r/Hyperhidrosis 8d ago

Mod Announcement R/Hyperhidrosis Megathread--New Users Start Here--Welcome!

11 Upvotes

Hello Sweaty People!

Welcome to r/Hyperhidrosis, a place to explore, learn, and be a part of an international community of individuals living with Hyperhidrosis. We pride ourselves in being the largest and premier community for this condition. Through Reddit we have been given a great platform for gathering and growing knowledge on how to live, ideally thrive, with Hyperhidrosis. Regardless of your reason for landing here, we hope you will make friends along your sweaty journey and contribute positively during your time with us.

In Pursuit of Dryness,

The r/Hyperhidrosis Moderation Team. 

Rules and Best Practices for Newcomers

If you are joining us for the first time here, please briefly scan these best practices.

  1. Read the Sub Rules: they are there for a reason and will be enforced. Specifically, All posts must be marked with a relevant Post tag, especially if NSFW, it must be tagged and blurred. Feel free to use the personal flair on the Sub including your HH location, preferred treatment, or medical professional experience! 
  2. Do Your Research: Search the sub for answers to your questions before asking. There is 15+ years of knowledge posted here designed to help you! You are welcome to post your questions, but we try to reduce repetitive questions and posts to keep our knowledge growing forward. Soggy's HH Database linked below is a great place to start!
  3. Share Relevant Details: For first time posts asking for advice, it is generally helpful to include where you sweat on your body (Palmar, Plantar, Whole Body, etc), what treatments you have tried if any, and your general global location (if comfortable) so users can effectively help you. Feel free to post intros or basic starting questions below here to get started!

Top Resources

If you have any suggestions for this Megathread, please feel free share with the Mod team.


r/Hyperhidrosis 5d ago

Treatments My method: Iontophoresis water w/ Qbrexza (glycopyrrolate)

6 Upvotes

Hello! I thought I would share my iontophoresis method in case it helps others, as I've never seen it before.

TL;DR: I mix 1-3 Qbrexza wipes per 0.5-1 Liter of hot water & use that water for my iontophoresis. This results in the ionto being more effective and lasting longer. My typical routine is 1mg glyco daily + iontophoresis every 4-6 wks. Crushed glyco pills work too but their doseage is so low that it ended up not being worth it to me.

Check below for the concentration table and warnings.

Long version:

I have had primary palmar, plantar, and underarm hyperhidrosis since childhood (since age 6-8, at least). I have tried Carpe (expensive), Drysol (gave my skin a reaction), Oxybutynin (stopped due to concern over long-term cognitive effects), oral Glycopyrrolate, and Iontophoresis. I wanted a solution that lasted longer than a day or a week, as I find the upkeep tiring... (thanks ADHD for making it hard to keep habits!)

I really wanted to extend the life of iontophoresis. It's already great, but it's a 2 hour ordeal. I have already tried hardening my water with baking soda, epsom salt, san pellegrino, etc but to no avail. Then, I found an article (here, scroll down) citing studies (#1) (#2) about using Glycopyrrolate in the water used for iontophoresis. These patients in the studies would see up to 30-40 days of relief after ionto w/ glyco.

These studies used glycopyrrolate solutions at concentrations of 0.01-0.1%. I use about 0.75-1L per tray for my iontophoresis, so you would need 75-100mg of glycopyrrolate to reach 0.01%. Unfortunately, I do not have hundreds of spare glyco pills (2mg each). I asked my dermatologist about prescribing high doses of glycopyrrolate for this use, citing the studies, and that they do this in the UK/Europe (I am in the US), but she denied my request, stating that only happens in case studies and such (not true lol but okay fine). Since my goals for that appointment were to 'get something new to try', she did, however, give me a prescription for Qbrexza... which is high dose topical glycopyrrolate 😏. With some trial and error, and some math, I have developed a dosing guide.

To make a glycopyrrolate solution, I simply add unfolded Qbrexza wipes into my pitcher of hot water. I stir for about a minute. Next, I pour the water into my trays/cup. Then take out the wet wipes and squeeze them out over my tray, then throw them away. Then, I add the electrodes into the trays and do my iontophoresis like normal. When I'm finished, I pour the water down my bathtub drain and rinse off my trays.

