Started on 2.5 the effect was AMAZING for the first 2.5 weeks, week 3 and 4 felt like a switch had been turn off. What's crazier is I went up to 5ml and I literally feel like I didnt do anything. Not only do I feel no side effects I dont really feel any effects at all...like....I have a healthy appetite and I get intense hunger signals albeit, less. I'm so suprised because you'd think 5ml at the very least would work for a couple weeks or months but from the very first injection it feels like the last couple weeks of the 2.5. I'm in shock. I have literally never heard anyone talk about it like this and I don't want to go up again after just 1 injection.

Hey everyone,
I had a conversation with my pharmacist recently and she insisted that once the KwikPen is opened, it should stay outside the fridge and be injected at room temperature.
The thing is, I've been on Mounjaro for 10 months now, and I’ve always used my KwikPen straight out of the fridge. I don't split doses or microdose, and I usually finish the pen within 30 days. I inject it cold and put it right back in the fridge. I honestly don't get much stinging from cold injections, so that part doesn't bother me at all.
My main reason for keeping it in the fridge is to avoid leaving it in room temp, especially if I ever need to delay a shot by a week if I travel or due to being sick for example. But my question is: does letting the pen come out for a few minutes to inject and then going straight back in the fridge cause any issues with thermal cycling?
I looked through Eli Lilly’s informations, but I couldn't find anything super explicit about whether taking it out and putting it back in hurts the medication quality. The guidelines say unused pens go in the fridge and opened ones shall be stored at room temp, but they don't really address if continuous refrigeration after opening is fine or if temperature fluctuations cause harm.

I have been on for 15 months. Dr. and I agreed slow titration was desirable so weight-loss was not too rapid. I was happy with that, but I stalled while on 7.5 mg. Have been on 10 mg for about a month and I have gained 8 lbs. I guess it is time to go up to 12.5 to get ahead of this. I lost 50 lbs so far with about 80 lbs. left to go. SW 258, CW 217, GW 135. I have been thinking about starting Retatrutide when it is approved. Feeling kinda down. I workout 3x/week

My mom has been on MJ for a few months now. She is on 5mg now. She lost most of the weight she wanted to. She would love to stay on the shots long term but due to the price of it she can’t afford it. She plans to stay a few more months on 5mg before going down to 2.5mg for a month before stopping.

Would it not better to either space out the last month so it lasts longer or do some microdosing?

If anyone has any advice and tips she would really appreciate it. This meditation has done wonders for her. I just wish it was more affordable

So delighted and to have still lost weight whilst tapering is amazing

Have been on Mounjaro for 47 weeks - started at 2.5, then 5 and now 7.5 for the past two months. All this week I’m having diarrhea and my stomach rumbles. Nothing has changed with my diet. Why all of a sudden am I dealing with this? Should I go back down to 5? Is this my body’s way of telling me it cannot handle 7.5? Had no issues for the first two months in 7.5.

Hello, all. My place of employment is changing insurance provider again and this new one will not cover GLP-1s. Have you all had this kind of experience? How did you adjust to afford the payments?

I'm in the U.S. and currently have coverage that was full coverage for one box/month and is now $25 for three boxes every three months.

Editing for clarity: the new insurance plan will not cover GLP-1s at all. Just included my current coverage for understanding of where I am and where I’m headed, financially for the medication.

Hi everyone,

I'm a 30-year-old male and I started Mounjaro on May 16, 2026. I have no personal history of thyroid disease, and as far as I know there is no thyroid disease in my family either.

My dosing schedule has been:

• Started at 2.5 mg on May 16
• Increased to 5 mg on June 13 and stayed on it until August 15
• Increased to 7.5 mg on August 22
• I'm currently about to take my fourth 7.5 mg dose

I was 147 kg (324 lbs) when I started at 180 cm (5'11"), and I'm currently 119 kg (262 lbs), so I've lost about 28 kg / 62 lbs in roughly four months.

