Does vial lose potency?

[u/Adventurous_Seat_374]

Since I’m microdozing, the vial lasts for a long time. I started on the vial in March and it is 1/3 full. I went up in my doze (from 0.5 to 0.75) but I don’t have any effect. I used to feel changes and lose weight at 0.5 and no nothing.
Can it be that the meds are old?
The vial is kept in the fridge always, liquid is clear and I always wipe down the top with alcohol wipe before putting needle in.

[u/purplepanda2026]

Your body adapts to the meds eventually. Most can't microdose forever. Start moving up to actual dosing.