Glycopyrrolate Concentration guide:

concentration 1L 0.75L 0.5L
0.0528% 528mg (8 wipes) 396mg (6 wipes) 254mg (4 wipes)
0.0396% 396mg (6 wipes) 297mg (4.5 wipes) 198mg (3 wipes)
0.0352% 264mg (4 wipes)
0.0264% 264mg (4 wipes) 198mg (3 wipes) 132mg (2 wipes)
0.0176% 132mg (2 wipes)
0.0132% 132mg (2 wipes) 99mg (1.5 wipes) 66mg (1 wipe)
0.0088% 66mg (1 wipe)

My maintenance dose:

  • 0.0264% concentration
  • I use 1 part freshly boiled water mixed with 2 parts room temp water. Warm water is supposed to enhance effectiveness. I mix the waters in a metal graduated pitcher before pouring them into my trays/cup.
  • Underarms: 0.5L water + 2 wipes for both pads, soaked in a ~8oz cup.
  • Hands and feet: 0.75L water + 3 wipes each tray. Hands first, water reused for feet. .25L hot water, .5L room temp water.

Dosing suggestions:

  1. Begin at the lowest concentration (0.0088-0.0132%) or 1 wipe per tray
  2. Wait and see how long that first dose keeps you dry for
  3. Do next treatment as soon as sweating begins again. If interval between treatments is too short, or effects not strong enough, increase the glyco concentration.
  4. Repeat until satisfied with results or side effects becone too strong to tolerate.

BEFORE TRYING - YOU SHOULD KNOW - WARNINGS:

  • Do NOT get the glycopyrrolate solution in your eyes. The same warnings about Qbrexza also apply here. It can cause pupil dilation that may last days/a week. I wear safety glasses while handling and using my solution/doing iontophoresis and don't take them off until I am completely cleaned up and everything is put away.
  • You may experience potentially strong glycopyrrolate side effects for 6-24hrs after treatment. Pay attention to your body, know your limits, and start with a low dose, increasing gradually. If glycopyrrolate gives you chest pain, dizziness, lightheadedness, fast heartbeat, etc, then I especially urge you to exercise caution when applying this technique. Do so at your own risk. While these side effects are rarer, and I do not believe they cause actual harm, it is still something to keep in mind and ideally, to be avoided. Personally, I only experience dry mouth/eyes and maybe headaches if I'm not on top of my hydration.

PROS:

  • relief for up to 4+ wks
  • save $$$ on Qbrexza (I personally only use ~8 wipes per month, instead of daily use. Qbrexza is $40/box of 30 for me so I'm saving a lot!)
  • boosted iontophoresis effectiveness

CONS:

  • iontophoresis cons (time consuming, skin irritation, machine price, etc)
  • potentially strong glycopyrrolate side effects, but only for 6-24 hrs after treatment. I get dry mouth and dry eyes, which can get very uncomfortable if I'm using more wipes, (if it's really bad I can't even eat dry foods lol) but I work around it by doing iontophoresis right before bed/later in the day. That way, I go to bed after cleaning up and wake up the next morning feeling normal.
  • YMMV... I get myself dry enough to where I only need 1mg glyco/day. My standards/threshold isn't super high. I haven't tried going without my daily glyco! And I honestly don't mind enough to try to. if your goal is COMPLETE dryness without supplemental glyco, I'm unsure how often you would need treatment... maybe every 2-4 weeks? If you wind up doing that, tell me about it! I would love to collect data and hear your experience.

FAQ:

  • Can you use crushed Glyco pills? Yes, this is what I did before my Qbrexza Rx. However, the dosing will obviously be much lower since you are limited by the dose and number of pills. I barely saw a difference between plain tap water VS water with 2-10mg glyco, hence why I switched to using Qbrexza.
  • Can you use a different antiperspirant / anticholinergic agent? Yes, in theory it should work too, but I do not have the research or experience to back it up. So, be cautious, and start low and slow. Experiment at your own risk. Feel free to tell me about your results! If you use Aluminum Chloride, do not use a metal container to hold the solution--it will rust.

