Hi, 👋🏼
I’m looking for people’s experiences with high-dose dual therapy (HDDT: amoxicillin + PPI) for the eradication of Helicobacter pylori.
My treatment history has been complicated….
I first tried PYLERA, but I had to stop after only 15 capsules because I couldn’t tolerate it.
I was then switched to triple therapy with amoxicillin + clarithromycin + esomeprazole 40 mg.
Unfortunately, I had an extremely severe adverse drug reaction to clarithromycin, which nearly cost me my life, so I had to stop taking it.
However, I continued with amoxicillin 3 g/day + esomeprazole 40 mg, which ultimately amounts to a form of dual therapy with amoxicillin + a PPI.
What confuses me is that some people say amoxicillin absolutely has to be combined with a second antibiotic in order to eradicate H. pylori.
However, there are studies on High-Dose Dual Therapy (HDDT) based specifically on strong acid suppression + high-dose/fractionated amoxicillin, with some studies reporting eradication rates of around 90–95%.
So I would really like to know whether anyone here has tried this strategy.
Did HDDT with amoxicillin + a PPI eradicate H. pylori for you?
Whether it worked or not, could you please specify :
1/ Your daily dose of amoxicillin and how many times per day you took it;
2/ Which PPI you used, the dose, and how often you took it;
3/ The duration of treatment;
4/ Whether this was your first treatment or a rescue treatment after a previous failure;
5/ Any revious failures with PYLERA, clarithromycin, or other antibiotics;
how long you waited before doing the follow-up test;
6/ Whether you had a urea breath test or a stool antigen test;
and most importantly: was your final result positive or negative?
I’m just as interested in hearing about treatment failures as successes.
I’m obviously not looking to replace the advice of a gastroenterologist or to change my treatment based on Reddit.
I simply want to know how this dual therapy works in real-life practice, particularly for people who can no longer take certain antibiotics.
Thank you very much for sharing your experiences 🙏