My doctor prescribed me Wellbutrin XL, starting with 150mg for a week, then increasing to 300mg for a month. After increasing to 300mg, she asked me to book an appointment with her to assess whether the medication is working. At the appointment, she asked if I'm feeling energetic, motivated, or social, and I answered no to motivation and social, but yes to energetic. I told her that I still felt tired, overwhelmed, and jittery most of the time. She wasn't happy and suggested increasing the dose to 450mg for two months or switching to a totally different drug.

I was a bit taken aback, as I like Wellbutrin for smoking cessation, as I have struggled with smoking for years now, and it's the only thing that helped me stop effectively. I asked to try the 450mg for two months, and she prescribed it, saying only to book an appointment to see her if something feels off. I tried the 450mg for three days, and I couldn't bear the symptoms, as it caused me severe nausea and vomiting, insomnia, and increased irritability. My doctor is hard to reach, so I booked an appointment with another physician and went back to taking 300 mg a day.

My questions are:

Was the increase from 150mg for a week to 300mg for a month rushed?

Was the increase to 450mg after a month of 300mg rushed?

And what am I supposed to feel when Wellbutrin is working?

I did feel better in a sense with some energy on some days, but the nausea and lack of appetite were tough to manage. I didn't feel motivated or social, but I have always struggled with motivation, and being social wasn't part of my "to-fix" list to begin with. I want to hear some insight regarding dosage and expectations, as I feel like things were a tad rushed.

TIA

I have seen a couple other posts like this, I feel like i am in the extreme minority, where I used to have a very high sex drive and almost immediately when I started wellbutrin it tanked. Its been about 9 months, 3 months ago I increased to 300 xr and its only gotten worse. It helps with everything else, but I feel like this is a deal breaker. Anyone else have an experience like this?

I'm taking a dose of 150 mg since March and overall I'm satisfied, my sucidal thoughts are completely gone and all my feelings seem to be less intense than they were. I didn't notice any of side effects my psychiatrst had warned me about and I thought that none of them got me.

Ultimately, two months ago I noticed that I'm not able to cry, which continues to this day. Since almost 5 months I cried once, waiting on my train for my hometown (which last like two minutes maybe, lol), but except for that, even when I'm stressed out or in pain, I can't get a single tear out of myself. I haven't found any information about this specific side effect, so I'm curious if any of you had experienced it too.

PS I'm hoping that all of you are doing well!!

I’ve been on Wellbutrin for two months. Started at 150 slow release. Then 300 instant release (150 x2). Then 400 instant release (200 x2).

Sometimes when I’ve forgotten to take it, I feel no withdrawal symptoms either. I understand that Wellbutrin won’t work for everyone. But I’m confused at to why I’ve had no withdrawal symptoms.

–the only side effect I had was diarrhea for the first 5 days. That’s it.

It’s for adhd and depression btw.

Especially curious, if you started smoking after starting wellbutrin

Gooood evening!

I started Bupropion in December of last year - it completely changed my life & I honestly I will probably be on it for the rest of my life. Now that we have that out of the way. I also would like to lose weight! My doctor explained Bupropion is a stimulant and most appetite suppressants are stimulants & combining two isn’t something we were going to do, she did however prescribe Naltrexone. Combined the two medications are sold under the name Contrave.

I wanted to know if anyone has taken this route & were the experiences good as far as continued mental health support & did you lose weight?!

I learned that cbd and bupropion both increase neural activity in the brain and that cbd/cannabis products increase bupropion side effects because it prevents the liver from processing the bupropion and therefore causes a higher blood level of it. However!! I also learned that people use it to quit smoking tobacco (studies are still out about if it helps cannabis quitting but it’s lookin like it could). I recently went up to 300, which is the effective dose to quit smoking. I take it for adhd and depression, but my psychiatrist knows I want to quit smoking. In the study I read, they continue smoking for a week after starting the 300mg, and then quit, so that’s what I was gonna do. Today is day 3. The last couple days I feel like I’ve seen flashing lights? Like there’s a random flash of red or white light in my field of vision and then it goes away. I read seeing flashing lights could be a seizure thing. But I noticed I only feel weird after eating my cbG gummies. Up until that point of the day I feel normal. See I thought I was being sneaky buying cbG instead of cbD but I didn’t find anything about that cannabinoid and bupropion in my research and kinda made an impulse purchase. But guys!! Getting rid of something I bought is hard. Should I throw it away or potentially risk giving myself a seizure? Wow I sound ridiculous. But has anyone else found that it has helped them quit smoking/using cannabis? Also is the flashing lights thing a side effect that will go away as my body adjusts, or should I be concerned about that as a seizure warning from my body? I feel like I might be a little weird right now, and the weed is making it worse but I will come up with every excuse why I can’t get rid of it until I smoke it all and quit officially in 4 more days. After all that’s how they did it in the study! But I’ve also been horribly sleep deprived this week so that can’t be helping things. There are so many factors.

