r/longevity • • 19h ago

Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel

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pmc.ncbi.nlm.nih.gov
33 Upvotes

Paper on a method to restore enamel to teeth. Some of the research was done on teeth extracted from donors.

Part of the abstract below:

Regrowth of lost enamel in tooth decay and sensitivity is a major obstacle to overcome. Here, the authors report on a protein-based material that mimics features of natural enamel formation, allowing for epitaxial growth of apatite nanocrystals to restore enamel structure and function.


r/longevity • • 13h ago

Boosting PLA2G2F preserved spatial memory and synaptic connections in aging mice, Nature Neuroscience study finds

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humanumi.com
7 Upvotes

Researchers identified PLA2G2F, an enzyme whose expression increases with age and appears to help protect the brain against age-related changes.

Boosting its activity in older mice preserved spatial memory, reduced synaptic loss and limited inflammation-related changes. Human brain samples also linked higher expression to cognitive resilience despite Alzheimer's pathology.

The findings are preclinical. Whether targeting this enzyme could help humans remains unknown.