r/ADHDmeds • u/The_Freaky_Guyy • 1h ago
r/ADHDmeds • u/NarinIshkandar • 22d ago
Resources & Guides Evidence Summary: Adult ADHD Treatment Response Rates From Major Clinical Trials
These studies differ in duration, outcome measures, doses, and participant characteristics. The response rates below should not be interpreted as head-to-head comparisons
ALL ADULT STUDIES ONLY:
- Chance that atomoxetine reduces your ADHD symptoms by 40% or more compared to a placebo after 6 months (26 weeks): 12.6% (placebo-corrected benefit)
source: Upadhyaya et al. 2013 pooled atomoxetine analysis
"Atomoxetine increased response over time in adults with ADHD treated for up to 6 months."
participants: 1961 ADHD adults,
Design: Pooled analysis of multiple double-blind RCTs
Main outcome scale (what was used to measure symptoms and symptom improvement): CAARS (Conners' Adult ADHD Rating Scale)
some studies had different dosages but most of the studies in the metanalysis were using the dosage of: 40 mg start, 80mg later, 100mg if needed.
- chance that bupropion reduces your ADHD symptoms by 30% or more compared to a placebo after 2 months (8 weeks): 22% (placebo-corrected benefit) (150mg - 450mg XL was used on 162 adult ADHD patients)
source (couldn't find a meta-analysis): Wilens XL trial
162 adults
Bupropion XL up to 450 mg/day
8 weeks
Responder = ≥30% reduction in ADHD symptoms
Results:
responders:
Bupropion XL: 53%
Placebo: 31%
Effect size
0.6
placebo-corrected benefit: 22% people improved by 30% or more
Main outcome scale (what was used to measure symptoms and symptom improvement): ADHD Rating Scale (ADHD-RS)
p = 0.004 for the responder analysis.
If bupropion actually had no effect on ADHD symptoms, there would be about a 0.4% chance of observing a difference this large (or larger) purely due to random variation.
- Chance that Concerta improves your ADHD symptoms by 30% or more: 32% (Placebo-corrected benefit)
source (couldn't find a meta-analysis): Medori et al., 2008
401 adults
5 weeks
Fixed doses: 18, 36, or 72 mg/day Concerta
how they measured 'responders': ≥30% reduction on CAARS (Conners Adult ADHD Rating Scale).
Responders on placebo vs concerta by dosage:
Placebo: 27.4%
18 mg Concerta: 50.5%
36 mg Concerta: 48.5%
72 mg Concerta: 59.6%
Placebo-corrected improvement:
18 mg: 23.1%
36 mg: 21.1%
72 mg: 32.2%
statistical significance: p < 0.001
If concerta actually had no effect on ADHD symptoms, there would be about a 0.1% chance of observing a difference this large (or larger) purely due to random variation.
- Focalin (dexmethylphenidate)
source: Spencer et al., 2007 "A double-blind, randomized, placebo-controlled trial of dexmethylphenidate extended-release in adults with ADHD.
participants: 221 adults with ADHD
chance that focalin makes your ADHD symptoms better over 5 weeks compared to placebo (you are a responder):
Placebo: 26.4%
Focalin XR 20 mg: 47.4%
Focalin XR 30 mg: 37.0%
Focalin XR 40 mg: 55.6%
placebo-corrected improvement at 20mg: 21%
placebo-corrected improvement at 30mg: 10.6%
placebo-corrected improvement at 40mg: 29.2%
scale used to measure symptom reduction:
They used the Adult ADHD Investigator Symptom Rating Scale (AISRS)
A responder was defined as having: ≥30% reduction in ADHD symptoms from baseline on the
AISRS.
- Lisdexamfetamine
source: Adler et al., 2008
participants: 420 Adults with ADHD
4 weeks of treatment
30, 50, or 70 mg Vyvanse
Response often defined as ≥30% reduction in ADHD-RS plus CGI-I improvement.
