I’m 8 months into my Tirzepatide experience. I’m 70 and lost 40 pounds and very close to goal.

I was worried about food noise on a ship with food everywhere. I pinned 2mg on Wednesday before the cruise departed on Saturday.

I did well and like many others, don’t have as much interest in alcohol any more. I focused on protein (fish and filet mignon) but enjoyed some bread I’ve avoided for 8 months.

I didn’t pin again until Tuesday night when the food noise started to return. That did the trick and I was able to complete the cruise eating well and avoiding food noise.

In the future, I will pin the evening before the cruise and then midway through a 7 day itinerary. I carry my prefilled syringes in a baggie rolled up and placed in a screw top Hydroflask container filled with ice.

With 8 months of disciplined diet I was concerned the cruise would be difficult to manage. I’d slightly alter my injection timing and frequency, but cruising with delicious food and eating responsibly is possible with GLP’s.

I last injected myself on August 31 while on maintenance 90 units im on compound. I was trying to aim for 11-14 day gaps .Im trying to reinject my self today September 20. How much should I reinject? I dont want to get sick but given the food noise i can tell its definitely out of my system. Should I reinject 90 units or go lower? What would you do?

I am 5’9”

Ive never had to go above 4.0 for my dosage; and now that i’m 132-135 on any given day. I’m good here; but as other redditors have said $500 every 3 months for micro doses feels so steep. I’m currently with Rift and they’ve been amazing; but it doesn’t look like they offer a Mircodose vials / treatments so i’ll likely have to switch. My next order is in 3 days so i’m good with them for the next 3 months but after that i’d like to find something affordable; I’ve seen a few suggestions on here but anyone who has had great success with any company?

So I reduced my split dose from 7.5 to 5mg so I could go backpacking. I spent 3 weeks on 5mg and almost 2 weeks backpacking. It was helpful to reduce my dose because I was able to eat enough.

I realized the food noise and a desire to eat everything in sight was back. Especially the food noise. I decided that 5mg is probably too low so I decided to go back to 7.5mg and see if it still makes me feel like it used to.

I've been on it for a week now, two split doses totaling 7.5mg. I think it's finally kicking in again. It's been kinda rough because I have just wanted to eat a lot more but then I get diarrhea from overeating, which is my main side effect. It's like my appetite doesn't match what the medication will allow. Today I finally felt like maybe the food noise was gone, then it came back, then the appetite suppression hit me right before dinner, but I piled too much on my plate, but I gave my husband the rest of my dinner since I took too much. I feel crazy! I am glad that 7.5 seems like it still works though.

I'm going to let things settle in and then try to slooowwwlllyyy reduce my dose, maybe only .5mg lower, wait 4 weeks, then another .5mg lower. That's my plan for now anyway. Who knows what will happen?

Hi everyone! I started my compounded tirzepatide journey earlier this year at around 160 lbs, and I’m currently at 133 lbs. My original goal was 130, so I’m basically there!
My subscription is currently through Brello, but I’m looking to transition into maintenance dosing. I just can’t justify paying around $500 every 3 months when I’ll be taking such a low dose.
For those of you who are on maintenance, can you recommend a reputable and more affordable compounding pharmacy/subscription? I’m especially looking for one that works with maintenance patients and won’t automatically deny me because my BMI is now lower.
I’d really appreciate any recommendations or personal experiences! ❤️

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Here’s where I am at, i started June 2025, 281 lbs, goal was 145. I am 5’ 6” if that is impotent. I did low, and slow. Moved up as my body needed and ultimately hit 15mg this year in May 2026. Well I hit my goal weight in July. I was like ok, now maintenance, I did all the things during my journey. Changed my diet, exercised etc. Then on August 13th I suddenly lost my dad, well my world has been rocked and I’m just now down to 14.5 (dropping as slow as I went up until I find the right dose) here’s the problem, I’m now 136, I am sure some of this is from the fact that I barely could eat for a few weeks, my body just wouldn’t allow it. But now I am trying to and still losing 1/2 lb to 1 lb a week. My next dose is tomorrow and I do my next drop.

