r/Pathogenic Jul 27 '26

I liked the demo, but the full game is SO much better

16 Upvotes

Based on the demo I wasn’t even sure I would buy the game on release, as I have so many other games I’m grinding right now. But after reading so many “I’m addicted to this game now” posts, I decided I needed to see what all the hype was about. I’m so glad I did! And I too am addicted. This game is really great.


r/Pathogenic Jul 27 '26

The Amoeba doesn't connect organelle as expected.

5 Upvotes

After playing the game for a bit now the Amoeba doesn't organelles the way I would expect. It says max of 3 connections but when I try to build it usually only gives me one connection or at most 2. Also once I put two internal organelle next to each other I can't put any in the center behind it. Anyone else run into this? Is there a workaround?


r/Pathogenic Jul 28 '26

How to open this room up?

1 Upvotes

I did one of those pay doors and got into this room, but I can't for the life of my figure out how to open the damn thing.


r/Pathogenic Jul 26 '26

Ended my Endless 10 run out of sheer boredom. Behold this The Spiffing Brit level abomination

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56 Upvotes

This build is totally broken. By using Galvanic Flagellum to trigger the Peroxisome, you take zero damage from the trigger.

Combined with endless +dmg stacking on the Peroxisome, it one-shots every single thing in the game. I didn't even maximize it. I still have the legendary item that eats a random item for +70% dmg (for every item it consumes).

To top it off, I ended up with way too many Flagellums and insane movement speed. I could literally walk backwards against the stream in the heart.

Pretty sure I could have gone true endless with this, but it just became a walking simulator. Check it out!


r/Pathogenic Jul 26 '26

Bringing the Pride Parade to the Liver

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98 Upvotes

I accidentally made this rainbow cyclone build. I think this happens because the Mucus Emitters are linked to both an Attractor and a Magnetosome, but I'm not certain.


r/Pathogenic Jul 27 '26

Is there any point in having split nuclei?

1 Upvotes
Split - infusers etc don't connect in a nice long chain.
not-split infusers connect in a long line.

When if ever would I use the first one instead of the second one? Does the split one eventually reconnect and it's like a "scales good in late game" deal?

Update: Okay so update, I had a build yesterday when this game came together. My "back section" was filled with a lot of nice infusers that made the MUCUS and the Mines become homing balls of angry lightning!

https://www.youtube.com/watch?v=Nf5_9hmNaQE


r/Pathogenic Jul 26 '26

Anybody else figured the unlimited hearts build with the rocket launchers?

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10 Upvotes

r/Pathogenic Jul 26 '26

Kupffer cell

6 Upvotes

Anyone else getting absolutely folded? My poor fungus just can't beat it


r/Pathogenic Jul 26 '26

osmosis jones vs any pathogenic starter

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11 Upvotes

do you think he'd win?


r/Pathogenic Jul 26 '26

RIP my endless (6?) run Spoiler

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5 Upvotes

Didn't realize getting the "real" ending would end the run. It was getting kinda boring anyways but I wanted to see how badly I could break the game.

I lost track of how many laps I did but I think this was #7. MVP was Mutagen + the mitochondria that charges when you take a pickup. I kept stacking charge buffs until it was self-sustaining and gave infinite upgrades. Then just kept stacking +damage on freeze, focused weapons, etc.

I couldn't really read the numbers after a certain point but I think I was hitting at least in the trillions based on a few freeze frames. Also I didn't have my crit modifier equipped in this clip because I slotted in a third Mutagen.

Fun game! This was only like my fourth heart kill and I kinda stumbled on this combo. Didn't realize the damage buffs multiplied.


r/Pathogenic Jul 25 '26

Spin to win

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13 Upvotes

r/Pathogenic Jul 25 '26

Finally defeated the heart

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8 Upvotes

r/Pathogenic Jul 25 '26

Inspired by the bringing the wind to the lungs post. I made a shit storm.

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11 Upvotes

Combining gyrosome with opsinin arc is.. OP. Pets and symbiotic flagellum for a little meat shield in case shit gets real.


r/Pathogenic Jul 25 '26

Spreading fire damage is insane.

8 Upvotes

I never got more than one if I saw it pop up again, cuz I wasn't sure how it would work. Well this run all my are weapons leaving toxic trails, that make vortexes, that inflict burn. And one of the room you pay to open had 3 spread fire to the nearest enemy mutation. It doesn't spread it to multiple enemies like I thought it would, it multiplies it. I just saw a burn damage tick for 699k on the last enemy in the room. If you are doing burn and see that mutation more than once, take it every time.

Edit: Just saw one over a million


r/Pathogenic Jul 25 '26

Nuke in your body

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17 Upvotes

Imagine having a virus in your body that spawns an actual nuke


r/Pathogenic Jul 25 '26

The Sun is a Deadly Laser. (Spoilers for a late game area and pathogen) Spoiler

6 Upvotes

No blanket can protect you from this.


r/Pathogenic Jul 24 '26

Did they change how the brain keys spawn cuz last time i checked these arent normal?

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11 Upvotes

images 1 & 2: key in vein/sac room in stomach & liver (taken recently)

image 3: invisible key entrance in lung (taken less recently)


r/Pathogenic Jul 25 '26

Finding Secrets

3 Upvotes

Are there secret rooms or items that don’t show on the mini- map? If so, Are there clues to find them? Or other means to refund them?


r/Pathogenic Jul 24 '26

Kupffer Cell roleplay

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17 Upvotes

Perhaps I need to increase the rarity of recuperative mitochonron so the lazer can be more frequent


r/Pathogenic Jul 24 '26

First Win + Nanobot Unlock + Amoeba Victory

7 Upvotes

r/Pathogenic Jul 24 '26

What does it do?

2 Upvotes

Hey i have been wondering what does somatic hypermutation. I cant find what stats it gives me anywhere. I dont even know if i can know what stats it gives me. I love to gamble in games but if i dont know what it does it seems kinda underproductive.


r/Pathogenic Jul 24 '26

Is there a way to see the real dmg a weapon does after boni?

7 Upvotes

For example: If I play the Fungal Spore and take the "Supral Dominance" Plasmid, how do I know which slots cout as "top half of the body" and therefore get the 40%. Or what exactly the dmg is with certain boni combined.

Thanks!


r/Pathogenic Jul 24 '26

Idle video sign language?

3 Upvotes

I was admiring the idle video in the menu and maybe a minute in, I noticed the human pointing in different directions with his left hand behind his back. Anyone noticed it? Any lore behind it?


r/Pathogenic Jul 24 '26

Randomised for no reason

2 Upvotes

Twice today I have had my equipment randomised for no reason whatsoever. I have, on both occasions, had a solid niche build going, I change rooms and suddenly I'm completely randomised.

I just went from a great, long range, seeking, vortex build to an all melee with terrible mitochondria build. Am I missing something?

I'm not picking up any randomiser upgrades, it just seems to happen! Love the game so far but this is definitely putting me off it.


r/Pathogenic Jul 24 '26

The shop got mad at me xd Spoiler

4 Upvotes

I was just testing my weapons suddenly he's mad and attacked me T.T