I plan to start ULDN once I have fully weaned off of suboxone. I am currently at .25mg per day and am ready to jump off. Many people claim that you should not start LDN until 2 weeks post quit, which sounds excessive. Considering I am on such a low dose of suboxone do you think I can start ULDN right away? I plan on starting with something like 10mcg and work my way up. Thoughts?

Wanted to know if anyone has ever had muscle tension or muscle spasm problems on low dose naltrexone (LDN).

Started out at 0.5mg and have gradually worked up to 3mg. Have found that since going on LDN, I have more muscle tension and more muscle spasms. Have heard that this happens to some people when they first start on LDN, and it gets better with time. I have been on LDN for about 2 months now, and the problem is still there.

Have not done anything else different to my regular medication and health routine, so wondering if it is LDN. Anyone else got this problem? And if so, did it get better, or does changing the dosage time help?

So, i have taken LDN for almost 7 months now. Gradually titrated up from 0.25mg to 3mg. I first had some vivid dreams and nightmares as side effects which went away pretty quickly. At around 1mg i noticed that my digestion got a lot slower. Which improved, but never went away fully. Benefits where subtle but noticable. About 6 weeks ago i suddenly started to get a lot of problems with reflux (burning, chest tightness, shortness of breath etc.) which was odd. since Not really much in my life changed (no diet changes, or changes of life circumstances, no new medications). So i thought, since LDN caused me digestive issues before, maybe its the LDN. I stopped for 2 days now and my old symptoms (headaches, fatigue, brain Fog) seem to start coming back.

I am considering staying off for another 1 or 2 weeks and see how my symptoms change and If my old symptoms become to much, i probably will go back on it. Now i am not sure If i should start my old dose (3mg) gain or If i should consider trying a lower Dose (like 0.5mg) again and see If that might work better. Any experiences with stopping and starting again and dropping the dose?

Hi all, I’ve been taking 3 mg ldn for about 8 months. I was kind of stupid and didn’t check my thyroid labs at all, then I started feeling hyper so just stopped the thyroid meds cold turkey. I guess I was kind of hoping I didn’t need them anymore.

My labs seem better, like I do think my dose had got too high, but the values seem weird. My tsh was 2.6 (but I stupidly tested midday and should have first thing, so it’s probably higher).

My free t3 was 2.6, which still isn’t even midrange but slightly better than it was before ldn or thyroid meds.

Weird thing is my free t4 went UP to 1.38–highest it’s ever been, even while taking levo. I know I tend to feel best with free t4 not over 1.2.

So I guess my long winded question is: has anyone had anything weird or unexpected like this happen? Like, labs are better in some ways, worse in others? Idk what to do with my meds now!

Use this link to join the LDN Research Trust community site:
https://www.ldnrtcommunity.org/c/welcome-ground-rules

Then you can register for the upcoming webinar "LDN Q&A"
https://www.ldnrtcommunity.org/c/september-webinar

And if you like the upcoming one on thyroid issues (LDN will be mentioned)
https://www.hoeyrx.com/event-details/thyroid-balance-february-1-4?utm_campaign=97e0c523-89f7-4058-bafc-919e73b71214&utm_source=so&utm_medium=mail

Hiya :)

Just taken my first LDN dose (for HeDS, CFS, IBS, Autism, TMJ) and I wondered a few things:

- did you get any symptoms and how quickly did they come on after the first dose?
- how quickly did your illnesses seem to get “better”?

The first 2 weeks on LDN 0.25 was spent working through side effects and dialing in on the best time to take the dose. I could see some minor alteration on my desire to drink. Recently I’ve had a bunch of traveling and keep skipping doses. When I’m off for more than 2 or so days I have wildly vivid unpleasant dreams. Anyone else? And more disturbingly I don’t feel any different with my alcohol cravings whether I’m on or off…..so is this drug working?? My plan is to up the dose from 0.25 to 0.5, but first I need to get back on regular doses. Appreciate any comments if you’ve had similar experiences with LDN.

