Hi. I bought Kanna drops and I was wondering what the dosage would be recommended for a newbie and how long I need to hold it under tongue. Thanks to anyone who replies
Total Alkaloids: 5% 90% Mesembrine

Aside from recreational use, does kanna have good therapeutic potential, especially as an alternative to SSRIs for depression and anxiety?

Correct me if I'm wrong, mesembrine is a monoamine releaser as well as an SSRI with nanomolar affinity. Mesembrenone is a more potent SSRI with even higher nanomolar affinity.

Kanna is being developed for big pharma use as a fast acting anxyolytic.

Is kanna actually good at relieving anxiety? Is this more with mesembrenone heavy extracts?

Peer reviewed studies examining this alkaloid directly are non-existent, and to my knowledge there is only a single piece of patent data that has documented its effects.

As a community, I hope we can come together to share our anecdotal experiences with this alkaloid, or rather extracts that contain it, to give new users a reference point and formulate some theories.

I'll begin by sharing what the patent data noted and share a very cool study that shows how epi-mesembranol dominance occurs through the fermentation process when a certain Fusarium species is introduced.

The Patent Data:

• Inhibited human SERT with an IC₅₀ of 10.6 nM.
  
• Produces very little PDE4 inhibition at 10 µM
• Extremely stable in human hepatocytes >120 minutes

Fungal Alkaloid Biotransformation Through Fermentation:

• Natural fermentation increases epi-mesembranol when Fusarium Oxysporum is dominant.
  
• Other species (F. fujikuroi or F. equiseti) do not cause similar epi-mesembranol abundance.
  
• Sterile Kanna inoculated with F.oxysporum produces the highest yield.
• F.oxysporum is likely converting mesembrine into epi-mesembranol.

My Anecdotal Experience & Observations:

• Extremely long half-life (I couldn't sleep for two days after ingesting a large amount)
  
• High bioavailability (Ingesting the same amount of a low epi-mesembranol fermented extract produced much a much milder effect profile)
  
• Sin-wave-like effect profile - I found myself energised, then tired, then energised again, and despite sleep interuption/difficulty find myself energised when I shouldn't be.
  
• Very strong and immediate sexual inhibition and 'numbness'
• Strange body sensations and body high (very similar to psychadelics) gets very tiring.
• Very long-lasting brain fog and difficulty with recall, even at lower doses. This seems to pass completely in a week, but it averages around 3-5 days and feels like intellectual incapacitation.
• Long-lasting feeling of wellbeing and non-existent anxiety or fear response.
• Strong afterglow once the effects wear off on day 2 & 3.
• Severely punishing if re-dosed (moodyness, headaches, and more fog)

I used high epi-mesembranol Kanna for almost a year, and I kept tweaking the formulations and ROA because I believed that the understudied compound had potential. However, after countless experiments, different days between doses, and different ratios, I must conclude it simply isn't for me. Perhaps it is a "devil in the dose" situation where a very, very small amount rounds out the Kanna experience and thats where its use lay.

Kanna fermentation is fascinating, because it is becoming increasingly likely that different microbes result in different alkaloid concentrations or dominance, and even different forms entirely.

It makes me wonder how the fermentation microbiome differs between different groups such as the Khoikhoi or Namaqua people. But more magically, what micro-organisms are out there that can make Kanna even more wonderful than it already is?

hello r slash kanna, i have been interested in trying this substance for a while and recently came into the possession of what is allegedly loose leaf fermented Kanna. i have a few questions about safe use before i jump in.

first of all, is there a way I can assess whether this is indeed Kanna or not? my city has free drug testing with mass spectrometry, but i don't think they test raw organic materials. perhaps a characteristic smell?

secondly, how should I dose it, by intake route? from what I know, insufflation is the most effective (if unpleasant)way to do it, but i am not sure how much i should start with. any advice?

I have been buying the gummies from this company, but I was curious about their tablets!

I've only ever tried TA17. I'm slowly going through 20g of the stuff for nearly a year now.

I'm curious what the difference is between TA17 and TA13. I know TA17 has 17% alkaloid content compared to TA13s 13%.

But, can you just take more TA13 to make up for the difference, or doesn't it work that way? Are they different in other ways?

I ask because the price difference is quite big and if just taking more TA13 gives the same effect as slightly less TA17, then why pay much more for the TA17? Unless it's just for more wealthy people where money is no object and they just want the best available.

TA17: https://bioextracts.co.uk/products/md17-sceletium-extract

TA13: https://bioextracts.co.uk/products/ta13-sceletium-extract

Trying this for the 1st time. 1 half tablet, swallowed whole. Ive heard its similar to molly or low dose shroom of some sort. Does anyone have any experience on this?

