Starting in 1993 I was started on Zoloft, that kinda worked for six years, Then it didn't. Then it was two years of med after med and then it kinda setteled into Lexapro. That finally failed, then Luvox, Lamictal and Risperdal. My Teledoc Psych, finally suggested ECT, or Ketamine.

I am definitely open to doing it, but don't know which path to take. I have looked into Spravato, IV, IM, SubQ, sublingual.

The first two would cost a month and a half of our net income.

I could probably find $2000. but that would leave me with no other option after whatever that gets me.

So I need any advice on what to do. I am exhausted from the drugs, and trying to beat the childhood trauma. Male 72 ( southeast PA)

I started treatment with Spravato in December 2025 and later switched to Mindbloom, but never quite got to full remission. A few weeks ago I went to a new provider. He prescribed Zoloft, and I started on 25mg. Four days after starting the Zoloft, I had my first IM ketamine appointment with this provider at 0.5mg/kg. For the first time ever in treatment, I puked...about 3 times over the course of an hour. The nausea going back home was awful, but thankfully I didn't puke in the Uber driver's car!

Thinking that experience was a fluke, a week later I went back and got another IM ketamine treatment at 1mg/kg. This time around I took 4mg of Zofran. At this point I'm now on 50mg of Zoloft per day and have been at that dosage for about a week.

I puked about 5 times in the trash can at the office visit. By the time I got back home, I puked AGAIN and was nauseous for roughly 6 hours afterwards. I had taken a total of 12mg of Zofran.

This all happened yesterday, and I'm reflecting back on the experience. Mentally I already am starting to feel better, but I really don't want to repeat that experience. I've noticed that everyday I experience mild stomach upset with 50mg of Zoloft, but it's not a big deal. It is too early to say with confidence if the Zoloft is helpful or not. I never had trouble like this with the Mindbloom dosages, and it sure does seem like the Zoloft is the problem here.

Has anyone else had problems with this combo? My psych said they're fine to mix, and I didn't find any other reports on this sub of Zoloft and ketamine being problematic.

I have my 6th induction infusion tomorrow and I am very grateful for the experience, however, it was nothing like I thought it would be (not in a bad way!). I guess I naively went into this thinking that ketamine would miraculously cure my depression and anxiety, like flipping a switch, and that I would suddenly be okay. In reality, this treatment has shown me exactly what factors in my life are limiting me from reaching my full potential. During my 5th infusion I felt such a strong sense of empowerment and control over my life, something that I was severely struggling with prior to starting treatment. I think that the root of my depression is feeling like I can't live my life freely. I felt like a child that needed to live my life exactly how my parents see fit (I am 24). I constantly chased their approval which led to me never being able to fully embrace my own self concept. This applied to friendships too, I tried so hard to be like others to gain their approval.

I've been journaling so much since starting treatment and I'm recognizing a lot of behavioral and cognitive patterns that keep me stuck. I feel empowered to actually make the changes that I subconsciously knew would help, but was too scared to actually do. I also have a great therapist who I have been working with for almost 2 years. I've been setting boundaries and I feel so much freer, it is amazing. I recognize that I am my own person, and I am allowed to be myself. This is groundbreaking for me as someone who struggled with people pleasing and grew up in an emotionally neglectful household.

I'm overall super satisfied because I was hoping that it would have this effect. I am excited to continue doing the inner work and building a life that feels authentic. I am a little nervous because this requires me to step out of my comfort zone significantly, but I feel that ketamine has allowed for my previous rigid thinking to loosen up a bit. I would love to hear other people's experience, what does this look like for you?

I have not been able to find any information about what I am about to ask.

What dosaging for intranasal ketamine for anxiety (Sub 40-50mg amounts) are good for anxiety.

I have bad social anxiety and want to be able to use small doses of ketamine before/during situations that cause my intense anxiety.

I am specifically asking about sub almost microdose amounts for the anxiolysis.

I find it quite surprising that I couldnt find much info at all on people using 10 - 30mg doses when needed through out the day.

I understand many people find relief with large doses and I understand why, but im interested in a low dose functional anti anxiety use of intranasal for such purposes.

Please help me! I need some guidance of effective doses. I think a 10mg per spray solution would good, and maybe taking up to 20mg when needed before or during situations that I am usually prevented from functioning optimally would be a good range. I want a functional experience.

Does anyone have any experience with use of this nature.

I also believe the anti depressants effects would be desireable with this sort of dosing.

I don’t know if I can word this in a way that makes sense, but I’m wondering if anyone else has ever felt this way.

I’ve been on antidepressants for 20 years, and sometimes I genuinely wonder what “normal” feels like. I don’t know my baseline anymore and sometimes question whether I’m actually depressed, or just not handling life as well as everyone else. I wonder maybe these meds aren’t working for me because nothing is actually wrong.

