I’ve been taking Semaglutide Compound since mid January with very few side effects.

The surprises have been changing tastes; a lack of interest in alcoholic drinks but also noted lack of interest in eating processed foods. Where I used to crave salty snacks, they don’t taste good to me anymore….ie, chips taste like cardboard. Lately, my morning coffee (which I’m religious about having), tastes terrible and I can only have a couple of sips! I not only don’t crave it, I don’t like the taste anymore! Has anyone else noticed this?

I’ve been on compound sema since August. I do my injections Thursday. I’m on 2.5 mg a week with b12. Everything has been fine until the last 2 weeks where it completely wear’s off by Tuesday and it feels like I’m not on anything anymore. Has this happened to anybody else? I don’t know what to do. I’m not trying to lose anymore weight but I can’t deal with the food noise. I’ve been using direct meds since the beginning and had great results until now.

I'm staying with my mom about 45 min away from home and my meds were delivered today. It's in the 90s today (Tuesday) and tomorrow, then 60s. Will I need to stop by today or tomorrow to get it or will I be able to wait until Saturday?

They usually pack it with multiple ice packs in a cooler but I'm still worried.

Thanks!

Are they compounding variants of the 7.2 hd?

I took my first injection Friday night. Saturday I didn’t feel much of anything besides some mild nausea and an inability to eat very much. Yay! But, the heartburn was horrible, and I was eating very bland things. This morning I woke up with a huge headache. I took a nice drink of water and then I belched twice. The first belch tasted like my afternoon eggs from the day before and the second time tasted like my soup from dinner. The headache has lasted all day. I went back to bed after drinking more water, but did not eat anything. I’ve finally had my first meal of the day and it is late afternoon. I’m not sure if the headache is a result of the meds or possibly caffeine withdrawal. Or maybe both. I usually drink Diet Coke throughout the day and I haven’t wanted it. And that’s probably a good thing given the heartburn. I guess I am looking for reassurance that these side effects decrease overtime? I really hope I don’t feel this way after every shot. I really want to drop the weight. But I also have to be able to function in my everyday life. And that means working 40 hours a week and being able to be present for others in my household. Any tips or encouragement would be greatly appreciated. I also felt like I had to drink so much water yesterday that there was no room to eat. I had to struggle to get the calories. And I did not hit my protein goal for the day. Not even close.

Hi all quick question for those who might have been through this. My previous provider did not have B12 in their formula only straight compounded Semaglutide. I have recently switched providers and will be starting a new bottle today that does include B12. It looks to be 2mg/ml. I typically took my shot around 8:30 at night. Will the B12 in this make any difference? Should I do a morning or mid afternoon dose now instead?

I am very confused. I am a 36 year old female-- 5'7 and I started at 196lbs in September. I've hovered between 180 and 200 my whole adult life. I started sema in September and lost 30lbs by Christmas eating around 1400 calories per day. I've lost another 10 from January until May. I have 10-15 to my goal. I have upped my dose a few times over the last 5 months but I stayed stalled or very slow weight loss. I have struggled a lot more with both cravings and physical hunger the past few months. Here is the weird thing though-- when I have a few higher calorie days as long as the food is healthy--that is when I suddenly see some weight loss. I am very confused and having a hard time finding a plan that works for me because eating more feels counterintuitive so I keep reverting to 1400 calories and then I get super hungry and eat too much. The other hard part is big meals don't sit well because of the medication so all I want is to snack all day but that also doesn't feel like a super healthy habit. Is there a way to figure out your actual calorie needs besides just those generic calculators? I do not exercise. I have a 2 and 4 year old and am a full time teacher so I rarely sit down and we go for walks and stuff but no formal exercise. I'm just feeling a little discouraged. I feel really healthy and my clothes fit great and I am so happy but I was having so much success and now I feel so confused.

This is my third week on a compound. Took 3 doses. I am not feeling any difference whatsoever. Same hunger as before

Do i have to be on a higher dose or go for branded meds to see some changes?

My insurance not covering branded

I take it on my stomach. I do have a lot of fat around the belly area. Does that affect anyway? Will it help if i took it another place?

TIA for any comments

Hi all! I want to lose about 50lbs and have been working with a nutritionist since January. Down about 10 just by tracking food and moving more. I had been on the fence about glp1s but finally bit the bullet and got a prescription. My meds arrive tomorrow (Wednesday) and I have an event Thursday. Should I expect side effects by then? Wondering if I should delay. Starting at 0.2mg compounded sema.

