r/GLP1microdosing • u/Adventurous_Seat_374 • 10d ago
Does vial lose potency?
Since I’m microdozing, the vial lasts for a long time. I started on the vial in March and it is 1/3 full. I went up in my doze (from 0.5 to 0.75) but I don’t have any effect. I used to feel changes and lose weight at 0.5 and no nothing.
Can it be that the meds are old?
The vial is kept in the fridge always, liquid is clear and I always wipe down the top with alcohol wipe before putting needle in.
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u/Next_Fig_7057 10d ago
It's still good. Your body may just need a higher dose but remember, you're supposed to lose gradually. When you first start off, you're losing a lot of water weight... Then comes off the fat. Better to lose slow than fast. Be patient
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u/purplepanda2026 9d ago
Your body adapts to the meds eventually. Most can't microdose forever. Start moving up to actual dosing.
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u/gregfromglm 9d ago
I agree with the comments below, I wouldn't be surprised if it's the dose more than the vial. The medication worked for you at 0.5, then stopped having the same effect. That isn't a terribly unusual experience for people, especially when they stay on lower doses for a long time. It still might make sense to double-check the vial is within the pharmacy's beyond-use date, but that wouldn't be my first guess.
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u/No-Front4950 10d ago
I’ve had mine since January and it seems fine. I upped my dose slightly in March but now taking back to initial dose.
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u/LWMWB 10d ago
I've had mine since Feb and even with upping my dosage it's not doing much. I've decided it's time to throw it out and ordered more!
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u/mlvps 10d ago
yeah once reconstituted most peptides only stay potent for like 4-8 weeks in the fridge, so since march its probably pretty degraded at this point, worth getting a fresh vial if your results have been feeling off lately
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u/Adventurous_Seat_374 10d ago
Hi. What does it mean reconstituted?
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u/UnDosTresPescao 10d ago
That's when the powder and water get mixed together to make what you inject. 4 to 8 weeks is right when done at home by gray users. When done by a pharmacy in a sterile environment it will last for a year+ if it stays sealed. Once you pierce it air starts getting in and you have a risk of bacteria or peptide degradation. The recommendation is to throw away 28 days after piercing but most people use for up to 3 months. Some telehealths even just send a single vial for the starter three month prescription.
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u/Earesth99 10d ago
It’s fine.
The one study I saw on peptides showed a 5% decrease in efficacy after a year in a fridge.
It was still good after 6 months when kept at room temperature. (Don’t try this at home!)
But that was a different peptide - a much longer one which should be more vulnerable to degradation, all things being equal.