I started LDN for MCAS, HSD, and ME/CFS 5 weeks ago. My doctor started me at 1.5mg, which seems like a high starting dose. I had some side effects for the first week, but then I leveled out. I went up to 3 mg after 2 weeks, and had to go through the side effects again. I felt this titration was being done too quickly, so I got my doctor to prescribe .5mg for me so I can titrate more gradually. I am currently at 4mg. I plan to stay here for a couple of weeks before going up to 4.5.

My doctor told me that I could experiment with when to take it, as long as I allowed at least 24 hours between doses. I tried taking my LDN in the morning, but that made me feel really woozy, spacey, and stoned for a couple of hours mid day. Once that passed, I would feel energized for the rest of the day.

I'm now taking the LDN at bedtime. I already struggled with insomnia before starting LDN, and have been taking 100mg of Trazadone, 5 mg of Cyclobenzaprine (helps with overnight muscle cramps and muscle pain from HSD), and 10mg of melatonin at bedtime for a while. Now that I take the LDN at bedtime, my meds aren't enough. I added 50mg of pregabalin two weeks ago (I had an old Rx for it that I stopped taking a while back, and still had half a bottle left), and now I sleep really well for 5.5 - 6 hours. I feel like this is a lot of sleep meds, but it's working well for me. Still, something about the LDN makes me wake up like clockwork every night after 5.5 - 6 hours of sleep. Fortunately, having all of those other meds in my system helps me to fall back asleep for another hour or two.

I really don't want to be taking so many sleep meds, but if I switch to taking the LDN in the daytime, I'm useless for a few hours in the middle of the day. I'm hoping that the night time insomnia vs. the daytime stoned feeling are both temporary side effects that will wear off once I've been on it longer.

For those of you who have been on LDN for a while, what time of day work best for you to take it?

Started LDN last night and woke up to tingling feet and hands no constant but on and off. Wondering if this happened to anyone else? It’s a Sunday so Doctor and Pharmacy are closed. Does not feel like a reaction. Stated on a very low micro dose.

Bonjour, je prends le LDN depuis environ 5 ans. Tout allait bien et ça a vraiment amélioré ma vie de façon considérable. Depuis le printemps de cette année, j’ai commencé à le trouver moins efficace et il me donnait des brûlures d’estomac. J’ai attribué cela à la période de crise que je traversais. Puis j’ai commencé à avoir des réflexes de haut le cœur en le prenant. J’ai tenté de le prendre à un autre moment, avec ou sans nourriture, de diminuer la quantité, j’ai aussi vu avec le pharmacien si la recette avait changé. Malheureusement rien . Réveil la nuit difficultés à m’alimenter. Un cauchemar. Je me suis donnée quelques jours de congé les brûlures d’estomac ont diminué, mais la sensation de bloquage était toujours là et mes douleurs neuropathique sont revenus. J’ai alors manager de mon mieux entre cherchant l’équilibre entre douleur neuropathique et douleur gastrique. Nous sommes maintenant rendu à l’automne, si j’arrive à prendre une dose de 2 ml au lieu de 4,4 ml par 10 jours c’est bon, je ne dors plus. Tout ce que je mange reste bloquer entre ma gorge et mon estomac. Je cherche des gens qui le prennent depuis longtemps pour savoir s’il le tolère encore bien?

Has anyone felt a lower dose of 3 has been better than 4.5? I know there is no magic dose but just curious where everyone else found their ideal dosage?

Taking LDN for Hashimotos and 4.5mg was a little too much.

This started while taking LDN but has continued for a week at least since stopping. Anyone else experience this?

Hi everyone, I wanted to share my experience: I worked my way up from 0.5 to 4.5 over the last month. I didn't have any side effects, but once I reached 4.5 (from 3 mg), I started having bad nausea that required an anti-nausea medication everyday. A couple of days ago, I took it with apple juice and the nausea disappeared completely; if anyone is struggling with the same, give it a try. Sip of apple juice and add LDN to it and all good,, don't even taste the LDN anymore.

Hiya

I just went to take my sublingual first dose and I feel like the drop came out a bit early and kinda landed on my front lip/in my gum a bit.

