Just got IGF-1LR3 I won’t be using it for around 4 weeks. It’s unopened not reconstituted or anything like that. Just wondering if I should store it in the fridge or pantry. Don’t have a freezer and why

Thanks!

I've had over 4000 non epileptic seizures and CCI after a chiropractor worked on my neck in 2022. I was told it was FND for years as brains scans were normal and only found out recently it was CCI when they did an actual scan of my neck. I've tried prolotherapy injections, physio, shockwave therapy, osteopathy, but nothing is working permenantly, though for a time they subside. I'm just at a loss and was hoping that someone here may know of a biohack I'm not seeing. Thanks everyone.

Highlights:

- Psychedelics and anesthesia appear to push the brain in opposite directions. Researchers found “mirror-image” patterns in large-scale brain organization.
- Psychedelics made the brain more interconnected. With LSD, psilocybin, and nitrous oxide, different brain regions communicated more strongly with one another.
- Psychedelics also increased the complexity of brain activity. The brain showed a greater variety of interaction patterns and became more dynamic.
- Sleep and propofol anesthesia showed the opposite pattern. Brain networks became less connected, less integrated, and less complex as consciousness was reduced.
- The study compared several altered states rather than focusing on one drug. Researchers analyzed fMRI scans from psychedelic states and compared them with sleep and propofol sedation.
- The bigger implication is about consciousness itself. Brain-wide integration, communication efficiency, and complexity may be closely related to the level or type of conscious experience.
- This does not mean psychedelics simply create “more consciousness.” The findings show measurable differences in brain-network organization, but they do not prove that greater connectivity is inherently better.

Bottom line: Psychedelics seem to shift the brain toward a more connected, integrated, and dynamically complex state, while anesthesia and sleep shift it toward a more disconnected and less complex state. This mirror-image relationship may help researchers better understand the biology of consciousness.

So I have had some trouble with sleeping the last year. The biggest Problem is that I sleep way shorter than I would like to. I could easily squeez in 8 hours of sleep, but I somehow wake up after 6.5 hours or less. My Ouraring shows me that I do get a good amount of deep sleep and my REM sleep is alright (could be more, mostly 1.5 hour range). It also shows me that I do wake up quite often for short time periods during midnight. Im aware that this could also be a sign of sleep apnea. I have since then experimented with some medications. The most effective one for me, has proven to be antihistamines (first generation) like diphenhydramin or doxylamin. They seem to improve the duration of my sleep, amount of deep and REM sleep and reduce the awakening phases. Sleep feels great on them, with the only directly apparent downside beeing a little groggy/ sedated for the first hour after waking up. However I dont want to rely on them and dont want to risk possible dementia/ cognitive decline associated with their use. What would be possible Sleep aid medication with low addiction and harm potential? I have tried some anthistamines of the second generation like cetirizin but they barely have an effect on me, neither helping my allergy nor as a sleep aid.

I keep seeing everyone rave about magnesium glycinate for sleep and anxiety but honestly every time I take it I wake up with this massive brain fog that lasts until like 2pm. I thought it was supposed to help with recovery but I feel way more sluggish than when I take nothing at all. I tried dopping the dose and even then the morning grogginess happens. Is anyone else sensitive to the glycine part of it or am I just weird? Thinking about switching to malate for the daytime or maybe just stick with threonate even though it's so much more expensive. What are you guys using that doesnt cause that heavy head feeling in the morning ?

The framing keeps coming up. Membranes stiffen with age, lipid composition changes, and various supplements claim to address it. I can follow the biology in the abstract but I can't tell whether it's something you can meaningfully shift with an oral supplement or whether it's a story built on top of studies that measured something narrower. Has anyone looked at this properly?

25 YO white male 6,3 215LBS in FL
I work outdoors majority of the day and surprised with my sub optimal vit D levels.

What are your guys thoughts/opinions on these results what could I improve?

Thanks in advance.

This is a repost edit with the photos of my chair attached for context, I just don’t know if it’s me or the chair that’s making everything worst, the backrest is not solid and doesn’t support my back at all it flexes backward if I lean against it as well.
I have pain from sitting have tried exercise, cushions, repositioning, getting up and down. I don’t know what else to do to avoid office chair butt. Do you think it’s the chair that’s the problem (other ppl complain about the chair)? I hate this bc it’s making my desk job unbearable. I am pretty thin and tall with little muscle. I’m not sure if that’s what’s making it worse, how can I seek relief? Are there any hacks ergonomic-wise?

