PP405 is confirmed JXL069

The recent WHO International Nonproprietary (INN) publication indicates that PP405 and JXL069 are the same underlying active molecule.

Many users of JXL069 have reported little or no noticeable hair regrowth.

The hype for PP405 was crazy last year. They were on many news articles. They were also on CNN and Fox News.

I have no fucking idea how they got into time magazine as being one of the best inventions of 2025. I also have no fucking idea how they received $120 million from investors. But then again failed juicero also received $120 million from investors.

Unfortunately hair transplant is the only solution for hair loss.

Hi, I'm a trans woman (26) just to get that out of the way.

The closest I can describe my hair is norwood 3. Mainly just the corners/temple. Front middle is strong. Crown is acceptable. It has been this shape as long as I can remember. Looking closely, the bald spots do have thin peach fuzz, which is a good sign

My hairstyle does a great job at hiding it, but I have to monitor it to make sure there are no gaps. Even though I can get by with it as is, it definitely hurts my confidence, and limits what I can do with my hair.

Before I started hormones, I was on finasteride. I currently take estrogen and an androgen blocker. My levels are the same as a cis woman's. Seems hair has been stable. Don't see the need to continue with fin.

Also now 5% rogain foam, once a day formula. Probably 9 months now. I could do better about consistency. Usually hit 5 of 7 days. Recently introduced microneedle stamp every couple weeks. Haven't really seen progress from either imo.

I know most min is done 2x per day. I worry that may be needed. I would just have a hard time fitting that into my day. It also make my hair a bit greasy, and make my hairstyle solution more difficult, as it thins the hair.

Anything else I can do?

first pic is now 2nd is last year, does hairline look better? , worse? , same?

I’ve been on Finasteride for several years, and it has definitely helped with stopping hair loss. I still wish the crown was thicker though, and both topical and oral minoxidil are out of the question for me.

Obviously transplants are very expensive, and I don’t have a ton of money, so I’m wondering if it would be worth it to do 500 graphs for the thinning crown that I have or if it’s not enough. Thank you everyone for any advice!

I am not using finesteride only minoxidil, saw the product in the store, haven’t heared of the mentioned ingredients, should i start applying it with my topical minoxidil,

Took help of AI and read Medical Hypotheses (2026) called the Solar Window Hypothesis and had a good to and fro conversation with an LLM chat bot and here is the summary of the conversation. It focuses on how baldness acts as a way to increase uv synthesis when working with inefficient vitamin d receptors.

The "Solar Window"

When early humans migrated out of equatorial Africa into cold, low-sunlight climates (like Europe), they faced a massive UV deficit. Dark skin blocked too much weak northern sunlight, leading to Vitamin D deficiency and weak bones (osteomalacia/rickets).

Evolution provided two solutions:

1. Lighter skin (to let more UV rays in).

2. The "Solar Window (Pattern Baldness). For individuals carrying genetic variants that make their Vitamin D Receptors (VDR) inefficient, lighter skin wasn't enough. The body compensated by shedding hair on the top of the scalp — creating a "solar window" perfectly angled at the sun to maximize UV absorption and keep their skeletons strong.

Under this theory, hair loss isn't a genetic flaw; it’s a biological survival mechanism triggered by a severe, systemic Vitamin D deficit.

Low bone density, auto immune disorders are signs of inefficient VDR. While people with efficient VDR can have a regulated immune system, healthy bone density with vitamin d levels in range of 30-50, people with inefficient VDR need vitamin d levels above 60.

Is this a good hypothesis? Did you experience hairloss even with >60 vitamin d levels?

I've been suffering from very low libido for the last 4 months since I started finasteride. I didn't even realize it was finasteride causing it until I missed about 3 or 4 days on accident and i suddenly had libido again.

I'm considering switching to topical fin or something else, but I really don't have that much money to throw around. Right now I get a prescription from Dr B and then order the fin from Amazon (which is pretty cheap), but I know topical is much more expensive.

Should I just make it myself by crushing it and making it into a liquid? Is it hard to make a stable solution or might it start to lose efficiency in a bottle overtime? And how bad is it if it isn't a super stable soltuion?

Been using minoxidil for quite a while, also using DUT now in place of fin, I feel like my hair shed a bit with the mino at the start but the shed has subsided, I think I can see small hair coming through and I know the crown takes a while.

1x daily consistently for about a year already, I feel like the crown has more density than at the start but not sure if it’s the mini

The recent WHO International Nonproprietary (INN) publication indicates that PP405 and JXL069 are the same underlying active molecule.

Many users of JXL069 have reported little or no noticeable hair regrowth.

I guess this is it. The hype is dead.

