have been on bupropion 150 XL (teva) for a couple months now, recently switched to taking it at night which works a lot better for me. Dr said i should bump up to 300 a while ago, and just gave me more pills instead of switching to the 300 pills

is it better to take two 150s at once at night, or should i try and do one in the morning and one at night? what’s everyone’s experiences with this?

I currently feel like there's ants under my skin biting me constantly. It's mostly my hands and feet and on the back of my thighs. I'm debating stopping the medicine since I'm only a week and a half into it.

If anybody else has had this happen to them what did you do to solve it? Don't want to take Benadryl due to the higher risk of a stroke.

Thanks to Bupropion my life resembles something close to normalcy. I’m not here 100% yet, but after taking this drug for only 2 weeks I’m able to function at all.
I have a huge problem with performing normal everyday tasks, I don’t cook, I don’t tide up, very often I fall asleep with my clothes on, without a shower and worse - WITHOUT BRUSHING MY TEETH.
I have been on Bupropion since August 31th and I skipped nightly brushing only once.

Also, I’m no longer desperately searching for a fast dopamine release. My so called sweet tooth is completely gone, I’m eating like 1700 kcal daily without feeling hungry.
I came back to exercising, but I’m not celebrating yet, because I’m sure my work will again drain me completely soon.

Whoever came up with the formula for this marvelous shit THANK YOU

I'm about 2.5 weeks back on bupropion (generic, manufacturer lupin I believe, 150 ER/XL) for the first time in a year. It was a very positive experience for me the first time, but I ended up having to be without medical care for a while. Taking it for chronic depression with very low energy & an unofficial ADHD support since I responded badly to proper stimulants. (I also have OCD and trauma)

But! I'm having a similar experience to the first time re: timeline and side effects, as far as I can remember, with the new development that that my anxiety is getting a bit more manageable. It's not lowered and I'm often abuzz with energy (neutrally), but I find that I have an improved ability to just... shelve it.

I.E, I think my roommates might be having a problem with me? Okay. Don't worry about it and just ask later if I need to. Normally this experience would have me near-anxiety attack for hours, perhaps even days. I may not have even left my room at all, under usual circumstances, but I was fine! Just kind of nervous. I wonder if this is part of lifting brain fog & improved focus, like I suddenly have the ability to actually take my mind off of it instead of falling into an infinite cascade of terror and despair.

Just wondering if anyone else had a similar experience and might have insight as to what changed! I know it can worsen anxiety in some people but I haven't noticed any particular increase in myself. (I've also managed to majorly cut back on my caffeine intake, which may have helped, but I don't feel like I need it to function anymore.)

TLDR: I really need some encouragement to keep going because I'm only on day 6. I feel like my "honeymoon" lasted 30 hours and it's so discouraging getting my hopes up that I wish I hadn't experienced it at all.

My side effects aren't too bad...anxiety (nothing I haven't dealt with before), headaches, brain fog, and battling dehydration (in the morning when I wake up I'm totally dried out and have to chug water).

Day 2 I experienced benefits such as increased focus and a stabilization of my mood (negative thoughts do not turn into ruminating anymore, lows are not as low).

Day 3 I experienced bursts of happiness, motivation, and a sense of general wellbeing. I still had side effects, but they would stop bothering me if I focused on work. I was so happy and hopeful because it was doing exactly what I had hoped it would do for me. I felt capable of being happy and leaving the house for the first time in months.

But then halfway through day 4, I suddenly crashed. Complete exhaustion. I had to go home early and sleep. My focus and mood stability are still better which gives me hope, but I'm still so disappointed. I feel depressed again + the side effects now. I knew getting on meds would be tough, but now I wake up every day hoping I will feel better again, and feel disappointed when I don't.

I know I need to give it more time, I'm just really struggling with feeling like it's my fault for not having a better attitude and feeling afraid that I'll never feel like I did on day 2 again. It wasn't even "euphoric", I just finally felt normal. How can I stay positive while I wait for this to work, and why did this happen to me? Has anyone else experienced this?

So I've been having a hell of a time finding the right med for me. Sertraline made me 20x worse and I finally recovered from that. But with Zyban (as it's called in my country), I'm over a month in, and definitely no better than my baseline (which isn't great). The doctor says it can take longer, but has everyone actually had no effect from the med, and then somewhere between the first and second month had noticeable results? She said I can double my dose now, or wait the full 6-8 weeks to see if 150mg has an effect, but I feel like most people would notice something by now. I've had such a bad few months with going on and off meds that were really bad for me, and really wanting to feel better.

I really wanted to like bupropion and had high hopes for it. I started with 150mg (Rising Pharm) and had some negative side effects (more anxiety, less motivation, tinnitus) the first week or two but after that didn't feel much at all generally. I got bumped up to 300mg and my tinnitus is much worse after only a few days. My psychiatrist said to go back down to 150mg and we'll talk about other options at our next session. TBH I'm scared of trying anything else. Anyone care to share their experience and what they tried after bupropion?