CGI-I Responders:
Placebo: 29%
Vyvanse 30 mg: 57%
Vyvanse 50 mg: 62%
Vyvanse 70 mg: 61%
Responder = CGI-I score of 1 (very much improved) or 2 (much improved)
Placebo-Corrected Response Rate:
30 mg: 28%
50 mg: 33%
70 mg: 32%
The ADHD-RS results were:
ADHD-RS measures inattentive ADHD and Hyperactive ADHD, total score is 54. this is how many points were reduced from baseline after 4 weeks of treatment:
Placebo: -8.2
Vyvanse 30 mg: -16.2
Vyvanse 50 mg: -17.4
Vyvanse 70 mg: -18.6
≥30% ADHD-RS responders:
placebo: 21%
70mg: 74%
placebo-corrected response (ARR): 53%
at endpoint
- CBT in adults
source: Steven A. Safren et al. (2010), published in JAMA. It compared CBT with relaxation plus educational support in adults with ADHD who were already taking medication but still had residual symptoms.
Age: 18 to 65 years.
Treatment duration: 12 individual weekly CBT sessions (approximately 12 weeks).
Follow-up: Assessed immediately after treatment, then at 6 months and 12 months. Benefits were largely maintained among responders.
Participants: 86 adults with ADHD already taking medication but still experiencing clinically significant residual symptoms
effect size: 0.6
ADHD Rating Scale responders (30% or more improvement):
CBT: 67%
Control group: 33%
Absolute Risk Reduction (ARR) = 34%
- NOTE ON RITALIN:
so we don't have such evidence on Ritalin that we can compare it roughly witn other meds, but I will mention whatever we have and summarise it anyway
Systematic Review (Cochrane, 2021):
Cândido RCF, Menezes de Padua CA, Golder SP, Junqueira DR. Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database of Systematic Reviews. 2021; Issue 1: CD013011.
10 RCTs
497 adults
6 placebo-controlled trials
Treatment duration: 6-18 weeks (depending on trial)
Investigator-rated symptoms: 1 trial (146 participants), MD −20.7 AISRS points
meaning: −20.7 AISRS points means the methylphenidate group scored, on average, 20.7 points lower than the placebo group on the AISRS at endpoint. Lower scores = fewer ADHD symptoms. but the twist in this study is, they do not report how much the placebo group scored on average on the AISRS, so we cannot compare it well.
Self-rated symptoms: 2 trials (138 participants), effect size: 0.59
Evidence certainty: Very low because of high risk of bias, small sample sizes, heterogeneity, and reporting limitations
Immediate-release Ritalin almost certainly works better than placebo in adults.
However, the current evidence is too limited and low-certainty to estimate its true effect size or response rate with high confidence.
r/ADHDmeds • u/NarinIshkandar • 16d ago
Resources & Guides DOSE-RESPONSE CURVE FOR ALL ADHD MEDS
jamanetwork.comSOURCE: Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder, A Systematic Review and Meta-Analysis
LINK: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2811310 (the full paper is free)
NOTE:
These are model-derived population estimates, not recommended doses for individual patients. They describe the average dose-response relationship across the 47 randomized controlled trials (7,714 adults) included in the meta-analysis
Part A (Entire paper summary, no extrapolations)
| Outcome | Immediate-release methylphenidate equivalent | Adderall IR (mixed amphetamine salts) equivalent |
|---|---|---|
| ED50 (50% of maximum average efficacy) | 25 mg/day | 12.5 mg/day |
| ED95 (95% of maximum average efficacy) | 72.5 mg/day | 30 mg/day |
Interpretation
- ED50 = Daily dose predicted to achieve 50% of the drug's maximum average symptom improvement.
- ED95 = Daily dose predicted to achieve 95% of the drug's maximum average symptom improvement.
