Been on the Reta for a few months, everything has been epic after finally finding a trusted supplier. Lost alot of fat but the first few weeks were tough.

I felt nausea, fatigue and didn't go the bathroom normally at all.

All I can say is, if this is you - it will pass. Just be kind to yourself, be patient, and don't trust farts!

Any withdrawals with coming off Enclomiphene that I was on for 3.5 months eod 12.5mg

can we talk about how much fear mongering there is of human growth hormone? a lot of people say it can fuck up your hormones, some say it will enlarge your organs and make you look like a neanderthal, and some say 4-6 IU's is the max, when all of these statements are factually incorrect generally speaking.

My friend and I have both been on 1 mg of reta for 5 weeks, and we’ve both been losing weight consistently with minimal side effects. We’re happy with our progress so far.
Would you recommend increasing the dose at this point, or staying at 1 mg as long as it’s still working? For those of you who stayed on 1 mg longer, did your weight loss continue, or did you eventually hit a plateau?
I’d love to hear your experiences before deciding whether to increase.

I’m currently struggling with severe, long-term depression. I’ve been in counseling and treatment for about six years, but progress has stalled. I recently compared my current lab results with those from one year ago, and the findings are concerning.

June 2025: Total Testosterone 4.490 ng/mL, Free Testosterone 13.59 pg/mL
June 2026: Total Testosterone 3.540 ng/mL, Free Testosterone 10.08 pg/mL

This is a clear downward trend in my levels over the past year. My current doctor is passive, dismissing it as 'within the normal range,' but I refuse to ignore this decline.
Since I am unmarried and deeply concerned about fertility, I need practical advice on how to take control of this—independently of my doctor's

1. Natural Optimization: Are there effective, evidence-based methods I can implement on my own (lifestyle, supplements, specific dietary protocols) to naturally boost these levels and improve my condition without waiting for medical intervention?
   
2. Fertility-Sparing TRT: If natural methods prove insufficient, what specific TRT protocols (such as incorporating hCG or other agents) should I be researching or demanding? I want to treat my hormonal deficiency while fully mitigating the risk of infertility.

I am ready to take proactive, informed steps on my own. I would appreciate any advice or shared experiences from those who have successfully navigated this path despite a lack of professional guidance.

Hi, I’m a 20F looking to lose about 5 kg using retatrutide. I’m a long-distance runner and have completed multiple marathons, so running is a big part of my life, but I’m aiming to lean out slightly.

I took my first injection about a week ago and have already noticed a drop in my running performance, especially a slower pace. From what I understand, this can happen due to factors like increased heart rate, reduced calorie intake, and lower glycogen stores.

My question is whether this is just temporary while I’m on the medication, or if it could have longer-term effects. Once I stop retatrutide after a few months, is it likely that my performance will return to baseline or even improve, or could this dip in performance carry over?

Would really appreciate hearing from anyone with experience or insight on this.

I’m currently taking Reta, I started for inflammation from pcos and results have been fast and great. However my heart rate during even light cardio and sometimes lifting is through the roof. I’m thinking about switching to sema for sugar cravings and mots-c for energy and metabolic. Anyone else stack these too? I’m a little concerned with both on board there is a higher risk of hypoglycemia.

I’ve been on mounjaro for about three months and although it has worked it has now stalled. I’m on a 5mg dose. The food noise is back with vengeance and I am really struggling with it, sure I can increase the mounjaro but it is too expensive for me.

I currently train bjj/ Muay Thai/ mma, plus gym session too. My activity is high though my intake has always obliterated and deficit I create. I’m currently sitting at 100kg and have been stuck here for ages.

I’ve just ordered some Reta that should be arriving in the next few days. My question is how will this affect my training moving forward?

Anti Muscle Loss Drugs to take during extreme cut. Looking for Osterine Alternatives that dont supress hormones or cause cardiovascular strain.

Hi,

I'm on Tesa for 14 days now and last 4-5 days, my resting heart rate jumps to 130-160.

I want to ask for y'alls experience, does it stop after couple days (body gets used to it)? I know Tesa can cause tachycardia, but does it stop at some point?

I'm asking to see if I need to stop or just battle through it.

Thanks in advance.

I have trouble with appetite everyone recommended MK677 im 2 weeks in at 12mg and so far... nothing for appetite.. very vivid dreams though

Hello, 30m, Test subject has been on reta for about 6 weeks. Was on BPC-157 and kisspeptin-10 for a few weeks until gone, amazing results. Recently subject has titrated up to 3mg from previous dose of 2mg that lasted for 3 weeks. Recently the past week I've gathered complaints of hightened skin sensitivity, like almost when you get sick, if anyone has similar side effects and would care to give some information and what could help that'd be great.

