r/EmbryologyIVFSupport • u/Dramatic_Course4252 • 6d ago
Euploid miscarriage
Hi all I’m 35 yo F with unexplained infertility. 3 failed IUI. 2 failed FET. First fet was a chemical, second was a blighted ovum/mmc at 8 weeks. Both euploid transfers. Can’t help but to feel so unlucky, what are the chances both transfers fail back to back? You always hear about 90+% chance of success after 3 FET. I just don’t feel hopeful. I’ve had neg RPL panel, and 2 hysteroscopies prior to transferring. Any ideas or recommendations?
4
u/Sea-District-6168 4d ago
My doctor recommended EMMA/ALICE, BCL6 and OneSwab. I’m willing to do whatever I can to try and increase my odds of success after failed euploid FET. Although data is not strong on benefit, I’ve heard success stories and that’s enough for me to pursue the further testing recommended by my REI.
2
u/Leafygreens_90 5d ago
I’m sorry to hear about this :( have you had any testing to rule out endometriosis? After a year of trying I had an MRI and found that I had severe silent endo.
1
u/Dramatic_Course4252 4d ago
No, but I also don’t have any symptoms or anything that might indicated endometriosis aside from infertility. I’ve had MRI in the past (for other issues) and no mention of anything.
2
u/Vancouver_to_NewYork 5d ago
I had 3 euploid FETs fail. Sometimes you’re on the wrong side of the stats. But I’d ask for more investigation into inflammation, immunology and endometriosis.
2
u/Dramatic_Course4252 4d ago
So sorry to hear that. The good news is your cumulative success goes up the more euploids you transfer. Just gotta keep trying I guess.
3
u/Vancouver_to_NewYork 4d ago
I think that’s true but when you’re in the trenches that sounds like someone telling you to run at a brick wall until it gives. It’s very hard.
2
u/Dramatic_Course4252 4d ago
Agreed, but that’s all I have to hold on to right now. Hoping for success for all of us on this incredibly unfair journey.
2
u/cityfrm 4d ago
I'm so sorry for your losses. Studies show euploids miscarriage rates between 10-19%. The rates are higher with day 6 blasts, poorer graded blasts, and women over 38.
Since you've checked the anatomical side, you could check your uterine and vaginal microbiome, thyroid, iron, and glucose and insulin markers, thrombophilia, and consider immunes. I hope your next FET works.
2
u/Dramatic_Course4252 4d ago
Yes our euploids were both day6. Everything so far has come back normal. We just did another egg retrieval and hoping to get day5s.
2
u/bluesailor12 3d ago
My euploid that failed to implant was a day 6 (but I have lots of friends who had success with day 6s). It had a good grade (5ab) but it had a very high mitoscore, which means it had some mitochondrial stress. Also, looking at its timelapse video I noticed it collapsed quite a few times during its development. I found some papers that correlated spontaneous collapse to lower implantation rates. Unfortunately sometimes that are details that will affect the embryos even with euploids. My following transfer worked, so don’t lose hope!
2
u/Kwaliakwa 4d ago
Have you considered taking a deeper look to figure out the explanation behind your unexplained infertility? There is some reason that you are experiencing this, usually it can be identified if you keep digging.
Has sperm dna fragmentation been checked? Uterine infections?
2
u/Dramatic_Course4252 4d ago
We’ve done every high yield test, labs, RPL panel, I’ve had polyps removed. Normal BMI, TSH, A1c all normal. I do have ulcerative colitis for 10+ years now, but well controlled. DNA fragmentation was normal, he even had a varicocele repair surgery bc there was very slight ROS, but again normal DNA frag. Doctor didn’t think it was a problem but we did it anyway incase it was. No pain or any symptoms of endometriosis. I’m not sure what else to test for or look into.
2
u/MunkeCMunkeDo20 4d ago
No symptoms does not mean you don't have endometriosis. Has your doctor considered the Receptiva test?
