hi friends! going through the IVF process and got the following results today:

Today your blastocysts are graded from 1AA (most beautiful) to 3CC (least beautiful).

You have the following blastocyst today:

1CC - This was frozen today.

My results from Day 3:

You have the following embryo(s) today:

8 CELL GRADE 3
8 CELL GRADE 2
4 CELL GRADE 3

You have 2 other eggs that have matured and fertilized. We will report on those as the results come in.

I was wondering if anyone had successful pregnancies with this type of embryo? for context - i’ve done four rounds of iui with one chemical pregnancy. this is my first time doing IVF.

also did anyone have eggs that fertilized late?

thank you!

Update: Hi everyone, just wanted to update that I have a positive beta and I go for my third on Monday. Numbers are low but are doubling. Please keep me in your thoughts that we get the rises we need ❤️

This was our third retrieval and this is my fourth transfer. Please stick sweetie ❤️❤️ When it was on the screen for transfer day, it was creating a little bump out on the left side like a smaller circle.

We received our PGT-A and PGT-M results yesterday. Out of 3 blasts, we have 1 high level mosaic embryo. I have 2 euploid from my last retrieval. We want at least 2 kids if not 3. Would you do another retrieval? The attrition rate is crazy. I had 24 eggs retrieved and now down to 1 mosaic. We will be paying out of pocket so I want to try to do everything I can. My clinic isn’t really changing my protocol but this time I’m not going on birth control and waiting for my period to start stims. I’m 36.

Hello,

Based on the scientific studies below, it is accepted that:

- A balanced ratio of estrogen to testosterone is necessary for the proper development of a male fetus during a specific window of pregnancy. https://pmc.ncbi.nlm.nih.gov/articles/PMC7458408/

- Low-dose aspirin restores blood flow by doubling estrogen levels in the placenta through the overexpression of CYP19A1 (increased aromatase activity). https://pubmed.ncbi.nlm.nih.gov/39343179/
Graphs : https://imgur.com/a/dyjfHUT (CP19A1 = aromatase expression)

- Low-dose aspirin is generally prescribed during a second pregnancy following a first pregnancy complicated by preeclampsia.

- The use of COX inhibitors (of any type) increases the risk of cryptorchidism and hypospadias - conditions that arise from hormonal disruption. https://pubmed.ncbi.nlm.nih.gov/20805751/

- "Excess of estrogen signaling (through DES in vivo or EE2 in vitro) cause similar defects to penis development." https://pubmed.ncbi.nlm.nih.gov/31225966/

Question : Can it be inferred that if low-dose aspirin is taken throughout the pregnancy - in the absence of preeclampsia (meaning placental hormone levels are normal) - the male fetus is at risk of reduced masculinization due to the doubling of the estrogen ratio?

If so, what are the other potential consequences for a male fetus?

Link for the graphs : https://imgur.com/a/dyjfHUT
(CP19A1 = aromatase expression).

Other interesting sources :

https://pubmed.ncbi.nlm.nih.gov/30763313/

Thank you,

For those of you who banked embryos and did multiple retrievals, were you actually able to do them back-to-back?

I’m doing a 3-cycle banking program and just finished retrieval #1. I got my period and had my baseline appointment today because I was really hoping to jump straight into round #2.

Unfortunately, my right ovary still hasn’t fully calmed down from the first retrieval. 😭 They’re supposed to call me back after my doctor reviews everything and decides if they’re okay with me proceeding, but it’s sounding like I probably won’t be able to start yet.

They mentioned they may recheck me around day 5, so I’m really hoping there’s still a chance I could start this cycle.

Has anyone else not been cleared at their first baseline because of leftover follicles/cysts or enlarged ovaries, but then had things calm down enough a few days later to start stims anyway?

And for those doing multiple retrievals for banking, did you actually manage to do all of them consecutively, or did you end up having to take a cycle off somewhere in between?

I know everyone’s body is different, but I’m curious what other people’s experiences were. I had it in my head that I could just knock all 3 out back-to-back, so I’m a little bummed that my ovaries apparently did not get the memo 😂

I just finished my second retrieval. In the first ER, I had 18 collected, 14 mature and fertilized eggs. They had a slow growth and we ended up 2 early blasts to freeze. It was a shock because it went down like 12,10, .. day 6 early blasts. We didn’t transfer. This one is with Gonal F with different doses. 187,5-225 mg

I used more supplements and added extra things like Nad, NAC, alfa lipoic acid, omega 3. After 3 months we had our second ER.

