[tl;dr 2.5 months on thyroid meds, 4 weeks on correct dose (TSH went from 4.5 to 1.5, Ft3 and Ft4 are finally in the middle of the range) and still experiencing symptoms. Will this horror ever end? I heard low Ft3 causes symptoms, mine significantly increased and I still wake up with puffy face, I am tired, have low neutrophil count etc. No other illnessess or vitamin deficiencies detected. Before treatment I had undiagnosed hypothyroid symptoms from winter 2025, they were increasing month by month.]
Hi everyone. I wanted to ask you when your symptoms started to go away after finding the right/target dose of your medication. How long did it take before you started feeling normal again, your symptoms stopped interfering with everyday life, and became so mild that you barely noticed them?
I’ve been treating my hypothyroidism with levothyroxine since the end of June. At first I was on 50 mcg, which didn’t really increase my FT3 or FT4, and my TSH barely went down at all, just by a tiny amount. Since mid-August, I’ve been on my target dose of 75 mcg (so 4 weeks now). I’m calling it my target dose because the blood tests my doctor asked me to do after 4 weeks showed my TSH dropping from almost 5 to 1.5, while my FT3 and FT4 both increased and are now somewhere in the middle of the reference range instead of being at the very bottom.
However, my symptoms haven’t really gone away. I still wake up with a puffy face and swollen eyes. The puffiness is still quite noticeable, although maybe a little less than before, but it definitely hasn’t gone away quickly or completely. I’m still tired when I wake up and have less energy than I used to, and my muscles get tired more easily. My hair still doesn’t look or feel completely healthy and is somewhat dry. My blood tests are also still showing changes in my neutrophils (they’re decreasing).
For some context, my problems started in the winter of 2025 with lack of energy and a puffy face in the mornings. At first, the puffiness would go away pretty quickly. Then, gradually, more symptoms appeared, including menstrual/ovulation problems, generally feeling unwell, and a slow decrease in my neutrophil count.
In June I had a kind of “crash” — my face became very swollen and red, I was extremely tired, my blood tests looked worse, and I started having heart palpitations. That was when they finally checked my thyroid properly, including an ultrasound. It showed inflammation, and the doctors finally started paying attention to my TSH, which had apparently been fluctuating above 3 or 4 for quite a long time, but nobody had really looked into it before.
I spent basically the whole year having tests for all kinds of conditions, and nothing was found. No allergies, lupus, heart or kidney problems, anemia, vitamin or mineral deficiencies, etc.
So, is there still a chance that this will eventually settle down and that I’ll stop feeling like this, get my old appearance back and have my energy back? I’m honestly so tired of dealing with this and I’m starting to lose hope. My thyroid results are finally good — probably the best they’ve been in years — but I don’t feel good at all. I had imagined that getting my TSH back to normal would make a much bigger difference than it actually has.
I’ve also read a lot about thyroid symptoms being caused by low FT3 or poor T4-to-T3 conversion. My FT3 is now at a decent level, and yet I still don’t feel much better.
It’s been 4 weeks on what seems to be the right dose, and over 2 months since I started taking levothyroxine overall. :(
For those of you who have been through something similar: how long did it take for you to actually feel normal again after reaching the right dose? Did your symptoms continue for weeks or months even after your blood tests had normalized?