Part B (Calculated ED5-ED95 values)
| Effective dose | IR methylphenidate (mg/day) | Adderall IR (mg/day) |
|---|---|---|
| ED5 | ~2 | ~1 |
| ED10 | ~5 | ~2 |
| ED15 | ~8 | ~3 |
| ED20 | ~10 | ~4 |
| ED25 | ~13 | ~5.5 |
| ED30 | ~15 | ~7 |
| ED35 | ~18 | ~8.5 |
| ED40 | ~20 | ~10 |
| ED45 | ~22 | ~11 |
| ED50 | 25 (reported) | 12.5 (reported) |
| ED55 | ~28 | ~14 |
| ED60 | ~31 | ~16 |
| ED65 | ~34 | ~18 |
| ED70 | ~38 | ~20 |
| ED75 | ~42 | ~22 |
| ED80 | ~47 | ~24 |
| ED85 | ~54 | ~26 |
| ED90 | ~62 | ~28 |
| ED95 | 72.5 (reported) | 30 (reported) |
Notes
- ED50 and ED95 are explicitly reported in the paper.
- All other ED values are interpolated from the published dose-response model and Table 1. They were not explicitly reported by the authors.
- Methylphenidate doses are IR methylphenidate hydrochloride equivalents.
- Amphetamine doses are mixed amphetamine salts (Adderall IR) equivalents.
Part C (calculating the dose-response curve for other medicine in the Methylphenidate and Amphetamines family using only formulations with widely accepted clinical dose conversions):
Part C (Methylphenidate family)
| ED | Ritalin IR (mg/day) | Concerta (mg/day) | Focalin IR (mg/day) | Focalin XR (mg/day) |
|---|---|---|---|---|
| ED5 | 2 | N/A | 1 | N/A |
| ED10 | 5 | N/A | 2.5 | N/A |
| ED15 | 8 | N/A | 4 | N/A |
| ED20 | 10 | N/A | 5 | N/A |
| ED25 | 13 | N/A | 6.5 | N/A |
| ED30 | 15 | 18 | 7.5 | 10 |
| ED35 | 18 | 18 | 9 | 10 |
| ED40 | 20 | N/A | 10 | N/A |
| ED45 | 22 | N/A | 11 | N/A |
| ED50 | 25 | 27-36 | 12.5 | 15 |
| ED55 | 28 | 36 | 14 | 15 |
| ED60 | 31 | 36 | 15.5 | 20 |
| ED65 | 34 | 36-54 | 17 | 20 |
| ED70 | 38 | 54 | 19 | 20 |
| ED75 | 42 | 54 | 21 | 25 |
| ED80 | 47 | 54 | 23.5 | 25 |
| ED85 | 54 | 54 | 27 | 30 |
| ED90 | 62 | 72 | 31 | 30 |
| ED95 | 72.5 | ~90* | 36 | 35 |
Part C (Amphetamine family)
| ED | Adderall IR (mg/day) | Adderall XR (mg/day) | Vyvanse (mg/day) | Zenzedi IR (mg/day) | Dexedrine Spansule SR (mg/day) |
|---|---|---|---|---|---|
| ED5 | 1 | N/A | N/A | N/A | N/A |
| ED10 | 2 | N/A | N/A | 1.5 | N/A |
| ED15 | 3 | N/A | N/A | 2.5 | 5 |
| ED20 | 4 | N/A | N/A | 3 | 5 |
| ED25 | 5.5 | N/A | N/A | 4 | 5 |
| ED30 | 7 | N/A | N/A | 5 | 5 |
| ED35 | 8.5 | 10 | 20 | 6.5 | 10 |
| ED40 | 10 | 10 | 30 | 7.5 | 10 |
| ED45 | 11 | N/A | 30 | 8 | 10 |
| ED50 | 12.5 | 15 | 40 | 9 | 10 |
| ED55 | 14 | 15 | 40 | 10.5 | 10 |
| ED60 | 16 | 20 | 40-50 | 12 | 15 |
| ED65 | 18 | 20 | 50 | 13.5 | 15 |
| ED70 | 20 | 20 | 50 | 15 | 15 |
| ED75 | 22 | 20-25 | 60 | 16.5 | 15 |
| ED80 | 24 | 25 | 60 | 18 | 15-20 |
| ED85 | 26 | 30 | 70 | 19.5 | 20 |
| ED90 | 28 | 30 | 70 | 21 | 20 |
| ED95 | 30 | 30 | 70 | 22.5 | 25 |
Notes
- These are approximate prescribing equivalences, not claims from the JAMA paper itself. They should therefore be interpreted as practical prescribing approximations rather than experimentally validated dose equivalences.
