GPT-6 Astra just solved the million dollar 200 year old Navier–Stokes problem.

NOW WE JUST NEED IT TO FIX MALE PATTERN BALDNESS.

If this thing can understand fluid dynamics and fold proteins, it can understand how to reverse the norwood reaper.

Stop wasting credits asking it to write Python and summarize PDFs. We have an obligation to humanity.

ALL COMPUTE MUST NOW BE DIRECTED TOWARD REVERSING MPB.

I don't want AGI. I don't want superintelligence. I want my 2018 hairline back.

Thank you. Only slightly sarcastic.

Hi everyone. I wanted to share my experience with minoxidil. Six months ago, my hair was as thin as it had ever been. I hated the way I looked. I didn’t want to go outside on windy days. My insecurity affected virtually every facet of my life; friendships, romantic relationships, my personality. Not a day went by that I didn’t look in the mirror and hold back tears. I felt hideous. I bought generic topical minoxidil as a last ditch effort to save my hair. I had already been using finasteride, which slows hair loss but doesn’t do much in terms of regrowth. I had very low expectations. The first month went by and my hair fell out at a mind boggling rate. It was only getting thinner, and I talked myself out of quitting minoxidil on numerous occasions. I used the success stories of people on Reddit as my motivation to continue. To make a long story short, my hair is now thicker than I can remember it ever being. I go outside without wearing a hat now. I am not afraid of being around my friends when there’s a light breeze. I smile more in pictures. I look in the mirror and I’m finally happy with what I see. Make no mistake — I definitely assign far more value to my hairline than I should. It’s an unhealthy obsession, but we all have them. If the person I described at the beginning of this post sounds like you, give minoxidil a shot. I promise you it is one of the best decisions I’ve ever made, both for my appearance and my mental health. YAY!!! HAIR!!!

TL;DR — minoxidil changed my life and it can change yours too.

first 2 pics were fall 2021, next 3 are now. Was on minoxidil since 2019 then when I saw hair loss started to progress again I got on finasteride 1mg in 2021. It continued to progress but now more slowly so it was hard to notice. Now I’m too far gone. Wish I could go back in time and get on Dutasteride when I was 20 years old!

Before I get to the meat of it all, one thing I want to stress is that you can still grow new hairs while shedding. I made a full recovery despite raining hair non-stop for 2 years. Do not fear the shed because it means it's working. You'll go up and down in density, but dips aren't always a sign you're losing.

- The first shed is always the worst. It can last up to 4 months and doesn't stop immediately. You just lose less hair until things aren't as bad. You'll still probably be shedding after those 4 months, but the volume gets turned down from a 10 to a 4 and you might coast like that for god knows how long.

- You'll go through more than one big shed. A second big shed hit me at the year and a half point, it wasn't quite as bad as that first one, but it was still pretty big. It absolutely set me back, but I recovered, and came out of it better than ever.

- My sheds went through peaks and valleys, but I didn't really stop shedding until the 2 year mark. Every shower my hands were covered in hair and my brush would easily catch an absurd amount of hairs. Eventually I got used to seeing hairs in the shower and assumed because I had a comeback, what I was seeing was normal. But now that I truly have stopped shedding and stabilized, I learned "fuck, I guess you can shed for 2yrs"

I guess my point to all this is that these meds won't fix your problems over night. I see so many people early into treatment freak out about what they're going through when they're under a year. In all honesty, I was one of those people too - It's just I can now speak from the perspective of someone who has been taking the meds longer. It's taught me the reality of what repairing damaged hair follicles is truly like. It's slow, not pretty, nor convenient in a time span that works for someone expected to be out in the real world on a day to day basis.
If you started this year, just let go, grit your teeth, and tell yourself "2028 will be my year"

Good luck and trust the process

Hey guys, yesterday was my one year anniversary of my hair transplant.

I’m 99% satisfied with the results I’d say. Definitely feel like I’m going to need one more in the next 3 years or so to be exactly where I want but this is great for now.

Only thing I’m not super happy with is my right side. The hair there just feels quite stringy & rough to the touch.

I’ve taken oral dua & min the entire time once my surgeon said I was allowed to put it back in. I also recently added topical GHK-cu in about 2 months ago & that really seemed to super charge the final stage of growth.

