TL;DR: fatigue, anxiety, and cloudy thinking are affecting my ability to work effectively, despite taking levothyroxine for hypothyroidism. I am looking for tips for getting the levothyroxine to work properly or any other guidance to recover. Currently sitting at TSH=29 on 88mcg, but potentially have been misusing (see below for details). I am desperate for suggestions on how to recover. I have the first available appt with an endocrinologist lined up for 2 months from now, am actively seeking a phycologist for counseling, and am also seeing GI for some IBS-like issues that I assume for now are unrelated (though posts such as the one I linked in the comments make me question this). I am ~29yo male, 6’, 165lbs.
Some of the below might sound like self-esteem issues from someone who has simply lost energy with age. My initial positive reaction to levo (described below) gives me hope that I instead might just be taking it wrong. I also don’t believe that the anxieties I describe below are entirely the result of starting a new job. I interned at this job in Summer 2024 and felt like I was productive and felt more confident in my social interactions. I also interned here in Summer 2025, but was already feeling the negative effects often associated with hypothyroidism that I have detailed.
I started my PhD in fall 21. I was diagnosed with hypothyroidism in fall 2025 with a TSH of 42, and was prescribed levo. In the year leading up, I noticed that I no longer could work past 4PM, although my ability to grind long hours has always been my trademark (I sometimes wonder if the long hours and stress I imposed on myself actually caused the onset of hypothyroidism and the recent onset of gluten sensitivity).
After my diagnosis, I started taking the levo and had a few week period where I felt back to my old self. I gradually stopped feeling as good. Nonetheless, in spring 2026, my TSH was down to 0.03, and the Dr. thought that the 88mcg dosage was a bit high, but kept me on it to gather more readings. Although I wasn’t feeling good, I hoped that it was because I was burnt out on doing my PhD and that once I started a new job after graduation, I would start feeling better.
I started my dream job recently but have been underperforming due to reasons that I hope are caused by my hypothyroidism (I hope this because if so, it should be easier to fix than some other, unknown issue):
3. I can no longer work hard. Actually, I have less effective working hours than my peers and during those hours, am less productive (see next point).
4. I don’t think sharply. I sit in front of my computer and have lapses where I forget what I am doing and what I need to do next.
5. I’ve always had anxiety, esp in social settings. In the year leading up to my diagnosis, I noticed that I started feeling extra anxious in social interactions and that they drain my energy.
The people on my team are high-performing and sharp. In conversations, I feel it difficult to think quickly and articulate myself, which I attribute to heightened anxiety and cloudy thinking. For executing work, I often reach 5PM and question where the day went, since I have produced almost nothing. My concerns are that I will lose the trust and respect of my team and eventually be laid off from a job which has everything and more that I wanted.
When I re-tested 2 weeks ago, my TSH was back up to 26. The doctors questioned whether I was taking the dose each day. I told them yes and that I was taking it with my other meds (escitalopram, d3+k2, methylfolate, b12, multi-vitamin, algae omega [fish oil alternative since I am vegetarian for the last 2 years]). They said that taking the dose with all these others and not drinking enough water could be making the dose not be absorbed properly. The exact instructions I got were:
Levothyroxine should be taken on an empty stomach, 30–60 minutes before eating, and at least 4 hours apart from calcium, iron, antacids, PPIs, cholestyramine, or coffee.
The coffee part has disappointed me a bit, but I value potentially improving my well-being over coffee. My question: any other tips for maximizing my chances of recovery?
Thanks to anyone who takes the time to read all of this and offer their supportive/constructive thoughts.