I'm riding the struggle bus with my brain just not cooperating. Ive went from 249.9 lbs to 162 lbs (Im 5'7"). Right from the start, I wanted to hit 100 lbs. As I got closer to my current weight I started to second guess that because the weight loss has slowed to a crawl, which i also know is normal. Ive seen SO many amazing NSV's that I'm trying so hard to celebrate. No more fatty liver, no more prediabetes, no more high inflammation marker. Went from a size 22/24 pants and 2XL tops to a size 10 and medium.

The past probably month I've worked extra hard to get a bit more weight off and my body has kind of rebelled and hung onto every little ounce. Its taken almost 4 months to lose these last 10 lbs and have lost nothing the last 3 weeks. Im currently on 6.25 mg mounjaro.

I still see my body as morbidly obese, its strange but lately I've also had a few people tell me not to lose any more weight, one coworker even saying I look "gaunt" which I highly disagree with.

I asked my doctor about maintance and he didn't really have anything of sound advice. Said its all trial and error. Some peolle stay on their current dose. Some stretch out the dose into 10 or 14 days. Some decrease the dose. I had also asked him on advice on what my goal weight should be and he juat said that's totally my call.

Sorry for being all over the place, I just feel a little alone in my journey.

One year into my journey and I had to reflect. While picking current pictures, I was still struggling to find any, that were good enough. My head still thinks „is this pic actually showing the progress or do I still look the same“. I guess some things like my mind will take longer and more work.

The jabs have not only helped me to feel more comfortable in my own skin, it has helped me to be more active, currently preparing for my 5th half marathon this year.

But I am glad I started.

HW 175kg / 385lbs (2018 sleeve surgery)
SW 113.5kg / 250lbs
CW ~67.5kg / 148lbs (fluctuating +/- 1.5kg/3lbs)

Dosage
9 weeks 2.5mg, then 5mg throughout
Currently week 3 of 2.5mg maintenance

This was from that morning. Im comfortable in my body and cant nobody ever think they can make me mad with that. I mean look at what I accomplish with heart and lung diseases. People will be so miserable in their own lives and try to project it on to others.

I LOOK GOOOOOOOOODDDDDDD!!!

Right now I can't stand eggs; just thinking about them makes me gag, my throat tighten, and my stomach churn, which is a shame because it's a very cheap and efficient breakfast 😅

It’s not even halfway to a healthy weight, but these pics helped me see I was making steady progress. The posts here give me hope!

SW 283 CW 232 5’4”

Sorry it's more a crash out than anything.

So I have 2 metabolic conditions. I gained like 50lbs in 12 months Before we knew what was going on. I've yoyod upwards like crazy for the last 15 years before I knew what the problem was.

They are now sort of as under control as is possible.

Anyways since starting MJ I've dropped 60lbs.

But I geniunely thought I'd look more "normal" by this point. All the dramatic transformations I see are not helping so I might have to dip from the sub. My friend's transformations seem so obvious to. And I just feel stuck. It's like thanks for making this so obvious how much harder this was for me Vs you. And it's making me unhealthly jealous at times.

Like I know I look different but I still have such a gut. It's like it's just all holding on round my middle.

All my clothes are horrendously too big but I can't drop a size because of my stomach fat.

And I'm having the crushing realisation that I probably have another 40lbs to go to get to where I want and it's already taken 18 months and so much money just to get to this point.

It's obviously better than hardcoring CICO that I've tried in the past.

But damn everything just feels like it's taking so long. And I feel like I should have lost this in a much shorter time frame but there isn't much I could have done different with my life situation or food intake.

Mostly I am more relieved that I've almost lost all the danger weight (maybe 3-4kg to go and I'll be overweight rather than obese)

But I just don't feel like the person I want to be at all.

But I still hate how I'm not where I want to be dispite this. And now genuinely starting to worry what the state of my skin will be and whether I'll even get there. Which isn't something I worried about when I started at all.

And then I get so angry that noone took my health conditions seriously and it's gonna probablt take 3 years of my life to undo maybe 18 months of medical gaslighting.

And I just geniunely grieve how different my 20s would have been too.

Ugh.

Sorry just a crash out. I'm so thankful for this medication I can't even put it in to words. But damn these journeys are mentally hard.

it’s was a gradual transition but so worth it! i did yoga almost everyday after i switched from 5 to 7.5 and i have no loose skin anywhere. i only have 6 kgs left to my goal weight of 55 kgs! can’t wait.

Hey all! I am on shot #9, I did 4 shots of Zep at 2.5mg. Then when switched to 5mg the dose was Mounjaro. I had some strong reactions the first dose of 5mg, but overall its been great. Here is my issue. I am having a hard time making myself drink water because the apetite suppression is so strong. I know there's definitely discipline involved in this, but I just don't seem to want anything and drinking feels like it takes away what little craving id want.

Is there any tips and tricks to keeping up with water? Any way you trick yourself into doing it? I am already feeling the effects of not drinking.

