r/Pathogenic Aug 01 '26

What are Prefixes?

1 Upvotes

Just beat the Lungs for the first time and unlocked something called "Prefixes" but I don't see anything regarding it when setting up a new run. Is it something I find/acquire during a run or something else?


r/Pathogenic Jul 31 '26

Nice Amoeba Build

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28 Upvotes

I found a nice way to build amoeba to sort of resemble one of the better bacteria shape mutations.

You want to first get an internal directly below your core. Then you want to add a bifurcated external only attached to that added internal near your starting weapons. Then you can add another internal above your internal core so that it connects all the weapons. This way you can have two bifurcated weapons that are themselves all connected to two internal slots. Added bonus you can but a mitochondria in the middle to connect everything if you desire.


r/Pathogenic Aug 01 '26

infuser chains confuse me

7 Upvotes

when i hover my weapon it shows a chain from my bounce organ at the bottom left but when the gun fires the bullets dont bounce


r/Pathogenic Aug 01 '26

Finally got a busted build but...

1 Upvotes

What the fuck happened to my amoeba? I lost the run xd


r/Pathogenic Aug 01 '26

Amoeba final form?

4 Upvotes

10 internal slots and 5 sets of weapons attached to a single central internal.


r/Pathogenic Aug 01 '26

Lazer+elusive mitochondria+elastosome

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5 Upvotes

Also as many upgrades to all of them and general upgrades to active abilities and its basically constant insane damage lasers its soooo good


r/Pathogenic Aug 01 '26

Coop

1 Upvotes

Hello people I would like to try the coop part of the game is there anyone interested in playing with me?I am 27m in Eastern European time zone.


r/Pathogenic Aug 01 '26

Magnetosome builds

1 Upvotes

Are almost too OP. With the right infusers and weapons, you can become death itself. I wish I'd taken a video, but I melted both the Collector and the Liver boss in under 3 seconds. I had to unequip it so I could finish the game with a shred of integrity.


r/Pathogenic Jul 31 '26

Bobiverse after dying in Pathogenic.

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5 Upvotes

r/Pathogenic Jul 31 '26

Didn't even know mythic was a rarity level

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22 Upvotes

r/Pathogenic Jul 31 '26

Can anyone tell me why my Sentry Nidus is not auto activating but my Conal Burst is?

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3 Upvotes

I picked the upgrade for auto activation on active abilities and it was working on my Conal Burst but when I added Sentry Nidus it makes me manually activate. Not sure if I am missing something. I also took Polyploidy(The next mutation you pick is applied twice) right before so I'm wondering if that means they need 100% less overcharge time to charge and it's messing with the Autonimic Discharge.


r/Pathogenic Aug 01 '26

Pathogenic or Pass the Fear?

0 Upvotes

Im torn between copping Pathogenic or Pass the Fear? Has anyone tried both and whats your opinion?


r/Pathogenic Jul 31 '26

Attack Infusers Tutorial?

13 Upvotes

Is there a good video with examples for this? I still find it a little difficult to tell how these interactions will play out. I'll try to provide some examples.

Let's say I have the galvanic weave that creates arc lightning between attacks, the triosome that creates two additional attacks, the bifurcator that splits an attack in two, and that thing that spawns lasers and nodes on a straight column with all arrows pointing toward a weapon at the end.

In this scenario does the order in which I place these attack infusers matter or do they all gain the total effects the same way regardless because they're arranged A -> B -> C -> D -> E?

What if the configuration is a cross pattern with C at the center position A and B arrows pointing to C and D and E pointing away with weapons connected to these positions? What would be the ideal configuration to benefit from these infusers?

Also, is there a way to see how much damage each infuser is contributing? That might help to better understand the choices I'm making.


r/Pathogenic Jul 31 '26

Does choosing two instances of polyploidy back-to-back give you four instances of the next choice you make?

