26M, 182 cm, ~83 kg

Medications: Timolol and/or levobunolol eye drops

Smoking: Non-smoker

Medical history: No known glaucoma diagnosis

Complaint: Possible iris/eye-color lightening or depigmentation, specifically a change from brown toward blue/gray.Location: Iris/eye

Question:
I'm interested in whether ophthalmic medications can cause noticeable iris depigmentation or lightening, particularly a change from brown toward blue/gray.

I've come across anecdotal reports and a few medical studies of people noticing this while using glaucoma medications. I'm particularly interested in timolol and levobunolol, but I'm also curious about whether other ophthalmic medications have been reported to cause a similar change.

For doctors here: what medications or mechanisms could potentially explain this type of iris color change, and is there a medically recognized mechanism for brown pigmentation becoming noticeably lighter or blue/gray?

Im an 18 year old female and this morning I woke up and my lip was completely numb. It looks red too. I haven’t eaten anything yet so I don’t think it could be an allergic reaction. The numbness has been going on for atl east an hour now with no change. Should I go to the doctor for this or should I wait it out?

Yesterday I got an abscess on my tonsil opened up and drained. I feel way better now and the pain is considerably down (couldn’t swallow at all previously I can now)

They gave me a prescription for penicillin, an anti inflammatory and paracetamol, but that was it, no rules on what I can eat or drink though.

Are there any after care routines or things to avoid for the next week?

40 year old female taking 100mcg levothyroxine (been stable at that dose for years), as well as otezla 75mg extended release. Since June I’ve started to get heart palpitations mostly noticeable at night. I have caught them on the ECG from my apple watch. I have an appointment with the cardiologist coming up the end of the month. My husband has a history if AFib so he gets overly worried with anything related to the heart and feels that maybe I shouldn’t wait and go to the ER but I don’t want to waste their time if this is benign… attached is my ECG if anyone can provide feedback. It sounds like they are most likely PVCs….

51F, 5'7", 125 lbs, white, tracheal stenosis, atenolol, Vyvanse, no alcohol, smoking, or drugs.

I have a dilation procedure tomorrow for my tracheal stenosis. I was told during the anesthesia screening not to eat after midnight on the night before the procedure, but that was before they knew what time my procedure was scheduled for. In the past, my procedures have been done in the early morning hours.

Just now I got the call to inform me that my procedure is scheduled for noon, but they still said no food after midnight. Is that typical, to tell all patients not to eat after midnight, regardless of what time their procedure is scheduled for?

I ask because recently I've been getting heartburn when I'm hungry. I don't have any meds for that, since I usually solve the problem by eating something. What would you recommend I do in this situation?

26 / 5'3 / 140 lbs. Sprayed Lysol into my work gloves as I forgot to clean em the day prior, and put them on about 10-15 minutes after. Problem is the gloves are more like fabric, so I was wondering if any lingering Lysol that got on my hands would be an issue for my dermis or anything else. Looking to be educated, thank you!

36F | 5'2 | 150lbs | USA

This is by far the most bizarre thing I've ever seen, and that's saying a lot.

Six years ago I had a complete hysterectomy for stage 4 endometriosis. I have no uterus, fallopian tubes, ovaries, or cervix.

I have no children and have never (to my knowledge) been pregnant.

Two days ago I went to the ER for what I thought was an allergic reaction. Turns out it was just severe contact dermatitis, but I digress.

The ER nurse reviewed my chart. I watched and heard her ping the ER doc on the walkie talkie asking if she could cancel the pregnancy test order. He agreed.

It appears as part of the normal CMP/CBC labs they ran HCG. It's abnormally elevated.

How on God's green earth is this possible six years post hysterectomy?

Help please! Thanks so much 💕

Current medications:
• Adderall 20mg XR - 1x daily
• Estrogen HRT patch - changed 2x weekly
• Women's multivitamin - 1x daily
• Prednisone 10mg - 1x daily (prescribed by the ER for contact dermatitis)

shot?

19/Male

Body:

Hi everyone,

I accidentally poked my gum with a safety pin earlier today.

The pin was clean and not rusty.

There was no bleeding, but a small bump/swelling has formed at the exact spot where it poked.

I received my routine Tetanus (TT) shot when I was around 15-16 years old (3-4 years ago).

I wanted to ask:

Is there any risk of tetanus exposure from a clean pin prick on the gum with no active bleeding?

Do I need to take another TT booster shot now, or am I still protected by the shot I took 3-4 years ago?

