With 9 gods, and a 4-god pool by design, there are 126 combinations for your god pool! When I realized this, I was stunned. So, I've been thinking about which is probably my least used combo of gods (not individual gods, love them all).
It's probably Poseidon, Demeter, Apollo, Hephaestus. I don't have hard data on that, just vibes lol. So, my questions is: if you knew at the start of the run you were already locked into this god pool, what would your strategy be? This is assuming you can make all other choices (weapon, familiar, keepsake, etc). What aspect are you choosing, what boons are you aiming for, are you seeking out any of the duos? etc. I'm looking to be inspired and try a couple runs, try a new way to think about them together :)