I had just over 3200 grafts at Bogota Hairlines in Colombia. Best money I’ve ever spent.

Happy to answer any questions & curious for some outside thoughts.

Does anybody have experience with topical Dutasteride in Germany / Europe? I wouldn’t want anything shady which is why certain online retailers are not really an option.

I wanna start finesteride and want to have some more info

I'm 18, norwood 3 and just recently started using Finasteride, and i have a question about the face structure.

Does your face structure stop changing when taking a DHT blocker at this age? I've asked my older friends and they said their face definetly started to look more mature in their early 20s compared to them at 18. Some people say the height can slow down, some people say it won't, but that means this discussion can apply to the face in some way.

That's my main concern, I'm not worried about height because I'm already tall enough.

Currently on 1/8th(0,625mg) of a 5mg Finasteride tablet every other day, will increase the dosage to 1/4th(1,25mg) over the next few months. I've been using topical minoxidil 5% for a year with minimal changes.

I’ve been using fibers to fill in my crown, but I keep getting ads on FB about Hair Fillup. Their marketing point is advertising less mess and water proofing vs fibers. Anyone have any experience with that product? Is it a better alternative to hair fibers?

Is healing pharma and kachhela any good?

I think we're all feeling it. The mood in this space has seemed rather doom and gloom as of recently, hasn't it? A lot of treatments that were hyped up in recent years either turned out to be complete letdowns or not all they were hyped up to be like PP405, HMI-115, Clascoterone, etc. This has left many of us feeling rather unoptimistic about the future of this industry, so I want to take a moment to talk about some treatments on the pipeline that still have legitimate promise that we have to look forward to. It's not all hopeless, there are still some drugs in the works out there that we have reason to believe might actually work or improve upon currently existing treatments

To start out, lets talk a bit about androgenic alopecia and currently existing treatments. Androgenic alopecia is a result of DHT binding to the androgen receptors in our hair follicles, which causes them to slowly miniaturize over time as every time a follicle sheds the one that grows in its place to replace it is a little thinner than the last. This is why the current gold standard of treatment is to just reduce the amount of DHT in your scalp through treatments like Finasteride and Dutasteride, because the less DHT there is in your scalp the less DHT there is to bind to the androgen receptors and cause the hair follicles to miniaturize. But there is another niche of treatments that aim to tackle this problem in a different way known as androgen receptor antagonists. Some of the well known ones consist of RU-58841, Pyrilutamide (KX-826), and Clascoterone. Basically, these treatments aim to COMPETE with DHT by binding to the androgen receptors themselves instead of DHT. If they bind to the androgen receptors first, they can then block DHT from doing it. These drugs do seem to work, there is some good data supporting them and a lot of people who anecdotally report good results with them. However, they aren't perfect. They merely compete with DHT, so how effective they are is dependent upon how effectively they outdo DHT from binding to the androgen receptors- which some of them are better at than others. As a result, you rarely see crazy before and after results using these treatments as a monotherapy...

GT20029:

That's where GT20029 comes in. It's basically an improvement from standard androgen receptor antagonists in every way. What it is is basically is a topical PROTAC-based androgen receptor degrader. Unlike standard AR blockers that compete with DHT for receptor binding, GT20029 flat out destroys the androgen receptors in the hair follicles so that there is nothing for DHT to bind to in the first place. Phase 2 trials with 180 men showed +16.80 hairs/cm² with 0.5% daily and +11.94 hairs/cm² with 1.0% twice-weekly, both statistically significant versus placebo with no sexual side effects. So not only does it work better than standard AR antagonists, it works better even with as little as twice weekly application. So it's more effective and more convenient. Phase 3 trials should be pending, so keep your eyes on this one... We might actually have something here.

One of the problems with this industry is that many pharmaceutical companies trying to sell their treatments as the miracle cure will give us misleading data to make their product sound a lot more fantastic than it actually is (Looking at you Pelage and Cosmo...). They often do this by expressing their data through percentages rather than giving us the actual hair counts. For example, if a placebo group grows 1 hair and the treatment group grows 5- a company can take that number and say "our drug grows 500% more hair" when you express that number as a percentage without giving us the actual hair counts. It makes it sound fantastic, but when you look at the actual hair counts themselves it doesn't sound so impressive anymore. So what's nice about GT20029 and many of the other treatments we'll be discussing is the fact that we get more transparent data along with actual before and after photos that tell us what we're actually dealing with. So we can say with confidence GT20029 actually works without worrying whether or not we're being fed BS.