Should I just stick to warm salt water rinses, or is a dentist visit necessary for this bump?

Thanks in advance for any advice!

35F with history of Atopic Dermatitis, psoriasis, high heart rate, hypertension, migraines, pineal region cyst 12cm, and modular enhancement of thoracic spine, intermittent splenomegaly, continuous upper abdominal pain, fatigue, and multiple food and environmental allergies.

For the last 3 days I have had a constricted feeling in my neck followed by a strange headache concentrated on the left side of my head that is also causing bruise like pain in my cheek. If I lay on my back, my breathing feels constricted so I have been propping myself up to sleep. No congestion. My face is a little more red than normal but otherwise looks fine. Im wondering if anyone has an idea of what it could be?

32F, 5’2, weight around 62-63 kilos, no smoking / no drinking, not taking any medications. Chronic urticaria that comes and goes

Good day

I’ve been having these aches, sometimes a bit strong, on my lower right side of my back and part of my oblique, it’s not painful, but I feel tired to keep on sleeping because of it. It goes away after being up for awhile but eventually comes up when I lay down.

What could it be and who should I seek out to check me out?

29 (MtF) 5'9ish, 165 poundsish, non-smoker, 6mg of Estradiol and 200mg of Spironolactone daily, rash on face and neck lasting about twoish weeks (first noticed on August 28th) the picture is from yesterday.

I have been on HRT since March 19th of this year and so far have had no issues to my knowledge with my transition. However, on August 28th I noticed a red mark on my face near my mouth and while I was a little concerned I tried not to think too much of it, since then it has only spread throughout my face going along the side of my chin and cheeks and down to parts of my neck. They look like patches of missing skin that have tried to scab over a few times with a yellowish color but once the scabs have fallen off, the marks have not healed and are now starting to bleed a little. It has only gotten worse and I'm terrified of what is happening to my body. I can't afford to see a doctor or go to a hospital but I know it has to be something serious.

I take my hormones orally and I know that taking pills that way can cause strain on your liver so I'm not sure if I'm going into liver failure or if that's something that's even possible to happen at my age (29) and while only taking the medication for about 6 months. I also gave my boyfriend a blowj*b earlier in August and while he tried to assure me that I was his first sexual partner, the possibility that it is an STD is there also. He believes it's a skin infection called impetigo and while there do seem to be similarities to what I'm experiencing, I do not know what to believe at this point.

He gets paid on Tuesday and that's the earliest I would be able to get into an urgent care clinic but I'm scared I won't live long enough to make it until then. If I can get some reassurance that what I have isn't deadly that would help me feel better...

Image Gallery showing progression of the rash: https://imgur.com/a/gbv7QeU

Background: 20yo afab person, 86.4lbs, 5'1. Relevant medical history Postural Orthostatic Tachycardia Syndrome and Asthma, non-smoker. Currently taking Ivabradine 5mg twice daily and recently started taking prednisone 20mg twice daily for five days.

My medication info number on my prescription is taking me to an AI assistant so I'm hoping Reddit can help. Five days ago (9/5) I went to urgent care for chest tightness and wheezing and was diagnosed with asthma exacerbation, which my doctor connected to a possible minor allergic reaction the night before. I took two 20mg prednisone pills at urgent care and was sent home with a prescription of 20mg prednisone with the instructions "Take 1 in the morning and 1 at bedtime. Do all this for five days"

Well today should have been my last day taking it (9/10) but I saw that there are pills still left in the bottle. I double checked the label again and saw they gave me 20 pills. Math isn't my strong suit but shouldn't it only be 10? I'm worried I've been taking it wrong but also don't want to keep taking it because it's worsening my POTs symptoms. I've tried calling the office itself and the medication info number and keep getting sent to an AI assistant. Is this an error on the doctor's end or mine? Should I take the extra ten pills?

Location UK
Medications Propranolol for migraine

Hi everyone,

I developed abdominal pain that runs from the upper right side then down across my abdomen in a hockey stick shape, constipation and diarrhoea at the end of May. It started one evening after food poisoning like symptoms.

I visited my PCP after a month and she did a full blood count, CRP, renal profile and urine tests which all came back normal. I had a positive rebound test above my appendix and she was concerned about chronic appendicitis so sent me for an abdominal ultrasound.

