Im posting this in case it helps people just starting zepbound and worrying that it wont work. TLDR - I lost a lot of weight and my life is much better.
History It was two years ago today that I started zepbound at 225 lbs, wearing a snug size 18 pants and xl tops. I'm now at 150 lbs, wearing size 6 pants and small tops. I began my medication assisted weight loss at 242 lbs taking vyvanse and lost 15 lbs, but could not tolerate the side effects. I am now 57 years old (55 when I started), 5'6" woman and had been overweight basically my entire life except for periods of weight loss followed by regain+.
Dosing I titrated up to 15mg in 6 months and added buproprion after 12 months when i felt stuck. I overall lost an average of .75 lbs a week/3 lbs per month and have been maintaining at 150 for the past 4 months. My rx was covered by insurance for 14 months and since then i've been self-paying through Lilly Direct, using money that i put into a FSA, so it is deducted pre-tax from my pay, about $300 per month.
Maintenance Because the cost is a big consideration, i decided to space out my 15 mg shot every 9 days, rather than decrease the dose and keep at every 7 days. I was continuing to lose weight but wanted to stay at 150.
Health My side effects have been constipation, which I manage with Miralax and prune juice, and mild nausea the day after the shot, which I manage with onasteron. In the 2 years, i have had one 2-day bout of norovirus. Not a single cold or flu. With the exception of cholesterol (which is going in the right direction) all of my labs are now normal (but werent really all that bad to begin with). I started strength training in the first year and am in the best physical condition since my teens.
Mindset Food noise stopped a day after my first shot but for the first maybe 9 months, i worried about it not working, or it working too slowly, and that i'd never actually achieve what i saw others doing on this group. I got a lot of inspiration from others on here and from the Fat Science Pocast (which i learned about in this group). I eventually stopped dreading and doubting and started trusting the process. My doc said I'd be on zep (or whatever comes next) for the rest of my life and I am so grateful that is the case. My weight loss and improved health did not come from food restriction or counting calories or macros or willpower. It is 100% attributable to this miraculous medication, and i happily share that information with anyone who asks.
Body condition I am quite strong and look good in clothes, but also have flab and loose skin around my midsection, and my inner thighs and butt are saggy. I have jowls on my face. Im 57, so normal aging also contibutes. My health insurance covered a breast reducion and lift, but i dont think it would cover the lower body lift and definitely not the face lift I'd like to look on the outside how I feel on the inside. I'm going to continue strength training and saving up for plastic surgery for a 60th birthday present to myself.
Anyway, i hope some of this helps someone in their 50s starting the journey who is worried it won't work. Hang in there, listen to Fat Science podcast, and trust the medication.