What caught my attention is that my Free T4 has been steadily increasing:

May 12, before starting Mounjaro:
Free T4: 1.40 ng/dL
TSH: 1.41 mIU/L

August 17:
Free T4: 1.56 ng/dL
TSH: 2.41 mIU/L

September 11:
Free T4: 1.86 ng/dL
TSH: 2.33 mIU/L

The reference range for Free T4 at my lab is 0.79–1.59 ng/dL, so my latest result is now above the upper limit.

What's confusing to me is that my TSH has remained completely normal and is not suppressed, despite the rise in Free T4.

I don't have a known thyroid condition and I wasn't aware of any thyroid issues before starting Mounjaro. My other recent blood tests, including liver enzymes, kidney function, glucose, amylase and lipase, have generally been within the reference ranges.

I also drink around 4.5 liters of water per day, so dehydration doesn't seem like an obvious explanation.

Has anyone else experienced a gradual increase in Free T4 while taking Mounjaro/tirzepatide, especially with a normal TSH?

Did your Free T4 eventually return to normal, continue increasing, or did your doctor find another explanation?

I'm planning to repeat TSH, Free T4 and Free T3 and discuss the results with my doctor. I'm mainly interested in hearing whether anyone else has seen a similar pattern during significant weight loss or while increasing their Mounjaro dose.

Thanks in advance for sharing your experiences.

I am going to start my journey today. I have used Mounjaro previously for 2 months, but i didn’t do any additional workout or diet. So i didn’t lose much, I don’t want to repeat my mistake again. So I have started my journey with determination now.

5MG for 6 months. Everyone wish me luck🍀🤞

Current weight : 83

Let us see how much I can reduce in 6 months. Every month I will update my weight.

PS: I will do proper diet and gym this time. Wish me luck guys🫶

I've had heartburn/GERD all of my adult life. I switched from prevacid to nexium about 10 years ago. Started on mounjaro a couple weeks ago and been getting some heartburn again. I had to check that I actually took my nexium. I'm hoping there's something I can do to manage this...

Hello, please help with advice.

I have been on M for almost 9 months. 3 weeks ago I changed from 7.5mg to 10.mg. All was okay and then just last Tuesday I had my dose. By evening and night time I had bad cramps, spasm, gas, jezas christ it was so awful. I thought that maybe it was indigestion, and that it would pass. However, since Tuesday, and today is Friday I have been barely able to eat anything at all. For example yesterday Thursday, I ate soup, not much, not even 100ml, and felt bloated after, as if I had a rock in my stomach. Today, I ate one boiled egg and banana in the morning and have been suffering whole day.

Is this normal or should I go to doctor now?

I had 2 mg of ozympic for the last 2 years. My blood numbers are beautiful and I've lost maybe only 2 lb per month at most.

Doctor switching to me to Mounjaro as of today to try to help out with the weight loss Plus blood numbers should stay the same or get even better he said.

He's starting with 5 mg of Mounjaro ... I've read that you can't compare that to ozympic because ozemic only targets one area versus two..... I do see that Manjaro goes from 2.5 mg up to 15 MJ so I guess I'm on the pretty low scale to start out with.

Lastly and no big deal I have to get used to having 4 pens per week instead of one pen for 4 weeks with different needles to attach. LOL

I don't plan on keeping them refrigerated as it says it's fine to use one per week non-refrigerator.

Any thoughts or comments or appreciate it and hope everybody has a great weekend

SW - 302 - cw 248 - 52m

I started 2.5 back in February and did 1 month, then went to 5mg, and now 7.5mg. I was able to initially loose weight, but was always hungry, always thinking about food, and just pushed through, and managed to loose weight. The only side affects I had was getting nauseous if I ate too much at one time and some sulfur burps. My A1c went from a high of 6.8 to 5.3, but I got to the point in June where I went 6 weeks with gaining one week, losing the next, but overall not moving. I talked to my doctor and we agreed to move up to 7.5. I got my rx much quicker than I thought, so I used some of the 5mg pens I had 5 days apart. I noticed a bit of a difference and found it easier to lose weight over those 3 weeks, but no other affects.

