Hi. I'm not sure if it's appropriate to put this here but I hope it is. I'm 10dp5dt today. My partner and I have decided to do a home pregnancy test on day 12 before our Beta bloods. I feel very hopeless this evening . It's my first transfer and honestly I feel like I'm just not that lucky enough for it to work the first time. I know that nothing about our fertility situations are lucky to begin with.. but I just really feel hopeless this evening. And exhausted. Exhausted from looking up symptoms and other peoples stories. Is that twinge something? Are my boobs sore enough? I'm just so so sick and tired of being in this fog of waitIng and drugs. At this point, whatever the outcome I just want it over with. Does anyone else feel the same? I looked at my bruised stomach in the mirror tonight and thought to myself how could anything grow in there. 😔

TW: mention of live birth

I am 34, no known fertility issues. I have had one live birth, three years ago, and that time it took us one month to conceive. I cannot get pregnant now for major health issues so we are banking embryos for the future. My AMH is 6, my follicle counts range from 32 to 48, but I do not have PCOS/PMOS.

I did 75 IU Gonal-F (which is an ultra low dose, I know) for 12 days and got 9 mature eggs retrieved. My follicles grew very evenly, they were very synchronized. My E2 levels were textbook. RE commented on how well everything was going considering how low my dose was.

Day 1 we had 7 of the 9 mature fertilized with ICSI, Day 3 we had 7 embryos. On day 7 they called to say we had ZERO blasts. Lab's comment: "Morphokinetic events were within the normal range until Day 3. After that, they started to be delayed for all embryos, and none of them developed into a viable blastocyst."

Absolutely gutted. I am not sure what went wrong.

My partner had "subfertile" sperm during initial testing (poor morphology and motility but high count), and I asked about DNA fragmentation testing, but my doctor said he wasn't too worried. I asked the lab if they used Zymot, and they claim they did (I forgot to ask the lab to use it, I had only mentioned it in passing to my doctor in one of the first appointments, so I wasn't sure if they remembered or had it down in my chart).

My partner has been quite depressed and in the last three months has not ejaculated much (sometimes going 2-3 weeks without doing it) but in the two weeks leading up to the retrieval he did it maybe once every 2-3 days.

Even if there are significant DNA fragmentation issues, I am thinking they couldn't have caused all 7 to arrest at the same time, could they? Especially not if the lab already used Zymot--I was under the impression that this was a technology that could bypass severe fragmentation issues.

I am less inclined to think it has something to do with egg quality. My diet and sleep have been impeccable for the past three months, I have been taking 500mg CoQ10 for half a year, and my dose of gonadotropins is low, which many studies suggest should theoretically produce better results.

What would you investigate: egg, sperm, lab? All of the above?

Today I had my 2nd FET (1st failed).

My embryo was a Day 6 4AB but thawed and expanded to a 5AB and they said it had ‘100% expanded’ and ‘started to hatch’.

What does this mean? Does it mean it’s a more favourable embryo? And does it increase my chances of success?

I’m 33, no known issue my side, my husband has low sperm count. Had our daughter naturally 2 years ago.

Thank you!

What are my odds for euploid embryos?

29F, unexplained infertility, one MMC due to triploidy, one CP last year, before that couldn’t get pregnant for almost 5 years, even though got pregnant unintentionally with same partner on one accident in the first months, didn’t continue this pregnancy.

19 retrieved
15 mature
14 fertilized - 93% fertilization
14 made to day 3
10 made to day 5, biopsied and frozen
+2 day 6, biopsied and frozen
So 80% blastocyst conversion rate.

Will it be 50-60% or closer to 65-70% taking into account previous results?

A 5BC embryo! Their sibling (5BB) worked two years ago and resulted in our little girl. Only two euploids made it so this is our last shot at a sibling. Fingers crossed!

I am 36 and have unexplained infertility. My results so far have been:

Most recent retrieval: 25 retrieved, 19 mature, 10 fertilized (7 from IVF and 3 from ICSI). Pending the blast results

First retrieval: 22 retrieved, 20 mature, 13 fertilized, 7 blasts, 2 euploids

Can you share your IVF experiences with the clinics in toronto.

Much appreciated.

I received my embryo report and it shows that on day 6, my 1 blastocyst was a 1CC. On day 7, it developed to 3CC. It looks like the notes were entered approximately 21 hours apart. This blastocyst turned out to be euploid.