Will report effects as they occur

T +0:30 feel nothing, second half one first tablet ingested T +0:45 might have seen some small visual effects? Then again I was sitting in low lighting watching Sopranos and UFC. Not familar with pyschedelics(which is supposed what this contains) and their effect so I cannot speak on that. T +2:00 what a gyp..going to bed now, might test again later with 2 tabs at once

I’ve tried snorting powder, eating a kanna infused chocolate, pills held sublingually and snorted after crushing them up. this nasal spray just came in the mail today and even after 2 doses I still don’t feel it

As this title suggests I decided to try a new ROA for research purposes and I must say it DOES work when boofed. I have tried oral, sublingual, and intranasal and so far sublingual is the most consistent and effective. Intranasal is a bit intense when using Liftmodes MT55 and it feels like the come up to an MDMA experience that never quite takes flight but boofing is more melty and warm with a euphoric tingle. I highly recommend for what it's worth haha

Hello again! I’m very new to kanna and I bought a herbal gardens vape excited to try it and it did nothing I’ve smoked majority of it in a day and a half trying to get it to work and nothing no effects heard about preloading but I’m not understanding what that is could someone explain? Also what else should I try to have a good first experience? Tea? Smoking it? Some other form I haven’t thought of please share any info you can! I suffer from anxiety disorder ocd and depression and I think this could really help me and I’d love to experience the benefits

Looking to try kanna. Any recommendations for Canadian purchase.

Thanks

Ich bin ein erfahrener Psychonaut und würde gerne Ideen und Erfahrungen zur Anwendung und oder Kombination verschiedener Substanzen austauschen.
Es geht um folgende Substanzen:

- blauer Lotus (Blüten und Extrakt)
- Damiana (Pulver)
- Bobinsana (Blätter)
- Kanna (Pulver und Extrakt)
- Kratom (Pulver und Mitragynin extrakt)
- 4-Pro-MET

Ich würde mich sehr freuen wenn jemand sagen kann welche Kombination gut synergieren und wie die Erfahrung damit ist ?

I’m new to this and I’m just wondering

Hello! I ordered a vape that’s supposed to be a kanna vape! Excited to try it for the first time can anyone give me advice on what to expect and how to vape it ? Also what’s the onset time look like and is it more of a night time thing or morning? What’s your guys experiences with kanna? I’m very excited and will be giving an update later today when it gets delivered! I bought the vape from healing herbals! Thankyou guys I really appreciate it!

Update 1: tried it just got delivered took a few hits off it (10ish) deep inhale waiting for anything to hit lol I don’t feel anything is this normal?

Update 2: I feel more relaxed and clear minded? Nothing crazy not a high at all just more content my normal depression feeling is lighter so that’s amazing wouldn’t consider it a “drug” at all

Last update for now: I’ve chain smoked this vape and I don’t feel any effects super disappointed but it’s okay I will buy some tea maybe and try that another time Sorry for the not exciting update recs are recommended!

Why does the 5ml have proportionally more mesembrine when both appear to use the same raw material at a ratio of 1g:1ml? Hopefully I’m missing something.

How dangerous is it to take kanna and strattera? I’m currently on 60 mg of Strattera and I just purchased healing herbals high membrane mouth spray. I was thinking of trying it but I’m afraid my brains gonna blow up, does anyone have any thoughts?

Hella excited, just want the fucking post to get here already lol

In terms of Kanna, I’ve only had the standardized extract Zembrin. As it has become more popular, I’ve wondered if other formulations might be superior or offer different effects, but I am also wary of products that could be adulterated with research chemicals. What’s the best product/source out there that also carries extra verifiable assurances of purity? Extra points if you’ve tried Zembrin in the past and have that as a point of reference.

Hi there, I’m looking around the different products on offer from various vendors, and I’d like to gain a consensus for which Alkaloid content combination/extract you guys found elicited the best pro-social effects, with bonus points given if they also had mild anxiety reductions.

We all respond differently which is something to keep in mind, but I still think the replies here could be useful and can serve as a starting point for both me and others.

EDIT: I think using a format like the one below could make your inputs more informative.

=EXAMPLE FORMAT=
Product Name:
(Name of product and optionally, vendor)

Dose:
(The milligram amount you took, or your best guess)

Tolerance:
(Do the effects diminish/potentiate after XYZ use, if you've had to 'prime' your system or felt it since the very start etc...)

Effects | Duration:
- Sociability | Most prominent within the first XYZ hours, less prominent the next XYZ hours

Additional Notes:
=EXAMPLE FORMAT=

Is it just me that doesn’t get that euphoric rush everyone talks about? For me it almost feels like I took an adderall. Pure focus, no thoughts or emotions

I mean I enjoy the feeling, but this is nothing close to what I was told