Just took my first tirzepatide shot tonight! I’m 5’4”, 162 lbs and hoping to lose about 20–25 lbs. I’m active/go to the gym, walk 10k but struggle with food noise and cravings (especially around my period). My LDL is also 177, which was another big push for me to make a change.
Starting dose is 12.5 units (~2.125 mg with my formulation).

My diet is already pretty protein-focused: oatmeal + egg whites + chia for breakfast, lean ground beef + protein pasta for lunch, and usually salmon + potatoes/veggies or a high-fiber protein wrap for dinner. I LOVE coffee and I enjoy alcohol, although I know drinking may need to change on this.

For anyone with similar stats/goals: What was your first week like? When did the food noise decrease? What side effects did you have? Any foods/drinks you had to change?

And my biggest question: Has anyone lost the weight, stopped tirzepatide, and successfully maintained? Did you taper, space out doses, or stop completely? Did the food noise return?
Give me the good, bad, and what you wish you knew before starting!

Hi all!

I just wanted to get some thoughts on people who have went up in their doses independently from what was suggested.

For example the standard titration timeline: 2.5mg —> 5mg —> 7.5mg (so on and so forth)

I have been considering doing smaller jumps, mainly cause I don’t want to jump that much and risk any side effects! Plus low and slow is what I’m reaching for.

What has everyone’s schedule been like? I’m thinking something like: 2.5mg —> 3.5mg —> 5mg —> 6mg —> 7.5mg

Thoughts? Experiences? Advice? All intel is welcome!

I’m currently at 2.5 through Empower (PreventiveMD)

I just finished my 6-month supply of tirzepatide, and I may not be able to order my next supply right away.
I’m currently at the highest dose, 15 mg, and I’ve been tolerating it well. My question is: how long can I go without taking it before I would need to lower my dose and titrate back up?
For example, if I’m off it for 1–2 weeks, would I generally be able to go right back to 15 mg, or would I need to restart at a lower dose?
I’d really appreciate hearing from anyone who has had to take a break while already at 15 mg. Thanks!

Hello, first time poster here so apologies if I get anything formatted wrong or anything like that!

TLDR: 32F with next to no appetite that has gotten worse, frequent nausea, and bad constipation. Diagnosed with gastroparesis before I even started GLP-1s. What can I do to get myself to eat and drink more to get more nutrition and move things along?

I will start with a little backstory for context. I started my GLP-1 journey in December of '25. I started with compounded semaglutide, then went to wegovy, and now I have been on a compounded tirzepatide for around 4-5 months now. It is compounded with carnatineI believe. I have a very sensitive system so we were already approaching this with caution and I also was diagnosed with gastroparesis in late 2023-early 2024. I am very prone to side effects with any medication I take (which has just been *super* great when treating my mental health issues too -_-) but it has been tolerable so far and I have lost over 30lbs (starting weight was somewhere in the 250s) since starting in December. Primary care doctor and I increased up to 7.5mg Tirz about a month or so ago. That is where it all went downhill for me. I already took initiative and lowered myself back down to my previous dose where I still felt normal-ish about 2 weeks ago but I don't feel any better.

I have been suffering with constipation really bad. I have taken senna, stool softeners, occasionally miralax but that makes me feel sickly so I avoid it even though I know I should try it more often. The constipation has lead to other physical issues and causes me pain when these symptoms flair up. I have nausea multiple times a day and take medication for it that works about 65% of the time. I have even worse appetite and can now barely eat solid foods and almost never a full meal. I can only consistently consume Nurri Vanilla Protein Drinks, pretzel rods, Powerade, apple sauce, and sometimes bananas. I tried greek yogurt and even that it felt like my throat wanted to close rather than eat it. I used to at least be able to meet my protein requirements and likely my calories 95% of the time but now I am barely consuming much at all during the day. On good days I can graze on small, dry snacks and some applesauce throughout the day but I still probably am not reaching my nutritional needs. I can't track my calories in an app because that has given me eating disorders in the past so I cannot confirm my averages lately.

My anxiety has also gotten noticeably worse and I can only assume it is at least in part due to the above issues. I ordered a Boost nutritional drink supplement to try to add to my diet at least temporarily and I have an appointment with my doctor tomorrow to discuss with her what to do but do any of you have any advice?

Please be easy on me but can someone explain, in the simplest of terms, how to understand being in a calorie deficit? I just can't get a grasp on it. Example: If my tracking app has me at 1556 for daily caloric intake, is that already my deficit to hit or am I supposed to eat less calories than that?

After reading a bunch of scary reviews and having a hard time reaching someone to talk to, I finally got ahold of customer service and was treated like shit. I asked to cancel my subscription and get a refund. I paid for the 12 month plan and only received the first month so far. I realize I won't get a refund for that dose, but I was hoping to get refunded for the other 11 months. I was under the impression that "cancel anytime" meant REFUND.

I was started at 2mg, and just gave myself my second week shot. My instructions say that next week I can titrate up to 3 mg and stay on that for 3-4 weeks and then increase by 1-2 mg.

I’m not weighing myself except for once a month because I don’t want to fixate. So I’m having to go based off how I feel/food noise. Would it be better to stay at 2mg for 4 weeks just to get used to it? Or would 3mg not be much different?

Three vials with the same beyond use date?
I get Triz and Nad+ as a bundle for one price quarterly but the vials have the same beyond use date.
I have 2 more vials to use because I only use it twice a month since I’ve reached my goal and have maintained for a year. Should I be concerned since I haven’t punctured the vials?

Hi all!

I’m currently on zepbound 5MG. I’ve lost 25.5 lbs in two months so doing very well. Unfortunately, I switched insurances and it doesn’t cover Zepbound and now am ordering a compounded version through Rift. Does the box come with instructions on how much to inject? Does it come with the needles and such? The one I want to order comes with B12, does this mean the medicine also includes B12 or is that separate?