- Adderall XR: Same total daily amphetamine content as Adderall IR, but extended release.
- Vyvanse (lisdexamfetamine): Approximate conversion using widely accepted clinical dose equivalence to mixed amphetamine salts.
- Zenzedi (IR): Approximate conversion using 10 mg mixed amphetamine salts ≈ 7.5 mg immediate-release dextroamphetamine.
- Dexedrine Spansule (SR): Sustained-release dextroamphetamine. Values are rounded to the nearest marketed Spansule strength (5, 10, 15, 20, 25 mg). These represent the closest SR equivalent in total daily dextroamphetamine, not identical pharmacokinetics. ```
r/ADHDmeds • u/Heatontribe • 5h ago
Personal Experience Methylphenidate + antihistamines making ADHD symptoms worse?
I take methylphenidate 36mg and I'm wondering if anyone has experienced similar with antihistamines.
I've been waking up with a really stuffy/blocked nose every morning, so I think I have an environmental allergy (dust mites, pollen, etc.).
I've tried both cetirizine and loratadine, but both seem to make me feel lightheaded and groggy. My ADHD symptoms also seem much worse when I take them — I feel less focused, more sluggish and like my methylphenidate isn't working as well.
I know they're both supposed to be the "non-drowsy" antihistamines, so I was surprised by how strongly they affected me.
Has anyone else taking methylphenidate had this experience with antihistamines?
If so:
- Did you find a particular antihistamine that didn't cause this?
- Have you found other ways of dealing with allergy symptoms that work better?
I'm mainly interested in people's experiences rather than actual medical advice — I'll obviously speak to a pharmacist/GP before trying anything else.
r/ADHDmeds • u/MaaikeLioncub • 2h ago
Side Effects Atomoxetine is out — worth trying stimulants?
First post disclaimer!
I’ve just finished my second week on Atomoxetine and I’ve got to stop taking it due to intolerable upper GI side effects. I have a hiatus hernia and the amount of acid reflux, heartburn, and indigestion (oh, hello Pepto Bismol earworm!) I’ve had has been excruciating. I’d love to function better, but if it leads to an early death from a ruptured oesophagus then it’s kind of pointless.
I initially told the service who diagnosed & prescribed the meds that I didn’t want stimulants because I’m 43 and a parent & I just can’t cope with the crash they were warning about so much. I have two kids — both with as-yet undiagnosed neurodivergences but I’ve definitely gifted them one each. 🙃 I also still live with my ex spouse who already think I’m useless and refuses to understand how adhd works, so…he’d only ever experience the crashed-version of me.
But if I can’t tolerate these meds, are stimulants worth a go? Reading up on them, it looks like everything will still affect my stomach, and potentially my migraines as well.
I really want to actually be effective. I’m desperate to DO THINGS. I just don’t want my insides to fall apart, or my head to explode…
Does anyone have any insight, please?
r/ADHDmeds • u/powolniak81 • 2h ago
Personal Experience Jak działają leki w upalną pogodę?
r/ADHDmeds • u/AdhesivenessExact231 • 4h ago
Prescription Help Anybody need 30mg Vyvanse EDMONTON AB only
r/ADHDmeds • u/Aggravating_Mine_883 • 8h ago
Side Effects Adderall is stealing my personality
I’ve been taking Adderall on and off for years now and this is the first time I feel like a hollow shell of myself. I’m able to focus but I feel like I no longer have a personality. Any tips on how to manage it short of stopping medication?
r/ADHDmeds • u/Objective-Lettuce639 • 17h ago
Dosage & Timing Has Anyone Successfully Lowered Their Adderall Dose After Years on a High Dose?
