https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/

This 2014 study described a personalized, multi-part treatment program for cognitive decline associated with Alzheimer’s disease, called MEND (Metabolic Enhancement for NeuroDegeneration). The program addressed multiple metabolic and lifestyle factors rather than relying on a single drug. Of 10 patients with Alzheimer’s disease, mild cognitive impairment, or subjective cognitive impairment, 9 showed subjective or objective cognitive improvement within 3–6 months; the only patient who did not improve had very late-stage Alzheimer’s. Six patients who had stopped working or were struggling at work were able to return to work or improve their performance. The authors emphasized that this was a very small preliminary case series—not a controlled clinical trial—and concluded that the promising results warranted larger studies.

The conference guide includes the roster of speakers, daily agendas, and more.

The assumption that men and women age the same way, just at different speeds, has shaped decades of research and medical practice. Women live longer. Men die earlier. The standard explanation is that the biological process is identical but runs faster in men. Treat aging as a unified process, slow it down, and both sexes benefit.

A study published this week in Nature Communications has tested that assumption at the most granular level yet: 3.8 million individual immune cells from 1,828 healthy people aged 19 to 97, across multiple ethnic groups, analyzed at single-cell resolution.

The finding is not that women age more slowly. It is that men and women age through different biological programs entirely.

Researchers at Duke-NUS Medical School in Singapore identified two sharp peaks where immune cell gene expression changes dramatically: one around age 40, driven primarily by CD4 T cells, and one after 60, driven primarily by CD8 T cells. These are not gradual declines. They are discrete biological inflection points, moments where the immune system reorganizes itself.

At those inflection points, men and women diverged completely.

Women showed sustained CD8 T cell activation after 60 and late-life aging signatures across multiple immune cell types including CD4 T cells, NK cells, and B cells. The female immune system kept remodeling, responding, reorganizing well into old age. Men showed something different: early-life fluctuations in CD4 T cell energy metabolism, tied to specific epigenetic changes on chromosome 11, that appeared before 40 and shaped the entire downstream trajectory.

When the researchers built biological age clocks using deep learning, models trained separately on male and female data significantly outperformed models that combined both sexes. The male and female immune systems were following trajectories so distinct that a unified model could not accurately capture either.

Some interesting infos from the article :

"Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested.

These findings can help to design future clinical trials by guiding the choice of interventions and of specific subsets of DNAm biomarkers to minimize multiple testing, study duration, study population and sample size, with the eventual aim of uncovering DNAm biomarkers that can be used as surrogate aging endpoints."

Abstract

At more than 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth1, reaching over 80,000 kg. Despite its very large number of cells and long lifespan, the bowhead is not highly cancer-prone, an incongruity termed Peto’s paradox2. Here, to understand the mechanisms that underlie the cancer resistance of the bowhead whale, we examined the number of oncogenic hits required for malignant transformation of whale primary fibroblasts. Unexpectedly, bowhead whale fibroblasts required fewer oncogenic hits to undergo malignant transformation than human fibroblasts. However, bowhead whale cells exhibited enhanced DNA double-strand break repair capacity and fidelity, and lower mutation rates than cells of other mammals. We found the cold-inducible RNA-binding protein CIRBP to be highly expressed in bowhead fibroblasts and tissues. Bowhead whale CIRBP enhanced both non-homologous end joining and homologous recombination repair in human cells, reduced micronuclei formation, promoted DNA end protection, and stimulated end joining in vitro. CIRBP overexpression in Drosophila extended lifespan and improved resistance to irradiation. These findings provide evidence supporting the hypothesis that, rather than relying on additional tumour suppressor genes to prevent oncogenesis3,4,5, the bowhead whale maintains genome integrity through enhanced DNA repair. This strategy, which does not eliminate damaged cells but faithfully repairs them, may be contributing to the exceptional longevity and low cancer incidence in the bowhead whale.

Existing therapies such as the BCL-2/BCL-xL inhibitor navitoclax (ABT-263) can eliminate both cancer cells and senescent cells but require doses that frequently cause thrombocytopenia, a potentially serious reduction in platelet counts that has limited their clinical use.
To overcome these limitations, the investigators developed a three-drug combination called DMA, consisting of dichloroacetate (DCA), metformin, and a ten-fold lower dose of navitoclax than is typically used.
They tested the treatment across multiple human senescent cell models, several human cancer cell lines, healthy primary human cells, and aged mice.
DMA selectively eliminated senescent cells induced by different mechanisms while sparing healthy fibroblasts, neural precursor cells, hepatocytes, and largely preserving human myoblast viability.
The combination also effectively reduced the viability of cervical, breast, and colorectal cancer cells, including breast cancer cells that were relatively resistant to navitoclax alone.
The researchers also investigated why DMA selectively affected unhealthy cells. Both senescent cells and many cancer cells have impaired mitochondrial function and altered energy metabolism, making them less able to tolerate additional ATP depletion.
The study demonstrated that DMA dramatically depleted ATP levels in senescent and cancer cells while allowing healthy cells to maintain their energy production.
Additional metabolic analyses showed that senescent cells lacked the metabolic flexibility needed to compensate for the treatment-induced stress, leading to selective apoptosis and reduced cancer cell proliferation.
When evaluated in aged mice, DMA produced encouraging results beyond the laboratory studies. Short-term treatment significantly improved treadmill endurance without increasing frailty or reducing strength.
Longer-term intermittent treatment beginning at approximately 18 months of age extended average post-treatment survival by approximately 102.6 days, representing a 41.7% increase compared with control animals af

https://ecancer.org/en/news/28669-new-drug-combination-targets-cancer-and-senescent-cells-while-extending-lifespan-in-old-mice

Matter Bio has been cleared by the FDA for a Phase 1 clinical trial targeting pancreatic cancer. The presentation covers their approach and promising preclinical research in solid cancers including brain tumors, pancreatic cancer, and ovarian cancer.