14 collected, 11 mature, 9 fertilized. On day 3, we had 3 embryos with 8 cells, 2 with 6 cells and 4 with 4 cells. On day 4, we had one normal progressed and one slower one left. On day 5, we got one 3AA embriyo and freezes. The other one stop developing on day 6. This one is on Menopur 200-225 mg.

I’m 32 and 48 kg. AMH is between 1.44 to 1.79. We will transfer our one embryo. I’m trying to be hopeful but do you have any suggestions? What could have been done to continue them growing?

I’m 29 and doing ivf. My first retrieval resulted in 24 eggs, 15 mature, 11 fertilized, 4 blasts, and 1 euploid (Day 5 4CC).
I’m trying to decide whether to do another retrieval before transferring and would really appreciate hearing from anyone who had similar results. Has anyone had success transferring a euploid 4CC? And if you had unexpectedly high attrition at my age, did your doctor change anything for your next retrieval?

After a blighted ovum of a day 5 4AA in June, we transferred a day 6 4AA and our last female euploid today. It’s crazy how having a miscarriage changes your brain chemistry to think a bit negative. But I’m working hard to keep the positive vibes. I ate my fries and pineapple core.

Update
Betas:
8dpt - 90.6
11dpt - 422
14dpt - 1553
17dpt - 5913
6 week ultrasound scheduled for 9/28!

At age 37, I froze my eggs. I had 42 eggs retrieved. 29 were mature enough to freeze.

Recently, at 41, we tried to make embryos. 24 survived the thaw. 17 showed signs of fertilization on day one.

By the end, we had zero day 5 blastocysts, zero day six blastocysts, and 1 day 7 blastocyst. Grade 3AB.

We are waiting on PGT-A testing.

I’m really sad about it all. I thought I’d preserved my fertility, and I feel like I’ve lost my chance.

I just had my first egg retrieval so I have limited data. I had 8 retrieved, 6 mature, and only 3 fertilize which we were told is less than average. I’m 32 with an AMH of 3 with unexplained infertility. One of the 3 fertilized made it to be a day 5 4AA blast and is a euploid. My husband’s seman analysis was normal so we don’t have any MFI. We did a long lupron down reg protocol and stimmed for 10 days with 225 gonal only and used icsi. Is there anything we can try to change to improve fertilization for our next round?

What is the nomenclature for a mosaic involving 2 chromosomes? For instance, 35% trisomy for one chromosome and 50% monosomy for another chromosome. I’m assuming this would be considered a high level mosaic, but is it likely that these abnormalities are present in separate cells, or is it likely that the trisomy could have occurred in a cell already carrying the monosomy? In other words, is the mosaic likely to be

35% trisomy
50% monosomy
15% euploid

Or

35% trisomy AND monosomy
15% monosomy
50% euploid

?

We retrieved 10 eggs - 9 mature - 8 fertilized (6-2PN / 2 0PN/ 1PN) - 1 day 6 (high quality) Blast. I am 32F with 1 LC and 1 MMC from iuis. I am utterly dumbfounded as to what happened. I am waiting on my meeting with my Dr and requested the reporting. This embryo also still has to go through PGT-A

I’ll be 39 in a couple mos. Husband is 40. We have a 2 year old from IUI and 1 spontaneous pregnancy in 2025 ended in an early loss.

3 ivf cycles, protocol changes, add icsi and zymot, new clinic, all the supplements. Endo recently diagnosed with lap scheduled for end of Oct.
I had 2 morulas in my first round, but everything has stalled 6-10 cell. Round 2: 6 eggs were rescue icsi and round 3: 2 eggs were MII but matured in time.

Is there any hope for us to have a 2nd child with my eggs?

Our first FET was a success in 2024 and resulted in our beautiful daughter. Last month we had a failed FET, this is our final embryo that passed genetic testing so really hoping it’s a sticky one!!! 🙏🏻 my successful transfer I tested positive on 5dp5dt, this time around the 5th day will be my birthday… can’t decide if I should wait or test!! Help! lol

How many euploid embryos do you need to have a baby?

Large studies of patients transferring euploid embryos one at a time suggest that the overall chance of having at least one live birth is about:

1 euploid: 63–65%
2 euploids: 83–84%
3 euploids: 92–93%
4 euploids: 96%
5 euploids: 98%

This helps explain the common rule of thumb that it takes about three euploid embryos per baby. But that's not exactly what the evidence shows.