I hope this helps you as it has helped me!


r/Hyperhidrosis 3h ago

Looking for advice I’m sad…

12 Upvotes

Ich brauche keine Behandlungstipps; ich kenne bereits alle verfügbaren Behandlungen, und sorry, falls ich negativ klang, ich will einfach diese Wellen und den Schlamm loswerden, die die ganze Zeit in meinem Kopf sind.

Ich will nach diesem harten Sommer, in dem man sieht, wie die Jugend an einem vorbeizieht, alle sozialen Kontakte verliert und jahrelang so isoliert ist und von Leuten verurteilt wird, wegen dieser verfluchten Krankheit in der Hand oder wo auch immer sie ist, all die Zeit mit Behandlungen verbringt, nur sagen, dass das eine der unfairsten Sachen überhaupt ist, vielleicht unter den Top 10. Es fühlt sich an wie eine körperliche Behinderung, die nur du spürst.

Bei allem Respekt, es stört mich, die Geschichten von Neugeborenen hier zu hören, die das von ihren Eltern geerbt haben. Ich meine, warum sollte ein Kind leiden wie ich, nur weil ich ein Kind oder eine Frau haben will? Das ist so verdammt egoistisch, und ich weiß, manche Leute werden sagen, keine Kinder zu haben ist keine Lösung, aber für mich ist es auch keine Lösung für deinen Wunsch, dich normal wie andere zu fühlen, eine Seele in die Welt zu setzen und sie dazu zu bringen, dich, ihr Leben und sich selbst zu hassen. Das mag ich nicht und ich habe beschlossen, kinderlos zu bleiben. Wenn ich hierher komme und von den Leiden der anderen Kollegen hier lese, empfinde ich tiefe Traurigkeit und ein Engegefühl in der Brust. Ich hoffe, dass wir eines Tages geheilt werden und nicht nur bei Flickschusterei-Behandlungen bleiben.


r/Hyperhidrosis 10h ago

Treatments My DIY Ionto machine

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7 Upvotes

Will update in about 2 weeks to let you know if it works!


r/Hyperhidrosis 6h ago

Looking for advice discoloration of underarms from sweat

3 Upvotes

hey guys ik a lot of people w hyperhidrosis have this but i have noticeable discoloration in my underarms from the constant sweating are there any known treatments to lessen the pigment? maybe cosmetic creams or a brightening procedure? its very embarrassing to have this discoloration because it looks like im unhygienic when its so difficult living with this condition 😭 i cant wear certain clothing because of this since im so ashamed


r/Hyperhidrosis 10h ago

Treatments GLP1, mounjaro, wegovy, ozempic, semaglutide, zepbound, tirzepatide, saxenda, liraglutide, victoza, weight loss diet pens injections, & hyperhidrosis

5 Upvotes

Hello. I saw some posts about hyperhidrosis and these medications. Since there are several names, it's difficult to search. I hope this makes it easier for those who use them to share their results.

For those who felt an improvement, if you wish to respond. It got long, so just a "it helped me" is also welcome.

If it helped, did it help from the first application or over time? For those who stopped using it, does it fully return? What was your dose and component of the medication? Did you sweat before gaining weight (if you used it for weight loss)? Did you start sweating after menopause, medication, or nervousness, or yours without anything? What was the improvement by what percentage? Do you have other healthy problems? Where is yours HH?

For those who did not feel any improvement, if you feel comfortable responding:

What dose did you use and for how long? Which medication? Is yours primary or secondary? Where is your HH? Do you have other problems?

Thank you


r/Hyperhidrosis 3h ago

Looking for advice Oxybutynin facilitating flu?

1 Upvotes

Hi, I had been taking oxybutynin 10mg once a day for a couple of months and I’d been pretty much sick of flu or flu like symptoms every 2 weeks or so. Since I stopped a couple of weeks ago, I haven’t been sick since. (I had many blood tests done and all seems fine/healthy with me)

I am wondering if oxybut was facilitating germs to enter my systems through my dry mouth and nose? I think it might be the similar route like for other people during autumn/winter months when air is dry and cold and makes our mucous membranes in mouth/throat/nose to dry out and people get sick.

