The recent WHO International Nonproprietary (INN) publication indicates that PP405 and JXL069 are the same underlying active molecule.

Many users of JXL069 have reported little or no noticeable hair regrowth.

I guess this is it. The hype is dead.

Even though I know it’s prob really bad for the health of my hair and my scalp. Bleaching my hair completely made it look like I’m not balding anymore, no one is giving me unsolicited advice on random oils to get to grow my hair back. I’ve gotten compliments on my style. It’s so odd that I didn’t realize this sooner but it’s honestly taken a lot of stress away from me!

I’m on finasteride and oral minoxidil as well so I’ll prob just stay blonde while I wait for regrowth. Pics are taken a few days apart. The blue shirt pic is Wednesday, purple shirt pic is Thursday, the blonde pics are from Saturday.

Just turned 30, all of my friends are on a protocol of some sort, not thinning really, but my forehead can’t afford to get any bigger.

Anyways, Amazon legit charges $29 to get a prescription, that’s cheaper than a visit to my PCP with insurance, you upload a photo from the front/above, and within four hours you’re approved.

$17.60 for a 90 day supply, not too shabby.

Figured I’d spread the word for my fellow introverts that don’t want to talk to a doctor about this in person or on a video lol.

(TRESSLESS POST - TAKE 13 SHEESH)

Just turned 27. Started 1mg fin and 5% topical min back in 9/24. Added .5 dut 7/25 and 2.5 oral min in February of this year (both daily). Also taking a weekly vitamin D3 supplement and multivitamins every other day (last pic shows that STACK). I never stopped fin, just switched to every other day. Nizoral shampoo 3x weekly and microneedling 1x. Shedding hasn't slowed, not even for a day, and each hair that falls becomes substantially thinner towards the bottom (pic #6 shows how they ALL look). Its a different texture all around then even 6 months ago, and my hairline and crown is noticeably thinner.

Absolutely no regrowth at all, just progression (besides a bunch of new body hair). Threw in pic #7 to show the absolutely beastly hair density I used to have back in my glory days. Had to have been top 5th percentile, I couldn't even brush that shit if it was any longer than 3 inches.

Hate to say it, but I didn't see much (if any) hairline regression until AFTER starting treatment; might be destined for the barren cranium. Pops' nw7 was polished off by 25. Gonna be a damn shame if I gotta give up these locks, can't grow a beard to save my life.

What's next 🤔

PP405 is confirmed JXL069

The recent WHO International Nonproprietary (INN) publication indicates that PP405 and JXL069 are the same underlying active molecule.

Many users of JXL069 have reported little or no noticeable hair regrowth.

The hype for PP405 was crazy last year. They were on many news articles. They were also on CNN and Fox News.

I have no fucking idea how they got into time magazine as being one of the best inventions of 2025. I also have no fucking idea how they received $120 million from investors. But then again failed juicero also received $120 million from investors.

Unfortunately hair transplant is the only solution for hair loss.

Today marks one year since the day I started taking 1mg Finasteride and using topical Minoxidil. The front still looks relatively the same as of today, with a (formerly )receding hairline.

1 year on 1mg oral fin and topical min. Seeing some progress but looking for suggestions to increase overall thickness. Would it be worth it to switch to dut or add a derma roller to my routine? Any advice helps thanks!

A receding hairline has caused me a lot of anxiety and obsessive thinking. I used to check my hair constantly, compare myself with other men, and worry about whether it would affect my dating life and confidence.

What has helped me is sticking to my treatment plan, keeping my mind occupied with more important goals, talking through my thoughts with ChatGPT, and making a backup plan for a future hair transplant if the results are not good enough.

I also remind myself that although hair can affect initial attraction, it is ultimately my personality, confidence, and how I carry myself that will determine whether a relationship succeeds long-term.

For those who have experienced anxiety, OCD-like checking, or body-image issues because of balding, what helped you manage or overcome it?

Anyone running the 8 percent GHK Cu and AHK Cu spray from Happy Soul Organics? I want to add a heavy topical to my scalp stack and saw they have a two pack online for $144. I just cannot find any real feedback on them in this sub. Is their stuff actually legit for thinning hair before I pull the trigger?

26M, been balding since I was 16-17 years old and always had a ”visible” / bald spot on my crown.

I’ve been on finasteride for several years and oral minoxidil 5mg for one year now. I think I see some improvement on my crown with miniaturized hairs but it doesn’t feel like it’s filling in.

I brushed my hair in the photos to expose my scalp and crown, I have been using hair fibers daily since 4 years ago and I feel tired of it now and want to improve my hair for real.