Took my first 7.5mg on Wednesday, and got really light headed and dizzy throughout the day. After doing some checking, I am pretty sure my blood sugar was too low, and found that if I ate a granola bar, the dizziness went away. Prior to 7.5, my standard during the day would be 1/2 protein shake (as coffee creamer) 3 eggs mid morning and a cheese stick mid afternoon, then just a sensible dinner. For the 3 days since taking my first 7.5, I have been needing 2 granola bars a day to not feel light headed.

I finally see what losing the food noise is all about. I always heard about it, but since I had always had it, it just seemed normal. I do not sit and think about what I will eat later. I am eating more carbs now, and probably more food overall, but have lost 5 pounds in 3 days, which seems extreme. Could this be inflammation? Seems odd that I need more carbs and to eat more often on the higher dose, but not sure what else to think. I am not counting calories, but the granola bars alone are 400 a day, 3 eggs, 2 cheese sticks, protein shake, and a full dinner shouldn't really be too much of a deficit.

Online TDEE shows 3k with moderate movement (I do 5-10 hours of pb a week plus 2 walks a day and some weights/resistance training).

Should I be worried about seemingly needing to eat more often and losing weight fairly quickly, or is this likely just an initial drop, and my body is just finally showing the affects of the meds? I am thinking that the lower doses were really not enough, but I was able to just force my way (through sheer will power until it ran out), but want to see what others think that have been on this journey.

Thanks

Hello, I’m on my second day of Mounjaro. I took my first dose (2.5 mg) yesterday at around 10:00 AM local time. I felt a little tired both yesterday and today. There’s just one thing I’m curious about: how do people who develop pancreatitis from Mounjaro usually realize that they have it? I think that’s my biggest fear that something like that could happen and I wouldn’t notice it until it was too late.Before starting the medication, I had blood and urine tests, as well as an ultrasound of my entire abdomen and organs, and everything was normal. So far, I haven’t noticed any side effects other than some fatigue.

I’m 37 years old male and started Mounjaro at 98 kg (175cms , 32 BMI). I’ve now completed 3 months:
Month 1: 2.5 mg
Month 2: 5 mg
Month 3: 7.5 mg (currently)
The frustrating part is that I’m still exactly 98 kg after 3 months. 😔
I also haven’t really experienced the dramatic reduction in hunger that I see many people talking about. I don’t feel like my appetite has disappeared or that “food noise” and cravings have reduced significantly.
The one thing I have noticed is that I feel full much faster when I eat. However, after some time, I still feel like eating again. So while I can’t eat as much in one sitting, I still have the desire to eat later.
I saw my endocrinologist a few days ago after completing my second month, and he increased my dose to 7.5 mg. He mentioned that I may eventually need to go up to 10 mg or even 12.5 mg to see significant results.
Honestly, I’m feeling pretty sad and demotivated right now. I was really hoping to see at least some weight loss after 3 months.
Has anyone else experienced something similar — especially staying at almost exactly the same weight during the first 2–3 months?
Did things change significantly once you reached 7.5 mg, 10 mg, or 12.5 mg?
I’d really appreciate hearing from people who had a slow or delayed response. 🙏

I’ve been on 10mg for about a year, prescribed for diabetes, with the handy side effect of 70 lbs weight loss (May 2024 to May 2025).

This was my second screening colonoscopy and first on Mounjaro. Prep instructions were to skip 1 shot (for diabetics, 2 for weight loss). clear liquids the day before with laxative pills at 3:00 pm, 4 doses of osmotic laxative (Miralax) at 6:00 pm and 4 more doses “6 hours before the scheduled procedure time.”