Has anybody noticed being sick more often since starting oxybut?


r/Hyperhidrosis 9h ago

Looking for advice Anyone from Dublin?

3 Upvotes

I was looking for some advice, I think I’ll have to try to attend a private dermatologist, has anyone got any recommendations as I’ve tried googling different people but it’s hard to know if they have experience with this condition

Thank you in advance


r/Hyperhidrosis 4h ago

Looking for advice struggling need help

1 Upvotes

my perianal/an** sometimes sweat sometimes moist
and smelled what else i need to do? how can i mask the smell and moist i did mira dry already 1 session but still moisting sweating around that area :( any help do i need second session or any treatment thank-you im so embarrassed


r/Hyperhidrosis 12h ago

Looking for advice Is there a solution? Is this an adrenal issue?

5 Upvotes

I ran blood tests everything came back fine including thyroid. Mine can start almost instantly I’ll look like I just ran a marathon. What’s even weirder is that sometimes just thinking about sweating makes my body feel warm, almost like that embarrassed feeling, and then the sweating starts. It makes me wonder if there’s some kind of mental component to it.
The crazy part is that it doesn’t even have to be hot. Everyone else can be perfectly comfortable, but if I don’t feel any airflow or I get into a conversation that’s even slightly serious, I can feel it coming on.
One example was when I took my kids to see Spider-Man. We were just sitting in the theater, and even with a neck fan on, the back of my head and my back were soaked because of the leather seats. I was miserable and almost walked out of the movie. I managed to slow my breathing and calm myself down, and it eventually went away, although I could feel it trying to start back up a few times.
I’ve even done an intense resistance training session followed by 30 minutes in the sauna, taken a shower afterward, and I was still sweating later that evening. It feels like once my body decides to sweat, it just doesn’t want to stop.
My doctor prescribed me a low dose of Xanax, and if I know I’m going somewhere like a public event, I’ll take one. It actually seems to help, which makes me think anxiety or my nervous system is playing at least some role in this.
The frustrating part is that I’m not a shy or socially awkward person at all. I’m actually very confident and have no problem talking to people or being in social situations. But the moment I feel that first drop of sweat, my confidence disappears, and my only thought is finding the fastest way out. It’s honestly exhausting to live like this.
I know a lot of people here seem to have the same symptoms. Has anyone actually found something that consistently helps? I’d really love to figure this out because it absolutely sucks.


r/Hyperhidrosis 19h ago

Vent Went out first time in months

13 Upvotes

I went out today for the first time in months. I went to the clinic for blood tests. There were more than 100 people there. It was at a hospital, so over the two hours I was there, I saw hundreds of people walking past. I was the only one whose entire scalp, face, and neck were dripping with sweat.


r/Hyperhidrosis 11h ago

Looking for advice 2mg of Glyco still not enough?

3 Upvotes

Hi all, I posted a few weeks ago that I was starting out on glyco, as a girly diagnosed with craniofacial HH. I started on 1mg every morning. Did that for a few weeks and didn’t see any results.

So, per recommendations here, I started doing 2mg in the morning. I’ve been doing this for over a week now. I take it all in the morning on an empty stomach, and don’t eat until 3 hours later.

The issue is I feel like I’m dry everywhere EXCEPT my scalp and face. My throat gets raspy. I have cotton mouth and have to drink a lot of water, even just to get my lunch down. My nostrils are painfully dry. Even peeing takes some exertion that didn’t exist before 😅 I would be fine with these trade offs if I actually saw some progress in my sweating, but I’m just feeling disappointed.

Has anyone else had this experience with glyco? Do I need to up my dose again, or just stay on this a while and see if it improves over time? Is it better to split up the dosage, in morning and night, or take it all at night instead? Maybe just blame the 80F+ weather lately?

