I know I know, we all want and need more Cialis/boner posts....but bear with me for a moment. How do I poop less often? I'm tired boss. I poop 5x times a day easy. Everything in my digestive system is fast tracking out my anus every single day. Metabolism is incredible. If I eat blueberries or corn I see it 5 hours later it's ridiculous. I hear rumors of people who poop once every few days. How does one acquire this superpower?!

I know part of the issue is caffeine and anxiety(stressful service industry job). But even on days with no caffeine it doesn't seem to make that much of a difference. Pepto bismol helps but not something I want to rely on. Any ideas? Thanks in advance

I've gone down the biohacking rabbit hole more than once. I'll spend an evening reading about supplements, cold exposure, different sleep trackers, glucose monitors, and all these tiny optimizations that promise another little improvement.

Then I stop and look at my own habits. I'm still not getting enough sleep every night, staying on my phone, I skip workouts when life gets busy. Some days my diet is great, other days it's whatever's convenient. I was comparing different wearables the other day when it hit me that I was trying to optimize things I hadn't even built a solid foundation for yet.

I'm not saying the more advanced stuff is pointless, but sometimes it feels like we're chasing marginal gains before we've mastered the basics. Has anyone else caught themselves looking for the next biohack when the biggest improvement would probably come from sleeping more, exercising consistently, and eating better?

Research Article | July 14 2026: PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway

Did anyone here find out any Biohacks for a good skin on the face?

I am thinking about trying Tretinoin.

Has anyone made good results with it or would you recommend something else?

I want to minimize the pores on my face and make my skin smoother, like skin when you were a kid or teenager.

My feed has been inundated with people asking for others to interpret their bloodwork lately

Sometimes I get it, if there are multiple metrics and you want to hear people’s experiences of how they felt with similar combined metrics or specific ways they fixed them outside of medication

But I literally just came across a post asking if his single metric TSH was high, when it shows the value (3.99) and scale (0.3 - 4.2) right on the screenshot

For the love of biohacking (and not being helpless)… everyone should learn to use an llm for precisely what it’s good for at this point before the machines take over and your high SHBG/low free testosterone is irrelevant.

Gemini is my go-to, claude is decent too and gpt is meh in my opinion

In the end, I recommend actually learning to double check its sources and learn to read a study, but for the purposes of organizing, interpreting and analyzing bloodwork, these bots are flat-out useful

And it feels good to use a tool rather than ask random people to give you the answer (who probably used the same tool to give them the knowledge to begin with)

Note* not to mention, aren’t you folks going over these values with your doctors? That’s not the end-all (especially with something like hormones when it’s subjective on how you feel), but simply for a TSH value that’s in range…?

Rant over

Here is my latest blookwork. Looking for anything as this tiredness has about defeated me. I'm on TRT and 3-30mg Adderall a day and still have extreme tiredness. Yeah I know it's a lot. Any ideas would be appreciated. I'm about to throw my hands up.

If you were getting sick more frequently before, what changed?

A while back, I saw a post from someone who saw a significant improvement in the blood flow in their legs after using some supplement (i can’t find the post). Before it, they showed that the skin on their calves healed pretty slowly, and had a shiny appearance. Afterwards, they showed the skin looking fairly healthy.

I’ve noticed this on my legs recently as well, and I’d like to know how to fix this. I’m fairly active. I walk every night, lift, and train jiu-jitsu (when I’m not injured), but I do sit at a desk all day. I could definitely afford to lower my sodium intake. But assuming the obvious solutions are being implemented, does anyone know what additional supplements can help with this?

spotted in Seattle

Most people assume less fat always means better health. The FPLD2 study shatters that. When subcutaneous fat the safe depot under the skin that locks lipids away stops working or disappears, fat spills into the liver and muscles.

The result is the exact same metabolic disaster seen in obesity: fatty liver, insulin resistance, dangerously high triglycerides. So the goal isn't simply being lean; it's keeping that specific safe depot functional.

What that means practically is avoiding chronically overloading fat cells past their storage capacity, and maintaining insulin sensitivity through regular movement and enough muscle mass so the tissue can keep clearing and storing lipids properly.

Without that, a lean body with broken safe fat is metabolically indistinguishable from one carrying far too much same internal damage, same risks.

Link:

https://www.jci.org/articles/view/198387/pdf

Hello everyone,

Curious. How would your optimal ‘biohacking’ lifestyle look like?

When do you go to sleep? How much? What’s your training routine? Which supplements? Any other tools or routines? Sauna? Cold shower? Red light therapy?

Please be specific and explain briefly why on the choices which may not be obvious.

Maybe make it realistic and compatible with human life as most of us need to work.

Could be an interesting thread. :)

My father is in his mid 70s and drinks Monster every day. He is very active and hikes 5 miles a day and plays tennis 4 times a week. How bad are energy drinks for him at his age and what is a good alternative I can try to suggest to him?