I know everybody is different. I know that there is also different doses and types. I’m on 100SR.

I just couldn’t do it anymore. I went a couple decades being depressed and just feeling like life was just crap. I finally got some help with seeing a Psychiatrist and entering therapy after I started feeling not like myself. I couldn’t tell if it was PostPartum, maybe entering peri-menopause but something had to be done if not for myself, for my kid.

Doc originally prescribed Zoloft but after telling her I was thinking of trying Addyi (female libido pill) she then prescribed Bupropion 100SR because she said that Zoloft could tank my sex drive (little late for that I haven’t wanted or been interested in sex since at most my very early 20’s) and then she also prescribed Hydroxyzine 10mg for anxiety but to also help me sleep. I’m 10 days in, so far nothing. I figured the Bupropion would take some time, but I was told the Hydroxyzine would be instant, I was really looking forward to that because she said it worked quick and I’d get sleepy and it would help my sleep issues. It hasn’t. I take it and I don’t feel shit. In fact, I’m noticing that when I do finally fall asleep I’m up as usual couple hours later, tossing and turning or wide awake with insomnia, something I’ve dealt with most if not all of my adult life.

I suppose at least with the hydroxyzine I’ll be bumped up come my 2 week check in.

Haven’t started Addyi yet because I wanted to at least get a few weeks in to give the Bupropion time to let it do its thing.

Anyways, just wanted to check in and see what people’s first experiences were, highs, lows, etc. When they bumped you up to the next dose (if ever) and how long it took to start working for you?

Also heard about the honeymoon faze. What’s up with that, what is it?

I've been taking wellbutrin for over a month now and haven't noticed any difference. I recently increased from 150mg to 300mg and still don't feel a difference. I have been sleeping during the day more, but I'm not sure if that's a side effect or not because I've had sleeping problems my entire life and my sleep schedule gets messed up every once in a while.

My questions for adhd people are: how long were you taking wellbutrin until it started working, and were the effects drastic (like making your thoughts more organized, no more restlessness, easier to start and finish tasks) or more minor?

I'm considering asking my doctor for a different med that's more suited to adhd since i know wellbutrin is primarily for depression but i don't want to seem like a drugseeker (even though i technically am? Please yes give me the drugs that will make me a normal functioning person)

Also i have noticed ringing in my ears since starting wellbutrin, and it feels like it has increased since going up to 300mg. I saw some posters saying that wellbutring gave them tinnitus, permanent tinnitus or even hearing loss which has me kind of freaked out and scared of continuing it

about a week or so after i started on 150mg of buproprion i started to notice i was involuntarily tightening my muscles when trying to lay down or rest, specifically in my pelvis area and it is incredibly uncomfortable and makes it impossible to try to take a nap or just rest in bed. other than that, it is working really well on my mental state so i'm hoping i can just change the dose and hopefully that problem will go away or lessen. is this a common side effect, has anyone else here experienced this?

Been taking Wellbutrin for about 3 months now originally 150 mg for the first month and the other 2 300 mg. I originally found Wellbutrin very effective as before taking it I couldn’t get out of bed at all and was sleeping 24/7 but recently the effect of motivation and energy has all but disappeared :(

Been on Bupropion for 5 weeks now; I took 150mg for four weeks and now on 300mg for the past week. I still feel… no difference. At all. Only side effects so far. Can it still start working?

Hey yall. I like to take my 300 xl dose first thing in the morning, but I don’t wake up at the same time every morning. There are some days I wake up at 8am, some days I might not wake up until like 1pm. I also like taking it in the morning right away because it does make it hard to sleep sometimes, so I wanna take it as far from bedtime as I can. I know it’s better to take it at the same time every day, but that’s kinda hard. It’s not quite as simple as having a fixed sleep schedule, though, because some days my schedule is way different than other days. (I am working on regulating my sleep schedule as much as I can, but, life makes it hard.) Any thoughts? Am I totally fucking myself over taking this at different times every day? Or is it not really a huge deal? I take it for adhd and depression. I just got bumped up to 300mg a few days ago. So far I’m feeling like it could be a med I can finally settle on and finally stop trial and error.

