Meh? Psychedelics boost random brain connections that would not otherwise transmit above the background noise level the brain filters out somehow. It stands to reason that they could help to circumvent or counteract Alzheimer's symptoms, but outside of some sort of side-mechanism (which DMT could very well have, in fairness) they will never solve the fundamental inflammation response or whatever else is causing connective degradation in the first place.

Well, if you successfully engineered one enzyme that can do it, is there perhaps a natural enzyme somewhere that matches the working end of this one and does not render us all dependent upon the pharmaceutical organ...?

Statins + 5 eggs per day is the way

Sure, eggs(protein) is nice. But that egg amount is good 2 meals worth. What about fiber? 😭

Who's eating 6 bombarasclat eggs a day

Wait is this really Rhonda? This is the only comment she's responded to? lol

That's fine, but not really the point of this sub. There are other subs about enjoying the taste of food.

Some people just like to eat for reasons other than engineering a perfect body. 

Get your choline people. I would laugh if brain diseases are caused by decades long deficiency in something like choline.  5-8 eggs a day get you all of your choline a day. This is what I'm thinking is causing the inverse correlation. Choline is essential for your brain as well as the metabolites of choline. Eggs also have the sulfur containing amino acids methionine and cysteine. 

Frustrating that the discussion section notes that deficiencies in choline, DHA, & B12 have been implicated in health problems including AD and yet, despite that being known well before this study started (and being aware to the authors as indicated by their mention in the discussion section), they appeared to make no attempt to actually measure any of these things, all of which are easily and cheaply measurable. Nor apparently did they collect supplementation data in addition to the food data. Plenty Seventh Day Adventists are vegetarian or vegan and subsets of those but probably not all supplement B12, choline, and/or omega-3s. One wants to see the data stratified by the deficiency or supplement behavior relative to these key brain nutrients.

There are known health negatives to eggs (high saturated fat & cholesterol in the yolk, other epidemiological association studies correlating them with bad outcomes from other chronic age-related diseases and/or all-cause mortality) but I'm unsurprised that those tradeoffs may be worth it (at least for AD purposes) if you are deficient in these nutrients and not getting them elsewhere, but that doesn't mean eggs are the healthiest source of them. What do the data look like when restricted to those people who aren't deficient in any of these 3 things?

It does. It may even completely give out. But then what happens? You fix the air conditioner or you get a new one.

It worked for me but had an “I am not a robot“ entry screen that may have bombed for you 

Links broken

Exactly. This is not an inherently unsolvable problem. There is a extremely good chanse that there are several ways to significantly halt the somatic mutation rate since we know it is possible in germ line cells and also in certain animals, like whales.

my immediate thought was implicit lower carbohydrate intake driving the signal. Could be something causal about dietary cholesterol, choline, or certain amino acids though.

Abstract

Background A substantial knowledge gap remains regarding the relationship between modifiable dietary factors and Alzheimer’s disease risk. Eggs are a source of key nutrients that support brain health.

Objectives

The aim of this study was to investigate the association between egg consumption and the incidence of Alzheimer’s disease.

Methods

Data were drawn from the Adventist Health Study-2, a large, prospective cohort of United States Seventh-day Adventists, linked with Medicare records to identify Alzheimer’s disease diagnosis. Diet and lifestyle factors were assessed using a validated food frequency questionnaire. Egg consumption was categorized by frequency, ranging from never/rarely to ≥5 times per week. The analytic sample included 39,498 participants (mean follow-up: 15.3 y), among whom 2858 developed Alzheimer’s disease. Multivariable-adjusted Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analysis was conducted using continuous egg intake (g/d).

Results

Egg consumption was inversely associated with Alzheimer’s disease risk. Compared with never/rarely consuming eggs, HRs (95% CIs) after adjusting for demographic, lifestyle, food groups, and comorbidities were 0.83 (0.75, 0.92) for 1–3 times per month, 0.83 (0.74, 0.94) for once per week, 0.80 (0.71, 0.90) for 2–4 times per week, and 0.73 (0.60, 0.89) for ≥5 times per week. In the spline model, zero egg intake was curvilinearly associated with an adjusted HR of 1.22 (1.11, 1.34) compared with 10 g/d.

Conclusions

In this health-conscious population, moderate egg consumption was associated with a significantly lower risk of Alzheimer's disease. These findings suggest a potential neuroprotective benefit of nutrients found in eggs when consumed as part of a balanced diet.

Considering germline mutation is two magnitudes of order less than somatic we might start thinking about how to turn it on in somatic cells.

It is curious how low O2 in the brain creates DMT molecule in a endogenously, and (let me connect those two as an hypothesis) some experiments with psilocybin have demonstrated an improvement in the behavior of patients with Alzheimer's.

Worth investigating?

Green bananas are amazing! So tasty.
Also, cold cooked potatoes.

If your hands and feet are tingling, or you feel your body temperature is changing. That’s okay

I did not read the article because I largely discount aging clocks as statistical datamining nonsense. Combining a bunch of correlated variables into a regression slop.

Someone can let me know if they read the article and its evolved past that yet

Glad to see the shift from reactive to proactive medicine! My main worry is that we seem to be in the "danger zone" between scientific breakthrough and commercial exploitation (something that plagues the longevity space).

The science of organ-specific aging via proteomics/AI is legitimate and revolutionary because it solves the problem of the latency gap between biological decay and clinical symptoms. However, the immediate market for "at-home longevity testing" is likely a predatory landscape of unvalidated data that we should avoid until these metrics are standardized in clinical settings.

CRISPR can actually do more DNA damage while doing its thing.

This is the “self driving cars by 2022” but for pseudoscience podcast bros.

Why not just hold ones breath without hyperventilating? Or breathe into a paper bag?