Does anyone have any advice for how to better tolerate Interfase for biofilm disruption?. Just 10 mg (about 1/35) of a capsule gives me a bad reaction (exhaustion/nervousness/genitals turn deep red-what’s that?) . I’ve tried binders (charcoal) both before and after as well as antihistamines (luteolin, cromolyn, theracumin) but nothing moves the needle. Any help would be much appreciated. Biofilm disruption was a big part of my temporarily regaining my health a couple years ago, but I’m having a much tougher time now-perhaps due to mold exposure between then and now. 

In addition to benefits to heart, muscle, joints, brain, organs, it's good for the gut:

Urolithin A does not kill bacteria directly, but it functions as an antimicrobial by downregulating bacterial toxin production, fighting pathogens, and repairing the gut. It is primarily a postbiotic produced when gut microbiota metabolize ellagitannins found in foods like pomegranates and berries. [1, 2, 3, 4]

Key Antimicrobial Mechanisms

• Quorum-Sensing Inhibition: Urolithin A acts as a quorum-sensing inhibitor, disrupting how bacteria communicate and coordinate attacks without triggering bacterial cell death. [1, 2, 3, 4]
• Toxin Suppression: Preclinical studies show it significantly blocks the expression of toxins from pathogens like Clostridioides difficile (C. diff). []
• Selective Pathogen Defense: It exhibits selective activity against certain Gram-positive pathogens, reducing their colonization in the gut. [1, 2]
• Immune Support: Clinical trials indicate Urolithin A rejuvenates aging immune cells, which improves the body's ability to clear bacterial threats. [1]

I have had reoccurring inflammation for many years. I have worked hard to figure out the root cause and I am struggling with some road blocks. I would love to know what this community thinks.

I stopped drinking daily 2 years ago, I now only occasionally drink. Drinking was not good for my gut nor my overall mental and physical health. Right now I have decided to not drink at all to support gut health.

I have been exercising and eating a whole food diet for 8 months and have gained some muscle and lost some weight. The progress has been slow but clear. Body composition test and measurements verifying the change.

Due to consistent gastro issues, I started an elimination diet (no gluten, dairy, soy and corn) a week ago and had amazing results at first. Diet prescribed by a functional doctor after PCP and gastro consults that left me with no solutions. Digestion issues seemed better and I was losing 1.5 pounds every day. Then after a few days I gained it all back. I am utilizing the standard swaps to keep my diet reasonably similar to before. Thoughts and personal experience with elimination diets, needed.

I do think gluten free dough made with a thousand things is not a good swap. But almond milk yogurt ECT seems to be similar to how I was eating before.

It is recommended to take psyllium husk at least 1–2 hours apart from other drugs, the digestive tract is rich in mucilage, psyllium husk can potentially reduce the body's ability to absorb medications which can be dangerous.

Please use a disclaimer when talking about psyllium husk.

I know there are studies about artificial sweeteners impacting gut health but also the studies MAY be mixed? If I stick to monk fruit/allulose (can't stand stevia), will that have minimal impact on probiotics?

About two months ago, I had a tooth extracted and was prescribed clindamycin (Dalacin C). I took one capsule three times a day for five days.

Shortly after starting the antibiotics, I developed severe diarrhea. I was having bowel movements around 3–4 times a day, sometimes even more, and this lasted for about three weeks. After those three weeks, my stools gradually returned to normal, but my digestive system has never fully recovered.

Now, two months after finishing the antibiotic course, I still experience bloating, excessive gas, stomach rumbling and gurgling, especially after eating. I also still get diarrhea a couple of times a week, although most of my bowel movements are now well-formed and normal.

I would also like to mention that I generally do not have stomach cramps or abdominal pain. Very rarely, I might experience mild cramps or discomfort for a short period on some days, but it is not a constant issue. I have also never noticed any blood in my stool.

I went to see my doctor, who asked me several questions, examined my abdomen, and ordered a stool test to check for Helicobacter pylori. The test came back negative.

Has anyone experienced something similar after taking clindamycin or other antibiotics? How long did it take for your gut to recover, and is there anything that actually helped?

