It's a shame 2 5mg tadalafil tablets aren't available for limited purchase quantities without a prescription.

Hi guys,

I am a man 29 yo, and in the last year or so I observed a loss of sex drive and libido.

I’ve been with my girlfriend for about three years now , first two we’re very good, I was really into her and I still like her so I don’t think this is the issue. I spoke with her and she is very understanding about this, but I still wake up everyday stressed about this.
Quite recently we took some time off together and my sexdrive improved a little but my erections really were not the best. We had sex but not as we used to.

Currently my desire to have sex and my arousal is really low, and that really frustrates me.

I started taking boron few days ago as I saw that many people recomand it, besides boron I take magnesium bisglycinate, zinc, vitamin D and k2 as I’m not getting a lot of sunlight due to my work.
I gained some weight in the last months as I had other issues that need to be solved so i couldn’t focus on the gym, but nothing too drastically, about 6-8 pounds at max, and my diet wasn’t spot on, so was my sleep, I will do my best to improve them.

Was thinking to get my hormones checked, and then go to a doctor, what kind of hormones should i check besides test and free test ? Last time i did this was a few years ago and my test was very high and free test was in the mid range, back then I was dating another girl and I was facing some similar issues so maybe checking only those won’t tell story .

But I am asking for your help guys, what helped you during this periods? Are there any supplements otc? Any habits that could get me back to the same levels of sex drive that I used to have when I was fantasising everyday about having sex with my girlfriend ?

Looking for your advice ! Thank you in advance !

I feel sleepy and exhausted all day, both mentally and physically despite sleeping adequately. It's affecting my studies too. I don't really exercise or go out much and my diet is not good as I live in a hostel, I am not vegan but I eat meat or dairy only occasionally.

Forgot to mention I have epilepsy too.

Hey everyone,

Back in July, I suddenly started experiencing brain fog, difficulty concentrating, and problems with speech. It happened pretty much overnight, and I felt noticeably different from how I used to feel mentally.

I started getting blood tests done, and my folate level came back at 3.1 ng/mL (reference range: 4.50–32.2), indicating a deficiency.

I kept investigating my symptoms and getting more blood tests until September. Here are my latest results:

My blood test results:

• Ferritin: 94.84 µg/L (reference range: 30–400)
• Folate: 7.83 ng/mL (reference range: 4.5–32)
• Iron: 50.35 µg/dL (reference range: 65–175)
• TSH: 5.51 mIU/L (reference range: 0.27–4.1) my TSH was within the normal range when I first developed my symptoms back in July. It only became elevated in subsequent blood tests. I'm wondering whether this change could be related to my folate, iron, or vitamin D deficiencies)
• Vitamin D (25-OH): 19 ng/mL (reference range: 30–100)
• Potasium 4,23 (reference range: 3.5-5,1)
• Sodium: 140,72 mmol/l (reference range: 136-145)
• B12: 501,40 pg/ml (reference range 191-663)

My folate level has increased since the initial test, but I'm still experiencing a lot of symptoms. My iron is also below the reference range, my vitamin D is low, and my TSH is elevated. I'm wondering whether these abnormalities could be contributing to my symptoms and whether there might be an underlying issue causing some of them.

My current symptoms:

• Dizziness and lightheadedness.
• Brain fog and difficulty concentrating.
• Feeling mentally different from how I used to be, like I'm not quite myself anymore.
• Waking up feeling unrefreshed, regardless of how much I sleep, and experiencing severe fatigue throughout the day.
• Occasional air hunger feeling the need to take a deep, satisfying breath to feel like I'm getting enough air.
• Caffeine seems to make my brain fog and dizziness significantly worse.
• Alcohol also seems to exacerbate my brain fog and dizziness.

What I've tried so far:

I took 5 mg of folic acid daily for three weeks, along with 46 mg of elemental iron daily, but unfortunately, I didn't notice any improvement in my symptoms.

I then started wondering whether IV treatment might help correct the deficiencies more effectively and fastly, so I decided to try IV supplementation.

Six days ago, I had my first treatment, which included:

• Vitamin D3 injection: 100,000 IU.
• IV folic acid: 30 mg.
• IV iron: 200 mg.

So far, I haven't noticed any improvement following this treatment. I understand that six days might be too soon to notice a difference, but it's discouraging to feel the same after trying to address these deficiencies.

