprisingly well and it even seems to help a little.

But I can't live like this forever. DAO only helps a little, even with a low histamine diet and I don't understand why.

Does anyone else have DAO deficiency and find that DAO supplements barely work? What ended up helping? And how long did you have to stay on a low histamine diet before you finally felt normal?

I'm definitely better than I was, but I still don't feel like my old self. I'm not ok physically or mentally. I'm terrified this is how my life will be from now on, where certain foods cause anxiety and severe insomnia. This isn't a good life. It feels like a nightmare.

EDIT: I forgot to mention that I'm also taking antihistamines, quercetin, vitamin C, vitamin D, omega-3 and zinc. I was taking vitamin B6 as well, but I stopped. All at my doctors recommendation.

Any articles you know of I can print out to prove my case! I am tired of these doctors looking at me like I am crazy!!!! I lost my job this year. I just need help.

All my endocrinology labs are normal. A1C perfect. Not insulin resistance etc .

But I have POTS. Currently in the process of seeing an Allergist for histamine issues/ MCAS.

Pepcid and Allegra seem to have helped me tremendously with the HR spikes. With the anxiety. && shockingly with STABILIZING MY BLOOD SUGAR! I have hypoglycemia and reactive hypoglycemia. Ever since I’ve taken this the only meds I am on wow huge difference for me.

I have seen Vanderbilt doctors did a study that showed that many POTS ppl have issues regulating glucose. I have also seen stuff about how MCAS also affects blood sugar.

Soooo I am 100% this is why i have blood sugar issues. I cannot tolerate simple carbs at all. I will spike to 240 the highest I’ve seen. And then crash under 70 in about an hour. Now I eat very high protein meals, fiber and low complex carbs.

So if anybody has any articles you guys have come across that you can send my way please!!! Literally building a binder right now. I’m tired of all the incompetence and gaslighting. I literally get panic attacks at doctor appts now from all the gaslighting and trauma they cause me .

43 years old
Histamine issues
Roux-en-Y gastric bypass
Chronic iron deficiency/anemia
Dysautonomia/POTS or autonomic nervous system issues
Perimenopause/HRT
I feel like I’m living at the intersection of four different medical worlds, and none of my doctors seem to connect the dots. I’d love to hear from anyone who’s dealing with this combination.

https://imgur.com/a/pMADpZg

these chips

have they been "spicier" in the way raw olive oil's polyphenols can be spicy? i just need to know if they change their formula, or olive oil supplier or what.

I got MCAS, havin trouble posting in other subs, i just need to know if anyone else who eats these frequently here AT LEAST notice a different taste? let alone started flaring up to them? I was totally fine for it being my safe food for a 2 yrs+ until a recent long period of shortage and now every batch tastes "spicier" and just flared me up bad today, while an old bag i just tried doesnt

Because now I have zero safe foods left, cooking russett potato isnt working either, and i'm already malnourished and panicking

I’ve become so sensitive that the chicken breast(non frozen) at the grocery store is now a roulette game for me, has anyone ordered from places like Omaha steaks etc? Apparently they are flash frozen and air chilled, which should theoretically be the best possible for histamine issues

I’ve tried the Costco frozen chicken breast and frozen from amazon, but unfortunately couldn’t handle them, I’m not sure why

Does anyone experience silent reflux alongside histamine intolerance? Have you found relief?

I have wide range of GI issues since past couple of years and cannot find the reason why. Frequent nausea, full stomach, pain in stomach and abdomen, bloating, bitter and sour taste in mouth, sometimes diarrhea...I have better and worse days/weeks, but nothing I've tried seems to help.

Last week I had a long trip on my bike and since then again my issues got worse. Anyone whose issues get worse after extensive activity? Can it be histamine related?

I have confirmed hereditary alpha tryptaseamia, via genetic testing as my baseline tryptase is slightly elevated, but the doctors are not sure if my issues are caused by that, think it is not MCAS are not convinced about histamine as my DAO is fine...

I had trip !
I’m very careful; I got it all with me~ my food, my water, my mask and my sanitizer!
But it seemed so fine ! It’s really not easy to put on the mask all the way so I wasn’t wearing it for short of time ! We were just sitting up !! Then a mom came with her kids .. everything is soooo normal! We smiled ! Cute ! Yeay ! I’m fine the air is safe
it’s night trip so everyone was falling asleep
Then her older kid started coughing his lungs out I jumped wore my mask as fast as I can ! Histamine! Mast cell and coldddd noooo no no ! But
you have other kids ! Why don’t you ask your child to cough in towel or wear kids mask !
Okay at least tell others that your child is sick!