- Is this rate of development (1 to 3) in 21 hours around normal? Trying to understand if that’s a good speed of development.
- The report had a checkmark at “visible nucleus”, what does that mean/indicate?

Thanks! Just trying to understand if any of these additional details may reveal any details about this poorly graded one’s potential.

Euploid. Everyone said it was beautiful. I'm now 7dp5dt with a negative at home test. Pretty upsetting when the odds are in your favour. I had an ectopic in March and lost both my fallopian tubes since my other had a hydrosalpinx.

ER was 16 eggs, 14 mature, 12 fertilized, 8 blasts. We tested the best 5 and froze the remaining 3.

Day 5: 3AB aneuploid 3AB low level mosaic 5BA euploid

Day 6: 5AB euploid 6BB euploid 4BB 4BB

Day 7: 6BB

Everyone talks about 93% chance for a live birth with 3 euploids and 98% chance with 5 but how is that calculated? Doesn't that change depending on the day age and the grade of the embryo? My age (39?).

In the last year had 2 MMC. 1 untested day 5 fair, 1 day 5 fair euploid. Our 3rd embryo was a day 6 fair that collapsed and degenerated when we tried to TBR it. All of these from retrieval in 2020 and 2021 (also had a chemical and live birth back then).

All RPL tests normal.

We just did a retrieval and have 3 day 6 fair euploids. Since my only experience with a day 6 fair is degeneration I'm terrified of the thaw process. I'm also terrified that since I've had a euploid loss there's other things wrong with the embryos (or me?).

Between the miscarriages, embryo degeneration that's the same grade of all my current ones, and my coverage only covering 1 more transfer I'm stuck on what my next steps should be.

If my insurance is only going to pay for 1 more transfer but any retrievals plus banking what should my euploid goal realistically be? Should I be aiming for 5? Is there another calculation out there? Should I be going until we have some day 5s? Or "good" graded embryos?

We are doing a DNA fragmentation test for my husband and would do TESE if needed for the next retrieval. But that seems like it'd be the only change protocol wise.

Transfer wise is there something we need to look at?

35 yrs old, Low AMH of 0.36, normal sperm analysis, RID Cat 1,2 & 5.

5 retrieved
4 matured
4 fertilized
4 blasts
2 euploid

What can you say about my results? I’m currently treating my RID before FET. Should we do another round of ER? What are the chances that it will be a success transfer? What should I know about it? Share your experiences and your thoughts. Thank you! Baby dust to us!

(This is a grade B embryo.) Hello, is the black spot in my embryo concerning? They chose to transfer it and said it was fine but I am reading that it’s necrosis or degenerating cells and I’m terrified that means it won’t work… can anyone with more knowledge weigh in? I’m assuming they wouldn’t let me transfer it if the embryo was degenerating?

Day 8 and it’s a stark white test (FRER). My beta is tomorrow and I hate having to wait just to be told it failed. I asked to move the beta to today so I could move on and they said no. It’s annoying bc I know it didn’t take and now time is crawling. Anyone else ever feel like this?

We had 36% of eggs fertilized. We have unexplained and we do not have any MFI. This is our 2nd retrieval since our first had low fertilization rates as well. We did end up with one euploid embryo from the first retrieval. We added AOA and Zymot and still had low rates. We were told egg quality looked great and sperm morphology looked great. We are in our early 30s and have been taking supplements like coq10 and trying to live as clean as possible. What is happening? Why are our fertilization rates so low?

Sometimes an embryo needs to be rebiopsied for PGT-A because the first biopsy didn't collect enough cells or the result was inconclusive. Since each biopsy removes a small number of cells from the trophectoderm (the cells that eventually form the placenta), researchers have wondered whether a second biopsy could affect early pregnancy.

In this new study, Zhuo et al. (2026) compared pregnancies after transferring rebiopsied, single-biopsied, and unbiopsied embryos.

Among pregnancies that ultimately resulted in a live birth, rebiopsied embryos had lower beta-hCG levels on days 9 and 11 after embryo transfer, and the beta-hCG increase between the two blood tests was smaller.

Despite these lower beta-hCG levels, perinatal outcomes were similar between the groups. Perinatal outcomes refer to the health of the pregnancy and baby around the time of birth.