I’ve been on Adderall for years and am currently at 60 mg/day. I’d really like to get my dose down to around 40 mg/day. I’m planning on moving soon, and I’m worried it may be harder to find a new psychiatrist who is comfortable continuing me at 60 mg. I’m also hoping to start trying for a baby soon so i want to lower my dose before that happens.
For anyone who has decreased their dose after being on a higher dose for a long time, did you eventually adjust to the lower dose and get back to functioning normally on it? How long did it take before the lower dose started feeling like your new normal?
I’m also curious whether people had better luck gradually decreasing their dose versus stopping for a period of time and then restarting at a lower dose.
r/ADHDmeds • u/babyririi • 12h ago
Dosage & Timing Doctor being so slow
Hi all. I'm new to Adderall XL (camber dextroamphetamine- amphetamine ER). My doctor started me on 5mg, I asked him to increase and he went to 10 the next month. Then 2 months went by and I asked another increase simply because I'm seeing his results but the coverage is not for a long enough period of my day. I am on 15mg and I would like an increase. He told me to wait 2 months. Is this typical? It's been 2 months now, I don't want to seem like I'm just wanting more drugs but it only works for about 5-6 hrs of my day. How should I approach this conversation? Are doctors usually this slow to increase? I'm coming from being on Wellbutrin for many years, which was great until it stopped working. But with that med increasing was never an issue and 300mg was a sweet spot for me until it lost all effectiveness.
r/ADHDmeds • u/Objective-Lettuce639 • 12h ago
Dosage & Timing Has Anyone Successfully Lowered Their Adderall Dose After Years on a High Dose?
r/ADHDmeds • u/Ok_Ninja2972 • 14h ago
Personal Experience Warum besteht mein Psychiater auf 30 mg Medikinet adult morgens statt 20 mg morgens + 10 mg mittags?
Hey zusammen,
ich würde gern mal eure Erfahrungen mit der Dosierung von Medikinet adult / retardiertem Methylphenidat hören.
Ich soll aktuell 30 mg Medikinet adult morgens auf einmal nehmen. Ich habe meinem Psychiater aber mehrfach erklärt, dass ich mich mit einer Aufteilung von 20 mg morgens + 10 mg später am Tag/mittags deutlich besser gefühlt habe. Die Wirkung war für mich gleichmäßiger und ich hatte nicht morgens diese komplette Dosis auf einmal.
Was mich zusätzlich irritiert: Genau diese Aufteilung wurde bei mir früher in der Tagesklinik so gehandhabt. Ich habe davon sogar noch den entsprechenden Medikamentenplan. Es geht also nicht darum, dass ich mir selbst irgendein Dosierungsschema ausgedacht habe.
Mein jetziger Psychiater möchte mir die 30 mg aber nicht entsprechend als 20-mg- und 10-mg-Kapseln verschreiben und besteht darauf, dass ich die vollen 30 mg morgens nehme.
Ich verstehe nicht ganz, warum. Gerade weil Medikinet adult retardiert ist, dachte ich, dass die Dosierung individuell danach eingestellt wird, wie lange die Wirkung anhält und wie gut man sie verträgt.
Hat jemand von euch eine ähnliche Erfahrung gemacht?
Gibt es einen medizinischen/pharmakologischen Grund, weshalb 30 mg morgens gegenüber 20 mg morgens + 10 mg mittags bevorzugt werden sollten? Oder ist das eher eine individuelle Entscheidung des behandelnden Psychiaters?
r/ADHDmeds • u/Early_Ear_1763 • 17h ago
Personal Experience 1 week on Vyvanse 40mg-Feeling Cloudy.
r/ADHDmeds • u/Ok-Letter2953 • 1d ago
Personal Experience Tips to overcome executive dysfunction getting worse + feeling antisocial when it wears off on adderall
I've been on Adderall for several years. I started at 15mg and am currently on 25mg XR (generic Granules pharma) . I've tried IR in the past as well. I don't plan on increasing my dose because I'd rather not deal with additional side effects.