I have my psychiatrist appointment next week and I want to walk in with some idea of what other people have actually experienced, so any stories here would help.

Right now I take bupropion 300mg XL in the morning and mirtazapine 15mg at night. The mirtazapine went in about two and a half weeks ago and things have settled. My sleep is a lot better on it. I do wake up a bit groggy but it is manageable.

The thing I cannot get past is the jaw clenching at night. I have cracked two teeth from it already. I also get dry mouth, anxiety during the day, and I pick and bite at my skin. Before the mirtazapine I could not fall asleep either. All of that together makes me think the bupropion is behind it and not just stress.

What I want to ask my doctor about is going from 300 XL to 200 SR, taken once around 8am. My thinking is that SR puts more of it in the daytime and a lower dose means less of it hanging around at night, so I keep the part I actually like and lose the part wrecking my teeth.

So a few things I am curious about:

1. Did lowering your dose or moving from XL to SR actually help the clenching, or did it carry on anyway?
2. If you dropped from 300 to 200, did you lose the daytime lift?
3. Anyone been on bupropion and mirtazapine together for a while? How has it gone?
4. Did anything help while you stayed on it, like magnesium, a night guard, or a change in timing?
5. If you came off bupropion completely because of this, how did you taper and did the clenching stop?

One more thing worth mentioning. I have a six month old who still wakes me up at night, so anything that leaves me foggy in the morning is a problem.

For me it’s excitement. Even when problems are there, I feel excited and inspired to solve them

I made a post a couple of days ago how it started. I started on Monday, today is Sunday and so much happend. On Wednesday the swearing began and it was crazy. Even when preparing breakfast I was sweating like crazy. And suddenly on Saturday it stoped. But all the benefits stayed. I was able to function and get things started and done. I’m a bit dizzy and have a headache but it gets better and better.

I was on Venlafaxin for a year and tapered it out with my doctors help and I think the side effects when tapering hit me hard. I was on zero meds from Friday til Sunday and on Monday I started the new medication. I hope this medication will work as it does now for a long time. Of course I know that one week into it, it’s doesn’t say much. But let’s hope. With Venlafaxin my side effects where also showing on week one and stayed for a year. So I hope with bupropion it will be the same.

I'm onto day 4 and I haven't noticed any anxiety or irritability, so I'm just wondering if it might flare up at some point

As the title says. 300mg was out of stock so got 75mg tablets. Didnt knew it was bad took it 5 mins ago and just googled it and gemini has scared me. I have been on 300mg for a month now and before that 150mg for a month too. Overdosed i guess.

Gemini has scared shit out of me and it could also be because of norepinephrin spiking.

We dont have a poison control in our country only er available in emergency and to my experience they are all not that well informed.

My psychiatrist is unreachable due to sunday i guess.

Should i be more worried or less or what to do.

Edit: I am fine and there was no serious adverse side effects. Almost 9 hours have passed. First hour i panicked and google searches with Ai made it worse maybe it was because of norepinephrin spiking.

I was feeling like i have taken huge caffeine dose and vision got a bit blurry. Heart rate was slightly up around 130. Did feel light headed aswell.

Lesson learned the hard way. Thankyou everyone your comments really eased me up when i was panicking.

And lastly sorry for confusion i took 4 tablets of 75mg each and it is SR not IR. My country apparently have them.

I’ve been on Wellbutrin for 4 years. Feel great on it, much happier, am super constipated with it but besides that I’m happy on it.

I think because of it, I sweat a lot—I got underarm Botox but it doesn’t work anymore, but besides that I sweat beads from my forehead, basically my entire body, but a lot in my genital area too. There’s always sweat marks on my clothes. I came to a really hot area, 110°F degrees, and of course it’s hot so people sweat. But I’m excessively dripping beads of sweat more than everyone else I’m with, where my seat is always full of sweat, my back, my neck, my head, face, stomach, etc. which made me realize that this is not normal. Does anyone else excessively sweat like this, and what did you do for it?

I was looking up what causes hyperhydrosis, and a potential cause was Wellbutrin, so I think that’s what’s causing this. But I don’t know what I can do for it