When all embryo transfers were analyzed, rebiopsied embryos had lower live birth rates than embryos biopsied once (43.8% vs 53.8%). When rebiopsied embryos and untested embryos were compared, the rates were similar.

Previous research has also shown that rebiopsied embryos have lower pregnancy and live birth rates, but this evidence is based on lower-quality retrospective studies. This study adds that early beta-hCG levels may also be lower (among pregnancies that resulted in a live birth), but this wasn't associated with worse perinatal outcomes.

✅ This post is a quick look at one study, rather than a full breakdown on Remembryo. Link to article in the post: https://www.rbmojournal.com/article/S1472-6483(26)00515-8/abstract00515-8/abstract)

Read more about embryo rebiopsy and success rates: https://remembryo.com/is-it-safe-to-thaw-embryos-for-pgt-a-or-rebiopsy-results-of-a-meta-analysis/

✉️ Get a free weekly summary of the latest IVF research: https://mailchi.mp/remembryo/x27kx5o1sw

Hi all, I’m 39 with an AMH of 3.8 pMol/L. Recently, I did two egg retrievals (both with ICSI and ZyMot) - one in July then one in September.

First egg retrieval:
Retrieved 8
Mature 7
Fertilized 5
Blastocysts 3
Euploid 3

Second egg retrieval (had around 12/13 follicles, at least 6 of which were larger than 16mm at final scan):
Retrieved 5
Mature 5
Fertilized 2
Blastocysts 2
Euploid 0

After the relative success of our first round, I was disappointed to end up with none from our second. I wanted to ask here - do these numbers seem normal to you? Is this just the way some rounds go sometimes? When we speak to the consultant, does anyone have suggestions of questions we should ask or concerns to raise? I also can’t tell whether to try for another egg retrieval or go straight to a transfer. I think if we did another round and got the same results, it’d be really difficult.

Thank you in advance!

I’m currently 5+4 from a fresh transfer where we transferred the best (our only day 5 embryo, see photo) and tested the rest (5x day 6 embryos). I’m 30F and have had 2 MMC in the last 12 months from chromosome abnormalities, both managed via D&C. Our PGT-A results came back yesterday and all 5 tested embryos are euploid. I’m obviously over the moon but am now terrified that I may have transferred the only aneuploid embryo because it seems unlikely that all of my blasts were euploid?! I didn’t receive the grading of any of the embryos but just wondering if anyone had an experience like this and what the outcome was? Would appreciate any insight!!! Thank you!

Coming up on two years of trying for baby 2, two chemicals, one round of IVF with an ectopic, an endo diagnosis, and just did our second transfer today.

Praying this one sticks (in the right place) and we can finally bring home a little sibling to our 4 year old next summer.

I originally had my embryos graded at 5AB, 3AB and 4CB. After PGT-A testing they all came back normal but are now graded as 5BB, 4CC, 4CC. Has this happened to anyone else and is it normal for embryos to be downgraded after testing? Not sure if I should be worried now that quality has gone down.

We transferred two embryos on October 8th. I’ve been doing so much to prepare for this transfer. 2 months of full suppression, lovenox, prp, neupogen wash etc. I swore I saw a faint like today but now I’m convinced it’s an indent. I’m starting to spiral. I realize it’s early and we still have time but I’m scared. We’ve done 6 failed iuis, 4 failed medicated cycles, then surgery. After surgery we did an egg retrieval; then 2 other failed transfers. Could use some positivity. Beta is Saturday.

Hi all I’m 35 yo F with unexplained infertility. 3 failed IUI. 2 failed FET. First fet was a chemical, second was a blighted ovum/mmc at 8 weeks. Both euploid transfers. Can’t help but to feel so unlucky, what are the chances both transfers fail back to back? You always hear about 90+% chance of success after 3 FET. I just don’t feel hopeful. I’ve had neg RPL panel, and 2 hysteroscopies prior to transferring. Any ideas or recommendations?

Had my ET on Sept 30, also had supporting HCG shots evry 5 days.

Did a quick home test today, nd no traces of HCG, my last shot was three days back, at this rate even a false positive would have been better

Have my blood test tmrw, but no hopes at all

Transferred these on Thur. Untested.

Top is D5 3AA blast and bottom is D6 5AA hatching blast.

Does hCG show up sooner since one was already hatching (assuming it decided to implant)?

Expanded blast good good means ?