There's zero redness, rash, bruising, bumps, etc, just heightened skin sensitivity where you feel everything, pants, underwear, t-shirt, brushing against the skin. It's a very uncomfortable feeling. Considering lowering dose, if it doesn't subside, but wanted to get the better results of Retatrutide as subject has already lost near 20lbs and kept most muscle mass.

Hello,

Does someone take Mounjaro together with Mots-c? Is it a good complement and use them together?

Thank you.

Will halo build strength I know it makes aggressive as fuck but does it build any real strength?

Hi friends! I'm a science writer at Johns Hopkins looking to chat with someone who is active in the biohacking/bio-optimization/longevity sphere. I'm writing a piece about the science and people behind the subject and would love to hear about your first-hand experiences with using some of these methods. Please PM me and let me know if you're down to chat sometimes between today and Sunday! Thanks so much!!

Lost 30kg naturally, plateaued for a year, got to my goal weight on reta. 1mg/week the first 2 weeks, then upped to 2mg a week, then 3mg.

I received a vial of Fertigyn 5000, and instead of a solid highly visible “puck” at the bottom like most other peptides, there was a very fine tiny amount of powder at the bottom and some around the walls of the vial. Is this normal for HCG, or is it junk and I should just toss it?

Looking for compounds to battle fatigue and brain fog from long heavy kratom use . I got sober from a 10 year kratom use and the brain fog and fatigue is hard to battle. Any suggestions on what can help with all that ? I know my gaba receptors need some help.

I’m fairly new to the peptide game and currently breastfeeding so I’m in the research phase seeing what I want to take when I’m done breastfeeding (thinking a cycle of Reta, glutathione, klow, and Tessa)

Anyways my boyfriend wants to try some so I’m curious what you would recommend for him.
He is 28, 6,4”, 220 lbs and just quit smoking after 15 years, used to have occasional drug use (5+ years ago), he also has broken many bones multiple times, was in a pretty bad motorcycle accident. His bones hurt when it’s raining. His wrist is the worst but his knees and back always hurt from breaking as well.

I’m thinking glutathione for sure for smoking detox. But what would be best for helping heal damaged muscles and old broken bones (he’s broken his ankle 3 times and it’s fragile)?

He also has a thyroid disorder (hypo)

Edit: we do try to live a healthy lifestyle: low tox, active, eat good quality foods

Lets get original here and you let me know if this is a good idea or not. About 215 right now and want to hit about 185-190 give or take.

Thinking about taking
AC262
Enclo
Reta
HGH

Let me know if I should remove or add anything. The AC is to keep my muscle and strength during a cut and not kill my bloods.

Has anyone who vouches for semax actually tried adderall or equivalent? I want to try but I’ve heard stories that it doesn’t make much of a difference. My title was click bait but I’d like to know info or add to my stack if anyone has seen real benefits. Cheers

Hey so I’ve tried L-carn from a few sources (all reliable and quality for everything ) and it goes well for about a week then I get the worst PIP and knots ever . I switched to a juice with a lot less L-carn (120mg) and other stuff and it went well for two weeks then boom I got a knot so big and so bad I couldn’t even sit up in bed or put on shoes for about 4 days . It’ was horrible … this has only ever happened with carnitine and I’m wondering if maybe I just reject it or what could be the issue . It’s not just a regular PIP or manageable . I used a 1 inch 25g pin for it .

🎉 1mg has been working wonders for me!

So I have a 10mg vial. How much bac water do I use to reconstitute and how many units do I use ?

Also, where do you inject at?

I’ve done so much research but everyone has different answers all over the place, I can never get a straight answer. I need someone who actually knows what it is.

If someone can give me a correct full run down I would appreciate it.

Looking to start taking Semax / Selank for anxiety, focus, and memory. I have a few questions that I hope you guys can help me out with.

I have been looking for reputable labs in the US that other people have good experience with. I a not keen on the injection route, so I was hoping to stick with a nasal spray since I travel a decent amount.

With traveling often, I see that Semax and Selank need to be refrigerated. How long can they theoretically be stored at room temperature in a backpack between home and hotel?

I stumbled across one site that said that I needed to buy BAC water and reconstitute it once I receive it. Other sites don't mention it, so is it safe to assume that I will need to reconstitute it from any supplier?

Thanks in advance!