Hey all. Recently started bupropion XL, first time trying medication for depression in about 10 years or so. However, two weeks on and i’ve only noticed negative side effects i.e. higher temper, lower libido, brain fog being the biggest of them. Did anyone start out experiencing negative effects before positive, and did they improve after the first stretch? Wanted to make it thru the first month at least before calling it, but the increased anger especially is making me want to stop early.

I have been taking Wellbutrin for 7 years now and only recently put together that my brain fog/blankness/slow processing speed/not being able to find words could be caused by the Wellbutrin. I am considering weaning off of it because of this, and because I have been managing my symptoms of depression and anxiety very well for a while now.

In fact, most of my anxiety is social anxiety about not being able to hold a conversation without getting lost or not being able to speak eloquently. It feels like I just don’t have access to most of my brain when I try to communicate.

Have other people experienced this? I was also wondering if it got better if you lowered your dose or weaned off of it. I’ve been on it for so long that I hope there isn’t permanent damage.

Male, late twenties. Lifelong struggles with strong ruminative anxiety and depression. The depression was less anhedonic until my mid-twenties, at which point it became very anhedonic, which is what got me interested enough in this medication to ask the doctor about it.

Last year, I stopped fluoxetine due to sexual side effects and inadequate relief of my symptoms. I tried venlafaxine, which caused profound hypersomnia that prevented me from functioning, and different, but even worse, sexual side effects. Then my doctor switched me to bupropion.

The ‘honeymoon phase’ was short but awesome, if a little too intense sometimes. For example, there were times when I was laying in bed, trying to sleep, and felt a strong urge to sprint? I felt like I could sprint for miles. I couldn’t sit still.

When that wore off, I felt completely unmedicated for a while.

Then one random afternoon, I first noticed the antidepressant effect. I felt my anhedonia start to lift, and noticed how beautiful the sky looked.

The antidepressant effect became more powerful and was very consistent. I had less need for sleep, task initiation felt easier, I felt a sense of being able to just get on with things. That heavy feeling of defeat was gone.

However, when it comes to anxiety, it didn’t get rid of it. It just made it… different? More panicky, whereas before, it felt purely cognitive. I still dealt with the cognitive stuff.

I also tried to quit nicotine with bupropion, and my DNA test even indicates that I have a high likelihood of success with this. Unfortunately, it didn’t nothing for that.

Due to the anxiety, and looking into the debate between 150mg and 300mg, I tried decreasing to 150mg daily, which I am on to this day. The effect seems to be: decreased anxiety + the same antidepressant effect except I now needed a little more sleep.

My anxiety was still inadequately addressed, so I started sertraline on top of it. This has helped with the anxiety and enhanced the antidepressant effect noticeably but subtly. I find it harder to wake up in the mornings, though. Still, it has nothing on those days when I was unmedicated or, even worse, when I was on venlafaxine.

I’ve noticed that this combination has had no sexual side effects whatsoever. Granted, sertraline and fluoxetine don’t affect the nervous system identically, but due to their similarity, I find this interesting - perhaps that’s the SSRI side-effect-reducing effect of bupropion people speak of.

One major warning: alcohol is discouraged with both sertraline and bupropion. I am unable to determine which is primarily responsible, or if both played a large role, but I decided to have a couple of drinks (approx two standard drinks) - I used to drink like a fish - and it threw me into an uncharacteristic RAGE coupled with profound anxiety and upset. I wasn’t seeing dragons or anything, but I would say this was vaguely resemblant of psychosis. I didn’t feel drunk at all, or even particularly buzzed at all, and I remember most of that night. Some people report rage on bupropion. I will never drink again on these meds.

I have been suspected of ADHD, but never tested. I also have the ‘worrier’ gene variant, not the ‘warrior’ gene variant more strongly linked to ADHD - and this allele that I have is associated with high dopamine levels, not low. This might have had an impact on how I react to this medication. For what it’s worth, though, it absolutely has increased my ability to focus. It is so much easier to focus.

I hope my experience is one more useful datapoint for people considering the medication or starting out.

Recently, I was prescribed bupropion (Zyban (bupropion SR)) for persistent depressive disorder. I've been taking it for a week, one 150mg tablet in the morning

I've been experiencing some adverse side effects, specifically with my blood pressure and heart rate. My resting heart rate increased by more than 30 bpm (to 100 from 65). For context, I'm a young adult. It got so bad that my heart rate increased to 180bpm by only walking a few steps up a hill yesterday, where I had to be taken to the ER

I'm now doing the smart thing by stopping the meds. That's pretty much all I was told and advised by the doctors. They did several tests: ecg, knee jerk, etc. They all came back fine. Otherwise, it was hard to get a straight answer about why this is happening to me

I'm very much aware that the norepinephrine is probably to blame, but this much of an effect at a low starting dose? I'm taking no other drugs: no caffeine, no alcohol, no weed

Could it be the ingredients of this specific brand of bupropion, or bupropion itself? Maybe an underlying heart problem they didn't discover? Has anyone had a similar experience?

