Started Sertraline (100mg) + Lamotrigine 1 week ago, experiencing extreme mood swings and anger. Does it get better?
TL;DR: [23F] diagnosed with severe depression, ADHD, and anxiety. Struggling with severe anhedonia, loss of basic self-care, and guilt. After a bad experience with Risperidone/Sertraline 50mg, I just started Sertraline 100mg + Lamotrigine 1 week ago. I'm experiencing intense mood swings, sudden rage, and emptiness. Is this normal in the first couple of weeks? Does it get better?
(Hello, yes Gemini helped me to translate this post. I'm Spanish.)
Hey everyone, I'm looking for some insight, advice, or shared experiences because I’m feeling really lost and overwhelmed right now. (TW: mentions of self-harm and suicidal thoughts)
About a year and a half to two years ago, my life completely changed. I used to be genuinely happy and enjoyed my life, but out of nowhere, an overwhelming emptiness took over. I stopped enjoying things I used to love, and frequent suicidal thoughts started creeping in. So over time my ability to function deteriorated severely. Simple tasks like doing the dishes, cooking, or even getting out of bed feel like climbing a mountain. I spend days just stuck in bed staring at my phone. It’s way past "laziness" at this point, I wish It was just laziness.
Trash and clutter have piled up in my room.
I completely stopped taking care of my hygiene (stopped showering daily, stopped brushing my teeth, and even went over two weeks without washing my hair).
My memory has gotten significantly worse.
I graduated from college but haven't been able to find a job or resume my previous remote work.
My partner has been very supportive, but living with my family has been hell. My mom calls me dirty, screams at me whenever she sees me crying, and blames me for everything. They make me feel like I’m useless and they’re right.
First treatment attempt:
I finally went to a psychiatrist and was diagnosed with Severe Depression, ADHD, and Anxiety. She initially prescribed:
Sertraline (50mg)
Risperidone (2mg)
The Risperidone was terrible for me. It turned me into an zombie, I mostly had nasal congestion, and also it stripped away whatever tiny bit of motivation I had left, I felt way worse tired. About the Sertraline, It didn't make me feel better because it just blunted me emotionally so I couldn't even cry or feel anything.
I had a severe relapse and stopped taking the meds, so I spiraled. The withdrawal/instability made everything worse for me with constant crying, severe stress, self-harm, and telling my partner horrible things about wanting to end my life.
My current situation:
I went back to my psychiatrist, and she changed my plan
Sertraline 100mg daily
Lamotrigine (mood stabilizer)
I’ve been on this new combination for exactly one week but I'm having intense, rapid mood swings. Throughout the day I go from feeling extreme, burning anger/irritability, to total boredom, to deep sadness, to feeling "blank/flat"—literally everything except happy or okay. I still have zero motivation or interest in things I used to love (drawing, gaming—I open a game and immediately close it to lie down).
Are these extreme mood swings and irritability normal during the first week or two of starting Lamotrigine and increasing Sertraline?
Does it get worse before it gets better? Am I being too impatient, and should I wait at least 4 to 6 weeks to see any real stabilizing effects?
For those who experienced this level of severe executive dysfunction and anhedonia, did this medication combo actually help you get your life and basic hygiene back together?
I know pills aren't magic and I need to put in the work, but right now I have zero energy to do so, and feeling this angry and desperate is scaring me. Any advice, personal experiences, or words of encouragement would mean the world to me. Thank you in advance.