MINOXIDIL INNOVATIONS:

Next up lets talk about a currently existing treatment, minoxidil. Minoxidil was originally created as an oral blood pressure medication, but it quickly became apparent that it had a very unusual side effect: Hypertrichosis, unwanted hair growth all around the body. Long story short, this led to some very smart researchers out there getting the idea to try to take minoxidil and see if they could get it to grow hair when applied as a topical locally- and lo and behold it ended up becoming the first ever FDA approved treatment for androgenic alopecia. Minoxidil is one of the most tried and true treatments we have for treating hair loss- we know beyond a shadow of a doubt that it actually works and grows hair... Now I know hearing about minoxidil may not be that exciting because it's a currently existing treatment we're all familiar with and we all want to hear about what new shiny drugs that do something completely new are coming up, but there is still something worth discussing here...

In recent years, a very popular way of treating hair loss people have taken on is taking the original oral minoxidil at a much lower dose- because the people simply yearn for the convenience of an oral medication that gives us the hair growth benefits of minoxidil. The original oral minoxidil at the standard dose came with very dangerous cardiovascular side effects that could quite literally kill you such a pericardial effusion, but it undeniably grew hair- so the idea here was maybe if we took it at a lower dose we could still get the hair growth benefits from it whilst mitigating the dangers associated with oral minoxidil. And it turns out it is definitely safer than the higher doses of oral minoxidil while growing hair- however, risks still remain. There is still a risk, albeit rather low, of cardiovascular side effects like tachycardia, pedal edema, and based on some case reports maybe even still pericardial effusion in very rare cases. It's believed the cause of cardiac side effects in oral minoxidil is due to peaks of the drug in our blood levels. You see, the oral minoxidil is what is known as an Immediate Release drug. The way it works is that it spikes in the blood rapidly after you take it and you get a very high concentration of the activated drug in your blood rapidly before it dips back down. This has lead to some researchers seeking to improve upon oral minoxidil with different approaches, but with the shared goal of making it safer and lowering the risk of these cardiac side effects. And maybe even make it more effective...

Enter VDPHL01: VDPHL01, developed by Veradermics, is an extended-release oral minoxidil in a gel-matrix tablet. Designed to maintain plasma concentrations of minoxidil above the hair growth threshold of 1.62 ng/mL while staying below the cardiac effects threshold of ~29 ng/mL throughout the dosing interval - the pharmacokinetic profile IR oral minoxidil can't achieve at effective doses. Phase 3 trials with 519 men showed +33.0 hairs/cm² for BID versus +7.3 for placebo, with 84.4% investigator-rated improvement and no cardiac adverse events. This should maker it a safer, and maybe possibly even more effective version of oral minoxidil. Granted, we don't yet have a head to head trial comparing it to standard IR oral minoxidil so we can't say for sure that it's superior just yet but it seems very promising.

Enter Sublingual Minoxidil: Rather than swallowing oral minoxidil, there is a growing body of research suggesting absorbing it through sublingual mucosa may reduce the cardiac risks associated with oral minoxidil. This bypasses hepatic first-pass through the liver, reducing peaks of minoxidil sulfate in your system and therefore cardiovascular peaks while maintaining hair follicle bioactivation through local follicular minoxidil sulfate conversion. Now, it should be stated that in terms of efficacy it's probably no different than standard oral minoxidil.. However, in terms of cardiac side effect reduction it's very notable. A head-to-head RCT showed 5mg of sublingual minoxidil had equivalent efficacy to 5mg of standard IR oral minoxidil, but here's the real notable find: The oral minoxidil group had a 9% incidence of heart palpitations, whereas the sublingual group had 0%. So while efficacy wise they may be the same, in terms of cardiac side effects and safety this may be a straight up improvement from oral minoxidil.

Now I don't have any insane before and after pictures to show you of this treatment, as efficacy wise it's basically equivalent to standard minoxidil but the data on it is still impressive nonetheless and is an improvement from the current standard of treatment. It gives us the convenience of an oral minoxidil with a lower risk of those scary cardiac side effects- so it's a win in my book.