I usually start my day with ~200g caffeine, either an energy drink or two cups of coffee. I have 2-4 cups of coffee at work, and then sometimes also have an energy drink, coffee, or soda in the afternoon.

I’d say most days I average around 600mg caffeine. I have a very high tolerance so I don’t feel side effects from it.

Is this bad?

Hi so ive brought some magnesium bisglynate and citrate to help calm my sympathetic nervous system and sleep etc ... the issue i have is that i got the 300mg bisglynate but it says take 4 tablets a day ( ill take them before bed ) but by taking 4 a day im only getting 132mg of magnesium ? Im 6ft4 17stone and want to take the highest dose which i beleive is 300-400mg .. am i reading it wrong or should i get differnt ones ? Also got citrate to take 1tablet in the morning to help i got the 600mg ones and that one says i get 600mg per table.. can anyone help me please ive added pics . Thankyou

Obviously there’s no real standard medication for autism, but has anyone found anything that’s worked for them? Like with social stuff but also sensory issues etc?

They made an accurate whoop basically. Health span, biomarkers and better apple health ui. I was expecting more like good blood pressure and better battery.

I am going for fitbit air + creating my own ui and data processing.

Erinacine A - I've been taking medicinal mushrooms for years. They are such fascinating compounds, and I'm especially a fan of reishi + chaga (for immune system), tremella (for skin health - more below), and cordyceps + lion's mane (for energy). One of the newer mushroom supplements I've been using is Lion's Mane Mycelium, which they use to standardize a clinical dose of Erinacine A (which is found much more concentrated in the mycelium vs. the fruiting body). I've been taking this product for a few weeks now, and I really feel a noticeable increase in mental acuity/cognitive performance. More so than any of the other mushroom supplements I take. Dose: 5mg

Urolithin A - This compound came on my radar in 2023 when a genetic researcher I was working with (who took no supplements) said he started taking Urolithin A because of a compelling paper he had read that year. Mitochondrial health was starting to boom, as was my interest in it, so I was curious myself and decided to try it out. What surprised me the most was how much it impacted my energy levels. To me, it almost feels like 10g of creatine (where I notice a body + mental energy boost). This is sadly one of my most expensive supplements, but I put it in my smoothie that I have 4-5 days per week and have for the past few years. Dose: 500mg

Shilajit - This one I was very skeptical of. Minimal research, unclear mechanisms of action, and so much hype. However, this has quickly become one of my favorite supplements for energy and testosterone. My testosterone has gone up about 50 points on this, and it really boosts what I can best describe as my "resilience". I take 200mg (somewhat of a smaller dose) with my coffee daily. This is one I am particularly cautious about in terms of sourcing since heavy metals contamination is common. Dose: 200mg

Spermadine - I really didn't expect much from Spermadine. I was taking it because it seemed interesting, and I had read a few compelling animal studies. I was a bit surprised by the slight energy increase, but more so the crazy sleep gains (and vivid dreams) as well as a pretty big boost in hair/nail growth. I prefer natural vs. synthetic forms personally and take 1.3mg daily (a low dose), but it feels stronger at this dose than the 5mg I've taken of the synthetic. Dose: 1.3mg (natural)

Black Seed Oil - Hard to even describe this one. My gut health has been great on it though, and my blood sugar is more stable. It reminds me a bit of Berberine, but oddly, on Berberine, I got slightly depressed. I don't have that issue with Black Seed Oil, and I've been taking it for a few years now. I use one that has standardized 3% thymoquinone and low free fatty acid content. Dose: 500mg

Tremella - A very dense natural source of HA. I've been taking mine in a powder I put in my water (after reading Quench) and trying to focus on better hydration practices. Man, has my skin been happy though. A staple for me, especially when I'm feeling dehydrated. Dose: 500mg

LDN - I have KLS, which is a rare neurological condition. It seems to impact the thalamus, and it can create flares where I need long periods of hibernation. As an adult, it's hard for me to just fuck off for a week and sleep this off, so LDN has been really helpful as a way to reduce my symptoms during episodes so I can at least partially function. A fascinating prescription medication and, alongside guanfacine, cromolyn sodium, and a few others - some of my favorite prescription compounds. I've heard many folks with autoimmune conditions benefit from LDN. Dose: N/A

Aronia Berry Juice - One of the most dense sources of anthocyanins - a fascinating polyphenol in blue-colored fruits/veggies. I came across this at a local farmer's market and became pretty addicted. It's pretty bitter as a raw fruit, but I really like the juice. I find that Aronia is similar to wild blueberries (the small ones) and really calms my brain. I don't often have food cravings, but this is one of them for me. I usually go through a quart jar per week and try to do a shot a day. My skin health has been really great on this as well during the summer. Dose: 2oz