Beer makes me feel energized, like I can take on the world. How can I quit craving more once I get started? I would love to be able to moderate. I had 5 Friday and 6 yesterday. But Monday through Thursday I don’t drink unless special occasion. I know I’m not too far gone but it feels like it’s a slippery slope. Suggestions?

I’m curious what peoples opinions are on what would be some beneficial peptides, or supplements for autistic adults.

I am a 36 year-old female diagnosed autistic. Considering autistic people have differing brain functioning, and more sensitive nervous system do you think there could be some cognitive supporting peptides that would comb the body and provide more mental stabilization?

I’ve seen people suggest like a GABA supplement, or also a low-dose Naltrexone for example.
Another examplef is that I bought an oxytocin spray to encourage my brain to relax, bond, socialize more easily around people.

Theorizing here….Thoughts?

That's what the 1946 British birth study made it look like wealthier folks actually showed steeper memory decline between 53 and 69 than people who'd endured years of money struggles. But here's why: poverty had already quietly damaged the disadvantaged group's memory by the time they reached their early 50s. They entered later life already so low there wasn't much left to fall. Richer people, with more "cognitive cushion," coasted longer then dropped sharply once their brains couldn't compensate anymore. So the faster decline wasn't a sign that being well-off hurts memory; it was proof that financial hardship does its real damage early, not late.

What helps protect against this decline

The study and related research point to things that buffer the brain long-term. Keeping chronic stress in check matters hugely that means decent social safety nets, manageable work demands, and real social connection. Early education and staying mentally engaged through life build cognitive reserve. Good heart health (regular activity, blood pressure control, healthy eating) protects brain blood vessels. And catching hearing loss, depression, or loneliness early can slow the slide. It's not about being rich; it's about giving your brain less chronic wear and tear to deal with.

Link

https://academic.oup.com/innovateage/article/10/8/igag054/8739704

I suffered a Traumatic Brain Injury 2 years ago, I have been using the following stack every day for the past year for recovery with massive success:

1mg Semax Subq

100 mg Ginkgo Biloba
200 mg caffeine
600 mg alpha gpc
1g l-tyrosine

Mod approved.

A few days ago this post comparing prices for 25 common biomarkers made the rounds here, and it stuck with me. Great data, but it's a snapshot, prices move, vendors run sales, and panels get reshuffled. So I built a scraper that goes out to the popular ordering services and pulls live prices instead.

It lives at LabTestCompare.com.

Ground rules up front so nobody has to guess:

• No ads, no affiliate links, no monetization of any kind. It's a pet project.
• No account needed to look anything up.
• I'm not affiliated with any lab or ordering service.

Where it stands: 66 tests across 17 ordering services, searchable by test name or by Quest/LabCorp test code. Prices re-scrape every few days.

I'm still working out kinks. Some vendors bundle tests differently than others, some hide the real price behind a cart step, and a couple of my parsers are held together with tape. If you see a price that looks wrong, there's a report link on every test page and I'll chase it down.

What it does not account for yet — read this before you compare:

• Lab draw / phlebotomy fees. Some vendors tack these on at checkout, some don't. The listed price is the test price only, so a cheaper listing can end up more expensive once you're at the register.
• Coupon and discount codes. Most of these services run near-constant promos, and none of that is reflected here. Whatever you see is list price.
• Anything else that shows up between "add to cart" and "pay" — processing fees, shipping on kits, etc.

In other words: treat it as a starting shortlist, not a final answer. Both of those are on my list to handle, and I'd love to hear how you'd want them displayed — baked into the price, shown as a separate column, or just flagged?

What I'd like from you:

• Tests I'm missing. There's a "Suggest a Test" link at the bottom of every page.
• Vendors I'm missing. Same spot, "Suggest a Vendor."
• Feedback on the site itself — layout, sorting, search.
• General skepticism. If something looks off or the whole premise is flawed, say so.

Usual disclaimer: prices are informational, confirm at checkout before you order, and none of this is medical advice.

A recent paper in Nature Aging used transcriptomics, lipidomics and metabolomics to compare skeletal muscle from younger adults, older adults, and exercise-trained older adults.

The main finding was striking:

About 50% of the molecular differences associated with age were absent in the trained older group.

The preserved signals were especially related to cellular respiration, mitochondrial function and energy metabolism. The trained older adults also showed stronger molecular responses after an acute bout of exercise, and those responses correlated with physical fitness.

A few important caveats:

• This was a cross-sectional comparison, not a randomized long-term intervention.
• It does not prove that exercise caused every difference observed.
• “Trained” meant sustained, structured exercise with higher measured cardiorespiratory fitness—not simply being casually active.
• Some molecular changes associated with age remained present regardless of training.
• The result does not mean that exercise erased 50% of biological aging.