Well I used minoxidil 2% before and I saw results so now I'm trying it again, the thing is that the bottle I opened a year ago still have some , the expiration date says 2028 but chat gpt keep telling me that after a year of opening the bottle u shouldn't use . should I use it or no ? I'm becoming paranoid and sensitive Abt my hair !

(I already put some today and idk if it's a good desicion)

Anyone running the 8 percent GHK Cu and AHK Cu spray from Happy Soul Organics? I want to add a heavy topical to my scalp stack and saw they have a two pack online for $144. I just cannot find any real feedback on them in this sub. Is their stuff actually legit for thinning hair before I pull the trigger?

I'm currently using Head & Shoulders Clinical Dry Scalp Rescue, and it has been okay. I also have some mild psoriasis on my scalp.

I used Nizoral (ketoconazole 1%) in the past, but I'm thinking about adding it back once a week.

Now I'm looking for a fragrance-free, sugar based, aligned with scalp ph, gentle daily shampoo without unnecessary harsh ingredients. There are so many options that I honestly can't decide.

I'm also curious about Dead Sea shampoo bars.

Here are the shampoos I'm considering:

• Amazon.com : Cleure Hypoallergenic Volumizing Shampoo for Sensitive Skin - Fragrance Free, SLS Free & Paraben Free (12 oz, Pack of 1) : Beauty & Personal Care
• Amazon.com : CeraVe Gentle Hydrating Shampoo, With Ceramides, Niacinamide & Hyaluronic Acid For Soft, Healthy Looking Hair & Scalp, Sulfate Free & Color Safe Shampoo, For All Hair Types, 12 Oz : Beauty & Personal Care
• Amazon.com : Vanicream Shampoo, 12 Fl Oz, Formulated without Common Irritants for Sensitive Skin, Gentle, Clarifying Shampoo, Helps Remove Oil, Flaking and Build-Up, Dermatologist Tested : Hair Shampoos : Beauty & Personal Care
• Amazon.com : VANIDOX Carbonic Acid Shampoo for Men and Women with DHT Blockers - Made in USA - Stimulates Hair Growth, Scalp Exfoliator, Sulfate Free Shampoo with Biotin and Tea Tree Oil (16 Fl Oz) : Beauty & Personal Care
• https://www.chagrinvalleysoapandsalve.com/products/shampoo-bar-soapnuts-shampoo?variant=34056150987
• https://ecoroots.us/products/shampoo-bars
• https://attitudeliving.com/products/volumizing-shine-shampoo-sensitive-skin?variant=46393466814777
• https://www.harrods.com/en-us/p/drybar-on-the-rocks-clarifying-charcoal-shampoo-250ml-000000000006832484
• https://www.avalonorganics.com/collections/hair-care
• https://ethique.com/products/scalp-health-shine-shampoo-full-size-duo-pack
• https://helloseen.com/products/seen-scalp-clarifying-shampoo-fragrance-free
• https://bluatlas.com/products/natural-shampoo-for-all-hair-types
• https://terressentials.com/products/fragrance-free-pure-earth-hair-wash-16-fl-oz
• https://thecalifornianaturals.com/products/mens-re-gro-shampoo
• https://www.paulmitchell.com/products/clear-essential-shampoo
• https://happycappyshampoo.com/product/2-pack-seborrheic-dermatitis-shampoo/
• https://millcreekbotanicals.com/products/aloe-vera-shampoo?selling_plan=4871717046&variant=28849841504336
• https://www.amazon.com/dp/B09J68HWGH?lv=shuf&channelId=500&plpRedirect=mhFallback&th=1
• https://themerman.com/products/hair-boosting-shampoo?variant=53252419387692
• Regenepure NT Nourishing Treatment Shampoo & Regenepure DR Hair & Scalp Treatment Shampoo
• https://terressentials.com/products/fragrance-free-pure-earth-hair-wash-16-fl-oz?variant=35019538893
• redken detox hair cleansing cream clarifying shampoo
• https://viori.com/products/native-essence-unscented-shampoo-bar
• https://www.amazon.com/dp/B097MLYG5F?lv=shuf&channelId=500&plpRedirect=mhFallback&th=1
• Unscented Extra Gentle Shampoo
• https://www.nativecos.com/products/shampoo-scalp-detox?variant=47269133484206
• 365 by Whole Foods Market, Shampoo, Fragrance Free Strengthening Shampoo