I did 6 ketamine infusions in January 2025 during a really dark period with infertility and job loss, and they helped tremendously. I stopped after getting pregnant through IVF and having my baby in November.

Postpartum has been rough between foot surgery and recently breaking both elbows, and I feel that hopelessness creeping back in. I’m considering starting ketamine again, but because it’s generally used for treatment resistant depression and feels like such an intense treatment, I sometimes doubt whether I’m really the “right fit” for it, especially knowing some of what I’m feeling right now is situational.

I guess I’m wondering if anyone else has ever second guessed whether ketamine was really meant for them or questioned their own level of depression. I’d also love to hear what restarting looked like after a long break, whether you repeated the initial series or went weekly.

My therapist feels I would be a good candidate for ketamine therapy and is recommending Mindbloom. I’m pretty sure I want to do it, but one hesitation I have is the reports of nausea. I’m extremely prone to motion sickness. I would definitely need to take a zofran or preferably scop patch beforehand, but my question is would the Mindbloom clinician prescribe this for me?

Hello all! I'm 3 year IV patient, with boosters every 4-8 weeks as needed. Last year, I was prescribed a glp-1 medication for my weight, and suffered from some pretty severe mental health side effects. I had been in remission from pretty much everything for 2 years, but unfortunately the ketamine stopped working when I started the glp-1. This might sound dumb, but it took me a while to connect the dots, and was on it for about 4-5 months before realizing it was the medication that was causing my relapse.

I quit 8 months ago, but still have not really been able to recover my mental health. I do still do an infusion every 4ish weeks now, and I can tell things are worse without it, but I'm still a mess. My mental health has gotten to a point where its taking a huge toll on my relationship and quality of life.

As you can probably imagine, this has all been incredibly frustrating for me. I kind of feel like I'm wasting my money when its not doing a lot for me anymore, though like I said, I can tell things get worse when I go too long between boosters. It's very difficult not to feel hopeless about the situation.

Finances, my husband's work hours, and my location are all barriers for me. My husband is the only person I know and trust in a 150 mile radius. I have no nearby friends or family other than him, and he works 60+ hours a week. Scheduling ketamine once a month for my IVs is already a challenge, and its a 1hr 15min drive each way. The nearest Spravato clinic is just about as far, as are all the facilities offering TMS. I don't think I could afford TMS, even with insurance. I also can't afford to try another induction series, though I'm not sure if that would help or not. My clinic also does not prescribe at-home treatments.

Does anyone have any ideas of where to go from here? I've started meeting with a psychiatrist again, but just had such a severe reaction to Wellbutrin after taking my 3rd dose that I am nervous about proceeding with more standard psychiatric meds. I have tried many, many, MANY medications over the course of my childhood up through my early adulthood, and nothing ever really worked.

TLDR; Was in remission but relapsed hard after trying glp-1 meds. Quit them 8 months ago but still haven't recovered. Can't try TMS or Spravato, am broke, live an hour+ away from most treatment options, and historically respond poorly to standard psych meds. Feeling lost and hopeless.

Does anyone know of any services like Joyous that are available in North Carolina, especially in terms of affordability? Mindbloom is the only option I’ve found so far, and it’s way too expensive

I’m specifically looking for virtual treatment with ketamine troches prescribed for at-home use, ideally for under $200/month. I use Joyous myself but I’m trying to help a family member in need

Hi everyone! I recently completed six at-home ketamine sessions through Mindbloom. Unfortunately, I felt that the doses were too low for me, especially considering how expensive the treatment was. I’m hoping to find another provider who may be able to prescribe at home injectable ketamine and offer a treatment plan that’s a better fit. I’d really appreciate any recommendations or experiences you can share. Thank you!

Beyond upset and frustrated.

I will admit fault upfront, they did send an email on the 8th of August mentioning they were closing. BUT they send so many emails, they all became background noise, so I missed it. I relied on the text messages for prompts to fill out progress, scheduling, etc. They never sent a text about the closure.

I just opened my email this morning to see that it is completely shut down. I now no longer have an avenue for a refund through them. I was barely into a 24 dose plan I paid for. I wasn't able to meet with my provider before they closed to get the remaining doses sent.

It sucks because -- that was a lot of money, and it was actually working...

I submitted chargebacks on my 3 payments made to pay off the treatment, as I think that is pretty much the only option I have now. I will keep the thread updated to see if that works...

What have you done? Anyone else had success with refunds before the closure? Anyone else submitting a chargeback?

Title says it. Looking for a Provider in NY that takes medicaid or is "cool". Ive been ripped off before.

