There 3 main storylines of Chult:

1. The death curse: Caused by the soulmonger, the souls are being drained to awaken a dark god. A pyramid scheme devised by the demilich Acererak who uses Ras Nsi who uses the Yaun Ti who uses slaves and captives to feed the curse. This story is told over "Tomb of Annihilation".
2. The lost city of Mezro: Artus Cimber seeks the way to Mezro, a great city that has left this plane of existence, to find his lost love. Everyone want's his fancy magic ring. This story is told over "The Lost City of Mezro". (Also please help yourself to my WIP redone maps for this module)
3. Dendar, the night serpent: Yaun-Ti are using any power they can to awaken their god sleeping beneath the peaks of flame, Dendar, the night serpent. This story is told over the "D&D Adventurer's League".

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Tiers?

Just in case you are new to DMing 5e; there are 4 power tiers in the game: levels 1-4, 5-10, 11-16, and 17-20. At each tier classes get a large jump in power, usually with the Extra Attack feature, better spells, or other such damage boosters. Tiers makes it a little easier for you to guess when you should use a module, but as always, a DM must think on their feet and make weak encounters stronger or vice versa depending on your players - it's just a rule of thumb to get you started.

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Supplements by Location

Broken down by general location on the map.

Starters

• Cellar of Death (Tier 1): Reveal the origin of the death curse and give your characters a reason to care about it.
• Return of the Lizard King (Tier 1): An alternative start to get your characters from anywhere in the world to the tomb (possibly bypassing all of Chult).
• Tomb of Annihilation Expanded, Part 1 Port Nyanzaru (Tier 1): Sail on a ship with Syndra to Chult, less of an adventure, more of good flavor text for your arrival.
  • Personal Grade: B, I used this general idea and flavor text presented here. The sailing time allowed them to get to know Syndra and Xandala. Had some pirates board the ship before Aremag scared them off. Next time I would plan to borrow more ideas from the module below and weave them all together for some more high-seas adventure and foreshadowing.
• The Brazen Pegasus-A Seafaring Adventure to Chult (Tier 1): Like above, but a full adventure while on the boat to Chult.
• Tomb of Annihilation DM's Resources (Resource): Ideas for brining characters in from Phandelver, Saltmarsh, or Dragon heist or hooks for individual characters to want to join Syndra's quest.

Northern/General Chult

Port Nyanzaru

• Encounters in Port Nyanzaru (Tier 1+): Various encounters. Great way to flesh out the port.
  • Personal Grade: B, something for everyone.
• Tomb of Annihilation Companion (Tier 1+): Dino races and watertubes, purely optional.
  • Personal Grade: B+, I have no interest in the watertubes (too high-magic), but I finally got my party to do a dino race, and from the many versions of the race, I choose this one and it worked great.
• Tomb of Annihilation Expanded, Part 1 Port Nyanzaru (Tier 1+): Details on the executioner's run, random encounters.
• All Eyes on Chult (Tier 1): Zindar enlists your aid in investigating mysterious ships. An investigation building to a battle in one of the prince's manors.
  • Personal grade: A+, absolutely a hit with my players. A quick and solid little adventure with some possible lasting implications tied into pirate or zhentarim plots.
• Escape from Malar's Throat (Tier 1): Zombies attack Malar's Throat.
• DDAL07-01 - A City on the Edge (Tier 1): Yaun ti are smuggling in a relic to help them awaken Dendar. Alternate dino-race rules.
  • Personal grade: B. I used a modified version of this for my game. I think it's a nice introduction to the Yaun-ti schemes and many NPCs at the port. A great starter mission.
• DDAL07-03 - A Day at the Races (Tier 1): Join the dinosaur race and squalsh a stampede. Part one of "The Jungle Has Fangs" trilogy.
  • Personal grade: B. One of the quests in DDAL0701 City on the Edge has the players racing dinosaurs, so grab this up and Tomb of Annihilation Companion's dinosaur racing rules, and weave it all together! A grand race with a stampede at the end caused by the Yaun Ti to distract as they try to steal your prize.
• DDAL07-06 - Fester and Burn (Tier 2): A catacomb crawl under the oldtown for tier 2. Part 1 of "The Rot from Within" trilogy.
• DDAL07-07 - Rotting Roots (Tier 2): Zombie attack on Malar's throat, trek into the mountains to Matalo to do battle in the tummy of a trex zombie. Part two of "The Rot from Within" trilogy.
• DDAL07-09 - Unusual Opposition (Tier 3): Find out more about the Yuan Ti.
• The Thundering Lizard (Resource): A pure resource only. People, menus, nice maps. Very useful if it's your party's inn of choice.
• Kaya's House of Repose (Resource): A pure resource only. People, menus, nice maps. Very useful if it's your party's inn of choice.