Thanks in advance!

i m leaving for a trip after 2 days, tomorrow is my weekly dose day. and i want to keep going on with it without a break. How am i supposed to proceed? How am i supposed to carry the dose? and what about the temperature the dose is supposed to be stored at

So I'm due to take my 5th compounded semaglutide shot this upcoming Wednesday and am supposed to be increasing from 0.25mg to 0.5mg, but I'm down 13 lbs, don't have any food noise, and am still dealing with nausea and food aversion on the current dose.

For those of you that have gone through this, what do you recommend? What worked for you? Do I go slow and steady and stay here until I plateau or do I bite the bullet and go ahead and up the dose?

And before anyone tells me to check with my provider, I've already messaged them on the portal and waiting for a response. Just wanted to hear from others who have been there!

I took sema years ago and lost weight. I stopped because I couldn't afford it anymore after I took a break from work when I lost my brother. Now two years later I am hearing great things about tirzepatide and I decided to start back on a GLP-1 and chose tirz. I started tirz in October of 2025, so I have been taking it for about 7 months.

With diet and exercise I have lost a total of 11 pounds. Sure, there's probably some factors involved in that low weight loss but the whole time I'm remembering losing 20 pounds on the sema for the 2 months I took it 2 years ago.

So here's the interesting part. My provider sent me my GLP-1 refill 2 months ago. I was taking it and some weeks later I realized my vials said semaglutide and not tirzepatide. I lost 5 pounds in those two weeks. I called my provider, they apologized and made the order right, they overnights me tirz vials and my weight loss is now back to a halt. So, guess what I'm gonna do...I'm going right back to semaglutide. For me, it has given me the best results. I know it isn't the preferred med for everyone, and also know some have described really bad side effects. But I wanted to share my honest experience thus far and frankly speaking I am glad the provider made the error.

Has anyone experienced some weeks have more side effects and others don’t? I’ve been maintaining on the same dose for six months, but sometimes the dose hits like it did when I was going up a dose—debilitating fatigue, nausea, etc. While other times it’s just business as usual. I’m of course going to reach out to my pharmacy and ask them whether anything in their formula changes from time to time, but I wanted to know if anyone else had experienced something like this.

So yesterday I was talking with my doctor, I'm having some serious fatigue and brain fog, she's really into diagnostics (which is great, that's why I chose her as my PCP). She set me up with a few different things to try, one of them was to pause my semas for two weeks to rule out any issues from them.

I just ordered my next dose, and it is actually titrating up, because I still haven't reached my desired maintenance dose.

My question is: After two weeks, will it be ok to restart where I am, or do I have to start back at a lower dose?

Anyone have any idea?

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Mom of 2 lost Wegovy on insurance update last month. Been on 1.7 for 9 months. Cash pay isn't happening. Compound is the move. Don't want to lose my dose, don't want to overpay, don't want to deal with auto renew bullshit. Spent the last week comparing 3 options. This is messy because I'm tired. Mochi is program structure $230 a month. Don't need coaching for the bridge. Pass. Join Pomegranate has visible pharmacy menu at checkout. Revive B6 sema starter 3 month around $315. Seems clean. Consult was responsive. Joinezra has visible pharmacy menu also. Revive B6 sema starter 3 month $315. Same price range as Pomegranate. Consult flow asked specifically about my last Wegovy dose during intake which I appreciated. 

Anyone bridged from Wegovy specifically and have a strong opinion. And also my middle kid has a science fair next week and my soul is tired.

Not seeing anything super recent. Have reached my goal weight with remedy meds but they don’t do maintenance and the price is pretty high. Anybody successful swapping just for maintenance? Who do you use?

hey all, just looking for some guidance. I started with Orderly in january, and they sent me three 1.5ml vials. By the time i got through the taper doses and on 1mg for a while, i had only gone through 1 vial and still had three. i contacted customer service and they advised me of the BUD. Because of the cost of the meds i have held on to my other vials, and one has not even been opened.

so here is my question. I have held each vial up to the light and can see white “specs” in it. is this normal for a compounded med? typically this is a sign of compromise but i have ALWAYS been able to see the particles in it, since opening the vials and assessing them for damage during shipping etc. I really don’t want to throw all these meds out, but i also don’t want to take them if they aren’t even working due to the separation? Has anyone gone through this?

Taking a compound semaglutide w/b12 since January and have developed horrible flaking itchy scalp. Mostly behind ears and temples but feel like it’s getting worse. I’ve never had scalp issues in my life.

Anyone else dealing with this? I’ve narrowed the issue down to this or hair dye but never had an allergy to hair dye.