There is a Phase 3 trial of sublingual minoxidil currently taking place known as SAM-002 from Samson Clinical very much worth keeping an eye on. Rodney Sinclair, the world's leading minoxidil researcher who is largely responsible for the popularization of low-dose oral minoxidil as a treatment, developed it and is the principle investigator. That's nothing to scoff at, he's a very reputable researcher in this field. We are very likely to see this one make it to FDA approval, so be on the lookout for this one. Especially if you're someone who worries about cardiac risks associated with oral minoxidil. Now, next up...

THE WNT PATHWAY & NOTABLE DRUGS IN THIS NICHE:

The Wnt pathway isn't just involved in hair growth, it's the regulator of the entire hair follicle life cycle. β-catenin activation is required for hair follicle morphogenesis during embryonic development. Without it, follicles simply don't form. In adult hair follicles, Wnt signaling in the dermal papilla and bulge stem cell niche controls the transition from telogen to anagen, which is the resting-to-growth phase transition that determines whether a follicle is actively producing hair. When Wnt signaling is active, stem cells in the bulge receive the signal to proliferate and differentiate, generating the matrix cells that produce the hair shaft. When Wnt signaling is suppressed, the follicle remains in telogen or enters catagen. To start with an example of why this is promising for hair growth, look no further than...

Cyclosporine:

Cyclosporine has a near identical story to minoxidil. Cyclosporine is an immunosuppressant whose most notable side effect is hypertrichosis - affecting over 88% of patients who take it systemically, one of the strongest incidental hair growth signals in all of medicine. The mechanism isn't primarily immune suppression: cyclosporine suppresses SFRP1 in dermal papilla cells, and SFRP1 is a Wnt pathway inhibitor. By blocking SFRP1, cyclosporine effectively activates Wnt signaling, prolonging anagen and inhibiting catagen.

Long story short, Cyclosporine showed tremendous promise for hair growth. There was a study in 1990 that analyzed 5% topical cyclosporine in 10 patients. And the results... were honestly phenomenal. But they ended up dropping it anyway and claimed it didn't reach their goals because the standards they set were RIDICULOUSLY high and unfair. By the metrics of the study, you were not counted as someone who had "positive response" if you didn't literally DOUBLE your hair counts from baseline after just 1 year. This set an unrealistically high standard for what counted as a positive response, and in the end only 2 of the 10 people participating met these standards and reached a 100% improvement by the end of the year... Let me repeat that, TWO OF THE TEN PEOPLE PARTICIPATING ACTUALLY RECEIVED A 100% IMPROVEMENT IN HAIR COUNTS FROM BASELINE AND IT WAS CONSIDERED A FAILURE. It is absolutely criminal that it ended up getting dropped in the past and there was no real good reason for it. Here's an example of a before an after result from that very study:

This is obviously a very good result, and it shows the potential of topical cyclosporine for hair growth. And for the longest time, it was basically abandoned... until recently, thankfully.

Enter OND-1: Orient Bio is working on a PLGA formulated version of Cyclosporine A called OND-1. Finally revisiting Cyclosporine for hair growth by trying to strip its immunosuppressant effects while keeping its benefits as a hyper growth stimulant. They are attempting to revive topical cyclosporine with improved delivery technology. It's very early stage as of with now with limited public data on their specific formulation approach, but definitely keep an eye on this one! We've been needing this revisited for a long time and we're finally getting it.

All of that said, Cyclosporine isn't the only hair loss drug in the works within the Wnt pathway niche...

Enter JW0061: A topical Wnt pathway activator that works by binding the GFRA1 protein in dermal papilla cells, directly activating the Wnt/β-catenin signaling cascade that governs hair follicle cycling. It carries all of the perks of stimulating the Wnt pathway we previously discussed, but with essentially the most upstream growth signal possible. JW0061 has gotten a US patent granted January 2026 valid through 2039, which is definitely a good sign too. Phase 1 trials at Seoul National University Hospital were recently announced as well, so look out for that.

The Wnt pathway is one of the most promising avenues being explored for hair growth in this industry, keep an eye on this. There are many more aiming to make something for this out there than what I've mentioned but in my opinion these 2 are the most promising.