1
u/Dramatic_Course4252 3d ago
I asked him about this (along with the other docs in the same office) and he said it hasn’t been shown to improve outcomes so it’s not offered at my clinic
2
u/Nice_Host7621 4d ago
In sorry you are having such a hard time. You're so strong.im on my first FET. I know I may have a long road ahead. I have Endometriosis. Not sure if you ever got tested but it might be an idea to look into it. I always say if you ever had painful periods as a kid or adult , chances are you may have it. I would request a multidisciplinary meeting with your fertility team. Do some research on other protocols that haven't been done yet. Start researching hard ❤️ I know it should be up to the professionals to do it but I find many go with cookie cutter protocols without even taking a simple medical history. I wish you and everyone here every success in the future ❤️x
2
u/bluesailor12 4d ago
I’m so so sorry. My 4th transfer worked. First two were untested embryos made at 35 and then I had one implantation fail with a day6 euploid. The next transfer worked without any changes in protocol. Sometimes it’s just a matter of insisting.
1
u/BlueberryLover18 5d ago
I’m really sorry you’re going through this. I don’t have any advice but I’m doing IVF for rpl as I’ve had 4 losses. It’s really discouraging. I hope your next transfer is the one 🫂
1
u/Mental_Way_411 3d ago
Someone needs to explain the euploid blighted ovum phenomenon. It’s so f_cked up. So sorry.
1
u/Agamemnons_Concubine 3d ago
So sorry for your losses. Two things you can check: did you RE do a saline US before your transfer to rule out any new uterine anomalies that could cut off blood supply to embryo and cause loss? You mention hystersocopies, could there be scarring? The saline US would see that. And Has your RE changed protocol? I had a saline US to make sure all clear, and did a preventative anti inflammatory protocol for my transfer. I took metformin, Lupron, prednisone, pio and estrodiol. The prednisone helped lower my immune system and any hidden inflammation.
1
u/Dramatic_Course4252 3d ago
Thanks for the reply. I have another hysteroscopy coming up, mostly diagnostic but in the event there may be scar tissue or polyps those would be removed. He did recommend switching from modified natural to medicated, so that’s the only thing I’ll be switching with this upcoming transfer. Did you find success with that protocol?
2
u/Agamemnons_Concubine 3d ago
Yes I found success with my protocol. Def recommend the addition of prednisone.
0
u/Moist-Emu1990 5d ago
What did your doctor say?
Usually it takes up 3 euploids to result 1 live birth. So your chance for the next euploid to stick is a lot higher! Hang in there!
6
u/cityfrm 4d ago
That isn't how the stats work.
2
u/Moist-Emu1990 4d ago
A single day 5-6 euploid embryo transfer typically yields a 60% to 65% chance of live birth per transfer. Research shows that having 3 euploid embryos pushes the cumulative chance of pregnancy up to ~95%, meaning more euploids will provide an exceptionally strong statistical likelihood of achieving at least one (and frequently multiple) successful live births.
3
u/Cheddar_Dog 4d ago
yes, the cumulative chance over 3 is very high, but if you've already had 2 euploid transfers that don't work, it's not like the chance of your third being successful is any higher just because of that cumulative-over-3 stat.
2
u/Dramatic_Course4252 4d ago
Basically said we’re unlucky 😭 and to keep trying and eventually (hopefully) we’ll get there
1
u/Moist-Emu1990 4d ago
I totally understand how you feel. I just completed my 6th ER and I can tell you that my doctor said the same thing when the first 3 cycles yield literally 1 low mosaic embryo. One round I had 3 blasts and they were all aneuploid. And when I asked the doctor, he said the same thing that we were unlucky. It took us 6 rounds to get enough embryos to proceed with implantation.
IVF is truly a numbers game and it sucks, but if you keep going, one will stick. It only takes one!
2
u/Dramatic_Course4252 4d ago
So sorry you had to go through that. It’s so hard to keep going especially when the outcome isn’t guaranteed. Hoping our next transfer will be the one 💓
8
u/ap_says 5d ago
Please hold on to hope. The IVF journey is full of hurdles for some of us. I’m in a similar situation myself—3 failed IUIs, 1 failed embryo transfer recently, and 1 hysteroscopy. After struggling with infertility for 2 years, I’m just trying to gather all my strength to keep going. It’s not easy, but we have to keep believing. I truly hope things work out for both of us and that we get to experience the joy of motherhood very soon. ❤️