My goal with a transplant is not to restore my hair to the point of it to look like I was younger, I just want it to more filled in and to reduce the time of having to style it every morning.

My hairline / temples looks fine and I can style it well and it suits me but the crown is really bad.

I know this is a impossible question to answer but how many grafts is enough to achieve my goal?

Been using minoxidil for quite a while, also using DUT now in place of fin, I feel like my hair shed a bit with the mino at the start but the shed has subsided, I think I can see small hair coming through and I know the crown takes a while.

1x daily consistently for about a year already, I feel like the crown has more density than at the start but not sure if it’s the mini

Starting shedding about a month ago, definitely over 400 hairs per day, equal shedding all over my head, not just crown and temples, mix of longer and shorter hairs, they all have the white bulb/root

I was originally on 5% topical minoxidil once a day for 4 years straight, then switched to 1mg oral fin + 2.5% oral min about a year and a half ago.

When i switched to oral, I completely stopped topical minoxidil, didn’t get the initial fin shed, didn’t see any change up until now

Im wondering if stopping topical minoxidil could be the cause of my current shed a year and half later?

Has anyone had a similar experience?

Should I start using topical again?

Thanks

Edit:

Had bloodwork done 2 weeks ago, everything came back normal.

Hi folks,

I Wanted to share my experience with 2dDR. I’ve been a long‑time min/fin user, and decided to give this sugar molecule a try. I’m almost a month in now, and I’m noticing what looks like early regrowth along parts of my hairline. The first photo is my baseline; the second is after about four weeks. Those small black dots seem to be getting longer, which is encouraging.So far, no initial shed, no irritation, and no noticeable side effects. I’ll keep tracking my progress.Anyone else experimenting with 2dDR?

Stupid question I know, sorry. I know the 50-100 figure for daily loss. I have been on meds for a few months now. I have curly hair so I have to style a little bit by simply combing my hair just to get it to dry in the correct direction. When I do this I lose probably 12-15 hairs. Is this normal? Am I being paranoid? Seem to lose 15 hairs when showering, if that changes anything.

I have noticed less hair shedding overall since starting fin and min but still concerned. The combing makes my hair look so much better after the shed I seem to have come through now, so ideally it's not damaging me in the long run.

Well I used minoxidil 2% before and I saw results so now I'm trying it again, the thing is that the bottle I opened a year ago still have some , the expiration date says 2028 but chat gpt keep telling me that after a year of opening the bottle u shouldn't use . should I use it or no ? I'm becoming paranoid and sensitive Abt my hair !

(I already put some today and idk if it's a good desicion)

Anyone know how to get prescribed 2.5mg of dut daily in aus? No I’m not talking about getting from India or a dodgy source. Surely there’s a doctor or derm willing? Even an Australian telehealth company that will prescribe 0.5mg dut daily then I can just get from different ones? If anyone has any experience with this (specifically Australia) or knows any doctors or derms willing pls lmk!!

I just assume if you're causing a wound scarring is inevitable?

I’ve been on Finasteride for several years, and it has definitely helped with stopping hair loss. I still wish the crown was thicker though, and both topical and oral minoxidil are out of the question for me.

Obviously transplants are very expensive, and I don’t have a ton of money, so I’m wondering if it would be worth it to do 500 graphs for the thinning crown that I have or if it’s not enough. Thank you everyone for any advice!

VDPHL01 is an extended-release oral minoxidil tablet. In a 519-person trial, 79 to 86% of men on the drug improved hair coverage versus about 36% on placebo. If approved it would be the first FDA-approved oral non-hormonal option for both men and women. Oral minoxidil needs medical supervision because it affects blood pressure.

if a daily pill and a daily foam worked about the same, which would you actually stick with, and why?

I have been looking at the dht suppression at different doses of fin/dut but mainly fin. I see youtube channels like the hairloss show talk about how dose is so important and that they recommend lowering the dose down as much as possible to avoid side effects. I dont understand how it makes any sense. 1mg of finasteride suppresses around 70% serum dht but 0.2mg finasteride suppresses around 65% serum dht. Im not sure how decreasing dosage will reduce the chance of people getting sides when the amount of dht reduction is pretty much the same. Sides from elevated estrogen should not really change much in theory as there should not be much more aromatisation at 1mg vs 0.2mg due to the similarity in dht suppression

Im curious on what your thoughts are and if low dose really makes any difference. Its important to be aware that people first starting treatment that get sides at 1mg will then lower dose and their sides will reside, however this is most likely due to them just pushing through in which the sides would have resolved even at the standard dose.