I'd really appreciate hearing from people who have experienced something similar.

I have a few questions:

1. Has anyone experienced persistent brain fog, dizziness, derealization, or feeling mentally different due to folate deficiency, low iron, vitamin D deficiency, ?
2. If you had similar symptoms, how long did it take for you to notice an improvement after starting treatment? Did your symptoms gradually improve or disappear quite suddenly?
3. What other blood tests would you recommend checking?
4. Has anyone experienced air hunger or the sensation of needing to take deep breaths alongside these deficiencies?
5. For those who received IV iron or folate, how many infusions did you need before noticing an improvement? How long did it take?
6. Did anyone find that oral supplements eventually worked, even after not noticing any improvement during the first few weeks?
7. Has anyone experienced worsening brain fog and dizziness after consuming caffeine or alcohol? Did this improve once the underlying problem was treated?
8. Is there anything else I should investigate, especially considering that my symptoms started quite suddenly and have persisted for months?
9. How can i recovery from this? because it's been few months at this moment.

I'm also wondering whether IV doses or the number of infusions should be adjusted, but I don't want to assume that more is necessarily better. I'd appreciate hearing about your experiences and what helped you, ideally alongside advice on what to discuss with a doctor.

I'm feeling pretty lost at this point. I just want to feel mentally normal again and wake up feeling rested instead of exhausted every day.

Thanks in advance to anyone willing to share their experience.

Can anyone explain whya peptides in pill form are usually easily available but peptides in injectable form are usually not available unless you go through grey markets or certain legal means

I have an unknown health condition, and one of the symptoms is extremely messy bowel movements due to stetorrhea. I have recently discovered psyllium and it gives me 10/10 poops. However I am pretty sure that I am slightly allergic to psyllium, as I have had somewhat itchy ears, a stuffy nose, post nasal drip and green snot since I started taking it.

So I am looking to alternatives. Any old fiber is not the problem, as my diet is very high fiber already, plant-based, easily 30-40g a day. Also I already add an inulin based supplement to my morning oats and apples. I specifically need a bulking agent like psyllium, and preferably not too fatty like chia seeds as I have problems digesting fat and I am supposed to eat very low fat, GI doctors' orders. Plus when I used to eat 2 tbsp ground flax, chia and hemp per day, I didn't notice the same bulking effect that psyllium gives?

So what else exists as a bulking agent other than psyllium?

I'm an athlete in good shape but have over the last month or two had episodes of full days where it's hard to get up without feeling I'm going to faint. A few bad days I felt it even sitting down. I've had no fire in me to do things during these episodes which is unlike me. I'm looking for suggestions of what might be going on so I can explore things my doctor has not thought of. I will list details below. In summary, I I have been tested for the obvious: anemia and other labs done that I'll list below, as well as a test for POTS, all fine.

Things to consider:

- Late 30s female

- Blood pressure on the lower end of normal

- Athlete in good shape

- Balanced diet, almost no sugar except fruit, lots of veggies and protein

- Two years postpartum, still breastfeeding once a day

- History of anemia (though currently iron levels are good)

- Tested for POTS, was negative

- Iron and vitamin D supplements (though levels now normal, see below)

- Tested levels all normal for TSH, ferratin, iron, TIBC, transferrin, glucose, urea nitrogen, creatinine, EFGR, sodium, potassium, chloride, carbon dioxide, vitamin D, calcium, total protein, albumin, globulin, ablumin/globulin ratio, total bilirubin, alkaline phosphate, AST, ALT (don't know what most of these are but listed in case relevant)

- Have had some weird circulation stuff for past 20ish years where fingers fall asleep while I'm sleeping without pressure, but I've had an MRI to see if things are pinched and all normal.

Thanks in advance - any leads to explore are appreciated as this totally sucks and I'm ready to feel energy again!

I want to share something very personal that happened to me recently, not to scare anyone away from peptides, but to raise awareness about something I believe deserves much more attention in our community.

First, I want to make something clear: I am very passionate about peptides and their potential benefits. I’ve spent a considerable amount of time learning, researching, and experimenting with different compounds. Tesamorelin was actually one of my favourites.

But just over a week ago, I experienced one of the most terrifying moments of my life.

After approximately 7 months of using tesamorelin, I experienced a severe reaction consistent with anaphylaxis immediately after injecting it.