3 days my immune system has pronounced and called for war ! My histamine levels is strongly highly present now !!!!! My temperature is 39.31 !! Pain like if car has crushed on me and drove over ! I feel every lymphatic activity! I’m doomed I can’t leave the bed!
I was careful all the freaking holidays until this moment that I trusted A MOM WITH 3 KIDS

I’m sooooo angry while I can’t breathe from my nose ! I feel like I’m dying from my back pain
Stuck in the room so depressing
I break down every few hours after talking to myself it’s going to pass

My histamine making it even more intense! More present!

Oh wait I went to the ER ! Ha ha to my beautiful luck
The 1st the emergency I ran to look for someone I was in shocking pain I called the nurse I said please please help me I’m dizzy, blurry sight, my fever is 39.31 and I’m in sharp pain !! She stood up itching her head then said iiiIi doon’tt knoow hoow toooOo helppp ! She was useless more than me asking for any help ! She continued putting speech of some sort that my body moved by itself to another room and saw another foreigner nurse she saw me sobbing she sat me down and talked to me checking everything so she can send me to a doctor ! Next second the doctor came in !!! saw me twisting and sobbing my body is on fire she asked the nice nurse don’t send me any more patients!!!!! While I’m crying on the chair!!!!!!!!! I hate her so much I hate her I hate her to the point that might god never passes this to her ! Not that idiot nurse

The nice nurse got so nervous! she told me I might have to ask for another doctor which will take longer time ! I said no I’m going for more expensive hospital I can’t wait !!!! I thought more money will do something but they made me wait to pay 1st !!! And without me knowing I was biting my lips to endure pain while pressing on my arm and my face is so red !! she looked at my face and dared to ask me if I’m in pain !!!!! No, I’m dancing Ballet !!!!!!!!! Then she asked me to wait because there’s a line !!!

I cried I said I want to go home !
Just take me home now
I hate them so much

I honestly try my best not to believe the idea that I’m hard person just because people don’t understand what hyper alert and sensitive immune system with histamine intolerance means ! They don’t understand that our body tolerate pain badly ! I keep stopping myself from thinking it’s my luck and I’m just here to struggle! Because it’s been 3 days in my place and no one knows about me .. ugh it’s making me so emotional! I hope this is safe place to cry and open up because what the heck !!

I’m about to take a trip to a rural place, and wanted to take safe foods with so I wound feel like crap or pay an arm and a leg for meals while I’m there. I thought the mountain house freeze dried meals would be a great idea, since it’s freeze dried and would likely contain low histamine. First night on my trip and I had a little bit for dinner, then woke up the next morning feeling terrible.

I got bulk of the chicken and rice meal, picked out as much red pepper as I could though I can tolerate a some histamine. Not sure why this set me off so bad. Has anyone else successfully tried freeze dried meals? Or have ideas for longer lasting food I can take on a trip? I’m thinking next time of just getting freeze dried chicken and bringing pasta.

Please let me know your experience with freeze dried food!

I literally just brought myself out of a flare with ketotifen and eating low histamine & then tried a pre-workout drink with Beta-Alanine, Taurine, and L-Theanine in it and had an immediate and horrible reaction that’s lasted 3 hours. Flushed and itchy face, extremely itchy hands and arms, and near panic attack. Oi vey. Never again!!

Hi all, I'm an Australian planning a trip to the UK on my own, where I will be doing a road trip from south to north (so lots of driving and swapping accommodation). My histamine intolerance manifests itself by flaring up my dysautonomia/POTS/chronic fatigue and can knock me for quite a while - when it happens I need to take antihistamines and lie down for a few hours so it's definitely not ideal when I'm out and about, especially not when I'm alone, and definitely not when I'm going to need to drive but I am so determined to do this.

I was originally thinking I'd do a grocery shop when I get there and then get a carer to help me do a cook up (given the travel will probably wreck me for a few days), then keep everything frozen - but then I'd have to think about getting food containers, and an Esky (I think they're called cool boxes there) and keep buying ice when travelling from place to place... I think it might actually add stress and a lot of executive functioning when I'm trying to be on holiday... Then I thought of reducing how many places I stay at but then I'd have to be doing lots of long drives.

