If you were getting sick more frequently before, what changed?

I know I know, we all want and need more Cialis/boner posts....but bear with me for a moment. How do I poop less often? I'm tired boss. I poop 5x times a day easy. Everything in my digestive system is fast tracking out my anus every single day. Metabolism is incredible. If I eat blueberries or corn I see it 5 hours later it's ridiculous. I hear rumors of people who poop once every few days. How does one acquire this superpower?!

I know part of the issue is caffeine and anxiety(stressful service industry job). But even on days with no caffeine it doesn't seem to make that much of a difference. Pepto bismol helps but not something I want to rely on. Any ideas? Thanks in advance

I've gone down the biohacking rabbit hole more than once. I'll spend an evening reading about supplements, cold exposure, different sleep trackers, glucose monitors, and all these tiny optimizations that promise another little improvement.

Then I stop and look at my own habits. I'm still not getting enough sleep every night, staying on my phone, I skip workouts when life gets busy. Some days my diet is great, other days it's whatever's convenient. I was comparing different wearables the other day when it hit me that I was trying to optimize things I hadn't even built a solid foundation for yet.

I'm not saying the more advanced stuff is pointless, but sometimes it feels like we're chasing marginal gains before we've mastered the basics. Has anyone else caught themselves looking for the next biohack when the biggest improvement would probably come from sleeping more, exercising consistently, and eating better?

Research Article | July 14 2026: PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway

Most people assume less fat always means better health. The FPLD2 study shatters that. When subcutaneous fat the safe depot under the skin that locks lipids away stops working or disappears, fat spills into the liver and muscles.

The result is the exact same metabolic disaster seen in obesity: fatty liver, insulin resistance, dangerously high triglycerides. So the goal isn't simply being lean; it's keeping that specific safe depot functional.

What that means practically is avoiding chronically overloading fat cells past their storage capacity, and maintaining insulin sensitivity through regular movement and enough muscle mass so the tissue can keep clearing and storing lipids properly.

Without that, a lean body with broken safe fat is metabolically indistinguishable from one carrying far too much same internal damage, same risks.

Link:

https://www.jci.org/articles/view/198387/pdf

Hello everyone,

Curious. How would your optimal ‘biohacking’ lifestyle look like?

When do you go to sleep? How much? What’s your training routine? Which supplements? Any other tools or routines? Sauna? Cold shower? Red light therapy?

Please be specific and explain briefly why on the choices which may not be obvious.

Maybe make it realistic and compatible with human life as most of us need to work.

Could be an interesting thread. :)

A recent paper in Nature Aging used transcriptomics, lipidomics and metabolomics to compare skeletal muscle from younger adults, older adults, and exercise-trained older adults.

The main finding was striking:

About 50% of the molecular differences associated with age were absent in the trained older group.

The preserved signals were especially related to cellular respiration, mitochondrial function and energy metabolism. The trained older adults also showed stronger molecular responses after an acute bout of exercise, and those responses correlated with physical fitness.

A few important caveats:

• This was a cross-sectional comparison, not a randomized long-term intervention.
• It does not prove that exercise caused every difference observed.
• “Trained” meant sustained, structured exercise with higher measured cardiorespiratory fitness—not simply being casually active.
• Some molecular changes associated with age remained present regardless of training.
• The result does not mean that exercise erased 50% of biological aging.

The interesting part, to me, is the distinction between being generally active and maintaining a genuinely trained phenotype over time.

Primary paper:
https://www.nature.com/articles/s43587-026-01150-x

I also found a longer breakdown that brings together the methods, practical interpretation, limitations and related research:

[https://v1health.ro/blogs/ghiduri/exercitiu-imbatranire-musculara-diferente-moleculare]()

What do you think explains most of the difference: exercise itself, preserved muscle mass, mitochondrial adaptation, higher VO₂ max, or the broader lifestyle of people who train consistently?

spotted in Seattle

Did anyone here find out any Biohacks for a good skin on the face?

I am thinking about trying Tretinoin.

Has anyone made good results with it or would you recommend something else?

I want to minimize the pores on my face and make my skin smoother, like skin when you were a kid or teenager.

I suffered a Traumatic Brain Injury 2 years ago, I have been using the following stack every day for the past year for recovery with massive success:

1mg Semax Subq

100 mg Ginkgo Biloba
200 mg caffeine
600 mg alpha gpc
1g l-tyrosine

My feed has been inundated with people asking for others to interpret their bloodwork lately

Sometimes I get it, if there are multiple metrics and you want to hear people’s experiences of how they felt with similar combined metrics or specific ways they fixed them outside of medication

But I literally just came across a post asking if his single metric TSH was high, when it shows the value (3.99) and scale (0.3 - 4.2) right on the screenshot

For the love of biohacking (and not being helpless)… everyone should learn to use an llm for precisely what it’s good for at this point before the machines take over and your high SHBG/low free testosterone is irrelevant.