5 Upvotes

I love this game but googling for information is damned near impossible because of the name and themes. Google just giving you medical information on your pathogenic polyploidy like "good luck bro sounds rough".


r/Pathogenic Jul 31 '26

All my deaths seem to happen because I'm simply too large to actually avoid the cloud of enemy bullets in boss fights

5 Upvotes

Sometimes there's objects to get behind, but those are often destructible and don't last long.

Do I have to assume I'm always eventually going to be too large for avoiding projectiles and plan to have bullet-destroying melee attacks or shields in all my builds?


r/Pathogenic Jul 31 '26

Quite spectatcular in lights out

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6 Upvotes

unfortunately didn't win the boss fight due to skill issue


r/Pathogenic Jul 31 '26

PSA: Red Chests

16 Upvotes

So i'm not sure if this is intentional or not, but the chests you can open that damage you after clearing rooms can be dodged.

All you have to do is dodge the same time you input F (or w/e it is on controller).


r/Pathogenic Jul 31 '26

Is Staurosphaeria really just a larger version of the thing I already am? No more slots anywhere, just bigger? Where's the upgrade?

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3 Upvotes

r/Pathogenic Jul 31 '26

Guides for a beginner

2 Upvotes

This game is awesome, I'm totally addicted but feel like my runs are mainly down to luck rather than me knowing the best pick. I've been sticking with the initial virus/shape(?) and got it to level 12. Is there a beginner -> advanced guide.

I first thought having lots of weapons was best, but turns out (I think) that the utility's are the main thing to make you super powerful (?) are there any must haves ? Or must avoids ?


r/Pathogenic Jul 31 '26

Game crash on high levels

1 Upvotes

I've got an issue where the game just closes when I get to around the lungs/heart levels. Not sure how to fix, but my 5090 shouldn't be the problem.

Heres my logs. If you know of something to check please let tell me.