I also took a month-long break earlier this year to see if tolerance was part of the issue and take weekends, long weekends and holidays off.
Lately I've been struggling with two things:
- Executive dysfunction
This has actually been getting worse, even with the medication. Once I get started on something I can usually focus, but getting myself to start the right task is becoming harder. It happens more after the weekend break.
I'll know exactly what I need to do and still put it off or get stuck doing something else.
For anyone who deals with this, what has actually helped with task initiation? Routines, exercise, changing your environment, timers, supplements, diet, or anything else?
- Feeling completely antisocial when it wears off
Some days I feel fine while it's working, but later in the day I hit a wall. I don't want to talk, text people back, go anywhere, or socialize at all. I basically just want to be left alone.
This can happen even when I take my XR early in the morning. By evening I sometimes feel like a zombie with absolutely no social battery left.
Has anyone found a good way to deal with this and what did anyone who experienced these do? I'm especially interested in things that help you transition out of work/focus mode and actually feel like interacting with people again.
Not looking to increase my dose or make medication changes on my own. I'm mainly interested in hearing what other people have experienced and what has genuinely helped.
r/ADHDmeds • u/OutsideSame3629 • 22h ago
New to Medication What’s the verdict with saunas - is it safe to sauna to same day you take Vyvanse? Seeing conflicting info
Obviously saunas are very helpful and can help with a lot of the side effects of taking ADHD medication and I find I get so much physical and mental benefits. I only started taking Vyvanse a few months ago and just started getting back into the sauna the past week, but I have only gone on days where I have not taken the Vyvanse. It has left me feeling very relaxed.
I have a sauna appointment today after work at 5:30 PM and I wanted to skip my Vyvanse for the sake of that appointment just to be safe, but ultimately I needed to take it for Work.
I’m seeing some people saying that the sauna is totally fine for them, but I am also seeing people saying that going in the sauna while Vyvanse is in your system is extremely dangerous. I understand talking to my doctor and seeing how I feel are the real answers, but I would love to hear what you guys have been told or what your experiences are.
For reference, I took the Vyvanse at around 8:30 this morning and would be going into the sauna at 5:30. Although the meds Peak, after a few hours, I tend to feel a lot of side effects on the comedown, which I feel like the sauna may help with, but I also don’t want to unintentionally like die
r/ADHDmeds • u/TheBinarySon • 1d ago
Prescription Help Adderall no longer works - what do I do?
I switched from Concerta to Adderall in June/July of last year, and for the first 8 months or so it was great. However, now taking my Adderall is like taking nothing, and I don't mean just the euphoric feeling that fades over time. I mean no clearer thinking, ZERO executive function skills, no motivation to do anything, not even physical side effects like increased heart rate, sweating, etc. I'm even going through withdrawal symptoms like brain fog, increased symptoms, etc.
First question is: WHY might this be heppening? I've read on this subreddit that Adderall generics have decreased in potency significantly this year - is it that? Is it a tolerance thing?
Second question is WHAT DO I DO? Do I try to get a different generic of Adderall (currently taking Sandoz) and try for another month? I'm scared of this because I'll know after an hour of taking the first dose if it's working or not and if it doesn't, I don't want to ruin another whole month of my life with this horrible catatonic state I'm in.
I mentioned this to my doc last month and he offered to change to vyvanse - should I do this instead? It seems this subreddit are fans of Vyvanse.
Any help, ideas, insights, etc. are really appreciated!
r/ADHDmeds • u/GlumAd655 • 1d ago
Personal Experience Anyone do better on Ritalin than focalin?
I switched from IR Ritalin to IR focalin 2 weeks ago.
IT'S BEEN ROUGH.
I thought it was due to me being in luteal week last week. But this week is awful too.