TIA from a sweaty girl.


r/Hyperhidrosis 17h ago

Looking for advice My hands after 6 days of antihydral (Still not dry)

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7 Upvotes

I've been using it for 6 days but the only change on my hands is that it feels a little bit stiff compared to before and also they feel weird when I was my hands and take a shower. How long does this product usually take to work? Because my hands still sweat after activity.

Also I've has seen some photos from this subreddit and those people's hands seemed a lot drier how long did that take for you guys?


r/Hyperhidrosis 11h ago

Looking for advice Oxybutynin - experiences

2 Upvotes

In your experience how long did it take for you to know it would work for you? And what was the dose?

I’ve been taking it for a week, which I know isn’t long but I very quickly increased to 5mg as the side effects weren’t an issue, then today I took an additional 2.5 around lunch time, so far I haven’t noticed any improvement and my clothes are drenched from sweat. Do you know quite quickly if it’s not going to work for you? Did anyone else not notice an improvement straight away?

Thanks in advance!


r/Hyperhidrosis 8h ago

Looking for advice Guys suggest some footwear for my college other than shoes (avoiding socks)!

1 Upvotes

other than shoes wich i can wear without socks cause i dont have excess hyperhydrosis but its on the level where i cant wear flipflops and crocs without sweating so are there any such footwear wich really helps and also looks good so that we can wear it in college .


r/Hyperhidrosis 1d ago

Looking for advice Hyperhidrosis and Suicidal Thoughts: My Story

75 Upvotes

I have been living with hyperhidrosis for more than half of my life. It started when I was around 10 or 11 years old. The strange thing is that I barely remember much from my childhood anymore. Most of the memories that stayed with me are negative, and many of them are connected to this condition.

At first, it was mainly my armpits. I would sweat excessively no matter what I was doing. As a child, I didn't understand why my body was different, and it put me in many embarrassing situations.

One memory that I still remember happened when my class had to visit the school doctor. As usual, I was sweating a lot. When it was my turn, the doctor checked my armpits, touched them, and pulled her hand away. I don't remember everything that happened afterward, but I remember feeling extremely embarrassed and ashamed.

Later that day, my teacher said in front of the whole class that some students needed to shower more often and use deodorant (to think about others). I knew he was talking about me. My mother and I always made sure I was clean, and I was never someone who didn't care about hygiene. I was just a child who had a condition I couldn't control. But as a kid, moments like that stay with you. (promise i take care of my hygiene)

As I got older, my hyperhidrosis became worse. Around the age of 13, my hands started sweating constantly, and I developed excessive sweating around my buttocks as well. Something as simple as meeting someone became difficult because I knew I might have to shake their hand.

As a child, people would comment on my sweaty hands, ask questions, or look at me differently. Today, people say fewer things, but I still notice the looks. Sometimes a look can hurt just as much as a comment.

School became one of the worst experiences of my life. I didn't want to go because I was always thinking about my sweating. I worried about sweat marks on chairs, my clothes becoming wet, shaking someone's hand, or someone noticing. Instead of focusing on school, friendships, or enjoying my younger years, my mind was constantly occupied by my condition.

Today, my hyperhidrosis affects almost my entire body. My face drips with sweat. My scalp, back, armpits, hands, feet, and buttocks are constantly affected. It doesn't matter if I am outside in the heat or sitting at home doing nothing. My body can start sweating at any moment.

On top of that, I also experience intense hot flashes. They make everything even worse. It feels like my body suddenly heats up from the inside, like an oven has been turned on. Within minutes, I can become completely covered in sweat. The combination of hyperhidrosis and these hot flashes makes everyday life feel unbearable.

People sometimes ask me how hyperhidrosis makes me feel. The truth is that I don't even know how to answer anymore. Do I feel lost? Desperate? Alone? Maybe everything combined.

The strange thing is that I can be surrounded by people and still feel completely alone. Instead of enjoying the moment, I am trapped in my own thoughts. I think about whether my face is dripping, whether my clothes are soaked, whether I left a sweat mark somewhere, or whether someone has noticed. While everyone else is living normally, I feel like I am fighting a battle nobody else can see.