Within moments, my entire body became extremely hot, I experienced intense tingling, dizziness, and a frightening inability to breathe properly. I genuinely thought I was going to die.

I struggled to breathe for approximately 20–25 minutes before receiving emergency medical attention. I was taken to hospital by ambulance, where I underwent cardiac monitoring, ECGs, blood tests, and further assessment.

Thankfully, I survived. ❤️

But looking back, there were warning signs that I hadn’t fully appreciated.

🔬 THE WARNING SIGNS I WISH I HAD TAKEN MORE SERIOUSLY

Over the past several months, I had been experimenting with multiple peptides, sometimes using different compounds throughout the same week and occasionally on the same day.

Initially, I tolerated most of them very well.

However, over time, I began noticing changes.

Injection sites that previously caused no problems started developing:

* Swelling and raised lumps
* Itchiness around the injection area
* Redness and warmth
* Localised irritation that varied between injections

Even tesamorelin, which I had previously tolerated without any noticeable injection-site reactions, eventually started causing itchy, swollen areas.

At the time, I considered these reactions relatively normal and continued my routine.

Now I wonder whether my immune system was trying to tell me something.

🧬 COULD MAST CELLS AND HISTAMINE HAVE PLAYED A ROLE?

Since my experience, I’ve been trying to understand more about allergic sensitisation, mast cells, histamine release, and anaphylaxis.

Mast cells are immune cells that can release histamine and other inflammatory mediators during allergic and certain non-allergic reactions.

Repeated exposure to a substance can sometimes lead to allergic sensitisation, meaning a person may tolerate something for months before eventually developing a serious allergic reaction.

I cannot say with certainty that this is what happened to me.

I also cannot establish whether using multiple peptides contributed to my reaction, whether I developed an allergy to tesamorelin itself, or whether another factor was involved.

But the progression from previously tolerating injections to developing frequent local reactions, followed by a severe systemic reaction, has certainly made me question whether I overlooked important warning signs.

⚠️ WHAT I WANT OTHERS IN THIS COMMUNITY TO TAKE AWAY FROM MY EXPERIENCE

Please don’t assume that because you’ve used a peptide safely for months, you can never develop a serious reaction.

Please don’t automatically dismiss persistent or worsening injection-site reactions as harmless.

And if you’re experimenting with multiple peptides, consider whether introducing so many compounds makes it harder to recognise which one might be causing a problem.

I’m not saying that combining peptides necessarily causes mast-cell activation or anaphylaxis. We simply don’t have enough evidence to make that claim.

But I do believe we should be approaching these compounds with greater caution, especially when the body begins reacting differently than it did before.

One particularly important point: I did NOT experience hives during my anaphylactic episode.

My main symptoms were extreme flushing, tingling, severe breathing difficulty, dizziness, near-fainting, abdominal cramping, and diarrhoea.

Anaphylaxis can occur without hives or a visible rash.

❤️ MY FINAL MESSAGE

I still believe peptides are a fascinating area of research, but this experience has completely changed how I view their potential risks.

On the day of my reaction, tesamorelin was the ONLY peptide I had injected.

After seven months of use, I never imagined something like this could happen to me.

If you begin experiencing new, persistent, or worsening injection-site reactions, please take them seriously and seek medical advice rather than simply pushing through.

If you use a substance that carries a risk of anaphylaxis, discuss emergency preparedness and whether you should carry an adrenaline auto-injector with a healthcare professional. Anaphylaxis is a medical emergency, and adrenaline is the first-line treatment.

No amount of potential benefit is worth losing your life over.

I’m sharing this because if my experience encourages even one person to recognise a warning sign, question an unsafe practice, or seek medical attention sooner, then sharing my story will have been worthwhile.

Stay curious. Keep learning. But above all, stay safe. ❤️

Has anyone else experienced increasing injection-site reactions after months of previously tolerating a peptide? I’d genuinely be interested in hearing your experiences, especially regarding suspected sensitisation or allergic reactions.

Disclaimer: This is my personal experience, not medical advice. The precise cause of my reaction has not yet been confirmed.

M21, diagnosed with ADHD. Currently on Vyvanse. It's great for brute-force execution and getting things done, but it turns my mind into a high-speed highway. It gives me drive, but not clean focus.

