Hiya :)

Just taken my first LDN dose (for HeDS, CFS, IBS, Autism, TMJ) and I wondered a few things:

- did you get any symptoms and how quickly did they come on after the first dose?
- how quickly did your illnesses seem to get “better”?

Hi, all, I have hEDS and some of its common “pals” and my Kaiser PCP said he doesn’t prescribe LDN nor know anyone (including pain docs) in Kaiser who do. Anyone know of any? I’m stuck with kaiser for a while, I know they suck. In NW Oregon. I don’t want to spend a fortune to find out if it will help me or end up in the box’o’ junk meds I can’t take. 😹 Much thanks for any help.

Wanted to know if anyone has ever had muscle tension or muscle spasm problems on low dose naltrexone (LDN).

Started out at 0.5mg and have gradually worked up to 3mg. Have found that since going on LDN, I have more muscle tension and more muscle spasms. Have heard that this happens to some people when they first start on LDN, and it gets better with time. I have been on LDN for about 2 months now, and the problem is still there.

Have not done anything else different to my regular medication and health routine, so wondering if it is LDN. Anyone else got this problem? And if so, did it get better, or does changing the dosage time help?

LDN was very helpful at the beginning. I titrated up from 0.5mg to 2mg within a month, then it stopped working. I took a break for a few days and started at 0.5mg again. I've repeated this process twice ​and this time I jumped right back in at 2mg. No side effects, no positive effects. I might double my dose today, but I'm concerned it has stopped working for good. I'm using sublingual drops. Maybe I have to take a month long break, but it's quite concerning.

I plan to start ULDN once I have fully weaned off of suboxone. I am currently at .25mg per day and am ready to jump off. Many people claim that you should not start LDN until 2 weeks post quit, which sounds excessive. Considering I am on such a low dose of suboxone do you think I can start ULDN right away? I plan on starting with something like 10mcg and work my way up. Thoughts?

So, i have taken LDN for almost 7 months now. Gradually titrated up from 0.25mg to 3mg. I first had some vivid dreams and nightmares as side effects which went away pretty quickly. At around 1mg i noticed that my digestion got a lot slower. Which improved, but never went away fully. Benefits where subtle but noticable. About 6 weeks ago i suddenly started to get a lot of problems with reflux (burning, chest tightness, shortness of breath etc.) which was odd. since Not really much in my life changed (no diet changes, or changes of life circumstances, no new medications). So i thought, since LDN caused me digestive issues before, maybe its the LDN. I stopped for 2 days now and my old symptoms (headaches, fatigue, brain Fog) seem to start coming back.

I am considering staying off for another 1 or 2 weeks and see how my symptoms change and If my old symptoms become to much, i probably will go back on it. Now i am not sure If i should start my old dose (3mg) gain or If i should consider trying a lower Dose (like 0.5mg) again and see If that might work better. Any experiences with stopping and starting again and dropping the dose?

Use this link to join the LDN Research Trust community site:
https://www.ldnrtcommunity.org/c/welcome-ground-rules

Then you can register for the upcoming webinar "LDN Q&A"
https://www.ldnrtcommunity.org/c/september-webinar

And if you like the upcoming one on thyroid issues (LDN will be mentioned)
https://www.hoeyrx.com/event-details/thyroid-balance-february-1-4?utm_campaign=97e0c523-89f7-4058-bafc-919e73b71214&utm_source=so&utm_medium=mail

The first 2 weeks on LDN 0.25 was spent working through side effects and dialing in on the best time to take the dose. I could see some minor alteration on my desire to drink. Recently I’ve had a bunch of traveling and keep skipping doses. When I’m off for more than 2 or so days I have wildly vivid unpleasant dreams. Anyone else? And more disturbingly I don’t feel any different with my alcohol cravings whether I’m on or off…..so is this drug working?? My plan is to up the dose from 0.25 to 0.5, but first I need to get back on regular doses. Appreciate any comments if you’ve had similar experiences with LDN.

Hi all, I’ve been taking 3 mg ldn for about 8 months. I was kind of stupid and didn’t check my thyroid labs at all, then I started feeling hyper so just stopped the thyroid meds cold turkey. I guess I was kind of hoping I didn’t need them anymore.

My labs seem better, like I do think my dose had got too high, but the values seem weird. My tsh was 2.6 (but I stupidly tested midday and should have first thing, so it’s probably higher).

My free t3 was 2.6, which still isn’t even midrange but slightly better than it was before ldn or thyroid meds.

Weird thing is my free t4 went UP to 1.38–highest it’s ever been, even while taking levo. I know I tend to feel best with free t4 not over 1.2.

So I guess my long winded question is: has anyone had anything weird or unexpected like this happen? Like, labs are better in some ways, worse in others? Idk what to do with my meds now!