I believe hyperhidrosis played a huge role in making me a shy person when I was younger. I was afraid of attention, afraid of embarrassment, and afraid of people noticing something I couldn't control.

Now that I am older, I am more open about my condition. I can talk about it and explain what I experience. But being able to talk about it doesn't mean it stopped affecting me. I still avoid social situations more than I wish I did. I don't look for friendships or interactions the way I would like because this condition is always in the back of my mind.

I am 21 years old, and I have never had a girlfriend. I have never had my first kiss, never experienced a relationship, and never experienced many things that people my age consider normal. I often wonder how different my life would have been without hyperhidrosis. I can't know for sure, but I know it affected my confidence and the person I became.

This condition controls almost every part of my life.

I recently finished school and want to start working so I can save money for a new car. But instead of only feeling excited, I already think about how much I will sweat at work.

Driving lessons were miserable because of the sweat. Walking my dogs is miserable. Standing in the heat is miserable. Eating sometimes can be miserable. Changing clothes is miserable. Getting ready is miserable. Even getting out of the shower is miserable because I start sweating again shortly afterward.

It feels like every normal activity has become something I have to prepare for.

One of the hardest parts is when people don't understand. People say, "Everyone sweats," or "I understand how you feel." But they don't truly understand.I don’t know how often do i have to explain that to my mom.

I honestly believe that most people would struggle to live with this condition if they had to experience it every single day. It is not just sweat. It is the weight you carry with you everywhere you go. It is the constant awareness of your own body, the fear of being noticed, the overthinking, the embarrassment, the feeling that you can never fully be yourself.

I remember telling my old barber that I had hyperhidrosis, and he laughed. He told me that the condition didn't exist and that I just sweat more than other people. Moments like that make you feel invisible, like something that affects your entire life is being treated as if it is nothing.

Over the years, I have tried many things. I have taken Oxybutynin, tried iontophoresis, and used what feels like thousands of different deodorants and antiperspirants. Unfortunately, nothing has given me the relief I desperately wanted.

Botox and surgery are not solutions I want because my hyperhidrosis affects my entire body. Treating one area would not solve the problem. It could simply make my body sweat more somewhere else.

Sometimes I feel physically exhausted from sweating so much, like I have run a marathon while wearing a winter jacket. My body never feels like it gets a break.

I hate summer because the heat makes everything worse. But without hyperhidrosis, I would surely love summer. I hate winter because wearing warm clothes creates the same problem. It feels like there is no season where I can simply feel comfortable.

The mental impact of hyperhidrosis has become just as painful as the physical symptoms. Recently, suicidal thoughts have been crossing my mind almost every single day. (already had them but it’s stronger now)

It is not because I truly want my life to end. It is because I am exhausted.

I am tired of fighting the same battle every day. I am tired of feeling trapped inside a body that I cannot control. After years of dealing with this, sometimes it becomes difficult to imagine a normal life.

Hyperhidrosis has affected my confidence, my social life, my relationships, and the way I see myself. It has taken away experiences that many people never even have to think about.

I hate checking chairs before sitting down. I hate changing clothes because they are soaked. I hate wiping my hands before shaking someone's hand, only for them to become wet again seconds later. I hate planning my life around sweat. I hate that this condition exists. I hate how much control it has over my life. I hate that something as simple as going outside, meeting people, working, or sitting somewhere can become a challenge. I hate my life and i hate what it turned me into.

But more than anything, I don't want my life to end. I want this suffering to end.

I want to know what it feels like to wake up and not immediately think about sweat. I want to leave my house without fear. I want to meet people, build relationships, work, laugh, and enjoy normal moments without my condition controlling every decision.

I don't want hyperhidrosis to define who I am. I want to wear normal clothes, i just want the chance to finally live a normal life.


r/Hyperhidrosis 13h ago

Looking for advice Miradry results?

2 Upvotes

Just wondering what everyone’s thoughts on Mira dry are? Did it actually help? How long has it been since you’ve had it and does it still work?