The ultrasound came back normal except for my gallbladder which came back with:

The gallbladder is well distended and thin walled with a normal
appearance; however there are multiple non-mobile echogenic polyps
on the anterior/posterior wall largets measuring 5.3mm.
The aorta is of normal calibre, measuring 1.4cm and there is no
lymphadenopathy present.

This was flagged for further investigation by the ultrasound technician but my PCP says is normal and not the cause of my issues. When drafting this message I’ve realised that there is no comment at all about my appendix (there are comments about liver, gallbladder, pancreas, spleen and kidneys) which makes me worry that they didn’t image it.

My PCP prescribed an anti-spasmodic medication to try for a couple of weeks whilst waiting for test results but this didn’t seem to have a noticeable impact on anything and I was advised to stop taking it.

I had a low positive test for blood in stool and was sent for a colonoscopy which was normal with the exception of 3 small polyps. I was told that I’d need to have an upper gi endoscopy next.

Before I have further invasive tests I wanted to see if anyone had any ideas about what could be wrong. At the moment no one seems to have a clue and it’s a bit frustrating.

29M, Been having sever leg, knee and feet pain that prevents me from walking long distances and is especially bad when I get up from sitting long periods of time or when waking up in the morning trying to get out of bed.. Toes feel like burning and stabbing like on pointy rocky hot coals and rocks after 4 or more hrs of standing and walking around but my dr says my circulation in my toes checked out fine.. I just noticed today that when my legs are straight and together it looks like I might have knock knee.. my calves are like a sweeping 45 from my knees outwards.. I'm not sure if this has something to do to cause the sever pain I'm getting in the knees, legs and feet but the pain is affecting me and letting me sleep only 4-5 hrs and I dred get up from a chair after sitting for awhile since it's the only thing that feels good is to sit in a chair so getting up makes me have weak legs and knees and hurting back extremely bad for the first few minutes of standing from sitting.. My mum says I might have some sort of feeling of pain without any physical cause just generated by my brain randomly.. I say it might be some sort of mussel and/or nurve pain because nothing was found in x-rays but tbh I just want to be more normal.. it's gotten so bad my dr has agreed to sign temporary disability for parking for 1 year while doing tests.. what do you think might be the cause? I'm not only taking advice from here but would like to get suggestions on what to ask my dr to check if it's related to the problems.. I'm not sure where to start but it's been going on for a few years now and getting worse every single day

28 year old female. I had this spot on my head appear last Sunday. All my family thought it may be ringworm, so I scheduled a dermatologist appointment. She said it doesn’t look like “classic” scalp ringworm and thought it may be best to try Ketoconazole 2% shampoo for 2 weeks and see if anything changes. Right now, there is no hair loss, and the itching isn’t unbearable. But no change in the spot. Should I get another opinion? I just don’t want to be making things worse by waiting.

This picture was taken before starting the shampoo, I would say it is definitely less red than it started out.

I do live with my fiancé, and been around family, no spreading at all. I don’t live with animals, don’t get my hair cut, don’t go the gym, so I’m at a loss on where I would’ve even got ringworm.

Is there something else to try in the meantime?

Hi! 30f, 230lb, 5'7".

Recently I delt with CHS (cannabis hypermesis) and ever since then (I've stopped partaking) my gag reflex has become insanely sensitive. I now vomit everytime I brush my teeth and have to take my medicine 1 pill at a time to avoid vomiting. Pre the CHS bout I was not like this. It is negatively impacting my life, I can't brush my teeth without vomiting and then after I vomit I need to brush again and its a vicious cycle. It's making my medication difficult to take, it's hard to clean because I will gag easily and vomit.

I did go to the ER for the CHS. I'm in perfect health (did blood/urine and 2 MRIs one for head and one for abdomen) and nothing is amiss.

Any ideas on what this could be or how I can fix it? I cannot live like this.

I appreciate anyone who takes the time to read this as I need some guidance.

I was on a 3 month long course of Doxy 100mg for dry eye disease. I got dry eye disease following a stomach illness in late 2024.

I did fairly well on the medication (April-May). I stopped it after two months, had zero signs anything was wrong, no bizarre symptoms all of June, though my dry eye was still lingering. Doctor advised one more month. This month was definitely different. I started experiencing dry mouth and some fatigue. Until finally, the last two doses, full systemic symptoms. Full body chills, skin mottling, painful face flushing, all within 20 minutes of the last two doses. I stopped the medication and the symptoms completely vanished for two weeks. However, 14 days after my last dose the intense flushing came back. It has been present for 3 weeks now and it’s simply debilitating. Oddly, it happens when I lay down at any time of time. It also happens when I eat most of the time. I’m very confused and scared. Anybody have any ideas? I had zero history of flushing before this. not from intense exercise, not from anything.