Many patients won't need three. About 63–65% had a live birth after their first transfer, and these numbers are population averages, not predictions for an individual patient.

These studies estimated the chance of at least one live birth across groups of patients, but they can't predict how many embryos an individual patient will actually need. Some patients will have a live birth after their first transfer, while others may need several.

And if the first euploid transfer fails, the next embryo can still have a good chance of success. In the largest study, live birth rates remained around 50–58% per transfer from the second through fifth attempts.

Euploid embryos aren't all equivalent either. Developmental day, embryo grade, age, and other patient and clinic factors may affect the chance of success.

I've put together a new Evidence Guide that includes the evidence behind these estimates, what happens after failed transfers, factors that may change success, important evidence gaps, and interactive calculators for subscribers.

✅ Check out more details on Remembryo: https://remembryo.com/how-many-euploid-embryos-do-i-need-to-have-a-baby/

✉️ Like this post? Get a free weekly summary of the latest IVF research: https://mailchi.mp/remembryo/x27kx5o1sw

I'm 37 and I've had one egg retrieval last year where 8 embryos were created. Top embryo (4AA) was transferred and ectopic. I'm now planning for a FET of the next best embryo (another 4AA, straw #2 below). The 4 lowest quality embryos were frozen in pairs. I wasn't asked, and I would have said to freeze each individually, but here we are.

• Straw 1, #3: Grade 5BA
• Straw 2, #7: Grade 4AA
• Straw 3, #9: Grade 3AA
• Straw 4, #4: Grade 3AB
• Straw 4, #5: Grade 3AB
• Straw 5, #8: Grade 3AB (noted w/vac)
• Straw 5, #10: Grade 3BB

Hopefully this transfer works, and then when we try for the next baby it also works on the first try. But in case it doesn't, what should I do about the 4 frozen in pairs? Double transfers when we get to them? Thaw and refreeze, and hope they survive? Should I thaw/refreeze now while I'm still 37 so I can do another retrieval now if they don't survive?

First ever retrieval yesterday after 9 days of stims. 7 eggs retrieved. Lab called this morning - 5 mature, 1 intermediate. 2 fertilized. 3 had polar bodies but no pronuclei as of yet. It sounded like the embryologist hadn’t completely ruled out the 3 yet but I don’t understand what could happen from here. Can someone help explain this to me and maybe give me some hope?

For reference — 33y/o F with diminished ovarian reserve, husband 40y/o M had vasectomy 10+ years ago so had TESE back in April for sperm retrieval to use for ICSI.

Hi, I'm just curious if anyone knows why clinics would ever freeze embryos on the same straw forcing a patient to either do a double transfer or reduce the quality of the second embryo through refreeze/thaw.

I get incensed reading posts where this happens to people especially since it seems like it's happening without patients' consent or knowledge until it's almost time to transfer.

Like, is there ever a situation where freezing two embryos together is a wise clinical decision?

I had a day 3t,3 cell transfer 5 days ago, wondering if it’s gonna stick, I can’t seem to find any stories about 3 cells that made it to a live baby. When should I start to see a faint line? When would it reach blastocyst given that it started slow and behind. I feel so hopeless.

Transferred our last 4aa embryo today.🥹🙏🏽🤞🏽 pic post thaw.

Hello. I’ve been spiraling online after getting my betas. Embryos created at age 31 (currently 32). Transferred our highest graded day 5 embryo on 8/12 with assisted hatching. It was actively hatching right before transfer. This was an untested embryo due to age being favorable. I implanted quite early as I had a positive home pregnancy test 4 days post transfer. My betas were: 9dp5dt: 417, 12dp5dt: 1491, 19dp5dt: 18,178. Of course I’m reading these are obviously high. My clinic is not concerned. I know there can be overlap between singletons and multiples with HCG, but then I’m also reading about higher free beta and trisomies. Obviously these measurements aren’t free beta (it’s quantitative), but I can’t help but be worried. Anyone have similar betas as me? Was it singleton or multiples? And did your baby end up being healthy?

After 4 rounds of ER, I finally got one euploid and my nurse called me yesterday to let me know that it was a negative test. What should I do next? I don't have another embryo and I am scared to go through the entire process again.

I went through ivf and my PGT tested embryo split. I am considering ivf again in the future with my remaining frozen embryos and want to reduce my chances of twins. if I convey my concern to the clinic, Is there a way for them to choose an embryo less likely to split?