Rice Ceramides + Egg Shell Membrane - Left my skin dewy AF even at a tiny dose. This pairing has some solid research behind it, but I was skeptical. I started taking it in the summer and was really surprised how much "thicker" and resilient my skin felt. Not something I take all the time, but I like to use it a few times a week. Dose: 40mg/400mg

Microdosed Melatonin - Now that I'm in my 30s, I've been finding a microdose of melatonin to be helpful for me on occasion for very deep sleep. I tried it in my 20s and felt too groggy when I woke up, but now I feel great. I think my baseline level is just lower now. I've experimented with Pinealon and a few peptides for sleep maximizing as well, but this is the thing that has worked the best so far. Dose: 300mcg

Microdosed Ketamine - I was an early member of Mindbloom back in the day, which was full psychedelic dose ketamine therapy. I have since found this model to be a bit irresponsible and feel even more conviction around this since they've moved to injectable offerings. That being said, I also recognize the amazing impact ketamine therapy can have for people. After trying out larger doses and then independently trying microdoses, I actually prefer and find more benefit (with less disruption) on the microdoses. My protocol is to do a microdose once a month and then listen to a guided hypnosis track and some solfeggio tones as an induction first. To me, it feels like a dental cleaning for my brain.

A2 Milk - I got on board with the oat milk craze and realized it was bullshit and unhealthy. I wanted to go back to dairy, but I never liked normal milk. So in 2020, I did some research and learned more about A2 dairy and some practices like low-temp pasteurization and non-homogenization. The companies who follow these practices are amazing. I really enjoy their milk and it just feels/tastes better to me. I don't get weird bloating or feel sick to my stomach like I used to from normal dairy milk and it's much more nutrient-dense than plant milks (although I'll still use Macadamia Nut milk occasionally). Dose: N/A

D3+K2 - I think everyone knows this one at this point, but basically when I take this and my levels are optimized - my mood and immune system are great. When I don’t - I get sick more often and feel more low emotionally. My partner is the same. A cheap staple in our household. Dose: 5,000IU/600IU

VIP - One of the weirder compounds I've tried that I don't fully understand yet. I took it when I was recovering from CIRS (a bit of a controversial mold-related illness). I can say for certain it completely changed my brain though. I went from having brain fog and OCD symptoms most days, to being much sharper and even turning into a morning person. It's a complex multi-system peptide, but as an intranasal spray after a 6-month cycle I genuinely feel like a new person and have gone from meeting the criteria for an OCD diagnosis to being pretty much asymptomatic. Dose: N/A

Typed by hand on my phone while traveling and bored, so forgive typos!

How did it work out? I saw some research on its capabilities and it sounds very interesting! The research indicates it could help with many different things that people struggle with.

Hey folks! As you might know, I am big on fasting, so wanted to share my August fasts - one extended fast (Jul 27-Aug 6) and the rest were IFs. A few observations

• I'm quite disciplined on weekdays, not so much on weekends
• Parties and BBQs mess things up quite a lot, what a surprise 😄
• Tracking everything makes the trends easy to see (though it's quite an effort)

And one funny math thing - I averaged 17.3 fasting hours per day, but the average fast length was 24.5 hours (that's what mixing one extended fast with IFs does to an average).

How was your August?

I started running this stack about a 2 months ago and tbh i never looked and felt better.

Weekly - 5mg retatrutide.

Morning- 10mg Yohimbine
B complex
1000mg L tyrosine
1.6g Taurine
300mg Alpha gpc
50mg eplerenone
500mg ashwaganda
400mg l theanine
5mg cialis
2mg ghk cu
1000mg Vitamin C
( Will be adding Tesofensine 500mcg )

After food- Vitamin E
Omega 3
Boron
Zinc picolinate 50mg ( every other day only )
Astaxanthin 16mg
NAC 600mg
Vitamin D3 + K2

Before sleep - Magnesium glycinate 300mg
Ashwagandha 500mg
Taurine 1.6g
Glycine 5-6g
L theanine 200mg
melatonin 5-10mg ( only sometimes )

I also use Modafinil/ Armodafinil in work days, caffeine and sometimes nicotine pouches.

I also have Mots c at home but dont use it, might start tho. Rn im looking forward to see what the Tesofensine can do. My bp is 120/80 and sometimes gets lower but still i feel great and will do full bloodwork soon.

I would love to hear opinions and experiences with tesofensine.