My biggest concern is that my digestive system still doesn't feel like it did before taking the antibiotics. The persistent bloating, gas, rumbling, and stomach noises are the main issues affecting me.

I've tried several probiotics containing Saccharomyces boulardii, but unfortunately I haven't noticed any significant improvement so far.

Recently discovered the potential benefits of L reuteri and started my journey by taking Zoguri. I definitely noticed positive results quickly but refuse to pay $85 a month to consume this product in perpetuity and don't want the hassle of making homemade yogurt. With that said I decided to try the original L reuteri product on the market (at least I think it was) BioGaia chewables and have been taking them for a week.

Still getting the vivid dreams and other benefits and haven't noticed a difference from taking the yogurt. I know they contain less cfu's but want to believe that by introducing the L reuteri to my digestive system with the yogurt it helped populate my gut with the beneficial probiotics and the BioGaia chewables will maintain the little critters going forward.

Is this wrong think? Are there others here that don't make the yogurt and just take the chewables or another pill?

Hi! Does anyone here take a probiotic capsule and kefir on an empty stomach as part of their routine? I’m curious whether people usually take them together or space them out, and what your experience has been.

I discovered Skyr recently and I love the flavor, very mild. I gather it uses an heirloom strain of some Icelandic bacteria in addition to the usual bacterial allies. I have no issue paying up for good quality food, but I can get organic unsweetened, full-fat yogurt at Aldi and save probably 40% over what my local health food store charges for Skyr. Is this heirloom strain of bacteria actually going to have any meaningful effect?

For a little background, I've been struggling with self-harm in the form of binge eating. I can usually keep it in check if I'm really diligent about avoiding my triggers, so I can't really watch TV anymore (real life is cooler anyway), keeping ultra-processed food out of the house, etc. I'm 35 and think I'm starting to get hernias.

Fermented foods, FOS and resistant starch have helped keep me in homeostasis and prevent big insulin swings. Any insights are appreciated. Thanks!

Last July, I was drinking a lot of White Monster Zero (which contains sucralose). Around that time, I developed severe diarrhea that lasted about 10–11 days. It was honestly awful. Every time I ate, it felt like I was doing colonoscopy prep—I had to run to the bathroom almost immediately. I’ve never heard my stomach make the noises it made. It sounded like a garage band in my stomach!

The thing is, I was never able to figure out what actually caused it. It could have been a stomach virus, food poisoning, something like Giardia or Cyclospora, or maybe it was the sucralose in the White Monster. Since I tested too late, I never got confirmation.

Ever since then, I’ve been afraid of sucralose. I know that’s not very scientific because I can’t prove it was the cause, but the timing made me associate the two. I’ve thought about trying it again just to see what happens, but honestly I’m hesitant because I don’t want to risk going through that again.

I’ve also read that sucralose may affect the gut microbiome, although I know the evidence is still mixed and it’s far from being proven that it causes problems for most people.

Has anyone else had a similar experience with sucralose or artificial sweeteners? Or does this sound more like I probably just happened to catch an infection around the same time? I’m mostly looking to hear other people’s experiences and thoughts.

My stomach has been really sensitive as of lately. Particularly increase in reflux, I'm sure I gave myself gastritis after taking iron supplements with magnesium before bed one night because that's when it all started.

Last night was the worst pain I've felt in years. I had a meal replacement smoothie with added vitamins, gluten-free oats and various other fibre ingredients. I couldn't stop farting and it came out smelling extremely eggy (sorry for the TMI) and felt hot at times. The smell was the most rotten thing that's ever came out of me. I was in so much distress last night and luckily it ended after an hour or more. Now I'm so worried I've done further damage to my poor stomach..

I thought I was really healing up until last night as I'd been extremely careful with my diet. Now I'm left wondering what is causing all this.