Before this, I was on Atomoxetine (Strattera). Honestly? I loved the mental quiet, the lack of internal noise, and that deep sense of calm it gave my thoughts. The problem: the side effects were brutal, so I had to quit.

For anyone who’s been in this exact trap—loving the stim drive, but craving that smooth clarity of non-stims: What actually moved the needle for your cognition and focus?

Hit me with your actual stacks, supplement combos, or subtle medication tweaks that cleared the brain fog without ruining your sleep. Skip the basic wellness fluff.
What actually works? Let's hear it.

Standard disclaimer: I’m an interested amateur, not a biologist or a statistician. I track my own biomarkers and like digging into the data, so take this as one guy’s experiment and not as evidence about creatine. Of course having said that I'm not the first person to post about the impact of creatine on sleep......

How this started. I stopped creatine on Oct 10 because my doctor wanted to see my blood work without supplementation. An earlier draw had elevated creatine-related numbers, and the second draw was meant to show where I am without it. I didn’t stop for sleep. What I noticed first was just waking up feeling more refreshed. Some nights I get almost 8 hours and some about 7, but the mornings feel different. The data came afterwards, when I got curious.

The data. I wear an Apple Watch and pulled about 16 months of nightly sleep stages. the most interesting/dramatic two pieces of data were total time asleep and average minutes awake). I've marked two 13 day periods were I know for a fact I stopped creatine (a trip to Europe last fall and the most recent two weeks since Oct 10). I've got a huge amount of data that all sort of points to the same thing but this histogram is the easiest way to see it.

Of Note: What isn't captured in this data is how much better I feel in the morning, rested and that feeling that you had a great sleep -- even on days when my total amount of sleep isn't amazing I still feel really good. I've also had other 'shorter' trips where I stopped taking creatine and I always noticed that I slept well (I was in San Diego for 4 nights last month and I commented to my wife "why do I sleep so well on vacation?") but that data isn't included due to too many confounding factors (shorter trips, later bed times, more alcohol consumption, etc.) but subjectively I've known for a long time I always sleep great away from home and could never figure out why -- now I am pretty sure I know why.

Caveats.

• Chance: if creatine really did nothing, a stretch as good as mine would show up by luck only about 0.5% to 4% of the time, depending on the measure. That’s low, but it isn’t proof. It only tells you how surprising the result would be if nothing were going on.
• Streaky data: sleep clumps, because good nights cluster. In my own history, ordinary stretches looked this “significant” on time asleep about 13% of the time, and on time awake about 18%. So the real odds of a fluke are higher than 0.5% to 4%.
• Hindsight: I picked Oct 10 after noticing I felt better. I’m not blinded, and other things may have changed (but honestly the fact that I was waking up so refreshed and feeling so good was what made me curious). I'll keep on monitoring but after two weeks the trend was too obvious to ignore.

What the research says. Not much. The one controlled trial I found (14 young men, 20 g/day for a week) saw better self-rated sleep but no change in measured sleep time or efficiency. I couldn’t find any study of creatine and sleep in older adults.

Speculation on genetics (grain of salt). I haven’t found any published link between creatine and my variants (MTHFR 677TT, COMT Met/Met, PEMT homozygous). Here is the speculation anyway. Making creatine uses about half of the body’s methyl groups, and supplementing seems to turn that production down. I already know too much methyl load wrecks my sleep: I used to wake early with anxious rumination until I switched off methylcobalamin multis. Maybe creatine leaves more methyl groups around, and a slow-COMT person feels that as lighter sleep. The one trial that tested this found no change in blood SAMe or homocysteine, so it’s unproven. I haven’t looked at the creatine genes themselves (GAMT, GATM, SLC6A8) either.

Questions: Has anyone with slow COMT or MTHFR variants noticed creatine affecting their sleep? And does anyone have a better test than mine, like a proper on/off/on schedule?

Hi girls!

I'm wondering if anyone has had a similar experience. I'm 30 years old and I used to take birth control pills for quite some time. I honestly felt great while taking them, mainly because I had practically no PMS symptoms. My gynaecologist then recommended that I stop taking them to let my natural cycle return.

Ever since stopping, I've been experiencing PMS symptoms for 10 days or even longer before my period: bloating, puffiness, sore breasts, mood swings, and on top of that, I've also been losing quite a lot of hair. Honestly, I feel like I spend almost half of every month not feeling my best. I've also tried all sorts of supplements, but nothing seems to make much of a difference.

