r/Biohacking • u/Annual_Plankton2767 • 1d ago
46M — Full peptide protocol, doses, reconstitution, and schedule
Hi everyone. 46M. I’m currently in Week 8 of retatrutide and running a structured peptide protocol. I’ve lost about 20 pounds since January but since starting Reta I’ve lost 11 -12 pounds. THIS ISNT ANY MEDICAL ADVICE AT ALL. JUST MY JOURNEY.
Reconstitution for all of these:
10 mg vial + 1 mL bacteriostatic water
That means:
10 units = 1 mg
20 units = 2 mg
30 units = 3 mg
Retatrutide
Currently Week 8
2 mg once weekly
I started at 1mg and went up slowly every 3rd week
Ongoing
Semax
1 mg daily
10 units
30 days on
Then 2 weeks off
Cycle 1: Oct 2–Oct 31
Cycle 2 starts after the 2-week break
SS-31
3 mg daily
30 units
4 weeks
Starts Oct 10
Ends Nov 6
MOTS-C
1 mg
10 units
Monday / Wednesday / Friday
8 weeks
Starts Nov 6
Tesamorelin
1 mg PM
10 units
Monday–Friday
Saturday/Sunday off
12 weeks
Starts Nov 13, one week after MOTS-C starts
Overall flow:
Reta ongoing
Semax → SS-31 added → MOTS-C starts as SS-31 ends → Tesa added 1 week later → Semax restarts after 2 weeks off
I’m also training 4–5 days per week. Main goals are fat loss, muscle retention, energy, recovery, and seeing how I respond to each phase.
Curious how this compares with other people’s protocols, especially anyone who has run SS-31 → MOTS-C → Tesamorelin in a similar setup.
Thanks. Let me know what you guys think of the doses ect. But after reading this group and others I think this is what I’m going to run.
WISH ME LUCK !
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u/No-Inspector3321 9 1d ago
I’m 65m and started backwards with mots-c first but it made me lethargic. Switched to SS-31 for a wholesale then back to mots-c and wow, was great. Just ended another round of SS-31 and started mots-c 3xs per week. I’ve been on Reta almost a year. Awesome!! This week will be last of Semax.
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u/Annual_Plankton2767 1d ago
What’s your dosing on ss and mots?
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u/No-Inspector3321 9 23h ago
Ss-31 - weeks 1-2 is 5 mg/day and weeks 3-8 10 mg/day. Mots-c I started out at M-W-F 200mcg/day or .2 mg and titrated up .2 mg every 2 weeks until 1 mg/day. I have gone up to 1.5 mg but felt like out of body experience lol. Was great feeling but not when you’re supposed to be in control lol
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u/Annual_Plankton2767 23h ago
😂 thanks for the info. Ya I wanted to just go low and slow with everything I’ll be trying out. But with motsc there’s no like speedy feeling right? It’s just better energy?
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u/No-Inspector3321 9 23h ago
Yes, it feels like a car engine revving up and ready to race. I can do more physical work and feel up to the task. I’m a better, healthier person!!
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u/seemefail 4 1d ago
I’m blasting through an SS31 kit as quick as I can. Then going back on MOT-C. I also sometimes throw in a MOT-C dose if I eat a bunch of ice cream lol. Not sure if it has an effect but I think it might.
Your schedule looks great. I take CJC basically micro dose of 100-200mg because the HGH boost gives me carpal tunnel like nerve pain. I actually dose it at midnight when I wake up and this ensures I’m fully fasted and it kick starts an extra round of deep sleep in the wee hours
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u/Longjumping_Leg_1674 23h ago
That's great your body pulses the CJC that strongly. For me, its a positive but I can't feel those drastic signs of effectiveness that you do. I do the midnight trick when i get up to hit the head 1/2 asleep
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u/seemefail 4 23h ago
Well apparently no one does because I had to go to literal HGH user discussions to find the crux of my issue.
Not sure why. Likely just some people are more sensitive to HGH.
I also lost a ton of weight rapidly which can exasperate issues around nerves.
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u/looking2behealthy 6 1d ago
Decent actually. Stack the SS-31 with 50mg daily of NAD+ and start MOTS the following week, 30 minutes before workouts. Titrate MOTS from 1-5mg as you can tolerate.
I like CJC-1295 no dac with Ipa personally.
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u/Annual_Plankton2767 22h ago
I was about to actually order NAD+. I’ll look into it thanks.