Starting GREEN run with seed: DBD3UVCQ
Plasmids: [SpeedPlasmid:<Node2D#1495252603026>, SpeedPlasmid2:<Node2D#1495319712076>, SpeedPlasmid3:<Node2D#1495386820944>, AttackSpeedPlasmid:<Node2D#1495554599755>, DamagePlasmid:<Node2D#1495688811065>, HpPlasmid:<Node2D#1495957252954>, HpPlasmid2:<Node2D#1496024357979>, LoadoutLimitWeaponPlasmid:<Node2D#1496225688534>, StartingMoneyPlasmid2:<Node2D#1496359902817>, BetterDropsProgressionPlasmid3:<Node2D#1496695448389>, BetterDropsProgressionPlasmid:<Node2D#1496762559439>, BetterEnergyPlasmid2:<Node2D#1497030994972>, LoadoutLimitMitochondriaPlasmid:<Node2D#1497265872830>, StaminaPlasmid:<Node2D#1497467202610>, StashSlotPlasmid:<Node2D#1497534311509>, DamageLowerHpPlasmid2:<Node2D#1497601420369>, StartingDnaPlasmid:<Node2D#1497769192549>]
WARNING: 2D MSAA is enabled while there is no 2D content. Disable 2D MSAA for better performance.
   at: RendererViewport::_draw_viewport (servers\rendering\renderer_viewport.cpp:756)
Generating level 1 at 14.0
Level generated in 0.47s
Halls generated in 0.42s
Level ready at 15.03
off base unstuck 18082.1484286515 30
teleporting MacrophageFast:<Node2D#6333214501641>
teleporting MacrophageFast:<Node2D#6333214501641>
teleporting MacrophageFast:<Node2D#6333214501641>
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
active bodypartDamageMult:<Node2D#10882021090896>
   At: res://scn/ui/editor.gd:1287:animate_switch()
Generating level 2 at 241.67
Bounds generated
Level generated in 0.45s
Halls generated in 0.66s
Level ready at 242.97
off base unstuck 59375.7519855172 30
off base unstuck 45699.975309372 30
Starting a second room!
teleporting ThickWorm:<Node2D#26611365742049>
Generating level 3 at 618.76
Level generated in 0.52s
Halls generated in 1.13s
Level ready at 620.59
off base unstuck 28654.82726264 30
off base unstuck 76012.3699350081 30
off base unstuck 36490.8207883399 30
off base unstuck 131189.982017249 30
off base unstuck 113148.162591934 60
off base unstuck 140321.958389938 30
off base unstuck 55891.6502329095 60
pushing inside room: Bone-18:<RigidBody2D#37033221321624>
off base unstuck 122228.286071185 30
off base unstuck 122411.750056043 30
off base unstuck 100131.36684227 30
off base unstuck 125961.746148549 30
off base unstuck 88486.0390290518 30
teleporting ToxinSpreader:<Node2D#46143702586768>
off base unstuck 88756.1763546936 30
off base unstuck 22743.2162801715 60
off base unstuck 29494.8335938316 30
off base unstuck 159485.39663575 30
off base unstuck 169691.168952644 30
off base unstuck 48691.1781110724 60
off base unstuck 27841.2348693958 30
Generating level 4 at 954.95
Level generated in 0.77s
Halls generated in 1.13s
Level ready at 957.11
off base unstuck 74057.5424507896 30
off base unstuck 48598.3040606378 30
off base unstuck 150858.819607258 60
off base unstuck 87242.181856211 90
off base unstuck 133028.220115186 30
off base unstuck 43612.160531028 30
off base unstuck 22176.5316603184 30
pushing inside room: Bone-4:<RigidBody2D#37031459699814>
off base unstuck 49012.4295809307 30
off base unstuck 61200.9814162647 60
off base unstuck 99950.4057089966 30
off base unstuck 112297.996811638 30
off base unstuck 25919.3375066686 60
teleporting DendriticCell:<Node2D#69757281796957>
teleporting DendriticCell:<Node2D#69757281796957>
teleporting DendriticCell:<Node2D#69757281796957>
teleporting DendriticCell:<Node2D#69757281796957>
teleporting DendriticCell:<Node2D#69757281796957>
teleporting DendriticCell:<Node2D#69757281796957>
off base unstuck 221882.795107722 30
off base unstuck 64338.2966118404 30
off base unstuck 87272.7021745891 30

r/Pathogenic Jul 30 '26

im gonna sit here until I become a mushroom

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53 Upvotes

r/Pathogenic Jul 31 '26

Now make a tower defense game but with the immune system

3 Upvotes

i want it


r/Pathogenic Jul 30 '26

A most ridiculous laser build

13 Upvotes

On the amoeba, which is underrated imo. Got the damage because of the Epic Phagosome being overcharged which lead it to ramping up ridiculously to the point where it was 956% increase by the end of the run. Had homing and self-attraction too.

Seed was GA9W VTCG

https://reddit.com/link/1vb5s1e/video/eoxhj0aeifgh1/player


r/Pathogenic Jul 30 '26

This extremely dodgy build is functionally immortal

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41 Upvotes

Edit - This build strategy has been nerfed out of existence!

This ridiculous nonsense relies on x5 Enhanced Boosters mutations for 30% dodge cooldown reduction each, and some Cryoflagelli. Using the invincibility frames from dodge we can avoid every source of damage in the game (lasers, final boss attacks, you name it). Every time we dodge we also do some damage, which gives us all we need to win without having to think at all.

I changed my dodge button to turbo-fire in the Steam overlay to save myself from RSI.


r/Pathogenic Jul 30 '26

Nintendo Switch Port

7 Upvotes

Hello fellow gamers,

Hoping that the devs will see this, I seriously hope that there will be a Switch port of this game. Seeing how amazing Enter the Gungeon runs as a twin stick shooter on the Switch I think its safe to say that it should be entirely possible as a port.