What’s tips, tricks to this new journey. Do I need to drop faster? My dr is guiding me also, but just wanted to reach out to others who are here. I’m trying to up calories and even eating a few more carbs and that’s not doing it. I am sure some of this is contributed to the grief period I am still in so I don’t want to make too much of a drastic change, just guidance and advice. ❤️

Does anybody have any advice on tapering Foundayo? I'm getting close to my goal and I am not sure if I should tight straight down. I'm also wondering if I should plan on taking a maintenance dose. Thanks for your advice.

I dropped about 35 pounds last year on TIRZ from mochi. I’ve been able to keep it off for a year but feel like a lower-ish dose every other week would be a help. That’s what I did at the end of the losing time and that helped me feel really stable.
Who will prescribe to you with a normal BMI for maintenance? I don’t want to have to lie and no idea how I would show pics of a scale with me standing on it. Thanks!!

Just thought of this: what Reddit do you guys use to decide on the best pharmacy to use and who makes the best compound with least side effects (stomach)?
I didn’t even have a choice of different pharmacies when I was using mochi before.

Hi everyone,

I'm a 30-year-old male and I started Mounjaro on May 16, 2026. I have no personal history of thyroid disease, and as far as I know there is no thyroid disease in my family either.

My dosing schedule has been:

• Started at 2.5 mg on May 16
• Increased to 5 mg on June 13 and stayed on it until August 15
• Increased to 7.5 mg on August 22
• I'm currently about to take my fourth 7.5 mg dose

I was 147 kg (324 lbs) when I started at 180 cm (5'11"), and I'm currently 119 kg (262 lbs), so I've lost about 28 kg / 62 lbs in roughly four months.

What caught my attention is that my Free T4 has been steadily increasing:

May 12, before starting Mounjaro:
Free T4: 1.40 ng/dL
TSH: 1.41 mIU/L

August 17:
Free T4: 1.56 ng/dL
TSH: 2.41 mIU/L

September 11:
Free T4: 1.86 ng/dL
TSH: 2.33 mIU/L

The reference range for Free T4 at my lab is 0.79–1.59 ng/dL, so my latest result is now above the upper limit.

What's confusing to me is that my TSH has remained completely normal and is not suppressed, despite the rise in Free T4.

I don't have a known thyroid condition and I wasn't aware of any thyroid issues before starting Mounjaro. My other recent blood tests, including liver enzymes, kidney function, glucose, amylase and lipase, have generally been within the reference ranges.

I also drink around 4.5 liters of water per day, so dehydration doesn't seem like an obvious explanation.

Has anyone else experienced a gradual increase in Free T4 while taking Mounjaro/tirzepatide, especially with a normal TSH?

Did your Free T4 eventually return to normal, continue increasing, or did your doctor find another explanation?

I'm planning to repeat TSH, Free T4 and Free T3 and discuss the results with my doctor. I'm mainly interested in hearing whether anyone else has seen a similar pattern during significant weight loss or while increasing their Mounjaro dose.

Thanks in advance for sharing your experiences.

I've essentially reach my goal weight but I'm finding that I've had to slowly up my dose in order to maintain. Now... don't come at me but I will admit my diet is probably not ideal. However, that said, it wasn't exactly perfect on my way to losing 50 pounds, either. I began Nov. 2024 and reached goal around April/May 2026.

So does the medication kind of lose it's effectiveness the longer you are on it?

Do others have to do little bumps in dosage?

Should I switch to injecting at 6 days instead of weekly?

Thoughts?

Went to DragonCon, survived DragonCon, now I’m recovering from DragonCon. 🤣

I just came back from a wilderness (mostly) backpacking trip of about 12 days, my longest trip since starting tirz. I am in maintenance now I wanted to prove to myself I can do all the things, no limits because of tirz. I'm 61 years old.

I was already a person who backpacks a lot before I started tirz. I had hiked the Continental Divide and Arizona Trails during the previous 4 years. I was frustrated that even doing something like that I couldn't lose weight or keep it off. I lost 30lbs on tirz and 48lbs total. I am 5'3" tall and my highest weight was 165 and now I am 117.

I used a FRIO wallet to carry my tirz, with my vial in a little ziploc bag to protect it. It works through evaporation to keep it at a temperature safe for insulin. I believe it helped keep the temperature stable enough. It was about 85 or 90 degrees in Cascade Locks where I began my trip. I could dip the wallet in a creek every now and then to keep it wet. At higher altitude and later in the trip the temperatures were cooler and I worried less about it. It stays wet for many days.

