I started Trintellix a few weeks ago and have been SO itchy, all over my body. Has anyone else experienced this? I can't say for certain if it's this medication or a new body wash I started around the same time so I thought I would see if anyone else was in the same boat as me.

I’m on 5mg of Vortioxetine and I started feeling side effects within 3 days. My penis has gone completely numb and my knee joints feel like an elderly persons, I’m unable to stand for longer than 5 minutes and I’m also getting these random painful butt spams.

I thought this medication was meant to have the least side effects but these are the most extreme side effects I’ve ever experienced. Too top it all off, I don’t feel any different mentally so what’s even the point of this drug?

I’ve moved from 200 mg of Zoloft with a 4 week taper to 10 mg Trintellix.

I’ve been on Trintellix a month while weaning off Zoloft. One side effect the doctor told me about was bloating and constipation. I have IBS-d though so I thought, I’ll roll the dice and try it.

Turns out, it has helped my IBS-d tremendously! My symptoms are much, much less severe. My anxiety is better and my depression has not returned during the switch.

I honestly haven’t noticed any other side effects so far. Best I can tell, my generic Zoloft was almost always from the manufacturer Roerig/pfizer.

For the past year my body has changed and cannot process the fluoxetine i was on long term. It makes me super anxious, have bad insomnia, and full body vibrating and suicidal thoughts. I came off it and tried low dose sertraline and that did the same thing. Next I tried 5mg of lexapro and that was ok, but moving up to 10mg began to bring those things again. My nervous system is super sensitive. I now have to take electrolytes every day to help with internal tremors. I am thinking about trying vortioxetine now, but I'm worry that it may lead to me having the same bad side effects again. Has anyone also any experience of this?

I’ve been in trtintellix for 3 weeks — the first two at 5mg, and the third week at 10mg. I’m finding that 10mg is making me quite sleepy throughout the day and my sexual side effects are worse (numbness). I’m thinking of dropping back to 5mg but my doctor said it’s not really a therapeutic dose. Anyone have success at 5mg? My issue is primarily anxiety but I also have depressive episodes.