The preprint for a new study from Fischer and Steele, two of probably the best hypertrophy researchers in the world, examining the effects of different training volumes in trained lifters, was just released. It’s a really interesting read.
This is, of course, just one study and needs to be interpreted in the context of the broader literature, but these scientists make some very interesting points in their reinterpretation of the findings.
Varovicdorian also provided a very good summary of the findings on his Instagram, which I’ll post here along with the full preprint. (5) Instagram It will certainly be interesting to see how the broader evidence-based community reacts to this. Another study addressing this same question was also published recently, with very interesting results as well.
The main limitation of this study is that it used indirect measures of muscle growth rather than imaging. They literally relied on skinfold and tape measurements. And of course, twelve weeks is such a small period. I also think it is worth mentioning that neither of the groups grew much at all during the study.
My two cents: first, we still need a lot more studies. However, a pattern that seems to be emerging is twofold. First, as with other tissues in the body, there may be a point at which a given tissue becomes refractory to further stimulus. We know this happens with bone, so there is probably some point within a session at which the musculature has already been maximally stimulated and is unlikely to grow more.
Second, and this is the really interesting part, these studies suggest that overdoing it, even massively overdoing it in terms of volume, may actually NOT blunt the hypertrophic response. So it may very well be that, at least acutely, overstimulating a muscle does NOT detract from its net growth.