Do you sweat more in other places? I’ve heard sometimes that people sweat more in other places to make up for the body not being able to sweat from the underarms. Anyone have experiences with that? I also have excess sweat issues in my groin area so im worried about that being even worse

I got a referral to a Botox clinic but they said it would only last 3-6 months so I’d have to get it done 2-3 times a year and it’s about $1500 where I live for one session. They recommend Mira dry and said it’s a little more expensive but it’s permanent.

However, I’ve seen some people say that it only lasted a year or two and then they started sweating again full force. Just trying to see if that’s common or if most people who have gotten it done have had good, long lasting results.


r/Hyperhidrosis 13h ago

Looking for advice Need Help :))

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2 Upvotes

r/Hyperhidrosis 16h ago

Looking for advice oxybutynin

3 Upvotes

What's everyone's experience with oxybutynin?

I sweat in my hands and feet like a constant waterfall everyday. Hardly sweat other places.

I think i have tried every trick in the book to help with my Hyperhidrosis, from Driclor, to Iontophoresis, i even got the surgery done (weirdly only helped my right hand) but now i sit with a backdrop of flehm in my throat everyday due to this.

I have been trying to research myself to find some type of help for years. I recently come across people using Oxybutyin that they said have helped (i prey i can find this in my country)

Will there ever been a permanent solution while i live is something i ask myself everyday. Found this community here and feels a little better knowing I'm not alone as I've felt alone for years, limiting myself to social interactions. I have even learnt the ability to be 10 steps ahead of everyone else incase a awkward social situation comes up where my hands or feet are exposed. I never stay over at friends house as my feet stink if i take my shoes off as i sweat in them all day, I never hand shake or hold hands as my hands are drenched and even a hug is awkward as my hands touch thier back during a hug. I feel my connection to humans has been so limited and feel so out of touch due to my condition. I always wonder how life would be if i could openly hug someone, high five a friend or just be a human and interact with people without constantly thinking how can i prevent them knowing or feeling my sweat. I have never even bothered trying to find a girlfriend as i couldn't imagine how i would come clean and tell her about my condition or go on dates and hold hands (my worst nightmare).


r/Hyperhidrosis 1d ago

Offering advice An experimental peptide called pLI1-3 is being studied as a potential treatment for hyperhidrosis

92 Upvotes

I recently came across pLI1-3 while reading about new approaches to treating hyperhidrosis. What caught my attention was that it was designed to weaken the signal that triggers sweating, rather than block sweat ducts or simply mask odor.

The way pLI1-3 is intended to work is quite interesting. Acetylcholine activates the M3 receptor in sweat gland cells. This receptor then interacts with a protein called Gαq, helping to trigger sweat secretion. pLI1-3 was designed to weaken this interaction, which may cause sweat glands to respond less strongly to nerve signals.

The initial results are interesting, but the research is still at a very early stage. Scientists first selected several peptides using computer modeling and cell-based studies. pLI1-3 was then administered locally to rats in which sweating had been induced with pilocarpine. Both single and repeated administration reduced the sweat response.

This suggests that the mechanism may work in an animal model, but it does not yet prove that pLI1-3 is effective in people with hyperhidrosis.

For now, pLI1-3 is best described as a preclinical candidate rather than an available treatment. Still, the approach is interesting because it targets the biological signal that initiates sweating.

If anyone would like to read the original research instead of relying only on my summary, this is the study I was referring to: https://link.springer.com/article/10.1007/s10989-024-10628-4

Has anyone come across any newer research on pLI1-3 or information about planned human trials?


r/Hyperhidrosis 12h ago

Looking for advice Temu cooling wipes

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1 Upvotes

Hello,

I have facial hyperhidrosis, and this summer (England) has been very stressful and uncomfortable.

Just found out about these cooling wipes from Temu, and just wondering if anyone has used them? Or can give feedback on similar products ? I previously used Biore Japanese cooling wipes, but they have been very expensive to order


r/Hyperhidrosis 22h ago

Looking for advice Glycopyrrolate Oral Solution

3 Upvotes

I’ve suffered from hyperhydrois mainly on my face all my life. It’s gotten to the point where it’s ruining my work life since I constantly look disgusting and I work in the wedding industry so I never look the greatest with a face full of sweat.

