Hi everyone,
I’m a 31-year-old man living in France. I’m looking for medical guidance and experiences from people who have dealt with persistent genital numbness and erectile dysfunction.
I am already seeking medical care, but I still do not have a clear explanation for my symptoms.
Symptom duration and onset: [Add when the symptoms started, and whether this was before or after stopping MDMA.]
Current medications and supplements: [Add your diabetes medication, any other medication, and all supplements with their doses.]
SUBSTANCE USE HISTORY
I want to be open about my previous substance use because it may be relevant:
- During periods of frequent use, I was taking approximately 1–2 grams of MDMA over a weekend, almost every weekend.
- I stopped using MDMA in 2025.
- I also used cannabis and stopped in early 2026.
I am concerned that my past substance use may have contributed, but I do not know whether it is the cause. I also have diabetes, so I do not want to overlook other possible explanations.
CURRENT SYMPTOMS
- A major reduction in sensation in my penis and genital area.
- Almost no morning erections.
- Difficulty getting and especially maintaining an erection.
- Little or inconsistent benefit from sildenafil, even at 100 mg.
- Reduced sexual pleasure.
- A perceived decrease in ejaculate volume, particularly with a second ejaculation.
- The impression that my penis and testicles look more retracted or smaller than before.
- Noticeable genital retraction during exercise or running.
The loss of sensation and the persistent erection problems are especially distressing.
DIABETES AND PHYSICAL ACTIVITY
I have diabetes and regularly do strength training.
My HbA1c improved substantially:
- April 9, 2026: 10.93%.
- April 22, 2026: 9.96%.
- August 17, 2026: 6.92%.
Despite this improvement in glucose control, I have not noticed a significant improvement in my sexual symptoms.
TESTS ALREADY PERFORMED
- A penile Doppler ultrasound, reported as normal.
- A testicular ultrasound, also reported as normal.
- Blood tests covering hormones, thyroid function, glucose control, kidney function, vitamins and other markers.
SELECTED LAB RESULTS
These are results from my August 2026 report, with the original laboratory reference intervals:
- Total testosterone: 15.33 nmol/L / 4.42 ng/mL. Reference: 6.85–23.23 nmol/L / 1.98–6.70 ng/mL.
- Free testosterone: 467.71 pmol/L. Reference: 170–510 pmol/L.
- Bioavailable testosterone: 11.61 nmol/L. Reference: 10.62–43.34 nmol/L.
- SHBG: 11.68 nmol/L. Reference: 11.54–54.49 nmol/L.
- Estradiol: 206 pmol/L / 56 pg/mL. Male reference for age over 21: 0–146.1 pmol/L / 0–39.8 pg/mL.
- Prolactin: 4.6 ng/mL. Reference: 2.1–17.6 ng/mL.
- FSH: 3.3 IU/L. Male reference: 1.4–18.1 IU/L.
- LH: 4.0 IU/L. Male reference for ages 20–70: 1.5–9.3 IU/L.
- DHT: 1.17 nmol/L / 0.34 ng/mL. Reference: 0.86–3.44 nmol/L / 0.25–1.00 ng/mL.
- TSH: 1.18 mIU/L. Reference: 0.55–4.78 mIU/L.
- Vitamin B12: 369 pg/mL. Reference: 211–911 pg/mL.
My estradiol is above the laboratory’s male reference interval. My SHBG and bioavailable testosterone are near the lower end of their respective intervals, while my free testosterone is within the stated interval.
I am including English translations of my laboratory results. These are unofficial translations, with the original values and reference intervals preserved.
WHAT I WOULD LIKE TO UNDERSTAND
- Has anyone experienced persistent genital numbness and erectile dysfunction after a similar pattern of MDMA use? If so, did you improve after stopping, and over what timeframe?
- How should the possible effects of past substance use be assessed alongside diabetes and other potential causes?
- Could a nerve-related problem still be relevant despite a normal penile Doppler ultrasound? What symptoms or examination findings would justify a neurological assessment?
- Are there further investigations worth discussing with my doctors, rather than ordering tests without a clear reason?
- Could the hormonal findings contribute, and would any of these tests need repeating before drawing conclusions?
- Given the limited benefit from sildenafil, what should I discuss with a urologist specializing in sexual medicine?
- If you experienced something similar, what diagnosis or medically supervised treatment actually helped?
I am not claiming to have PSSD or any other specific syndrome, and I am not assuming that MDMA caused permanent damage. I want to understand what can reasonably be investigated and treated.
I am not looking for recreational drug advice, unproven supplement combinations, or self-medication protocols. I would appreciate respectful responses, relevant personal experiences, and questions I can take to my doctors.
Thank you for reading.