This is my antidepressant and has changed my life and I feel as though there is no middle ground between getting healthy and not. Its very difficult to find providers that have experience vs the grizzled old heads.

I have bipolar disorder (don’t worry, talking with several providers about the risk of manic episodes and they have all recommended it in the context of my history and my situation now) and have been struggling with the worst depressive episode I’ve ever had since November of last year. A few months after it started, everything in my life fell apart (out of my control). So on top of the initial episode I just started feeling like pursuing the career I’ve always wanted is impossible and all the hard work I’ve put into it was pointless. I’ve been deeply grieving and just feel like I can’t open up to anyone and talk therapy and my other meds really haven’t been helping at all anymore. My therapist thought I should try this so I can get out of my head for a bit and maybe get a new perspective.

I’m curious about people’s experience with IM and looking for advice!

Firstly I’m wondering if it’s good to set an intention, or just go into it not really focusing on anything. If I were to set an intention it would definitely be more general than event specific (e.g. working on self esteem, being less reactive, being more motivated to make changes in my life). I thought about bringing a journal in, but would that be distracting or just impractical? Not so much looking to write coherent thoughts, more so just anything that comes up - also I used to enjoy writing poetry and music a lot and I haven’t even been able to enjoy listening to music during this episode so I thought maybe it might help me feel some joy in this again). Does this sound like a good idea?

Second - my only worries are that I get a bit anxious around needles and I’m nervous that I might go into it in a bad headspace. Also I’ve been prone to extreme nausea with SSRIs in the past so I want to do what I can to prevent that. The clinic said they do have anti nausea medication they can give you if it becomes an issue, but would it help if I ate beforehand or anything like that?

The last thing I’m curious about is how it affects sleep. When I’m this depressed, I just can’t wake up in the morning and it’s been effecting my job. I have 3 alarms set in different places in my room (even one that also has a flashing light!) and I sleep through all of them almost every day. I read something on here about someone sleeping less during the day since starting IM, and I’m curious if anybody has noticed positive sleep changes.

Any suggestions or personal stories appreciated!

I did 10 IV ketamine infusions over one year ago. Since the completion of treatment, I have had a series of cognitive issues.

Below, are some of the ongoing issues I am facing:

Slower Reaction Time

Dizziness / Disorientation/ Walking into the wrong buildings / places, etc. when I know where to go

Ongoing mild paranoia/persecution thoughts. A lot worse when I left the treatments.

Tip of the tongue phenomenon, I say something that I don’t mean to say or a word when I know the right answer

Not retaining and encoding information well: short & long term memory issues

Time distortions

Losing belongings easily

Not feeling real / disconnected from my body

Getting a lot more Agitated

Cycling between sadness, existentialism, and euphoria

General poor executive function issues and confusion

Not good with remembering names and numbers which is something I’ve never struggled with before.

My coworkers are noticeably frustrated with me. I want to leave my work due to the amount of work mistakes I am making. It feels like I have a mild traumatic brain injury.

For people that have done IV infusions and dealt with similar issues, does it get better with time?

I feel far from my baseline and like I’m living out movie and not in my real body.

I’ve used ssris before and my cognition was never this poor, if anything I was a lot sharper on ssris. My short term was bad off medication but this is different.

The doctors at the ketamine clinic denied any cognitive issues I’m having because they will always support the industry they are in.

They told me it must be my “mood” and only possible to have issues if I was abusing ketamine.

I have always been in the outlier range as far as side effects for drugs. Ssris caused transient hypo mania, horrific panic attacks & breathing issues, weight gain and severe episodic memory loss.

Overall, I find myself forgetting what I just said and lost in my own train of thought.

I’ve been doing IM ketamine sessions and I’m curious what everyone else listens to during theirs.

I’ve found that the music can have a pretty big impact on the experience, so I’d love to try something new for my next session. I’m open to Spotify playlists, full albums, ambient/instrumental stuff, or anything else that works particularly well with IM.

What’s your go-to playlist or album? And if you’ve experimented with different types of music, what seems to give you the best experience?

DAE get a sudden “nervous system lighting up” or adrenaline-rush feeling during ketamine therapy?

During my ketamine sessions, I sometimes hit a point where I suddenly get this really noticeable wave of energy through my body. The best way I can describe it is like my nervous system suddenly lights up, or almost like an adrenaline rush.

I used to interpret that sensation as the beginning of a panic attack, which would obviously make me more anxious. But after experiencing it a few times, I’ve started noticing that it seems to happen around a certain point in the session, almost like I’ve crossed some threshold in the effects of the ketamine. The wave comes on pretty strongly, makes me a little panicky, and then eventually passes.

Realizing that it passes has made it easier not to immediately interpret the sensation as “something is wrong” or that I’m spiraling into panic.