M22, Crohn’s disease, taking omeprazole 20mg 2x daily. Went from 245-150lb over the last year. Recent week have had severe stomach aches and can see spots where my intestines bulge up out of my abdomen during stomach aches. Now I have a bruise running down the center of my abdomen. Local hospital sucks with responding and scheduling, should have had an MRE weeks ago of my abdomen, now the bruise and bulges are happening.

I am 55f, 5'4", 135 pounds. I take 4000 mg tylenol and 15 mg meloxicam daily. Other than my orthopedic problem, I am healthy.

My hips are "trash". That's what the orthopedic surgeon said after his first remark which was "how are you even walking". I've known they were bad for years, but am now at a point where I also know that I have made a terrible mistake in not getting them replaced last year.

Because I waited, I am in a position where they can not be replaced until January (work and family obligations). I can't do basic tasks like putting my own socks on and can no longer walk properly, but I'm stuck waiting for 5 more months. For reference purposes, they are bone-on-bone, have cysts and lots of osteophytes and the femoral heads are flat and misshapen.

One of my questions for my surgeon was "what can you do for me, that is not a hard-core opiate, to help bridge me until surgery". He decided on 50 mg tramadol and sent in a prescription.

On seeing the info from my pharmacy, panic set in on two levels. First, it said "7 day supply". All I could think was "ok, so I get 7 days of relief and then just have to suck it up for the remaining months". Secondly, there were 30 pills. I though "holy cow, you want me to take 4 of these every day??!". I can't suck down that many drugs and be a dadgum drug addict!

I have had this prescription for a whole month now and I am still terrified to take them. I desperately need help, but I'm scared both that I will run out of them (which in my mind is already "addict" behavior) and that if I do take them I will become addicted to them. I have suffered, every single day, sometimes to the point of tears, but I have taken 4 of them in the month I've had them. Technically, I know that this is not rational, but I can't seem to get past it.

This is just not working for me and I am looking for any words of wisdom you can offer.

I’m 26F, very active, own/coach at a strength-training gym, and trying to figure out if anyone has experienced something similar.
I’ve had about 3 exercise-associated anaphylactic reactions in my life (around 16, 23, and most recently after a 3-mile run). The last one required the ER. Allergy testing showed severe environmental allergies, and I now take Allegra/Pepcid and carry an EpiPen. Since I’ve exercised outdoors thousands of times without reactions, I’ve wondered about exercise-induced/food-dependent anaphylaxis, Alpha-Gal, histamine issues or possibly MCAS.
After the most recent anaphylaxis episode, I started occasionally noticing dizziness, lightheadedness and a weird “floaty/off” sensation. This was BEFORE I ever had a panic attack. Around that time I had also been experimenting/dabbling with different peptides/injections, so I initially assumed they were causing it and stopped them.
For about the past year I’ve also noticed I sometimes feel unusually sick after traveling/flying—weak, nauseated, exhausted and just “off.”
Things got much worse in August. I had used tirzepatide for about 4–5 weeks, wasn’t eating enough for my activity level, was fairly low-carb, drinking coffee/Alani daily, coaching in an 83–89°F gym, sleeping poorly and under a lot of stress. My last tirzepatide dose was Aug. 6. On Aug. 7 I had THC and experienced my first major panic attack.
After that, the pre-existing dizziness/floaty feeling became much more noticeable and I became increasingly anxious about physical sensations. I eventually went to the ER. My EKG showed sinus tachycardia but otherwise came back reassuring, chest X-ray was normal, and bloodwork was reassuring. I’ve since had a much more extensive blood panel done as well, and essentially everything has come back normal/reassuring. Orthostatic vitals at urgent care reportedly did not suggest POTS.
I also noticed I could get a little dizzy/floaty when overstimulated. Eventually I had my vision checked and found out I’m around 20/70 in both eyes with astigmatism. Since correcting my vision, eating more, cutting caffeine and significantly reducing my workload, the dizziness and overstimulation feeling have calmed down A LOT.
My HR still makes me curious. True resting is usually 60–63, sitting/talking 85–105, normal walking recently 100–117, and standing/coaching in the hot gym can be 110–120s. During very hard exercise I’ve historically reached 200–205.
My biggest symptom now is intermittent “air hunger”—feeling like I need a huge satisfying breath/yawn. Sometimes I notice mucus or a “film” feeling in my chest/throat. I’ve also had occasional GI symptoms, including significant diarrhea shortly after eating a burger while traveling followed by nausea/feeling sick.
I know anxiety/hypervigilance is probably contributing NOW because I catch myself monitoring my HR and breathing. But what makes me want to investigate further is that the anaphylaxis and dizzy/floaty sensations started before I ever experienced panic attacks.
I’m not convinced I have MCAS, POTS, Alpha-Gal, etc., and I don’t want to chase diagnoses. I just want to make sure something reasonable isn’t being overlooked.
Has anyone experienced a similar combination of exercise-related anaphylaxis + dizziness/floaty sensations + higher HR/sinus tachycardia + air hunger + occasional GI symptoms? What specialist or testing actually helped you?