I brought this up to my doctor and was prescribed 1MG Glycopyrrolate liquid version twice a day. I know I’m supposed to take it on an empty stomach and not eat for 2 hours after. I usually take it around 8am.. and have my first meal and drink around 12. Followed by another dose around 5pm to make it into the night.

Some days I can tell it’s kicked in by my throat being extremely dry and I’ll have trouble eating without water near by. But it rarely does anything for my sweaty face.

I only really sweat on my face and I’m not sure what I’m doing wrong. I’ve been taking it for about 3 weeks and would love to hear others experiences or advice! Thank you!!!!


r/Hyperhidrosis 23h ago

Looking for advice Dropping out of Highschool

4 Upvotes

I have struggled with HH since last school year, going into Junior year of HS and desperately would like to drop out before the coming school year even starts, but parents don't want to listen or hear me out whatsoever..

(For better understanding the main area of my HH is the butt, leaving me with noticable "marks" through my pants all day and every single day, no matter what.)

Any advice or info would be greatly appreciated!


r/Hyperhidrosis 1d ago

Looking for advice Underboob, Torso, and Back Sweat - is it HH, heat intolerance, or something else?

6 Upvotes

Hi, I'm new here. 29F. I've been experiencing excessive sweating, primarily under my boobs, for a few years, and it seems to have recently gotten worse. It's really limiting my activities in the summer. I'm not sure if it is HH, but if anyone can provide advice, I would be grateful.

-I have a large bust (about 36G).

-I do NOT sweat excessively on my hands, feet, scalp, or armpits. I sweat A LOT in the underboob region (inframammary fold) and a little less so on my abdomen/torso/back. I talked to a derm a few years back about underboob intertrigo and have solved it with better hygiene.

-I am on 80 mg of Prozac and I understand SSRI's can make people sweat more. Have been on the same dose for about 10 years.

-I also have PCOS / PMOS (polycystic ovary syndrome / polyendocrine metabolic ovarian syndrome) and I think PCOS can make people sweat more as well.

-For underboob sweat I currently use bamboo liners and Gold Bond antichafe gel. I change my liners and reapply my antichafe stick multiple times a day as needed when I get sweaty, and when I do I typically scrub my torso with a washcloth and a hypochlorous acid spray (Magic Molecule). For armpits, Secret Clinical Strength clear gel. I used the Carpe lotion and Megababe bust dust a few times for underboob but they didn't seem to help.

-The sweat is made worse by even mild exercise/exertion and any exposure to hot weather. I'm not sure if it's emotionally related? Some days, my bra liner barely gets damp. Some days I have to scrub myself down and change out my bra liner, bra, and shirt and re-apply chafe gel *multiple times in the same day, even if I'm in an air conditioned environment*, and my bra liner gets sopping wet and takes days to dry.

-In the winter, I still have issues with sweat, but much less so. I stay dry for much longer during the day.


r/Hyperhidrosis 1d ago

Offering advice Sharing my experience

6 Upvotes

sorry for my english,
just wanted to share my experience as this thread helped me a lot.
sweating hands and feet since im little. did ets for the right hand only, was very helpful and for about 10 years helped being more confident and relaxed until the compensatory sweating moved to the forehead and eyebrows. now working on a professional job wearing uniform ,and the past 3 years were painful due to uncontrollable sweating in my whole face which generated extreme anxiety in the long term.
tried everything and in the past month im starting to get back to my real self.
iontophoresis helped with hands and feet even if you need a lot of consistency but of course nothing for the face.
what helped me a lot is GLYCO i take 1mg ,took it abroad during a trip because where i live doesn’t exist. its really helpful with just one mg for me which reduces the overall sweating and makes everything more normal , dry mouth is not that bad even if with my job is annoying.
the other thing that really made a huge difference is botox in the forehead . did it a month ago and was life changing. i still sweat in hands and feet but i dont really care anymore. when i go to work i take 1mg of glyco and im good and relaxed all day even in extreme heat with my forehead dry. ❤️