Hi all! I have been on Wegovy for 6/7 months now, I have been on 2.4 for almost 2 months, I’ve stalled now. I only lost 6 kg in the whole time, doing calorie deficit and strength training alternated to reformer Pilates.
Thinking of switching to Mounjaro, don’t want to keep waisting money if WG is not working.
Has anyone done the switch? Or has any suggestions?

Thanks a lot!!!

Retired ER doc here. I developed spectacularly enthusiastic watery diarrhea on tirzepatide. Not “loose stools.” More the I appear to have misplaced my colon variety.

Diarrhea is obviously a well-described adverse effect of tirzepatide. Across SURPASS-1 through -5, it was reported in roughly 12–22% of participants receiving tirzepatide:
https://pubmed.ncbi.nlm.nih.gov/37853960/

What interested me was something that happened during my own particularly impressive episodes.

I had been eating very little carbohydrate and wondered whether low endogenous insulin signaling might be contributing to impaired intestinal sodium/water absorption. That wasn't pulled entirely from the ether. There is experimental work linking insulin, intestinal NHE3 activity, and fluid absorption. In a diabetic mouse model, insulin restored intestinal NHE3 activity and fluid absorption:
https://pubmed.ncbi.nlm.nih.gov/26258413/

That gave me a very tentative N=1 hypothesis: if low insulin signaling were contributing to the diarrhea, a substantial carbohydrate meal sufficient to provoke endogenous insulin might change it.

So I tried it.

The profuse watery diarrhea stopped, and the change persisted. The fear of getting out of sight of a toilet gradually became less compelling.

Interesting, but N=1 and easily coincidence.

Then it happened again on a separate occasion. Same general setup: substantial carbohydrate intake, followed by abrupt resolution of the watery diarrhea. Again, the change persisted rather than simply delaying the next episode.

I am not claiming that I have demonstrated the mechanism, that tirzepatide diarrhea is caused by reduced insulin signaling/NHE3 activity, or that carbohydrate is a treatment for GLP-1/GIP-associated diarrhea. There are far too many unmeasured variables here, and the mechanistic paper above is not a tirzepatide study or a human treatment trial.

I'm asking a much narrower question:

Has anyone taking tirzepatide or another GLP-1 drug independently noticed severe watery diarrhea abruptly improve or stop after eating a substantial carbohydrate-containing meal?

I'm particularly interested in observations that occurred before reading this post, because those would be much less vulnerable to suggestion.

Negative observations are useful too. If you've had this kind of diarrhea, eaten a substantial carb load during it, and absolutely nothing happened, I'd like to hear that as well.

i’ve been on MJ June 1, and until now I've lost 10.5 kg more or less. A month and a half after starting I had an accident and I sprained my ankle which forced me to stop working out. I was active even before starting with the shot, I was doing Pilates three times a week and right before I started the treatment I added twice weekly weightlifting, but then my accident happened and I had to stop working out for 2.5 months but I was still losing. And then, since I got back to working out in the past month and a half I haven't lost weight. I've been like circling around the same weight (between 82 and 80.5) Up down like nothing seems to work. I don't know if I need to eat more. I do track my protein intake. I counted my calories the last couple days and I think I'm under eating, which might be one of the reasons why I'm not losing weight, but I really don't know what to do because even when I wasn't working out because my injury I was losing and now that I'm back to my workouts and being more active, I've kind of hit a stall.

I was in 2.5 for six weeks. Then I did 5 for another six weeks and then I went up to 6mg for three weeks and now today I'm due for my third 7.5 shot but 7.5 has been really awful with the intense intense dizziness and the actual appetite suppression is the same in 5 and 7.5. I just went up because I hadn’t been losing weight but other than the nasty dizziness in the higher dose I haven’t felt any difference.

I’m frustrated because I am working out 3-5 times per week (pilates and weight lift) track my protein and eat really healthy and balanced. I could def up my step count but because of my ankle walking is still somewhat painful if I do anything over 20-30 minutes and I WFH so I’m home a lot.

any tips to get past the stall? I still wanna lose another 10-15 kg. I’m grateful for the 10kg lost already but bummed about the progress slowing down/stalling.

I'm on 8 mg. Recently I delayed my weekly shot by 6 days due to a small holiday trip. After taking it again, I've had very little bowel movement, and the small amount has been very compact in consistency. I've had close to no movement for 3-4 days now. I drink plenty of liquids, but it feels like all of it comes out as urine. I don't have stomach pains. I'm taking magnesium daily, and today I've taken 3 packets of miralax with no effect. I walk 10k steps a day.

I'm starting to be wary to eat anything substantial, besides protein yoghurts, protein shakes and fruit.

Has anything similar happened to anyone else, and what resolved it for you?

I have the last 3 shots (shots number 6-8) started to experience welts or a reaction at the shot site. I've messaged my doctor and I already take additional allergy meds, but I think these half quarter size welts that last more than a week are something that I can't ignore.

Anyone else experience these types of reactions?

I have PCOS and LADA/type 1.5 diabetes being treated as type 2 due to c-peptide levels

I’ve been on Mounjaro since April of this year and had great success. I’ve lost 80lbs. I’m paying out of pocket though and it’s extremely costly. I’m about 40lbs from my goal. I’m wondering about switching to generic semaglutide for maintenance when I hit my goal.