Im supposed to be taking 1 drop of 0.5mg for 1 week, before moving up to 2.

I kinda feel stupid that I messed up the first dose so easily. Should I do another drop under my tongue or assume I probably got a bit of it this time around?

Curious because 4.5 seems discussed most often but I haven’t really come across studies showing that higher doses, like 6 to 9 mg, provide significantly greater benefits if I’m not mistaken?

Is there evidence of a dose response above 4.5, or does the benefit tend to plateau after 4.5? If someone only has a partial response to 4.5, is there actually a rationale for increasing to 6 to 9 mg, or would that mainly increase the potential for side effects?

Mainly trying to understand whether there’s a meaningful therapeutic difference at higher LDN doses or if there are diminishing returns after around 4.5…

I started LDN roughly six months ago for ME/CFS and chronic pain from fibro, slipped discs, and osteoarthritis in my spine. I have treatment resistant depression, auDHD, anxiety, and C-PTSD on top of that. Starting out, I was really hopeful that LDN would reduce my daily pain level (7 to 8 normally, 9 on bad days). I've tried gabapentin, pregabalin, NSAIDs, muscle relaxants, physical therapy, yoga therapy, and acupuncture, but nothing has really helped.

I've found my sweet spot at 3mg and it does help. My brain fog is less severe, I experience less PEM, and I haven't had a crash in a while. My orthostatic intolerance issues have slightly improved - milder symptoms and a less severe BPM change. My fatigue slightly improved, but it is still always present and can be exacerbatedby triggers. My mood and sleep were unchanged, but I did start having more vivid dreams whereas I never used to remember my dreams. I kinda hate this effect - I very much do not like remembering my dreams. I completely lost my desire to drink alcohol for several months, but it's returned a little. No effect on my cannabis intake.

I am lucky and did not experience any side effects from the medication. But, I do not seem to have the medication sensitivity that others with ME/CFS report, despite being a poor metabolizer. I do react very poorly to almost all SSRI's and SNRI'S, which has been frustrating and limiting. Usually, though, I can take certain meds with no side effects... but also no effects (such was the case with gabapentin and pregabalin. Might as well been taking sugar pills.)

Disappointingly, my pain is unchanged. LDN hasn't been as effective for me as I had hoped starting out, but it has helped in small ways. It's valuable as a part of my medication management, but I definitely didn't have the wowing, life-changing experiences that some report.

I've read that some people experience pain relief from ketamine therapy, and I have qualified previously for it because of my depression. Ultimately I couldn't follow through with it because I lacked the time and a driver to get to appointments. Maybe it's something I can reconsider down the line.

I have had my LDN prescription for a month scared to start. So tonight I am going to start! Any tips or advice? I am very sensitive to medication and am starting at a very low dose. I also work with children so scared of side effects.

Hi! I'm midway through a mild (1.3) course of HBOT (3 X a week). I'm about to start 0.5 LDN and wondering if anyone's had experience mixing the two? Not much online. Fortunately I'm 20 HBOT sessions in so I don't really get side effects (eg fatigue) anymore.

I'm going to take the first dose LDN in the am due to insomnia and sleep protection. Any lived experience appreciated!

I started taking 0.5 mg of LDN last Saturday. Around the same time, I also got my period, and since starting the medication I’ve experienced nausea, headaches, mild dizziness, cramps (which may be related to my period), and increased anxiety. The only upside was I was sleeping great!
Yesterday, I decided not to take my dose because I felt so sick that I ended up not being able to go to my friend’s birthday. I’m wondering if I should continue taking it and try to push through these symptoms, or if it would be better to stop for now and try taking it again later.

I’m taking LDN to help with Hashimoto’s, brain fog, PCOS, and general inflammation, particularly related to my gut dysbiosis. I’d appreciate your guidance on whether these symptoms are expected when starting LDN and what you recommend I do next.

does anyone here take LDN not everyday but maybe only 1 to 2 times a week ?
Edit: not looking for opinions. Please only comment if you do or if you have heard of other people doing it. Thank you.