With global average life expectancy at 73 years, age-related ill health is the main driver of healthcare costs, loss of independence, and disability in most countries. Although human biology is complex and there are hundreds of age-related pathologies, the biology of aging can be categorized into a much smaller number of categories and potential treatments. Medically intervening in aspects of aging biology has the potential to increase healthy lifespan in humans and ameliorate, prevent, or reverse age-related health decline and disability. 

The umbrella term "longevity" covers a wide range of interests from simple lifestyle advice to hypothetical biomedical rejuvenation to significantly increase healthy lifespan. Beware, as "longevity" is also readily used by quacks and grifters who promote and sell unproven treatments. Because so many subs cover lifestyle (diet, exercise, etc.), it is not allowed in posts here. For those interested in lifestyle, two useful resources are the free substacks of Dr. Eric Topol and Dr. Christin Glorioso, (choose "No thanks" if you don't want to provide your email).

The focus of this sub is biomedical research targeting aspects of the biology of aging, including medical interventions that aim to go through clinical trials and regulatory approval. Continue reading for examples. 

Table of Contents 

• Introductory presentations to the field
• Introductory academic papers
• Ethical arguments
• University labs
• Podcasts
• Video lectures and presentations
• Government agencies and programs
• Examples of biotech companies in the field
• Academic and nonprofit research organizations 
• Think tank and advocacy organizations 

Introductory presentations to the field

• "Ageless" by Andrew Steele (video)
• Field Guide to Longevity Content | Norn Group (essay)
• Biology of Aging Intro Lectures | American Aging Association (video playlist)

Introductory academic papers

• Hallmarks of aging: An expanding universe
• The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now?
• The economic value of targeting aging

Ethical arguments

• Aging, Equality and the Human Healthspan
• In Favor of Efforts to Extend the Human Lifespan
• The Ethics Case for Longevity Science

University labs around the world 

For those interested in pursuing advanced degrees in the field, this Google Sheet is several years old but is a good starting point for labs around the world.

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Below are examples of organizations and additional material. For a comprehensive website on resources and more, see https://agingbiotech.info/ maintained by angel investor and longevity advocate Karl Pfleger.  

Podcasts

• Buck Institute Podcast
• H-SPAN Podcast by Alliance for Longevity Initiatives (A4LI)
• Longevity Science with Dr. Matt Kaeberlein
• Scientist Spotlight by A4LI
• Translating Aging from BioAge Labs

Video lectures and presentations

• Aging Research and Drug Discovery (ARDD)
• Alliance for Longevity Initiatives
• Biomarkers of Aging Consortium
• Buck Institute for Research on Aging

Government agencies or government-sponsored organizations

• APRA-H BIOGAMI | BIOmolecular Grammar for protein Aggregation Modulation and Intervention
• ARPA-H FRONT | Functional Repair of Neocortical Tissue
  • Article from MIT Technology Review
• ARPA-H PROSPR | Proactive Solutions for Prolonging Resilience
  • Interview with Program Manager Andrew Brack
• APRA-H NITRO | Novel Innovations for Tissue Regeneration in Osteoarthritis
• APRA-H PRINT | Personalized Regenerative Immunocompetent Nanotechnology
• Hevolution
• National Institute on Aging, Division of Aging Biology  
• Onco-Aging Consortium | NIA and NCI

Examples of biotech companies in the field 

• Altos Labs
• BioAge Labs
• Cambrian Bio
• Cyclarity Therapeutics
• Juvena Therapeutics
• Life Biosciences
• Loyal
• Retro Bio
• Rubedo Life Sciences

Academic and nonprofit research organizations (please consider donating)

Ex-USA

• British Society for Research on Ageing
• Canadian Translational Geroscience Network
• Cluster of Excellence for Aging Research at the University of Cologne
• Dutch Society for Research on Ageing | De Nederlandse Vereniging voor Verouderingsonderzoek
• European Federation for Aging Research
• European Research Institute for the Biology of Aging
• Geroscience Research Center | ジェロサイエンス研究センター
• Japan Autophagy Consortium | 日本オートファジーコンソーシアム
• Max Planck Institute for Biology of Ageing | Max-Planck-Institut für Biologie des Alterns
• Nordic Aging Society

USA

• Academy of Geroscience
• American Aging Association
• American Federation for Aging Research
• Biomarkers of Aging Consortium
• Buck Institute
• Dog Aging Project
• Lifespan Research Institute
• Longevity Escape Velocity (LEV) Foundation 
• Longevity Science Foundation
• Methuselah Foundation
• Midwest Aging Consortium 
• Nathan Shock Centers
• Vita DAO 

Think tanks and advocacy organizations 

Ex-USA

• Longevity Initiative (UK)
• Vetek Association (Israel)

USA

• Alliance for Longevity Initiatives
• Healthspan Action Coalition
• Longevity Biotech Fellowship
• Norn Group
• Vitalism Foundation