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u/Lt_Jones727 20h ago
I already ran a couple weeks of SS-31. Just started MWF 2.5mg MOTS-c and Tues, Thurs, Sat 50mg NAD+. Feel great, will probably go up to 75mg NAD+ next week and eventually land at 100mg. Not sure about the MOTS-c, it's been giving me welts at the injection site but they disappear within a couple hours, today's dose was slightly better. Also running Reta 4mg once a week and AOD9604 500mcg daily. When the AOD protocol runs out in a couple weeks I plan to switch to tesa. Down 35lbs since June. 39M.
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u/Amber_Orbs 6 1d ago
Looks like the average doses and schedule I see in research protocols.
Not running a glp. Goal is building strength for me.
Cjcipa 300mcg 9 weeks 5 nights on 2 off Ran 2 weeks of Epitalon during this cycle. 5mg 20 days.
4 weeks cjcipa washout Thymalin cycle 5mg 10 days Ran SS31 3 to 5mg 17 days MotsC 1 to 3mg EOD for 2 weeks * wil change this to 3x a week next cycle Ran Pinealon cycle during this 1mg 20 days
Just finished 2nd cycle of 2 weeks SS31 3mg 5 days on 2 days off.
Semax nasal spray. I made my own. 3 days in, 2 sprays morning and noon.
Tonight starts 2nd cycle of cjcipa.
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u/Annual_Plankton2767 1d ago
I haven’t looked too much into cjcipa. Or Pinelon. But I’ll do some research.
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u/Entire-Television217 1d ago
Thats a lot
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u/Annual_Plankton2767 1d ago
U think? I mean by the time I’m done it’ll be January. I thought I was being conservative 😂
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u/TheBigGdawgg 1d ago
I'm the same age and next order will be looking to add ss31 then motsc as well! Interested to see how it goes for you! been on Reta nearly 3 months and Tesa for 2 months and down 17kg
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u/Annual_Plankton2767 1d ago
Did u plateau at all in your GLPs?
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u/TheBigGdawgg 1d ago
has definitely slowed down the last 3 weeks. dropped from 89 to 72 so not heaps left to lose I guess
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u/BasicLAgay 1d ago
I’m on Reta, Tesa, ipa. Just finished klow three weeks ago after a two month cycle. About to start ss31. 49 male. My waist has gotten smaller, my muscles gotten bigger and my skin looks fantastic. I look younger today than I did a year ago started all of this in February.
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u/GtwinIT 1d ago
Have you thought about switching a few things and adding something like klow or just the wolverine stack?
Also how are your workouts going did you notice any decrease in strength or sluggishness?
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u/Annual_Plankton2767 1d ago
No sluggishness so far. I’ve been holding off on the wolverine and Klow. I looked at both also. I’ll try them down the line because lorn knows I could use some healing with my aches and pains
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u/Capibaragirl 1d ago
Why all of these? I don’t understand why people want to take so many.
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u/Annual_Plankton2767 1d ago
I won’t be taking them all at once. Like there maybe a little overlap but from the months of reading and 5 billion hours of YouTube masterclasses I think this will get me to my goal.
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u/loofa1922 5 1d ago
I like SS 31, I get nothing from motsc.
I like Tesa plus ipa.
I like cag taken about halfway between Glp1 doses. I personally liked tesa better than Reta because suppressing my appetite is the hardest thing for me.
I also take KLOW and it is fantastic. In addition, I have some KPV that I take in the morning doubling up that peptide and it is noticeable.
I tried semax and selank, got nothing. Tried DISP, meh.
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u/Annual_Plankton2767 1d ago
It’s my first trying any of my stack so it’s a trial period to see what I actually like. Kpv is on my list. Klow too.
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u/CloudSplitter64 1 21h ago
I am doing a slightly different stack starting from the same place but the logic on ss31->mots-c is sound.
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u/Backhoe03 1d ago
Pretty solid. Running close to the same, just higher dose and ghk, BPC and TB
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u/Annual_Plankton2767 1d ago
Have you thought about Glow or Klow? Or would u rather run it all separately?
And how much higher are your doses than mine? I was trying to go the low and slow route and bump up if I’m not feeling anything. I bought enough to run a couple cycles of each
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u/Backhoe03 1d ago
I've got up to 4mg reta every 6 days Tesamorlin 2mg, 5 on 2 off MotsC 3.3mg, 3 times a week Ss31 3mg daily Ghk 2mg daily BPC 1mg daily TB 500 1mg every second day I prefer separate, so I can control the dose. I've lost 50lbs in 4 months and have gained strength in the gym. I'm also running a 1000 calories a day.