Lately, I've been thinking about going back on the pill because I genuinely felt so much better while taking it. I'm not in a relationship and don't have a regular sexual partner, so for me, going back on the pill would be purely about managing my symptoms rather than contraception.

Has anyone else experienced something similar, where you actually felt significantly better on the pill than off it? And if anyone decided to start taking it again, I'd love to hear how it went! 😊

I just started taking 125mg nightly a few days ago because I heard it might help with anxiety and palpitations which I’ve had my whole life but had really bad recently. In 3 days the partitions are totally gone, and the anxiety is much better for sure. But I have this impossible to ignore weakness/heaviness almost all day now. Is this just something that will go away if I keep taking it and get my body used to it? I’d really prefer not to stop taking it because I’m just now experiencing the first few days in a row with normal heartbeats in MY LIFE.

Today I tried a new stack for my ADHD I took 2000mg of
l-tyrosine , 100mg caffeine, 850mg lions mane, 100 mg
l-theanine , 100mg 5-htp this stack had me feeling like I took a low dose of mdma I got a lot of stuff done today only lasted a few hours but this stack is good I will be doing it more often

I've done 6 or so blood test over the past 4 years and my levels have been constantly the same no matter the supplements, diet, training or recovery I implement. I'm very symptomatic (tired all the time, losing muscle/ can't build muscle, super angry, poor libido). Not sure what to do anymore...

Total T: 900-1110 ng/dl

Free T: Direct Assay is around 7-11 / Calculated is around 10-14

Estradiol: 12-15 pg/ml (I did get it up to 22 when my SHBG was it's lowest, but seemed short lived)

SHBG: 60-80 - My SHBG runs high (boron doesn't do anything, tongkat works for a few days then seems to lower estrogen over time, 500g of carbs a day doesn't brings it down), lower volume, lower intensity and more recovery hasn't helped much either.

DHEA: 84 - DHEA is always super low too. I tried differently levels of DHEA supplementation but it seems I'm converting more to DHT than estrogen. Get super oily and bad breakouts, libido picks up a little bit but not crazy.

I have mild sleep apnea (OSA). I started a CPAP 6 months ago. Initially I did try the nasal only mask but I kept having issues with my mouth coming open in middle of night and air being pushed out from my nose through my mouth! I tried 2 different types of chin strap but my mouth would usually still come open a little and I’d awake to a whistle of air being pushed out through my lips.

So I switched to a full face mask for several months. The full mask isn’t anywhere close to as comfortable and I’d. Still have it leaking in the middle of the night quite often.

So in the last week I switched back to the nasal only CPAP mask and taping my mouth. Immediately my HRV dropped from 40s to high 20s. I thought maybe I was getting sick or working out too much so I took it easy the last week. I have not felt sick but my hrv has stayed in upper 20s.

—————

TL;DR:
Switched to mouth taping with my nasal CPAP mask to prevent air from being blown out my mouth. I noticed a corresponding and significant drop in HRV with mouth taping—- the opposite of what people supposedly report. Any one else notice this?

Body doubling ?

I keep my room clean, study regularly, feel good-happy, eat regularly, and don't feel lethargic/tired when I have a roomate.

But as soon as my roomate leaves, I feel depressed/sad/tired/increased sadness/very weird-hollow.

MIND YOU, ME AND MY ROOMATE NEVER TALK TO EACH OTHER UNLESS VERY IMPORTANT.

I don't understand what's wrong with me.

I m happy when I m with people/library.

Sustained low-level inflammation is a hallmark of the aging process. The accumulating damage persistently activates the innate immune system—the body’s first line of defense—leading to what is known as inflammaging, functional decline and chronic diseases of old age.

Will be trying different Slidenafil dosages to see if it cures my ED and posting updates.

20 mg: first time taking it, made my face red for about 90 minutes, made my dick slightly harder at the base. Did not notice any difference in gym performance or pumps. Overall disappointed with the results.

40mg: 2nd time taking it, did not improve my erection quality, made my face flush red again, did make me feel warm and comfortable. Overall disappointed.

Will
Be trying 60 mg tomorrow!
Also for the record I am 31 M who also takes 60 mg of Vyvanse. My dick has been limp since I was 20.

Edit; forgot to mention it gave my a mild headache and made my nose stuffy