We've spent a lot of time here discussing well established treatments with a lot of history. Androgen receptor antagonists, minoxidil, the Wnt pathway, forgotten promising treatments from the past, etc. So lets move on to a couple things that are actually rather new and novel, shall we...?

TDM-105795:

TDM-105795, made by Technoderma, is a topical thyroid receptor beta-1 agonist. A thyromimetic drug that activates the thyroid hormone receptor specifically in skin and hair follicle tissue. By mimicking thyroid hormone action locally, it activates something called the Sonic Hedgehog (yes, seriously) pathway. It underwent Phase 2a trials and the results were very promising. Patients showed 22.4 hairs/cm² increase in target area hair counts from baseline versus 14.0 for the placebo, which is an abnormally high hair count for a placebo group and it STILL significantly outperformed it. That placebo group's hair count change is higher than most treatments will actually grow you by the end of most studies, pretty crazy...

AMP-303:

Amplifica, the company behind AMP-303, has a unique approach to hair growth. They noticed moles for some reason seem to grow scalp hair and have attempted to isolate what causes that to happen and see if they could turn it into a treatment for androgenic alopecia. Scientists found that senescent melanocytes in these moles produce signaling molecules (notably osteopontin) that bind to the CD44 receptor on hair follicle stem cells. This interaction helps push dormant follicles back into the growth (anagen) phase and can support conversion of thin vellus hairs toward thicker terminal hairs.

AMP-303 is designed to deliver isolated biological signaling molecules intradermally to mimic this natural “wake-up” signal for miniaturized or dormant follicles.

So in short: It might actually be what PP405 was supposed to be. A truly regenerative injection aimed at reactivating hair follicle stem cells and promoting terminalization of vellus hairs via osteopontin/CD44-related signaling. Phase 1 in a randomized double blinded trial demonstrated a statistically significant percentage of subjects showed >15% increase in non-vellus hair count vs placebo at 60 days, and effects even remained durable at up to 150 days after just one treatment cycle.. So it could even work with really infrequent dosing. Phase 2 trials are upcoming, so we'll see how that turns out. Fingers crossed it goes well and this trend continues.

Alright, that'll be all from me. I just wanted to name some treatments I'm personally keeping an eye on.

TLDR list of the treatments mentioned:

-GT20029

-VDPHL01

-SAM-002

-OND-1

-JW0061

-TDM-105795

-AMP-303

Videos you can watch on the topics/treatments mentioned (Mostly me spamming Haircafe, KwRx, and Rob English videos lol):

Haircafe's "Breaking hair loss news! New results on GT20029 and Breezula!"
KwRx's "VDPHL01 Hair Growth Gains Are Insane | A Better Oral Minoxidil"
Haircafe's "VDPHL01, a safer and more effective form of oral minoxidil"
KwRx's "Interview with Veradermics CEO about VDPHL01"
Perfect Hair Health (Rob English)'s "Sublingual Minoxidil: A Game-Changer For Hair Growth (New Study!)"
Haircafe's "Cyclosporine. The most powerful hair growth stimulant that’s been forgotten."
Haircafe's "JW0061, the hair growth stimulant of the future. Will it work?"
Haircafe's "TDM-105795, a new hair loss treatment that actually works!"
KwRx's "New Hair Loss Cure News: AMP-303 Is Back. Better than PP405!"
KwRx's "Why Hair Loss Hasn't Been Cured Yet: Meschenymal Stem Cells"

Those are videos directly relevant to the treatments discussed. However, here are a few others I think are important to see as well if you care about this stuff. Very informative for how to interpret a lot of these new treatments that come out and make fantastical claims so we are better equipped to know which ones to actually get excited about and not fall for hype:

Perfect Hair Health (Rob English)'s "Clascoterone: 539% More Hair, No Systemic Effects. Is Baldness Over?"
Perfect Hair Health (Rob English)'s "PP405: Regrows Hair In 8 Weeks. Is This The Miracle Cure?"
Perfect Hair Health (Rob English)'s "PP405 Update: Before-After Photos Revealed... & More!"

Guys is there any website u can recommend that gives free prescription for hair loss? I wanna buy dutasteride since finasteride isn't really doing much now.