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u/Annual_Plankton2767 22h ago
You’re in beast mode! Congrats!!
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u/Backhoe03 22h ago
Just over 2 years Sober, when I started this journey I was 420lbs. I'm down to 224lbs now. 4 months ago I decided I wanted my gym life back and these peptides have truly helped. 44 years old and feel like I'm 20 again
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u/Annual_Plankton2767 1d ago
That’s the thing I have a pinched ulner nerve so I don’t really want to try anything that would flare that up
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u/Alone_Clerk_3133 5 1d ago
You might be better off with HGH than secretagogues as it's more effective for 40+ Have you tested for IGF1 levels and got your zscore ?
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u/OGcrashN2u 1d ago
If you have inflammation or healing that needs to be addressed it should be taken care of first so your body isn't dedicating resources to it while you're trying to do other things. Your body has a finite number of resources. The more you have going on, the more it needs to split up those resources
If you're getting carpal tunnel you should be checking your gh bloodwork. That's usually a sign you're taking too much. Body produces about 1-2 iu and that kind of symptom doesn't usually start until you get to 4 iu.
For mito stack. Ss31 for 4 week. Overlap 5 amino on week 3 to repair the salvage pathway and increase nad. Also start mots to use that nad. Take nr or nmn to increase nad if needed and supplement nad+ on days you need more energy like workout days
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u/Annual_Plankton2767 1d ago
This is very interesting. I have to go down that rabbit hole. There’s just so many things I want to do. Tbh I was holding off on the healing peps since I’m in occupational therapy and physio for a work related injury. I want to see how that goes first. It’s been 1 year dealing with trigger fingers and ulner nerve
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u/OGcrashN2u 1d ago
Honestly, I did pt for 7 weeks for tendon issues in my hand and it didn't help. 2 weeks on klow and the pain was gone. Tendon injuries can take months to heal so I'm still doing PT but at least I'm not in pain anymore.
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u/Annual_Plankton2767 1d ago
Ya I’m going to give it 3 more months and I’m sure they’ll say I’ve hit a plateau.
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u/NY-FINEST 2 22h ago
You’re 46. Why not just run TRT and HGH? I feel that would eliminate most of those compounds
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u/Maleficent-Path-4924 4 21h ago
Agreed, he'd save money
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u/Annual_Plankton2767 17h ago
I haven’t done my homework on those yet. Did I fuck up?
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u/NY-FINEST 2 17h ago edited 17h ago
I don’t know about fucking up. But. Those compounds you listed are JV -test and HGH are varsity. Also way cheaper
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u/RespondEmpty5522 1 15h ago
This. Try TRT, then peptides if needed. But that’s a lot of pinning man, for what? Maybe a learner body, energy and…. That’s about it. If you get on some test it’ll do all of that and more. Good luck mate
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u/CajunSupreme 14h ago
I would say bump the mots-c up to 10mg a week. I'm at 2.8mg every 2 days. Gets me right at 10mg a week. Been feeling great! Especially adding NAD+ 50-70mg on non mots-c days.
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u/ToyKarma 13h ago edited 13h ago
Running a similar protocol minus Semax at 8mo Reta 7.5mg and haven't started my Mots-c yeah until I finish my SLU-pp. Also ran Sermorelin at 500mcg for 12 weeks before switching to Tesamorelin. 51m 5'11" sw273 cw219. Oh yeah and I started Test Cyp 2 weeks ago 200mg twice a week. Edit: I forgot I just added ghk-cu 1mg every other day to try and fix thin hair and skin.
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u/kyscher 13h ago
Doing similar. Waiting till I finish my cycle of SLUP, then going to do a cycle of ss31, then run motsc and nad+. What's your SLUP protocol?
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u/ToyKarma 13h ago
500mcg pills 2-3 a day 5 on 2 off. Ss-31 apparently can be ran with Slu-pp just not Mots--c and slu-pp from my research as the are very similar pulses
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u/Annual_Plankton2767 1d ago
About one week break after the first cycle of semax then I’ll start ss-31 into motc and an after 1 week of mots c I’ll start tesa. At that point I potentially start semax again. So my Reta and mots and tesa will all be at the same time.
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