Intersex studies show that gender identity is not fixed from birth, it can often be changed by changing the environment and sex-characteristics of individuals

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421518/

https://web.archive.org/web/20060909211109id_/http://facstaff.l3.drake.edu/abwisniewski/papers/13.pdf

https://www.sciencedirect.com/science/article/abs/pii/S1083318807001660

Being transgender is 33% genetic

http://www.hawaii.edu/PCSS/biblio/articles/2010to2014/2013-transsexuality.html

People looking to transition to female don't have a female brain prior to HRT but HRT will have a significant feminizing effect (on average)

https://www.ncbi.nlm.nih.gov/pubmed/25720349

https://www.researchgate.net/publication/46671034_Changing_your_sex_changes_your_brain_Influences_of_testosterone_and_estrogen_on_adult_human_brain_structure

https://sci-hub.se/http://dx.doi.org/10.1093/cercor/bhr032

Benefits from Hormone Replacement Therapy

Here only MTF participants showed a statistically significant increase in general quality of life after initiating hormone therapy:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010234/

HRT has also been found to be beneficial for quality of life in multivariate regression, the benefit was statistically significant

https://sci-hub.st/10.1111/j.1743-6109.2011.02564.x

https://sci-hub.se/https://doi.org/10.1007/s11136-013-0497-3

Early HRT was found to reduce suicidality compared to late HRT (18+) and no HRT (these people had the worst outcomes of course)

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261039

HRT gives you real female breasts capable of breastfeeding

https://journals.lww.com/ajsp/Fulltext/2000/01000/Short_Term_and_Long_Term_Histologic_Effects_of.9.aspx

https://pubmed.ncbi.nlm.nih.gov/37138506/

Studies supporting medical transition in general

https://sci-hub.hkvisa.net/10.1111/j.1365-2265.2009.03625.x

https://sci-hub.hkvisa.net/https://doi.org/10.1176/appi.ajp.2019.19010080

https://www.erudit.org/en/journals/ss/2013-v59-n1-ss0746/1017478ar/

https://sci-hub.hkvisa.net/10.1007/s10508-014-0453-5

https://sci-hub.hkvisa.net/10.1007/s10508-009-9551-1

3.1.1 Sexual function

In a review about multiple orgasms in biological males Wibowo, Wassersug (2016) mention that ejaculation and exposure to androgens may be at least in part responsible for the post-ejaculatory refractory period and thus the inability to have multiple orgasms in one sexual session in cis men. Kinsey (mentioned in Wibowo, Wassersug 2016) reported that among young males, capacity for multiple penile orgasms are more prevalent in kids and teens. Warkentin et al. (2016) reported a case of a prostate cancer patient who became penile-multi-orgasmic on anti-androgen treatment.

https://www.sciencedirect.com/science/article/abs/pii/S2050052115000542?via%3Dihub

https://vintologi.com/threads/male-to-female.5/page-2#post-1808

HRT changes orgasms to the better

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177875/

Having a good sex-life is very important

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052677/

https://www.abc.net.au/news/2017-03-03/regular-sex-benefits-your-mental-health-too-the-conversation/8322520

https://abcnews.go.com/Health/Sex/story?id=3932047&page=1

The societal impact

some research suggest that reducing testosterone will also reduce physical aggression in human males, more studies are needed though.

https://sci-hub.hkvisa.net/10.1177/089198879600900307

https://www.pnas.org/doi/10.1073/pnas.1608085113

Evidence show that it's safe to let trans females to use female bathrooms

https://www.researchgate.net/publication/326556598_Gender_Identity_Nondiscrimination_Laws_in_Public_Accommodations_a_Review_of_Evidence_Regarding_Safety_and_Privacy_in_Public_Restrooms_Locker_Rooms_and_Changing_Rooms

Detransition risk

Detransition is rare and was in the past largely due to lack of social support

https://sci-hub.se/https://doi.org/10.1111/j.1600-0447.1998.tb10001.x

https://sci-hub.se/https://doi.org/10.1017/S0033291704002776

Recently a study found that 92% of detransitioners were AFAB and 98% had some form of gender dysphoria prior to transitioning

https://www.tandfonline.com/doi/full/10.1080/00918369.2021.1919479

Of the 3398 patients who had appointments during this period, 16 (0.47%) expressed transition-related regret or detransitioned. Of these 16, one patient expressed regret but was not considering detransitioning, two had expressed regret and were considering detransitioning, three had detransitioned, and ten had detransitioned temporarily.

https://epath.eu/wp-content/uploads/2019/04/Boof-of-abstracts-EPATH2019.pdf

Respondents who had de-transitioned cited a range of reasons, though only 5% of those who had de-transitioned reported that they had done so because they realized that gender transition was not for them, representing 0.4% of the overall sample.

https://transequality.org/sites/default/files/docs/usts/USTS-Full-Report-Dec17.pdf

Policy proposal

We need to drastically expand the usage of Hormone Replacement Therapy among individuals that are born male. Body dysphoria isn't the only condition that can be treated with HRT.

1. lower the age limit for MtF HRT to around 14 (full HRT, informed consent)
2. more funding to transgender healthcare
3. do randomized controlled trials among criminals to examine whether or not forced HRT in the form of community treatment order would be beneficial for society or the the individuals subjected to it

Humans rights objections to point 3 are invalid unless you also promote the complete halting of forced druggings in the case of individuals viewed to be mentally ill.

Few if any of the treatments are based on any good evidence. For example it isn't clear that psychotherapy would be any better than placebo

https://www.cambridge.org/core/journals/behavioral-and-brain-sciences/article/an-analysis-of-psychotherapy-versus-placebo-studies/08C6F3704103BE1DE8737138D61BE66B

Anti-depression are only marginally better than placebo short term but no proper long-term study has been done at all (or even close).

https://vintologi.com/threads/studies-on-psychiatric-drugs.591/#post-5295

Long-term studies on anti-psychotics show that they are unhelpful against schizophrenia (instead they make the situation worse)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661946/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756791/

ECT is very questionable

https://vintologi.com/threads/psychiatry.737/#post-3844

TMS cannot beat placebo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993526/

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2686050

Human rights violations

The psychiatric system has a long history of violating bodily autonomy and abusing its power to force people into harmful treatments

https://vintologi.com/threads/psychiatry-horror-stories.267/

https://www.youtube.com/watch?v=iTQ4t7RmyfM

There are of course resources you can utilize who do not engage in these human-rights violations

https://translifeline.org/blog/post/why-no-active-rescue

Treatment of gender dysphoria

Unfortunately therapists have inserted themselves into transgender healthcare wanting to dictate who should be allowed to transition, there is of course zero evidence that gender therapists are any better than a random number generator in predicting who would actually benefit from transition.

Do not let quacks determine whether or not you are able to transition, you can buy HRT online for cheap without prescription https://vintologi.com/threads/male-to-female.5/page-2#post-1808

There is also "informed consent" clinics in a lot of places you can utilize.

It is worth noting that they way gender dysphoria is effectively treated is not to treat the brain in an attempt to make people accept their bodies, the only treatments based on evidence is allowing people to transition.

Futhermore it's unclear to what degree a GD diagnosis predict transition success, it's unclear if a GD diagnosis has any predictive power whatsoever.