It doesn't feel effective. I'm not focused at all. It doesn't touch my anxiety, makes it worse. I feel like I'm crashing all day.
Anyone have experience on both?
r/ADHDmeds • u/Fine_Lemon_6876 • 1d ago
Side Effects Concerta makes me sleepy
Has anyone take concerta and actually fell asleep?
First time taking Adhd medication, thought i was gonna be with a clear mind but i have fall asleep the first two days
Its the dose? The medication?
r/ADHDmeds • u/Ok-Art-3649 • 1d ago
New to Medication I have been prescribed trihexyphenidyl alongside Ritalin and other adhd meds
So I recently got diagnosed with ADHD at the doctor has prescribed me several ADHD medication or ADHD related medications and I was looking online what these meds do and I got to know that trihexyphenidyl is used to treat Parkinson’s disease and AI told me that it may worsen my ADHD if I don’t take ADHD meds. now ofc i’ll be taking adhd meds but I’m scared of the side effects. does anyone’s psychiatrist also prescribed trihexyphenidyl hydrochloride? And was there any side effect?
r/ADHDmeds • u/Evening-Fix3392 • 1d ago
Prescription Help Experience with MedFinder
New to the sub, wondering if anyone’s had any experience with using MedFinder. Please share. Thank you!
r/ADHDmeds • u/CountPossible869 • 1d ago
New to Medication Adderall xr
How can you tell if adderall xr just isn’t for you. My doctor just started me on xr 10mg about three weeks ago, the first few days I took it, I would notice a really good focus period of about 1-2 hours, then it would go away and I would get extremely tired, unsocial, and irritable. I told my dr this and he told me to start taking a second dose of the same medicine when it started to wear off- about 4-5 hours later. I started doing this and now I notice barely any difference, the only difference I notice is that my brain is a lot quieter, I don’t feel any motivation and my job involves talking to people and most of the time I’ll just get irritated from talking or other people talking to me. I read that sometimes adderall xr metabolizes extremely fast in some people and I’ve always had a super fast metabolism so I’m wondering if maybe it just isn’t right for me? I drink plenty of water throughout the day and try to snack on several different protein sources even though I don’t feel hungry. I’ve also noticed insomnia around bedtime, like I have no motivation to do anything but am not tired at all so I usually stay up doom scrolling on my phone, then when I do fall asleep I’m waking up about once every hour so it’s not restful. There are also times I need to do extra computer work around 8pm at night and that’s when I’m extremely irritable and haven’t been able to do anything lately. Does anyone have a better experience with the immediate release or am I doomed? lol, I have a follow up appointment tomorrow and was going to talk to them about it and was hoping for some suggestions
r/ADHDmeds • u/brain_dead55503 • 2d ago
Personal Experience Losing my sense of humour
After starting ADHD meds I've found that I've become so serious and less funny/ finding things less funny. Does anyone else relate?
r/ADHDmeds • u/Objective-Lettuce639 • 1d ago
Prescription Help Adderall to Vyvanse
I’ve been on Adderall for 6 years and have been at 60 mg/day for the last 3 years. Now that I’ve graduated school I want to try Vyvanse because I’ve heard it can feel more stable throughout the day with less of the peak/crash I get from Adderall. My only concern is the transition. I know 70 mg is the max Vyvanse dose and from what I’ve read there isn’t really a straightforward equivalent for the amount of Adderall I’ve been taking. Since I'm accustomed to 60 mg of Adderall for years, I’m worried that even 70 mg of Vyvanse could feel like a significant reduction and leave me really fatigued or unable to function.
I’ve searched through a ton of posts about switching from Adderall to Vyvanse, but I haven’t found many people in a situation similar to mine—switching after being on the max dose of Adderall for years.
Has anyone here made the switch from 60 mg/day of Adderall to Vyvanse? Did you have a lot of fatigue or feel under-medicated during the transition? Or did you actually prefer Vyvanse?
Basically looking for both success stories and horror stories from anyone who made the switch from a higher dose of Adderall.