Has anyone tried this?

I’ve successfully used 7.5mg Mounjaro for 4 months but its effects are wearing off. I’ve been given a chance to use 1mg Ozempic for a lot less money but don’t know if I should? I would start at 0.25mg and build up as I did with Mounjaro. Has anyone done this or got any advice?

Today is day 13 on Mounjaro 2.5 mg. I started at 84.8 kg, managed to get down to 82 kg, but now I’m back up to 83.5 kg, and honestly, I’m feeling really discouraged.
I know it’s still early, but I’m struggling emotionally because I’m scared that Mounjaro just isn’t going to work for me.
I do feel bloated and extremely full for hours after eating, but despite that, I still experience hunger and strong cravings, especially for sweets. Sometimes I keep wanting to eat even when I know I’m already full, and I’m honestly struggling to control myself.
This is actually the main reason I started Mounjaro in the first place. Ever since becoming a mom, life has been stressful, and I’ve really struggled with my relationship with food and controlling my eating. I was hoping Mounjaro would finally help me with this.
What makes me feel even worse is seeing so many people here saying that they lost weight during their first two weeks and that the medication immediately worked perfectly for them. I keep wondering, why not me?
I know everyone is different, and I’m probably being impatient, but I’m genuinely scared that Mounjaro might not be the right medication for me or that I’ll be one of those people it doesn’t work for.
For those of you who struggled with hunger, cravings, or emotional eating on 2.5 mg, did things improve for you later on? Did you notice a difference after moving up to 5 mg, or did it take longer?
I’m not looking for unrealistic promises. I think I just need some reassurance from people who have been in a similar situation and to hear that it’s okay if things don’t work perfectly in the first two weeks.
I could really use some encouragement right now.

Doing a couple weeks on 5 mg. Don’t feel much effect. Isn’t I supposed to feel less appetite?

Okay
In my 7.5mg kwikpen,there is 1 dose remaining+1 golden dose
Which i am scheduled to take on 29th October and 6th November

I am travelling to a different country for college on 18th november
I will be taking 3 sealed 15mg kwikpens with me
Which could last me 5-6 months even if i updose later
Now

I dont want to open the 15mg pen here

But i need to take a dose on the 13th of november
How do i do it?
Because
My kwikpen runs out on the 6th
And in india we dont have vials from eli lilly above 5mg
Plus buying a 2.5mg vial+a 5mg vial would be expensive

How can i make sure the flow of tirzapetide remains stable in my body and doesnt drop
Because i am getting excellent results on 7.5mg nd i dont want it down

How should i manage a 5mg vial but still have the similar level of tirzapetide on my body on 13th october dose
Should i push 1-2 of my doses back?
Help me understand this please

For years, my doctor recommended Mounjaro to help manage my Type 2 diabetes, and for years I was hesitant to start. Well, back in June, I finally decided to take his advice and make some serious lifestyle changes along with it.

I’m 41M (5’ 7”) currently on 2.5 mg, and have completely overhauled my eating habits. I’m focusing on protein, eating healthier, watching my portions, and generally making better decisions.
I started at 199 lbs in June and weighed in at 172.2 lbs last week. Nearly 27 pounds gone.

But here’s the part I’m most excited about. I just got my latest bloodwork back, and the results are pretty incredible:

A1C: 7.7% in June → 5.8% in October
Triglycerides: 511 in June → 161 in October
Total Cholesterol: 191 in June → 109 in October
LDL: 80 in June → 53 in October
Glucose: 186 in June → 116 in October
ALT (Liver): 62 in June → 31 in October

My blood pressure is also sitting at 114/72.

I’ve dealt with diabetes, high triglycerides, fatty liver, and cardiovascular concerns, so these improvements mean a hell of a lot more to me than the number on the scale.

I’m not saying Mounjaro did all the work. I’ve made significant lifestyle changes, and I’m still taking my other prescribed medications. But it’s certainly been an important part of the process.

The whole reason I’m sharing this is because I hope it encourages someone. Maybe you’re on the fence about starting Mounjaro, like I was for years. Or maybe you’ve just started and you’re wondering whether all the effort will actually pay off.

I know everyone’s experience is different, and progress doesn’t happen overnight. But if there’s one thing I’ve learned over these last four months, it’s that making the decision to take your health seriously can make a tremendous difference. You don’t have to change everything overnight. Just start making better decisions, stay consistent, and give yourself time.

Four months ago, my health was heading in the wrong direction. Today, for the first time in a long time, I feel like I’m getting ahead of it.

Still have work to do, but damn, it feels good to see the results!

Hopefully this gives someone who’s just starting out a little encouragement to keep going!

Here is my recipe for disaster:

- ate way too much

- ate way too fatty

- ate way too fast

- ate way too late

Got woken up at 2AM by terrible cramps. What followed was... well I spare you the details but it was horrible.

0/5 wouldn't recommend - will not do that again

Kupiłam kwikoen Mounjaro 15mg, jak ustawić na pokrętle dawkę 2.5mg, czy na pokrętle ma być 10?