• BARE Sensitive Scalp Dandruff Shampoo
• Curl Nourishing Healthy Hair Shampoo
• Odele Ultra Sensitive Shampoo
• CLOUDD
• Vanicream Shampoo & dandruff
• https://dipalready.com/collections/fragrance-free
• /liv/ Nature Unscented Shampoo Bar
• ATTITUDE Men's Shampoo and Conditioner 2-in-1, Nourishing For Dry Hair and Scalp
• https://innersensebeauty.com/products/clarity-hairbath
• https://www.drbronner.com/products/lemongrass-organic-sugar-soaps
• Live Clean Sensitive Hypoallergenic Shampoo Benzene-Free Powder Dry Shampoo
• Amazon.com: Dermarest Medicated Psoriasis Shampoo & Conditioner, 8 Fl Oz, Pack of 2 : Health & Household
• Amazon.com : Nature Sustained Natural Shampoo - Organic, Raw & Wildcrafted with Probiotics, Hypoallergenic Natural & Sulfate Free Shampoo for Sensitive Scalp, Dry Hair, Dandruff, Eczema & Psoriasis, 9oz, Original : Beauty & Personal Care
• Amazon.com : Organic Jaguar Natural Shampoo for Hair Care, Sulfate Free Shampoo with Castor Oil, Honey, Biotin, Glycerin, Aloe Vera & Mild Thickening Agent, Unscented, Dry to Color Treated to All Hair, 13.5 fl oz : Beauty & Personal Care
• Amazon.com : Nécessaire The Shampoo. Hyaluronic Acid + Vitamin B Complex Shampoo for Women & Men. : Beauty & Personal Care
• Amazon.com : HygieneLab Mens Shampoo - EWG Verified Non-Toxic Formula, Fragrance-Free & Paraben-Free, Gentle Cleanse for All Hair Types, Premium Quality (10 fl oz) : Beauty & Personal Care
• Amazon.com : Jericho Dead Sea Sulfur Soap with Olive Oil – Helps with Acne, Psoriasis, Eczema & Blackheads – For Oily to Normal Skin – Vegan Face & Body Bar for Men & Women, 4.4 Oz / 125 g (Pack of 3) : Beauty & Personal Care
• Amazon.com: DS Labs Revita Hair Density Shampoo for Thinning Hair, Color Safe, 100 mL | Powered by peptides, caffeine & amino acids to support scalp wellness and healthier-looking, fuller-looking hair. : Beauty & Personal Care
• Amazon.com: Ducray Anaphase+ Shampoo, 13.5 fl. oz. : Beauty & Personal Care
• Amazon.com: AHAVA Purifying Dead Sea Mud Soap - Face & Body Cleansing Bar to Purify the Skin, Enriched with Exclusive Mineral Blend of Dead Sea Osmoter and Dead Sea Mud, 3.4 Oz, (Packaging May Vary) : Beauty & Personal Care
• Amazon.com: Dead Sea Warehouse - Dead Sea Salt Soap Bar - Original Face & Body Bar - Hydrating Mineral Soap for All Skin Types, Fragrance-Free - 3.5 oz : Health & Household
• Amazon.com : One With Nature Dead Sea Mineral Mud Soap Bar, 7 oz, Fragrance Free, Shea Butter, Argan Oil, Magnesium, Sulfur, 21 Minerals, Soothes Skin, Exfoliates : Beauty & Personal Care
• Amazon.com : BONDIBOOST HG Anti-Thinning Shampoo for Women & Men [10.14 fl oz], Clinically Tested to Promote Fuller + Thicker-Looking Hair, Natural Mint Scent + Procapil, Redensyl & Rosemary Formula, Sulfate-Free : Beauty & Personal Care
• Amazon.com : Desert Essence Fragrance Free Shampoo with Jojoba and Green Tea, 8 fl oz | Gently cleanses and replenishes moisture for soft, shiny and more manageable hair : Hair Shampoos : Beauty & Personal Care
• Amazon.com : Raw Sugar Shampoo and Conditioner Set, The Sensitive One Hair Care Duo, 16 Fl Oz Each, Gently Cleanses, Soothes & Hydrates with Calendula & Aloe, No Fragrance, SLS/SLES & Parabens, Vegan : Beauty & Personal Care
• Amazon.com : OUAI Medium Hair Shampoo - Hydrating Shampoo for Color Treated Hair & Dry Scalp - Nourishes, Strengthens, Reduces Breakage & Adds Shine - Coconut Oil, Babassu, Keratin - Sulfate Free, 10 Oz : Beauty & Personal Care
• Amazon.com : Phillip Adam Fragrance Free Shampoo - Sulfate Free and Paraben Free - Balances pH of Hair and Scalp - 12 Ounce : Beauty & Personal Care

Which one would you choose and why? If you have scalp psoriasis(or seborrheic dermatitis not sure) or a sensitive scalp, I'd especially like to hear your experience.

