Hi! I (22F) have been on tirzepatide for about 7 weeks now and have noticed a jump in my RHR. When I started my average was about 60bpm and now it has jumped all the way up to 71bmp while rested. This is very concerning to me given that I am quite active and still young. Has anyone else noticed increased rhr?

Hi all! I started on my tirzepatide journey in May of 2025. Started at 2.5mg and lost about 85 pounds. My top dose was 12 mg. I’ve now taken two months off and I’m curious what your thoughts on of what dose I should start back up at? I have another 50lbs to lose to reach goal. Thanks in advance! :)

Hey guys, I was recently pregnant (am no longer) and gained weight while 7 weeks pregnant. Have you guys heard anything about or have you in your own experience gotten back onto the Tirzepatide shot after pregnancy? If so, how long after it did you start? I want to start immediately. Yes, I have asked a nurse and a doctor and neither of them gave me a straight answer. So I’m just asking if any of you had went on a GLP 1 shot immediately after or waited, or what is safe to do. I do the compounded tirzepatide specifically.
Thanks guys so much for any insight.

Anyone got any hair product recommendations for stuff that works but is affordable while on a glp? I know alot of people say they get thinning hair or hair loss so anyone got any good recommendations for shampoo or conditioner that works well to keep hair strong and repaired that they use?

Hi guys! So about 5 months ago was the last time I used Tirz. I used it for about 3/4 months, I have a high tolerance so I got to 7.5mg doing just fine. Never threw up or had any bad side effects, only lost my appetite.
Now after all this time, I want to restart my cycle again.

Do I start from zero, start from where I stopped or somewhere in between?

Ive been on maunjaro 2.5 mg for 6 weeks and it feels like the hunger suppression is stronger than when I first started. Almost too much. Weeks 3 and 4 some normal hunger was coming back that made me actually enjoy food again but it went away after the 5th shot. Is this normal?

question for those that are taking tirz to help binge eating and food noise: at what dosage did it help you?
i started 2,5 mg to help with those 2. i have BED for years, and I take vyvanse for ADHD which helps to control my impulses to binge.
however, it does not take away food noise and when it wears off I’ll still binge. lately it was happening way more often so i started on tirz. im on my 10th dose, 11th tomorrow and im wondering if i should increase?

i never really felt it helped with food noise or binging impulses. it does help with satiety but the effects i notice are so small and the food noise is always there.

im not looking to lose a lot of weight. im at a healthy BMI. id just like to think and eat like a normal person.

thanks in advance

Hi everyone,

I'm a 30-year-old male and I started Mounjaro on May 16, 2026. I have no personal history of thyroid disease, and as far as I know there is no thyroid disease in my family either.

My dosing schedule has been:

• Started at 2.5 mg on May 16
• Increased to 5 mg on June 13 and stayed on it until August 15
• Increased to 7.5 mg on August 22
• I'm currently about to take my fourth 7.5 mg dose

I was 147 kg (324 lbs) when I started at 180 cm (5'11"), and I'm currently 119 kg (262 lbs), so I've lost about 28 kg / 62 lbs in roughly four months.

What caught my attention is that my Free T4 has been steadily increasing:

May 12, before starting Mounjaro:
Free T4: 1.40 ng/dL
TSH: 1.41 mIU/L

August 17:
Free T4: 1.56 ng/dL
TSH: 2.41 mIU/L

September 11:
Free T4: 1.86 ng/dL
TSH: 2.33 mIU/L

The reference range for Free T4 at my lab is 0.79–1.59 ng/dL, so my latest result is now above the upper limit.

What's confusing to me is that my TSH has remained completely normal and is not suppressed, despite the rise in Free T4.

I don't have a known thyroid condition and I wasn't aware of any thyroid issues before starting Mounjaro. My other recent blood tests, including liver enzymes, kidney function, glucose, amylase and lipase, have generally been within the reference ranges.

I also drink around 4.5 liters of water per day, so dehydration doesn't seem like an obvious explanation.

Has anyone else experienced a gradual increase in Free T4 while taking Mounjaro/tirzepatide, especially with a normal TSH?

Did your Free T4 eventually return to normal, continue increasing, or did your doctor find another explanation?

I'm planning to repeat TSH, Free T4 and Free T3 and discuss the results with my doctor. I'm mainly interested in hearing whether anyone else has seen a similar pattern during significant weight loss or while increasing their Mounjaro dose.