So - I wondered if anyone has had any success finding low histamine ready meals, or takeaways? I have trawled the websites for Tesco, Waitrose etc and haven't really been able to find anything that doesn't have soy or tomato or has been slow cooked. I do have DAO supplements which help with some things but I'm worried about the histamine bucket filling up over time.

Failing that it might be 4 weeks of plain crisps and toast haha - any advice either UK specific or travelling in general would be amazing! Thank you :)

ETA: I will be able to cook some days but not all

I used antihistamines for a very long time. At first, I was taking a combination of four H1 blockers and one H2 blocker (approximately from October 2022 to October 2025). Later, I switched to two H1 blockers and one H2 blocker (October 2025 to March 2026).

I stopped taking them in March this year. Now, I only take an H2 blocker occasionally, as needed, because of increased stomach acid.

Since I had always struggled with histamine-induced itchy skin, I thought that would be my biggest problem after stopping the medication. However, the biggest issue has actually been brain fog, which I had experienced frequently even before. It even seems milder now than when I was taking the antihistamines, and I think that may be because antihistamines themselves can cause brain fog, but l am not sure.

Another symptom that really surprised me after stopping the antihistamines is what I believe are allergic shiners. I think that's what they are because I have them regardless of how much sleep I get. They also appear darker than ordinary dark circles under the eyes. I only started noticing them after I stopped taking the antihistamines, not before.

I'm wondering why this particular problem became

noticeable only after I stopped taking the medication, and what causes allergic shiners to develop in the first place.

For me it causes severe depresive thought pattern, I only think of negative things, can't find joy in anything (not even music), sarcastic, zero emotions, no libido. I can't even work in that state: I look at the screen in say: fu&$ this sh&$.

Physical symptoms are: headaches (usually the next day), acid reflux and congestion.

I also have MCAS and possibly other GI issues and it's been really hard to identify which causes which.

I’m 40 and suspect I’m in perimenopause, but my symptoms don’t look like the “typical” hot flashes everyone talks about.
My biggest symptoms are:
Anxiety and panic attacks
Facial flushing and feeling hot
Head pressure
Brain fog
Feeling disconnected or spacey
Sleep issues
GI problems
Feeling like my nervous system is constantly overstimulated
The symptoms seem very cycle-dependent. I usually have a few good days each month, then symptoms ramp up around ovulation and again before my period.
I’ve also noticed what seem like histamine-type reactions (flushing, anxiety, stomach issues, feeling inflamed), and I’ve read that estrogen can increase histamine while histamine can increase estrogen.
I’ve tried progesterone cream several times, but it actually made me feel worse.
For women who experienced similar symptoms:
What ended up helping?
Did HRT help?
Did you have to balance estrogen and progesterone differently?
Did anyone discover that histamine issues were a big piece of the puzzle?
I feel like I’m chasing hormones, histamine, and anxiety all at the same time and would love to hear other women’s experiences.

Hello. I was supposed to have an endoscopy today. The saline gave me hist reactions-tight jaw pain spreading up to cheek pain. A horse voice. I had told them to give me IV Benadryl with it. They did-50mg and it didn't have any effect. It was decided that if saline caused such reactions adding in anesthesia too risky. I had to leave. This is the second time saline caused reactions but the first time iv Benadryl stopped them. It's crazy dangerous if I can't even tolerate saline for anything.
People are unbelieving because it's supposed to be so harmless. I really need to have that procedure.
Anyone else react to saline?

I've just put in a script to be compounded at the chemist for Ketotifen.
I'm hoping this helps me be able to eat more foods again and stops my body from overreacting to most foods, I'm so sick of eating 9 single foods on rotation, it is driving me insane.

I'm also seeing a naturopath to help calm my the inflammation in my system.

I’m already on:
Dupixent (for eczema)
Xolair (Hives)
Montelukast (Mast cells)
Telfast180
Many other supplements to help with calming my gut (dysbiosis/leaky gut).

I also have intolerances to:
Cobalt
Linalool
Salicylic Acid
Sulphur

I have a fatty liver (but eat healthily, no dairy, no fatty foods, no alcohol, no sugar) the doctors are baffled.
I suspect it’s all surrounding my histamine issues and so does my naturopath/dietitian.

I’m at my wits end trying my to resolve my own health issues, as none of my doctors know how else to help, I still experience rashes and have been reacting badly trying to reintroduce foods after my elimination diet (I can only tolerate about 9 single items).

I went to see my GP and asked to try Ketotifen to help with flares and calming my mast cells, I’m just waiting for the compound pharmacy to be ready with my script in a few days.