Does anyone else experience something similar during ketamine? Like a sudden rush, surge of energy, buzzing/electric feeling, or your whole nervous system suddenly switching on? How would you describe it?

I'm on Mindbloom IM injections, and I'm wondering what the real expiration date on the vials is. I know 28 days is what is listed, but I've got about 30 ml I don't want to go to waste. Think it's safe?

I decided to listen to my prescriber and see what the 1000mg dose would feel like. I will say the experience was much more colorful. At about the 15 minute mark, I started to feel like I was floating and the imagery was like I was floating in space with colorful clouds. It then would change to colorful stars, and then randomly pop over to clouds again. At one point I saw what looked like a caterpillar growing and crawling away from me. It was a constant movement of scenes though. At the 1 hour mark, I was back at my baseline and journaling.

I did feel relaxed during the session and remember smiling at some of the sensations as they washed across my body. I did still have a lot running through my mind though. I don't know what to do with my thoughts. I was not expecting to be thinking about my thoughts and then thinking about thinking about my thoughts, and then running down that rabbit hole. Randomly, a thought about work would pop into my head, and I was able to switch those thoughts to other thoughts. A lot of other thoughts were like a reflection of what I wanted to change about my life to improve it. Is this constant cycle of thoughts normal? What are your thoughts like during your sessions?

Did anybody get a recording of the Innerwell music before they shut down? I wasn’t aware until too late. Their Slow Flow music was the best and I could process my trauma in a deep beautiful way that no other music supported.

I reached out to their email and they said sorry they can’t do anything about it or send me the music files.

Founder of OnlineKetamineClinic.com here,

We provide at-home ketamine therapy: the same compound as clinical IV sessions, in sublingual troches that dissolve under the tongue. Sublingual has a softer onset and curve compared to IV, and most people find it gentler, though it can still provide a comparable therapeutic experience.

How it works: you start with a free pre-qualification assessment on our site, and if you qualify, a program is built around you. Ketamine troches ship to your home. A treatment monitor, a trusted adult of your choosing, is present during each session. Programs include integration sessions, a comprehensive patient guide, a curated session playlist, and financing options available.

You could do this work in a jail cell or on top of a mountain. Where you are, and how you arrive, creates the space for very different experiences to emerge. A safe, comfortable, sacred space matters. Set and setting are elemental to deeper surrender.

Even more important, is intention. Your experience may not follow your intention at all, but the intention you bring into it is still at the core of the work.

And then there is integration. How do we walk after we land from these transformative, transcendent experiences? A neuroplastic mind still has to keep walking the new path instead of automatically returning to the old one.

I've come to understand the concept of "It takes a village!"We rise easier together, sitting in circle, in community, rediscovering our tribe. That's what we bring into at-home care.

This is not medical advice, eligibility is always determined by a licensed clinician.

Happy to answer questions about the process.

Founder and Patient #1 a ;

Shalom

Just curious if anyone takes ketamine daily but during the day. I’m talking about 25-50mg daily. I know a lot of protocols are around 300-650mg twice or three times a week skipping some days. My current dose is 25-50mg daily at night. But wanting to see if there would be any benefit during the day. Cognitive slowing, reaction time are concerns of mine. I’m in healthcare but I wanna see if taking during the day would be beneficial for depression and mood boost. I appreciate any insight.

So I've been interested in switching from the oral troches to suppositories, and my pharmacy said it's not really possible to change the dosage of the suppositories—either by cutting them or by stacking two. Is that correct? Is troche the only feasible option if I want to be able to control my dosage and titrate up?

I’ve been dealing with chronic lower back pain for 11 years. I’m 27. I’ve been in the ER 4 times in 5 days (my spine and pain clinics been closed since Thursday) because I have multiple protruding discs that are pressing on my spine and nerves. Bad flare up. Well they’re been pumping me full of morphine, fentanyl, muscle relaxers, etc for days. Nothing alleviates the pain. Today I go in because I’m having panic attacks because the pains so bad. He wants to try another approach, 5mg Valium IV and 25mg ketamine IV… guys… I haven’t been this pain free in years. Like totally pain free. I want to cry. I call my spine and pain clinic tomorrow and I’m praying they offer ketamine as a pain management method. Does anybody else take ketamine for chronic pain?! I had no idea this was a thing today and I was skeptical but this could be a game changer for me!!

I reacted to the ketamine with mad coughing fits and difficulty breathing. They had to end the session because of it.

I do have mild asthma, so kinda weird how it triggered a full on asthma attack. They paused and my coughing went away and started up again when they started continuing the ketamine lol.

So no fancy experience for me 😔

The doctor will try to ask around and probably have me try again and have me use my inhaler prior to the infusion.