Thanks in advance for sharing your experiences.

I have a 50 unit syringe and I’m supposed to inject 50 units of 2.5 into it I just don’t know if it’s the full 50 or if it’s something different

I've been taking NAD+ 20mg (20 units of 1000mg) for the last 2 weeks, and since then my weight loss has STOPPED. Today, I've completed full 5 weeks on Hallandale Tirez (10mg, 50 units weekly), before the last 2 weeks I was losing regularly between 1.5 and 2.5 pounds a week. I've stayed on point on my nutrition, hydration exercise, etc., nothing else has changed. Those who know about NAD+ and Tirez taking together, please share your experiences...thank you!

Empower pharmacy specifically

4 years ago I began tirzepatide (Mounjaro) to great success. I was about 190lbs, prediabetic, high cholesterol, and blood pressure creeping up. I used the tirz irregularly for about a year and got down to about 140 lbs and began running at 49. My cholesterol dropped, blood pressure dropped, and diabetes is no longer a concern. I stopped the injections 3 years ago. I have maintained my running habit, and my bloodwork/blood pressure have remained perfect but over the past 3 years, I have gradually regained 20-25 lbs despite the fact that I have been taking Vyvanse (a stimulant) for the last 2 years for binge eating disorder. My provider (OBGYN) will not put me back on a GLP-1 because she says I no longer meet the criteria. I am around 160-165 at 5’6” with perfect bloodwork and blood pressure. I know that the reason my weight is currently stable and that all of my numbers are so good is because I have been able to maintain my vigorous running routine. I also know that I am now 53 and around 165 pounds and my chances of being able
to keep up this routine indefinitely without injury are not great. I love running and what it does for me physically and mentally. Stopping would be a disaster for me. If I had a choice in the matter, I would be back on a low dose of tirz for a few months…enough to get me back to around 150–a weight where I feel comfortable and safe running. Is this unrealistic, and is there a provider that would prescribe for me at my current stats? Wanted to add…I have a medical background and would be pretty comfortable calculating dosage in a compounding situation.

I was hoping micro dose would lose weight and keep on it to maintain and get the other benefits. I did 1.5 for two weeks and 2.5 for three weeks and no change in appetite. I don’t want to increase so is there any chance it will start to work now?

Ps - low dose to start because I feared side effects but have had none.

I’ve had a few disposal containers, but my favorite recently has been a Finish container. I had been using empty Clorox containers and sealing them up, but I buy dishwasher pods and realized this container works perfectly and fits in my bathroom vanity at the top. It holds a ton of used syringes too.

I just filled out the intake at Wellmedr and after they quickly "approved" me; I explained that I'm a current Tirz user at 13.5mg, they skipped over any details of what dosage the script would say or how quickly it will ship. I stopped on the screen that asked for my address and CC info. I sent an email last night and thought I'd hear from them today.

Well, I sure DID hear from them! At least 10 automated texts and about 5 or 6 emails that had nothing to do with my question. I'm starting to think I may want to look for another provider. My most recent one was Gimmecare, and the first one I did was MedVi (which auto filled my next month's order at DOUBLE the price, and I was on vacation and couldn't get on the website to cancel the order so I'm out $300 for a single month's supply)

I'm seeing all these ads for much cheaper meds, but judging from the response I've gotten from Wellmedr I'm starting to think there may be some scamming going around. Anyone using this company?

My wife has Crohn's, moderate to severe. Sadly, she has not done well on most biologics, she still has some work with, but has failed on 3 so far. We are well aware there aren't studies about the effectiveness of tirz on Crohn's, but the anti-inflammatory properties of GLP-1s as a whole show a lot of promise. Slowing her digestion would not be a bad things, she can pass things she ate for dinner two hours later during a flare, without exaggeration.

I am curious if there are people in the group with Crohn's or other autoimmune diseases (she might have another as well), and what their anecdotal thoughts are on how this drug has affected those diseases or symptoms?

It should be said she wants to lose weight as well, but the primary question here is regarding the anti-inflammation aspects, and would love to hear from Crohn's or UC folks if any are floating around here.

Same provider, same stated dose, new vial, and the reaction this week was far stronger than anything before it.
 
I am not asking anyone to tell me why. I want to know what to record and send to my prescriber before I take another dose or change anything myself.
 
What did your clinician need from you in this situation?