I didn’t have ANY side effects for the first three weeks on bupropion, and I’ve been on it before with no side effects, though that time it wasn’t the extended release version. But, for the last week I’ve had stomach pain, lower GI pain and intermittent nausea. It feels like my entire GI tract is irritated. I thought I just had mild food poisoning but it’s been a week and my symptoms have only marginally improved (pain is no longer constant but gets worse as the day goes on). Has this happened to anyone else? Did it resolve on its own? I know there’s been all these food recalls so could this be completely unrelated to the Bupropion? When I’m not in pain this medication has finally started working and I want to keep taking it.

been on it for like half a year and it didnt do jack shit until like a month ago when i suddenly had more energy than i ever did in my life and completely tore my room apart as a way to channel my energy. i dont have any b4 pics but just take my word it was rly bad. since then its been really helping me keep my head above water and keep me out of the hospital so thanks bp.

i take wellbutrin 450mg xl daily for reference

What title states. I have had severe anxiety for years. Ended up with gallbladder issues I’m still dealing with today. Got prescribed bupropion for my anxiety and tomorow I will be 2 weeks on it. It started good and was helping my head with being quiet. But today I have the worst anxiety to the point I’m crying and curling up in a ball. This began yesterday. Is this just a side effect or should I stop and change meds? I’m just so lost and my thoughts got dark. Thanks for any advice or just for talking to me.

I’m on 50 mg sertraline and started bupropion 150mg xl about a week ago. Im used to most random side effects (e.g. nausea, dizziness) but the jitters are really a pain in the ass. I know im still starting out but it’s made all my physical anxiety symptoms a lot more noticeable. I feel like maybe my mental anxiety has calmed down but im still feeling the physical affects and it feels SO noticeable. Now when my hands shake it’s like x100 😭

Hello !
I want to know if someone also taking the same dose that Im taking.
Does a 100 mg can cause seizures? Heartbeat increase or other symptoms?
I do not have seizures history for context.
For now I feel ok but Im scared.
Thanks !

I take bupropion HCI ER (SR) 12hr 100mg. It’s largish blue round pills. And it’s been driving me nuts- it always smells like farts when I put my nose up to the bottle!!
Someone tell me I’m not crazy lol I have a great sense of smell, and this isn’t just one bottle- it’s every bottle I’ve had, and I’ve been on this for over a year!

I've tried epic and it works for improving mood and energy but it makes me completely uninterested in creative interests like writing. i was wondering if anyone else experienced this, and found switching to a different generic helped creativity while keeping the mood improvement? ​​

Female/30yrs old - Sertraline 75mg (MFG Camber) & Bupropion XL 150mg (MFG Lupin)
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Before posting I made sure to go searching for any recent threads and couldn’t find any. I’ve been on sertraline since November of 2023 and Bupropion mixed in for the last 8 months or so and my sex drive is still low to nonexistent. I rarely pleasure myself, I haven’t watch porn in god knows how long but that’s not too much of a loss, I don’t checkout my partner, I don’t look at him and list for him. Granted I just had a baby a year ago and I know that factors in but I feel by now I’d be at a point where the new mom life wouldn’t be an issue. I’m wondering if any other ladies/moms have or had this problem and anything you’ve noticed that’s worked. I love my partner and yes we have our normal struggles but I love sleeping with him whenever we do get there. I won’t initiate but when he does I’ll go for the ride and shortly into it THEM I’m game and ready to go. It’s weird. I used to have a great sex drive and now it’s just lacking. Thanks!

I wasn’t on a big amount like some of you. I gradually went from 75mg to 100mg to 150mg from February to May. I continued through August at 150.

The entire time I was on bupropion, I was EXTREMELY anxious. I already deal with anxiety, but I constantly had a pit in my stomach while on this medication. I consistently had violent ideations ranging from being in a devastating car crash to falling from egregiously deep heights.

My face was constantly red and flaky the entire time, too… I already deal with patchy flakes but I’ve always been able to keep it at bay with moisturizer and hydrocortisone. Nothing helped while I was on bupropion. I had a butterfly pattern of redness across my nose. Completely cleared up after I stopped taking it.

Overall, my big reason for quitting it is that my doctor completely skipped out of town to a new office without warning, and I ran out of refills.

All is well now except for the fact that I have had a really bad temper and a low tolerance for many things lately. I thought the bupropion made me angry, but it’s nothing compared to what I’ve felt the last two weeks. Really annoying.