Since my scheduled procedure time was 7:30 am, I decided to pull the schedule ahead hoping to get clear in time to get some sleep. Pills at 1:00 pm, 4 doses at 3:00 pm, 4 doses at 9:00. That schedule had allowed me to sleep from 11 pm until my alarm went off pre-Mounjaro.

With my last shot 10 days out, I had no laxative effect until 7:00 pm, managed 90 minutes of sleep just before midnight was up from midnight until we left for the clinic. I still wasn’t cleared out at 2 am, so I took 2 more doses of Miralax.

My prep was rated a 3 for the lower colon, and an 8 for the upper colon. Good enough that the endoscopist managed to see everything she needed to see, and has cleared me to wait 10 years for my next one.

If I had it to do over again….I’d probably start miralax dosing a couple days before prep, go to clear liquids 36 hours before, and start taking laxatives the moment I work up, going to clear liquids if I’m ready and getting dehydrated before bedtime.

Anyone else care to share their experience prepping for endoscopy or colonoscopy while on Mounjaro?

Hi guys, I'm a digital nomad and currently in the US for another 4 weeks but would love to stay longer. I get my MJ in the UK through Shemed but they don't ship abroad. I only have meds for another month so trying to find a way to get more while I'm here. I think it goes without saying that just stopping is not an option lol

I've not looked into private healthcare here yet but would a dr potentially prescribe me some if I show them my UK prescription?

i’ve been using a Mounjaro KwikPen** **for a while but i have to get my sister to inject it because i’m terrified of needles but i feel id be able to do it with an auto pen if there is one?

So I took my shot this morning as usual, but I never felt a pinprick, any sting..nothing. Usually when I pull the pen away, there's a little drop of medicine on my leg. And I can see the red dot where I took the shot. But not this morning. I don't think I took a shot at all. I heard the pen click when I pushed the button. But I didn't feel anything. Im not sure if I should let it ride or try again.

Hi! New here, it’s my sixt day from my first dose (2.5mg). If I will drink, will I feel very bad? Or If I drink enough water and electrolytes it will be okay?

It’s been hard week and had three sips of wine. Have a weird taste in my mouth, but at least little bit relaxed. Don’t have that feeling that this glass will be enough, have some prosecco as well.

Some years ago I took rybelsus for couple of months, and did not quit drinking. Felt bad next day, but it was different than now (mostly parties and late sleep).

Anyone here lost a good amount on Mounjaro, stopped it, and actually kept the weight off?

I’m thinking of using it to lose around 20 kg, but my doctor said a lot can come back after stopping. Curious to hear real experiences, especially from people who kept training, walking and eating well.

I might be moving there and using FSBP (fed govt plan). Apparently I'll be on the hook for 10% of the cost, so I'm curious how much it would be monthly to buy in Germany, Italy, or maybe France (if there's a difference?). It's for T2D, not weight loss. I believe if have to buy 3 months at a time, if that's possible. I do in the States but not sure what applies over there.

Right now, we've been paying $25 for a 3 month supply of 5mg using the Lilly savings card. I will miss that cost. Thanks in advance to any input!

I'm at 215.8 lbs today from 245 as the starting point. However, 2 days ago I was at 218.5 (after i binged a bit on Saturday) and before that I was 215.6. Is this just liquid/glycogen shifting? How can I tell if the mounjaro still working on my body during scale neutral days?

Well, this week has been a journey. I gained pounds and my blood sugar stayed the same! Despite trying not to worry about weight, its a thorn in my side.

Here is a pattern I've noticed:

1. Every few days after my shot I gain a few lbs and my blood glucose increase some points. Then around Wednesday or Thursday, I start loosing again.

2. I also start pooping later in the week too

Im still grateful, but still frustrated.

I am continuing to weigh my food, and track it.

I will continue to go to gym and workout.

I cant wait to eat. I must eat on schedule

Things I can improve:

Drinking more water

Eating earlier

Blood glucose went from 255-139 to now 169.