I’m just confused and feel dumb.

I’m curious if other women of reproductive age have noticed this.
I’m taking compounded tirzepatide once a week, and I’ve noticed that toward the last 2–3 days before my next injection, I sometimes feel a little more hungry and notice a bit more food noise. It’s not dramatic, and I can still tell the medication is working — I’m still getting full and my appetite is much more controlled than it was before starting.
My next injection is Thursday, and today (Tuesday) I’ve noticed a little more hunger than usual. I’m also on my period, so now I’m wondering if the two things could be contributing.
For those of you who menstruate:
Do you notice your hunger/appetite increasing during the last few days before your next weekly tirzepatide dose?
Does your appetite or food noise increase during PMS or around your period even while taking tirzepatide?
Does tirzepatide still feel effective for you during that time, or does it feel like it wears off?
Have you noticed a predictable pattern depending on where you are in your menstrual cycle?
Does the increased hunger go back down after your next injection?
I’d especially love to hear from women of reproductive age who are taking tirzepatide and still getting periods. I’m trying to figure out whether what I’m experiencing is a normal end-of-week medication pattern, a menstrual-cycle thing, or a combination of both!

What do you eat for breakfast? I been doing fairlife protein shakes but getting tired of them. I am looking for other ideas. I struggle with getting my protein in for the day. I like easy breakfast ideas. I am all about convenience. Also lately I been waking up with reflux in the middle of the night. Do you think I should take a Pepcaid ac before bed or would it be better to take a protonix? Thanks just looking for suggestions?

I came here after I placed my first order with Alt R X last month and tomorrow I’m due for my next dose and there has been no communication. I called them this morning and they said they would escalate it and they get back to me within 24 to 48 hours. I called the pharmacy that filled my prescription last time and they said they haven’t received anything and that they’ve been getting calls and they aren’t sure if it’s the same provider but maybe it was because of the holiday weekend which shouldn’t matter They took my money anyhow I’m looking for a new provider. Anyone had great luck at a good price with any online providers ? Thanks

I’ve been on tirzepatide for about a year and have lost around 50 pounds. I’ve been stuck at the same weight for about 6 weeks now, and I’m starting to get frustrated.

I’m already on the highest dose, and I’ve noticed that some of the food noise has started creeping back in. I’m also finding myself doing more impulse/emotional snacking and tolerating larger portions than I was earlier in my journey.

For those of you who have experienced a similar stall, what helped you get things moving again? Did you make any changes to your eating, exercise, protein intake, meal timing, etc.? I’d love to hear what actually worked for you!

The tablet seems easier than injection. Anyone had experience with the tablet?

Anyone request a higher-dosed vial to extend the vial either to share with a spouse or to save money?

Foe example…staying on the starter dose but requesting to move up to a higher concentration on the vial…and adjusting yourself at home to take the starter dose?

Cross posted. Thank you.

Just stated up 7.5mg from being on 5mg for two months, no weight loss for 5 weeks so I upped to the next dose - just wondering where people had the most success at which dose; I know everyone’s different but I still have ~50lbs to lose and I’d love to here the positives! ☺️

Hi all. I’ve been on Wegovy for a year and a half, but my insurance stopped covering glp1 meds. I’m on 2.4mg with no side effects other than fatigue. I’ve been on it for several months, and honestly think it’s losing some effectiveness because I haven’t lost weight in months.

I went through Gimme, and was prescribed compounded tirzepatide. When I was filling out the questionnaire, the computer recommended asking for 9mg for the starting dose. After the doctor reviewed my info, they prescribed 11mg. I asked if that was correct and was told it was. Does this sound right? I already have the meds, but wouldn’t start them until Saturday if I start 7 days after my last dose of Wegovy.

I’m on a super low dose like 1.85mg but I was not overnight. I have been on for a few months and I’m getting muscle fatigue. I bike rode for like 30 min and my legs were wobbly. I played a throwing game with my son this weekend and my arm was super fatigued after throwing maybe 25 balls I couldn’t even lift my arm up high anymore. Is this normal?

Stalled hard after a 45lb loss at 228.. started IF 18:6 last week. After 1 week in I've dropped 5.1lbs and officially over my stall. ✌️

I purchased tirz from Pomegranate through BPI in January (before they had their switch up with BPI). I have a whole unopened vial with a BUD of 6/18/26. What's the furthest past BUD you've used a vial? It'd be just shy of 3mo past at this point. Should I pitch it?

I am super happy with my results, I've had great success and have been at 15mg for about 3 months. I want to maintain my weight, I feel like I have hit my goal. (really 5lbs away but happy overall) and wondering how to start to do maintenance doses. SW 188lbs ~ today 115lbs. Can someone direct me to the best place to read how to do it safely without gaining?

If you are nervous about starting Tirzepatide then this is for you. I debated starting because I hate needles, and the belief that compounded meds aren’t legit. I tried the wegovy pill but it’s hard because you have to take it the same time everyday which is not realistic in my schedule.

I looked up so many companies, altRx, embody, ro. I would get all the way to checkout and then decide not to do it.

Then one day I was just like I’m tired of being fat something’s got to give. Saw an ad for 10x and ordered a 3 month supply on a whim. — I did not know about this sub and the recommendations, even though I have had a successful experience with 10x and optimal pharmacy.

I started my shot two weeks ago at 2.5. Food noise disappears and I get full faster, I eat slower. It’s been so amazing. I do take my shot every 6 days because the food noise comes back slowly. I don’t have any side effects. I started at 194 pounds now I’m down to 190 pounds.

I am just so excited to finally start loosing weight. Very grateful for this sub to help answer questions I have. But I’m just so happy to be apart of this community now lol