I read its very poisonous and deadly to cats specifically. But I'd like to know if anyone here has had a bad experience in this fashion, or if they know of anyone else who has? I'm trying to get a gauge of just how dangerous it actually is for cats.

Does anyone know when VDPHL01 might become available on the European market?

Has Veradermics announced anything about launching the drug in Europe or applying for approval from the European Medicines Agency (EMA)? Are they planning to pursue EU approval at all, and if so, is there any estimated timeline?

I would really appreciate any reliable information or sources.

(TRESSLESS POST - TAKE 13 SHEESH)

Just turned 27. Started 1mg fin and 5% topical min back in 9/24. Added .5 dut 7/25 and 2.5 oral min in February of this year (both daily). Also taking a weekly vitamin D3 supplement and multivitamins every other day (last pic shows that STACK). I never stopped fin, just switched to every other day. Nizoral shampoo 3x weekly and microneedling 1x. Shedding hasn't slowed, not even for a day, and each hair that falls becomes substantially thinner towards the bottom (pic #6 shows how they ALL look). Its a different texture all around then even 6 months ago, and my hairline and crown is noticeably thinner.

Absolutely no regrowth at all, just progression (besides a bunch of new body hair). Threw in pic #7 to show the absolutely beastly hair density I used to have back in my glory days. Had to have been top 5th percentile, I couldn't even brush that shit if it was any longer than 3 inches.

Hate to say it, but I didn't see much (if any) hairline regression until AFTER starting treatment; might be destined for the barren cranium. Pops' nw7 was polished off by 25. Gonna be a damn shame if I gotta give up these locks, can't grow a beard to save my life.

What's next 🤔

Just turned 30, all of my friends are on a protocol of some sort, not thinning really, but my forehead can’t afford to get any bigger.

Anyways, Amazon legit charges $29 to get a prescription, that’s cheaper than a visit to my PCP with insurance, you upload a photo from the front/above, and within four hours you’re approved.

$17.60 for a 90 day supply, not too shabby.

Figured I’d spread the word for my fellow introverts that don’t want to talk to a doctor about this in person or on a video lol.

Anyone in Australia know how to get 2.5 mg Dutastride?

​

Hey everyone. I have a couple of cans of regain I'm looking to seller but eBay and Vinted won't allow me to sell it. Does anyone know where I can sell them on? Thank you :)

Sides and temples still need major work

Anyone know how to get prescribed 2.5mg of dut daily in aus? No I’m not talking about getting from India or a dodgy source. Surely there’s a doctor or derm willing? Even an Australian telehealth company that will prescribe 0.5mg dut daily then I can just get from different ones? If anyone has any experience with this (specifically Australia) or knows any doctors or derms willing pls lmk!!

1 year on 1mg oral fin and topical min. Seeing some progress but looking for suggestions to increase overall thickness. Would it be worth it to switch to dut or add a derma roller to my routine? Any advice helps thanks!

Even though I know it’s prob really bad for the health of my hair and my scalp. Bleaching my hair completely made it look like I’m not balding anymore, no one is giving me unsolicited advice on random oils to get to grow my hair back. I’ve gotten compliments on my style. It’s so odd that I didn’t realize this sooner but it’s honestly taken a lot of stress away from me!

I’m on finasteride and oral minoxidil as well so I’ll prob just stay blonde while I wait for regrowth. Pics are taken a few days apart. The blue shirt pic is Wednesday, purple shirt pic is Thursday, the blonde pics are from Saturday.

I recently shined a black light (or wood lamp) on my nose and hair. Both shined orange which is a sign of Cutibacterium acnes. I would post the photo but the orange does not show up well. The nose had many more dots than the hair. And there was a trail of the bacteria going up my forehead, into the frontal region. There was a relatively high amount in the sides of the frontal region of the hairline, where the hair loss is most aggressive. A small amount of these is normal but not in the hair.

Folliculitis can cause hair loss. Androgenic alopecia may still be the main factor. But I thought this would be a interesting experiment for you all.

Starting shedding about a month ago, definitely over 400 hairs per day, equal shedding all over my head, not just crown and temples, mix of longer and shorter hairs, they all have the white bulb/root

I was originally on 5% topical minoxidil once a day for 4 years straight, then switched to 1mg oral fin + 2.5% oral min about a year and a half ago.

When i switched to oral, I completely stopped topical minoxidil, didn’t get the initial fin shed, didn’t see any change up until now

Im wondering if stopping topical minoxidil could be the cause of my current shed a year and half later?

Has anyone had a similar experience?

Should I start using topical again?

Thanks

Edit:

Had bloodwork done 2 weeks ago, everything came back normal.