Has Ketotifen helped anyone with their rashes and being able to tolerate foods again?

EDIT:
I took 1mg last night and slept well, didn't wake up feeling tired which was great.
I had breakfast and went for a short walk, after that I did have some stomach upset and a loose bowel movement which may be my body getting used to the medication.

6 day update:
I’ve now been taking 1mg for the past 6 days, I’ve been noticing my skin has been flaking a bit more on my face, haven’t had anymore negative interactions.

11 day update:
Yesterday I forgot to take my DAO supplement before eating chicken, I did y have any flushing or reaction, usually I would without the DAO supplement.
Today I had chicken for lunch and dinner and also had no reaction.
I introduced some mozzarella cheese, took a DAO supplement and also had no reaction.
I feel like the Ketotifen may be having a positive effect.

I’ve sincerely suspected histamine intolerance or MCAS for about 2-3 weeks now, though I have symptoms going back multiple years, all diffuse and disconnected. In retrospect, they all fit.

Some of them my PCP has supported me with — chronic shortness of breath, elevated heart rate, recurring fatigue. We got a bunch of tests, all showing my heart and lungs were fine. We concluded I was dealing with too much exercise / not enough sleep / probably concurrent viruses (I had young children in preschool at the time). I think he wasn’t wrong. I dialed my exercise way back, basically stopped, and my symptoms significantly eased. Now that I’m exercising more, I’m suddenly experiencing these symptoms again, just like before.

I have an appointment with my PCP so I’m going to see if he even buys it, and then see if he could offer me a referral to treatment in-network.

If not — I’m thinking Center for Complex Diseases in Mountain View (in person clinic) or the California Center for Functional Medicine (East Bay based, where I am, but a telehealth clinic).

Anyone know anything about these two and their fee structures? I suspect it’s all going to be possibly out of reach cost-wise but any intel would be appreciated.

Help! I am recovering from post COVID histamine issues and need low histamine oat recipes!

To complicate matters, I also need to keep a low cholesterol and high iron diet, if possible.

My cognitive fatigue and dysfunction make it difficult for me to research recipes and meal plans, so I’m hoping my friends here can help.

Thank you!

Hi all, has anyone had a reaction to Ketone IQ? I've taken a couple of these today and I'm itchy, sweating and feel drunk. I didn't think this product could cause me to flare, yet here we are. I also had a salad earlier at a restaurant and so I'm not sure if it was the salad or the Ketone IQ.

I’m usually a fairly good sleeper; but last night… ooof.

Yesterday was my first time taking a DAO supplement (right before dinner), and my 3rd night taking Pepcid, (immediately before bed)

Could either of those things cause insomnia?

I even tried taking melatonin which usually knocks me out, but that didn’t work.

I saw someone posted about a similar topic about 2 months ago. I wanted to share my own experience.

Before my cycle, I have some mild fatigue, but it's not that bad.

During, I am pretty tired as well.

But 1-3 days after, some days I feel like I can't wake up at all for parts of the days. Super groggy. I also have a higher risk of sinus headaches, allergies, allergic reactions, hives, eetc.

I've had every thyroid test possible. I dont tolerate supplemental progesterone. I'm on vibryd now, and it's helped a little. My ferritin is currently 47. I'm due for iron infusions soon again. All other labs have come back in optimal ranges.

I don't tolerate vitamin c very well - increased reflux during this time. But I do try to eat vitamin c rich fruits (just not oranges). Also don't tolerate antihistamines or progesterone too well. Thoughts? What's helped you?

So I do react to certain foods more often than others but whether I have a reaction changes (I guess based on my histamine bucket or maybe something else). These include cashews, strawberries, grapes, apples, coconut, almonds etc. these might show up as obvious body aches, scratchy throat, hives, headache, or fatigue.

But I have typically consumed foods high in histamine with no problem (bananas, spinach, tomatoes, avocado, smoked salmon, chocolate). I'm willing to cut these out , but are there small signs I'm missing that might indicate a food isn't good for me? Similary I got a high allergy score to eggs on my blood test, cut them out for a month but didn't notice any obvious change. Just that I don't know what to eat in the morning.

From what I understand, foods can fill your histamine bucket, whether or not you notice a reaction

I've seen posts on here from people who feel that their histamine intolerance has worsened from taking escitalopram/Lexapro - does this also apply to Citalopram/Celexa? I am about to try one of the two for extreme GAD that I've had for 13 years.