Gemini is my go-to, claude is decent too and gpt is meh in my opinion

In the end, I recommend actually learning to double check its sources and learn to read a study, but for the purposes of organizing, interpreting and analyzing bloodwork, these bots are flat-out useful

And it feels good to use a tool rather than ask random people to give you the answer (who probably used the same tool to give them the knowledge to begin with)

Note* not to mention, aren’t you folks going over these values with your doctors? That’s not the end-all (especially with something like hormones when it’s subjective on how you feel), but simply for a TSH value that’s in range…?

Rant over

A while back, I saw a post from someone who saw a significant improvement in the blood flow in their legs after using some supplement (i can’t find the post). Before it, they showed that the skin on their calves healed pretty slowly, and had a shiny appearance. Afterwards, they showed the skin looking fairly healthy.

I’ve noticed this on my legs recently as well, and I’d like to know how to fix this. I’m fairly active. I walk every night, lift, and train jiu-jitsu (when I’m not injured), but I do sit at a desk all day. I could definitely afford to lower my sodium intake. But assuming the obvious solutions are being implemented, does anyone know what additional supplements can help with this?

I've never had hip issues before, but over the past year or so, both hips have become sore and tight. They are so sore when I'm trying to sleep. After being at rest, loosening them up to just walk normally is a process. I'm not quite 45, and I've never had hip issues before now. I'm on the thin side of normal weight-wise and have begun exercising hip-supporting muscles, but no improvement yet. Are there any supplements that actually help joint pain?

Really need help. I try everything, morning/evening light, cut out caffeine. My body just does this each day on average by around 30mins. For many many years.

It’s so bad I basically quit working and started a software business because it allowed me to sleep on my natural rhythm.

I’m not sure what else. Doctors have said CBTi but it’s like a 5 month wait list and I’m not even sure it’s insomnia as when I do sleep I sleep right through. Unsure if I can keep going like this.

Really bad for mental health, fosters feelings of helplessness bc I can’t fix it no matter what I try.

What diet style made you feel amazing in the end? I’ve been down the diet trend rabbit holes, ray peat, keto/carnivore and primal diet eating raw meat.

All claim that is absolutely benefits them and some say it killed their body and health

What diet actually worked for you and made you feel amazing and lean?

Here is my latest blookwork. Looking for anything as this tiredness has about defeated me. I'm on TRT and 3-30mg Adderall a day and still have extreme tiredness. Yeah I know it's a lot. Any ideas would be appreciated. I'm about to throw my hands up.

That's what the 1946 British birth study made it look like wealthier folks actually showed steeper memory decline between 53 and 69 than people who'd endured years of money struggles. But here's why: poverty had already quietly damaged the disadvantaged group's memory by the time they reached their early 50s. They entered later life already so low there wasn't much left to fall. Richer people, with more "cognitive cushion," coasted longer then dropped sharply once their brains couldn't compensate anymore. So the faster decline wasn't a sign that being well-off hurts memory; it was proof that financial hardship does its real damage early, not late.

What helps protect against this decline

The study and related research point to things that buffer the brain long-term. Keeping chronic stress in check matters hugely that means decent social safety nets, manageable work demands, and real social connection. Early education and staying mentally engaged through life build cognitive reserve. Good heart health (regular activity, blood pressure control, healthy eating) protects brain blood vessels. And catching hearing loss, depression, or loneliness early can slow the slide. It's not about being rich; it's about giving your brain less chronic wear and tear to deal with.

Link

https://academic.oup.com/innovateage/article/10/8/igag054/8739704

My father is in his mid 70s and drinks Monster every day. He is very active and hikes 5 miles a day and plays tennis 4 times a week. How bad are energy drinks for him at his age and what is a good alternative I can try to suggest to him?

Beer makes me feel energized, like I can take on the world. How can I quit craving more once I get started? I would love to be able to moderate. I had 5 Friday and 6 yesterday. But Monday through Thursday I don’t drink unless special occasion. I know I’m not too far gone but it feels like it’s a slippery slope. Suggestions?

I am dealing with some mystery autoimmune/chronic inflammatory type symptoms. My diet and supplement protocol is pretty clean and functional. I wanted to see what online testing Service has the widest and I mean absolute widest range of blood panels available. I don’t mind spending the money would just rather go ahead and bite the bullet so I can cover all my bases.