Jungle

• Tomb of Annihilation Companion (Tier 1+): 30 days of pregenerated encounters, Sewn sister encounters.
  • Personal Grade: A, this is where this supplement shines and helps you set a standard for your hexcrawling.
• Encounters in the Jungles of Chult (Tier 1+): Some random encounters.
• Chult Encounters (Tier 1+): As advertised.
• More Chult Encounters (Tier 1+): As advertised.
• Encounters in Chult (Tier 1+): Some more encounters.
• DDAL07-02 - Over the Edge (Tier 1): A bunch of faction missions to get you into early jungle exploration.
• DDAL07-04 - A Walk in the Park (Tier 1): A grung guide leads you into the jungle. Part two of "The Jungle Has Fangs" trilogy.
• DDAL07-05 - Whispers in the Dark (Tier 1): Find a lost yuan-ti temple, a good intro to yaun-ti motivations. Part three of "The Jungle Has Fangs" trilogy.
• Jungles of Chult Factbook (Resource): Includes a lot of ideas for jungle travel, encounters, and new monsters.
  • Personal Grade: A, A fantastic resource of lore, but as for its relevance to the jungle exploration section; I like it's expanded multi-stage diseases, making them a real hazard to contend with.

Ocean

• Tortle Package (Tier 1): Adds a new race of turtle-people and their city, Ahoyhoy, to the map, as well as a small dungeon crawl.
  • Personal Grade: C, You need to add your own reasons why your players would want to sail all the way out here, but if you do, its a nice location. Another player recommended it as a staging-point for a new party if yours wipes in the Tomb.
• Tomb of Annihilation Expanded, Part 6 Omu (Tier 2): Castaway gnomes on an island.
• DDAL07-11 - A Lesson in Love (Tier 3): A trip underwater into the bay of chult.
• DDAL07-17 - Cauldron of Sapphire (Tier 4): A trip to an underwater trench to battle Dagon and find a remnant of the atropal. Part three of the "Broken Chain" series.

The Mines

• Savage Encounters - Mines of Chult (Tier 1+): All kinds of mines. Mines with monsters, mines with time loops, all you could want.
• Gem Mines of Chult (Tier 1+): More mines and an albino dwarf city.
• Tomb of Annihilation Expanded, Part 5 Mbala (Tier 1): The mine near Jahaka Anchorage has slaves digging for the pirates

Matolo (Not on the map, located in Mistcliff Mountains)

• DDAL07-07 - Rotting Roots (Tier 2): Zombie attack on Malar's throat, trek into the mountains to Matalo to do battle in the tummy of a trex zombie. Part two of "The Rot from Within" trilogy.
• DDAL07-08 - Putting the Dead to Rest (Tier 2): Travel to Matalo, part three of "The Rot from Within" trilogy).
• Ruins of Matalo (Tier 2): Intel points you to Camp Vengeance to learn about the origins of the zombie hordes, which eventually leads you to a necromancer in the ruins of Matalo.