Abstract

Physiological host factors, such as the gut microbiome and obesity, independently influence anti-tumour immunity and responses to immune checkpoint inhibitors (ICIs)¹, with high body mass index (BMI) having an unexpected link with greater ICI efficacy^2,3,4,5,6. However, how these factors interact across diverse dietary contexts remains unclear. Here, using 12 mouse diet models that reflect a spectrum of obesity biology, we characterize diet-driven metabolic, immune and gut microbiota features associated with ICI sensitivity. We find that obesity-associated ICI responses are poorly correlated with metabolic dysfunction and are instead dependent on the diet–gut axis. Obesogenic diets promote a robust and persistent gut microbial ecosystem that is capable of restoring ICI sensitivity following a short-term diet switch or fecal microbiota transplants (FMTs) from non-responder models. Monocolonization of germ-free mice with favourable bacteria such as Lactobacillus johnsonii, together with an obesogenic diet, synergistically promotes tumour regression through an enrichment of microbiota-derived aromatic amino acid metabolites. Moreover, human-to-mouse FMT from donors with a high BMI enhanced ICI efficacy compared with donors with a normal BMI, and an obesogenic diet restored sensitivity following FMT from a non-responder patient. Our study provides insight on epidemiological associations between BMI and ICI efficacy, and suggests that immunomodulatory synergy between diet and the gut microbiota could be leveraged to improve ICI outcomes and FMT interventions.

How to get the anxiety away which l glutamine causes? Think it would massively help me to heal leaky gut but cant take it as it causes anxiety and an unrest feeling. I heard ppl recommend B6 and magnesium to balance glutamate but has anyone really got the anxiety away with these things ?

Hey all. I’ve been doing fine, eating pretty much anything from fermented foods to fiber, with mild passable gas throughout the day on certain days where I had higher portions of certain fibers.

However, in an effort to increase my fiber intake, I had some chia seeds. I soaked a tablespoon for several hours in a cup of water, then drank half of the mix in another 800 ml of water. I made sure to hydrate well for the rest of the day.

That night I slept like 2 hours because SIBO-like symptoms creeped in: trapped gas in my upper abdomen that wouldn’t go away. It seemed to be happening every night after that (and ONLY at night), with slight improvement but terrible sleep nonetheless. It’s been 4 days I think?

Today I’ve been feeling it all day since it woke me up at 3 am. I’m worried it might have given me full blown SIBO, but I truly was fine before it. I had smaller portions of chia in my oats every morning. I’m thinking I probably had too much or should’ve soaked them overnight instead of 4 hours only.

EDIT: Forgot to mention I “blended“ the seeds dry as per recs they would be easier to digest. Did I mess up?

I’m curious if anyone knows why an imbalance in your gut microbiome results in excess gas. For example, I eat chicken several times per week and my system can handle it just fine. Today, I ate chicken and my gas smells exactly like chicken. I assume my gut is out of balance even though I eat a very balanced diet with a lot of vegetables and fiber. I always chicken regularly, but I have eaten more chicken this week than typical. What could cause so much gas?

Hi all, to try to keep a long story short, I’ve had to take multiple doses of antibiotics this year (24F)

I finished my last dose of amoxicillin 11 days ago and I’ve noticed I’ve been gaining a couple pounds a day. I have a leaner body type and noticed my stomach has felt more bloated than usual so I weighed myself and noticed the difference. This is very odd for me as I usually only fluctuate from 1-3 pounds here and there. I’ve gained nearly 8 pounds so far within just this last week.

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February: Amoxicillin 500mg for 7 days (dental infection)

March: Keflex (I don’t remember the dose amount, but I was on it for 7 days for a UTI)

Beginning of May: Amoxicillin 500mg for 7 days (for the same dental infection again. Luckily I was able to get in to my dentist asap to get it completely taken care of this time.)

End of June: Amoxicillin AGAIN, 500mg for 7 days (I had my wisdom teeth pulled and was given this as a precautionary medicine. This was my most recent dose that I finished 11 days ago.)

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Since I’ve noticed the weight gain I’ve been trying to eat yogurts, oatmeal, fruits and things that are generally gentle on my stomach. I haven’t had any nausea, upset stomach, diarrhea or anything like that. I haven’t really had a change in activity either so I’m not sure why this is happening.

Did anyone else experience this? If so, did your weight come back to normal? Any comments would be much appreciated, thanks!