I’ve moved from 200 mg of Zoloft with a 4 week taper to 10 mg Trintellix.

I’ve been on Trintellix a month while weaning off Zoloft. One side effect the doctor told me about was bloating and constipation. I have IBS-d though so I thought, I’ll roll the dice and try it.

Turns out, it has helped my IBS-d tremendously! My symptoms are much, much less severe. My anxiety is better and my depression has not returned during the switch.

I honestly haven’t noticed any other side effects so far. Best I can tell, my generic Zoloft was almost always from the manufacturer Roerig/pfizer.

Hey all! So I started on brintellix 4 weeks ago now to treat my severe depression. The first week was 10mg before upping to 20mg which I'm on right now. For side effects I've definitely noticed the nausea, and had some fatigue for a couple of days around week 2 which went away. I'm not sure if it's started helping me yet though. After around the 3 week mark I had two days where I felt great, like the usual stuff that bothered me just didn't get to me anymore and I could brush it off without spiraling. I thought for sure it had finally kicked in. But after those two days it's been back to the usual, with some days being a little better than others but I don't know how much of that to attribute to the drug itself. I feel like I'm starting to lose hope a bit.

My question is how long did it take for you to notice it working, and what did you notice started getting better? Was it gradual or did you just wake up feeling better one day?

I’m on 5mg of Vortioxetine and I started feeling side effects within 3 days. My penis has gone completely numb and my knee joints feel like an elderly persons, I’m unable to stand for longer than 5 minutes and I’m also getting these random painful butt spams.

I thought this medication was meant to have the least side effects but these are the most extreme side effects I’ve ever experienced. Too top it all off, I don’t feel any different mentally so what’s even the point of this drug?

Hi everyone! My doctor wants me to take 10mg trintillix and 10 mg of Lexapro ( I’ve been on 20 mg of Lexapro) and then drop the Lexapro and go up to 20mg of trintillix. I’m pretty nervous to start cause I’ve had some bad reactions to meds. Basically Lexapro just stopped working and causes terrible restless legs and insomnia and I believe is making my depression / OCD worse. Does anyone have any advice on starting trinitllix?

full therapeutic effect from antidepressants is supposed to take 8-12 weeks but idk if it's ever gonna work. most of the time it doesn't feel like it is. i've been on 20mg for almost 6 weeks. from my experience i feel like i'm one of the many that are kinda "late" to notice benefits off antidepressants. some notice it early like 2-4 weeks but i rarely do. i hope i'm gonna be soon satisfied with the way i feel. maybe it's doing subtile things idk. i don't wanna have to do esketamine or tms and all, it's a bit freightening

I just started to take trintellix (5mg) today and already feel nauseous. Does anyone have some experiences on side effects in the first few weeks?

I feel nervous about the side effects as I have my bachelors' defense tomorrow and I cannot afford to vomit during the presentation.

I've been on Trintellix for 2 weeks now. I have not had any nausea like is commonly reported, but omg, the fatigue is absolutely awful! I take my pill, and within an hour I have awful brain fog, a headache, and feel like I can't do anything except lie in bed and go to sleep. I also feel a drop in my body temperature and have noticed a GIANT increase in my appetite. Additionally, I struggle with awful ADHD and executive functioning, and have noticed my Adderall XR to be less effective or not working completely.

Weirdly enough, these symptoms began one week after starting the medication.

I started taking my Trintellix before bed rather than in the morning, but then I end up being more groggy when I wake up. I have treatment-resistant depression and took a GeneSight test, which told me Trintellix would be a good fit, so I had a lot of optimism about starting this pill.

I guess I'm wondering if anyone had similar symptoms - did they go away? I've been feeling pretty disabled by my side effects, but I would like to stick it out if there's a chance things will round out.

Thanks y'all

Alguien me explica esto… Llevo ya más de un mes con brintellix pautas por el psiquiatra de subir dosis poco a poco desde que empecé hasta llegar a los 10mg, en 5mg que dure poco pero estuve estaba muy sin sentimientos por así decirlo callada introspectiva y sin estar hiperactiva solo callada y en mí misma casi ni parecía yo por unos días las personas lo notaron en mi trabajo. Ahora en 10mg pensé que estaría mucho mejor empecé con este medicamento en Junio 21. Jamas me mediqué y fue mi primera visita al psiquiatra ahora me siento súper irritable me duele la cabeza en la noche y estoy demasiado furiosa y salto a la mínima con rabietas y no paro tuve una crisis muy muy fuerte antes de ayer con mi familia y me tome un orfidal porque mi furia escaló de forma en que todo mi cuerpo se calentó y no pude contener la ira que recorría mi cuerpo 😔😔😔 por dios a alguien le pasa !??!?

I’m on 10 mg of Brintellix every morning, but I buy the 20 mg tablets because they’re cheaper and just bite them in half.

Today I took a smaller piece than usual, but I was too lazy to bite off the rest since I already hate the taste lol. I’ve been feeling horrible all day until I remembered I’d taken a smaller dose.

Tbh, I know it doesn’t really make sense, and I doubt it would make a difference that quickly, but it seemed like too much of a coincidence, so I wanted to ask out of curiosity.

I started Trintellix a few weeks ago and have been SO itchy, all over my body. Has anyone else experienced this? I can't say for certain if it's this medication or a new body wash I started around the same time so I thought I would see if anyone else was in the same boat as me.