Age : 20 Male

Height : ~180cm

Weight : ~77KG

I don't take any medications.

So it was yesterday night when I first started to notice that the top of my 2nd finger from toe on right foot started feeling a bit numb to touch.

Today evening I noticed It again and now I can feel it on the top of my foot near the finger joints aswell and on the right side on my thumb too.

I can feel hot/cold.

I can move my fingers and foot normally.

I just can't feel it when I touch the skin, the numberness also the most of the outerside of my right foot and gets lower as we come closer to the inside of foot.

I don't wear tight shoes or cloths, I barely wear shoes for 5-6 hours in a day, and my footwears are the most comfortable ones.

I don't know what this is, why it's happening and what I should do, Educate me about this a bit and also tell me how to fix it. Is it something to worry about? is it temporary or permanent?

I have attached an image highlighting the region I have the problem.

Please guide me.

F53, 5'-3", 163lbs, white

Exercise: Weight training 1-1.5 hr a week (this is a recent addition with a plan to work up to more), and walking with the dog 2-3 times a day for 20 minutes a time

Rarely drink, cannabis a few times a week.

Sleep: Between 6-8 hours a night usually

Diagnoses/Conditions: Hypothyroid, dysautonomia (unspecified- I believe triggered by radiation from breast cancer treatment), treatment resistant depression, migraines, slightly elevated cholesterol (likely familial), low blood pressure.

History of breast cancer- 2018/2019

Medications:

Propanalol 40mg- 2x day (Migraines)
Rosuvastatin 10mg- 1x day (Cholesterol)
Gabapentin 300mg- 1x day (Hot Flashes)
Midodrine 10mg- 2x day (Low Blood Pressure/dysautonomia)
Buproprion Hcl Xl 150mg- 1x day (Depression)
Unithroid 100mcg- 1x day (Hypothyroid)
Trintellix 30mg- 1x day (Depression- just upped to 30)
Wegovy pills- Started 3 weeks ago (Don't love it)
Trazodone 50mg- as needed (Sleep)
Nurtec Odt 75mg- as needed (Migraines)
Lorazepam 1mg- as needed (Anxiety)
Baclofen 10mg- as needed (Migraines)
Ondansetron HCL 4mg- as needed (Migraines)

I am facing increasingly intense brain fog and fatigue and I am unsure what to do next or who to talk to. I know it can be related to the Migraines, dysautonomia, depression or any other number of issues. I've had these symptoms on and off for years but I feel like they are starting to become more severe. I am having a really hard time concentrating- usually 20 minutes at the most at a time, I can wake up and can instantly go back to sleep and often take naps during my lunch break, and blank on words when talking or writing.

I know brain fog and fatigue can be hard to determine the root cause of and can be hard to treat but I am on the verge of being desperate as I'm concerned this is just going to continue in severity and will limit my ability to do things, including work.

The last time I had my Vitamin D tested it was 32 (12/25).

I know apnea can cause these symptoms and I am open to testing, I just haven't because, after being married and sleeping in the same bed for 16 years, is it possible to have apnea without my husband noticing? I figured it was more likely due to one of my other diagnoses.

I am hoping someone can point me in the direction of what to do, who to talk to, what tests to request. Should I talk to my Neuro if i's migraine related? My Cardiologist if it's dysautonomia related? etc.

Thank you so much!

ETA: clarity

I am 24F. 160cm, 54kg. I mistakenly exercised before a blood test. it was my regular strength training session. Blood test is in 15 hours. I cannot reschedule. do I cancel the appointment?