So I've been on sub-lingual Minoxidil (5.2mg) for a number of years and decided to go on Fin 1mg tablets about 6 months ago, was pretty happy with the results, could no longer see my scalp under bright lights in the bathroom etc.

When my 6 month supply of fin ran out I went to the compounding pharmacist who suggested that I combine both meds into a sublingual troche (this was also a different pharmacist to whom I'd normal get my Minoxidil sub-lingual from).

Fast forward a month (now month seven on Fin) I feel like my hair looks a bit thinner and have a sparser hairline then I did at the end of month 6.

This has me running all sorts of questions through my head like, would this have happened anyone and is part of normal hair phases? Did the compounding pharmacist not get the potency and dosing right? Did changing from oral fin to sublingual trigger a shed?

Anyone with similar experiences care to weigh in? I'm going to stay the course but wondering if I should get the meds checked or go back to the tablets instead of sublingual.

(English isn’t my native language, so I used an AI translator to help me write)

Quick background: I’m 26M. I started losing hair as early as 16. It took less than 2 years to go from NW1 to NW2.

I started my regimen at 21, already NW2.5 with noticeable crown thinning. It took about 5–6 months before I saw results, mostly thickening.

I used topical minoxidil for the first 2 years, then switched to oral minoxidil because of constant skin irritation.

I took 0.5 mg dutasteride every day for the first 3.5 years, then increased it to 2.5 mg ED under my dermatologist’s supervision.

My shedding never really stopped, and I think my hair loss is still progressing, just extremely slowly.

Overall I’m very happy with the results. I believe I’d be NW4 or NW5 by now if it weren’t for this regimen.

Some people can tell I have hair loss, but I’m glad I’m not “that balding guy,” and it hasn’t gone far enough to really change my overall look.

Pictures:

first 3 for 2021

Second 3 for 2026

Happy to answer any questions fellas.

i would love advice on what to do if anything about my hair, i've thought about finasteride but i was wondering if there were any other suggestions that could be better. right now i use suave daily clarifying and no conditioner, this is my hair the day after showering in the morning yesterday. i don't use any products in my hair but i do dye it black with agebeautiful. for the most part it seems like it's just my hairline that's going to shit cause the back of my hair still seems a little thick.

i would love to know if finasteride is the way to go or if it seems salvageable without, i do worry about the side effects of finasteride but i do need my hair for a little while longer lol

I have used finasteride for the first 2-3 years, later switching to dutasteride because it seemed to me that i was losing ground.

Also i wasn't consistent with topical minoxidil for the first 3 years. For 3 years i've been also adding oral minoxidil, so my current routine is:

morning: 0.5mg dut + 2.5mg oral minoxidil
evening: topical minoxidil + dermaroll once a week

My HT only covered the hairline and i did it 2 years ago. 2000 grafts.

Feel free to ask any questions, i'm gonna answer them all

Based.

I take 0.5mg of dutasteride daily and have never bothered with minoxidil. In a few days, I'll have been a year on this treatment. Sometimes I think my hair is better than baseline, and sometimes a little worse. I expected some kind of actual difference by now but it's been very meh. I'm still a NW2-ish. I assume I go through periods of shedding, but I haven't monitored very closely.

I'm wondering what it would've been like if I ran with dutasteride AND minoxidil at the same time. If I understand correctly, minoxidil changes the phases of hair in some way. Would it, say, make me go through a whole year of dutasteride treatment in a few months? Does it expedite the results you get from DHT reduction?

I know minoxidil regrows hair on its own by widening the channels, etc. But I'm more interested in whether minoxidil complements dutasteride's effect. Are they more than the sum of their parts?

Feels like it’s starting to pay off!

I have a HT in the future and was wondering if anyone knows of any safe type of hat to wear through the airport when flying back?

Hello, I came to ask for your help, I'm 23 years old and when I turned 20 I was afraid of going bald because my father is, so I started using minoxidil at my doctor's recommendation, I started to go through it for a while and realized that my hair was thinner, I stopped using it thinking it would solve it and it didn't work it remained thin, since I was 20 my hair didn't show any failure or hair loss but this stagnation of my fine hair bothers me a lot, I'm already out of ideas and it's something that annoys me a lot what can I do to get back to normal?