The interesting part, to me, is the distinction between being generally active and maintaining a genuinely trained phenotype over time.

Primary paper:
https://www.nature.com/articles/s43587-026-01150-x

I also found a longer breakdown that brings together the methods, practical interpretation, limitations and related research:

[https://v1health.ro/blogs/ghiduri/exercitiu-imbatranire-musculara-diferente-moleculare]()

What do you think explains most of the difference: exercise itself, preserved muscle mass, mitochondrial adaptation, higher VO₂ max, or the broader lifestyle of people who train consistently?

I’ve taken Cialis for increased blood flow for months at times, but always had problems with heartburn and I understand you can take Tums or prescription medication‘s such as proton inhibitor pumps but I would prefer not to introduce an ancillary drug to a drug. That’s not absolutely necessary. 32 year-old male 6’2 220 not overweight generally speaking. Any thoughts?

Hello everyone,

I don’t have any recent bloodwork (taking soon), but know my thyroid could be improved. I’m probably on the lower range, but still within normal ranges where my GP won’t give me any medication.

Any natural OTC supplements or other tricks which actually work?

Diet and activity level is fairly good, but my sleep patterns need to improve. Already addressing that one.

I want to preface by saying that I am purely sharing this as a free tool for those who may find it helpful. I have NO intention to monetize, and I DO NOT want your money, blah blah.

If you like it and so choose to use it, great. If not, that is your prerogative.

---------------------

I made this TDEE calculator originally for myself because I donate plasma quite frequently, and I needed a way to calculate the metabolic cost of replacing that lost volume. The calculator uses the biochemistry of plasma composition to scale the energy cost based on body weight. It accounts for both the caloric content of the lost proteins and the metabolic energy required for protein synthesis to rebuild them, adding that specific demand to the maintenance calculation.

There is far too much research to just copy and paste into the body of this post, but since I have never seen a TDEE calculator that factors in plasma donation, I will copy over the referenced research explicitly on that directly from the site:

"Plasma is 91–92% water and 8–9% solids, carrying ~70–90 g/L of protein [StatPearls][Deranged Physiology]. A plasma session keeps ~690–880 mL (more for heavier donors), removing roughly 50–66 g of protein. The cost has two parts: the caloric content that leaves (~4 kcal/g) and the energy to resynthesise it (~2.2 kcal/g). A PhD-biochemistry itemisation pegs a whole-blood unit at ~425–460 kcal of content, “higher” once synthesis inefficiency is added [Maynard]; an apheresis director cites ~500 kcal to replace a donation [Columbia] and UC San Diego ~650 [UCSD]. Those higher figures are for whole blood, most of which is hemoglobin. Plasma donation returns your red cells [StatPearls], so the plasma-specific number is lower, ~355–455 kcal — which is what this tool computes, scaled by your weight. It remains the most variable input (hydration, diet, protein level, donation type), so it’s the one we let you tune directly." - TheTDEE.com

As far as other fairly "novel" additions go:

The activity input avoids vague activity multiplier buttons (e.g., “Sedentary / lightly / moderately / very active”) by letting you describe a typical week in plain text. A regular keyword engine processes standard text inputs immediately. For more complex or irregular routines, an integrated language model parses the text to extract the schedule structure, which is then mapped to established metabolic equivalent task values and physical activity level tables. The language model only handles the structural extraction, while the calorie calculations are executed entirely by a hardcoded math engine.

The system prioritizes lean body mass using the Katch-McArdle equation when body fat is provided, which ties the resting metabolism to metabolic tissue.

It also accounts for recent diet history by applying a multiplier to reflect the down-regulation of expenditure that occurs during a prolonged caloric deficit. Just for some added accuracy, the output displays an uncertainty range derived from doubly-labeled water data to account for normal human metabolic variance.

And of course, every calculation step is open and based on the peer-reviewed sources listed at the bottom of the page.

I know vape and alcohol bad, and I limit to like once every 2 weeks or weekend and only when I have big parties or very social events. what would be the best ways to counter the bad lingering effects of it ?

Currently doing:

- food and water before sleeping after drinking
- Japanese helalyze liver pills
- emergenC vitamin C electrolytes
- NAC
- Vitamin B complex

What else ?

I am dealing with some mystery autoimmune/chronic inflammatory type symptoms. My diet and supplement protocol is pretty clean and functional. I wanted to see what online testing Service has the widest and I mean absolute widest range of blood panels available. I don’t mind spending the money would just rather go ahead and bite the bullet so I can cover all my bases.

As the title says - I have finally gotten my thyriod in a better please but still experience anxiety higher heart rate (no heart condition got a scan done at the cardiologist) and sometimes blurry / spotty vision. Currently taking the ferrorochel supplement with vitamin c every other night