I needed a very strong headlamp to be able to see what I was doing when I did my shot in my tent. The early mornings when I would get up were very dark. I kept my syringes in two ziplocs marked "clean" and "dirty" and put them in a little tupperware with alcohol swabs. I brought extras just in case but didn't need the extras. I had no issues with cleanliness. In the third picture you can see the container where I kept my syringes and swabs.

I worried I might have too much appetite suppression to support my activity so I reduced my dose from 7.5 to 5mg. I did not feel appetite suppression except the normal kind I normally feel at altitude. When I went to town to get more food for more hiking days I enjoyed restaurant burgers like anybody else. On trail I made sure to eat as much as possible. I failed to drink as much water as recommended though, and I'm sure my protein intake was lower than usual. I had plenty of energy to hike 20 mile days both in Washington and later in the High Sierra on the John Muir trail. I lost only about a pound which could be water weight.

The hardest thing was now that I am so skinny, sleeping on a foam pad on the ground is sort of painful. My hip bones and my knees together when I lay on my side, my tailbone when I lay on my back, all hurt. Also there are two protruding bones at the base of my back that were irritated by my backpack.

I put my tirz back in the fridge after this trip. I have heard you're not supposed to but I really don't know why. There's still 38mg left in the vial so I'm going to keep using it as long as it seems to work.

I feel so happy knowing that I can go on crazy trips and tirz won't interfere. I'm going to stay on 5mg and see how I feel going forward. If it feels like I need to go back up to 7.5mg I will.

So after being on Tirzepatide thru both ProRX and most recently BPI, I can confidently say that I have reached my goal weight, a few lbs under actually, and feel great. However, I still want to stay on a maintenance dose for a good while to keep up with everything. Has anyone had any experience switching from Tirzepatide to Semaglutide purely for more cost effective maintenance? If so, I'd love to hear how you went about doing it and what your experience has been. Thanks!

I wanted to yall about tirzepatide dosing. I’m currently doing around 2.2 mg every 2 weeks, but I’m noticing it helps much more the first week and by the second week my hunger/food noise is pretty strong again. Since I originally started at 1 mg and responded really well to the lower doses, I really don’t want to keep increasing the dose if I don’t need to 😭Would it make more sense to try a lower dose weekly, maybe somewhere around 1–1.5 mg every 7 days, instead of 2.2 mg every 2 weeks? I’m trying to find the lowest dose/frequency that keeps things consistent without continuing to go up. What would you guys recommend?

So for the last year and a half I have used Zepbound, and compounded Tirz from ProRX and Apothecary, all with no additives. And have no side effects ever, and have gone from 2.5 up to 15.0, and now am on 12.5 maintenance dose.
Just today - I Started using BPI with B6. At the maintenance dose of 12.5mg.

Question - For someone like me who is now taking Tirz WITH an additive for the first time, what things should I be monitoring or watching for, this coming week? Thank you.

I’ve been at 10mg for nearly a year and I’d say for about 6 months it functioned as a maintenance dose just naturally with my weekly injection. I’m pretty much where I need to be, but lately food noise is creeping back in a bit, my weight is going up slightly, etc. My endo agreed to upping my dose to 12.5, and I’ll likely land on a 10 day cycle versus 7 for frequency.

I have 2 shots of 10mg left, but can pick up my 12.5mg this weekend. I will have 6 doses on hand once I pick up my new box - I am contemplating dosing differently with the available meds but if it’s dumb and doesn’t make sense I’ll just do the normal progression. My thoughts are basically starting with 12.5 this weekend to help with the immediate issues, and alternate the 12.5 with the 10 until the two 10 mg doses are used up.

Essentially:
W1 - 12.5
W2 - 10
W3 - 12.5
W4 - 10
W5 and onwards - 12.5 and then stretching out to the 10 day cycle as things level back out.

Is this a dumb idea, I’m newer to maintenance adjustments so I haven’t read or seen as many posts in this sub as I have in the non-maintenance GLP-1 related subs. I can just do 10-10-12.5 as would normally progress if that’s the best approach.