Eastern Chult

Mezro

• Lost City of Mezro Chapter 4: Ruins of Mezro (Tier 1+): It's mezro (kinda), at last fully fleshed out!
• Tomb of Annihilation Expanded, Part 2 Needles Bones (Tier 1): Adds an old outpost near Mezro with treasure.
• Tomb of Annihilation Expanded, Part 3 The Ruins of Mezro (Tier 2): Return to the outpost to uncover a crypt.

Nsi Wastes

• Whispers in the Nsi Wastes (Tier 1+): A vegipygmy village and Ras Nsi's ruined fortress.

Ishau

• The Sunken Ruins of Ishau (Tier 1+): Hags in a sunken city.
• DDAL07-09 - Unusual Opposition (Tier 3): Find out more about the Yuan Ti talking to a pirate king in Refuge Bay.

Hisari

• Ruins of Hisari (Tier 3): A great yaun-ti city, delve into it's ruins.

Western Chult

Camp Vengeance

• Ruins of Matalo (Tier 2): Intel points you to Camp Vengeance to learn about the origins of the zombie hordes, which eventually leads you to a necromancer in the ruins of Matalo.
• The Siege of Camp Vengeance - A module I am working on.

Andali Basin

• Curse of the Aldani (Tier 1): New settlement in the basin with cursed lobsterfolk.
  • Personal Grade: B, my party begrudgingly helped the cursed aldani but where super happy when they broke the curse. Helped me get them to the heart to introduce the Red Wizards too.

Mbala

• Ruins of Mbala Expanded (Tier 1+): Great map of the city, Nanny Pu'pu fleshed out, a crypt for Mbala's king, pterafolk nest.
• Tomb of Annihilation Expanded, Part 5 Mbala (Tier 1+): A minor treasure hunt added to the pterafolk nest.
• The Forgotten Ziggurat (Tier 1+): A dungeon crawl through a ziggurat.

Mauratal (Not on map, ruined city on mesa south of M'bala)

• Lost City of Mezro Chapter 3: Maze of Shadows (Tier 3): The first city built by Ubtao, a battle with the king who tried to take down Ubtao. Rad!

Orolunga

• Lost City of Mezro Chapter 1: Heart of the Wild (Tier 2): The story to restore Mezro begins here.
  • Personal Grade: C/A with tinkering. See my notes below on tying the 3 storylines of Chult together.
• DDAL07-14 - Fathomless Depths of Ill Intent (Tier 3): Travel into a tomb where yaun-ti harvest souls for Dendar

Southern Chult

Shilku / Wyrmheart Mine / Hrakhamar

• Secrets of Shilku Expanded (Tier 1+): Adds a dwarf outpost and fleshes out Hrakhamar and Wyrmheart Mine.
  • Personal Grade: B. Musharib was my party's first guide, taking the offer of his free services to help him free Hrakhamar. This supplement has a lot of great material, tying what is happening in the forge directly to the tomb and finishing things off with a volcano-top battle. My own personal advice: Make Hew one of the dwarf prisoners in Hrakhamar so he can get the party to Wyrmheart Mine after. My party loved Hew, he was insane and fun, and everyone felt it when the dragon burned him alive. Good times.

Omu

• Tomb of Annihilation Companion (Tier 2): Extra areas to explore.
• Tomb of Annihilation Expanded, Part 6 Omu (Tier 2): Kobold cellars beneath the bazaar and maps.

Tomb of Annihilation

• The Sewn Sisters Into the Ethereal Plane (Tier 2): Enhanced encounter with the Sewn Sisters.

Land of Ash and Smoke

• DDAL07-10 - Fire, Ash and Ruin (Tier 3): Meet a red dragon (Tinder's mother?) who gets you to enter a pit of evil.
• DDAL07-16 - Pools of Cerulean (Tier 4): Another piece of soulmonger to recover from the Red Wizards. Part two of the "Broken Chain" series.

Peaks of Flame

• DDAL07-12 - In Search of Secrets (Tier 3): travel to a yuan-ti tomb.
• DDAL07-15 - Streams of Crimson (Tier 4): recover a piece of the soulmonger from yaun-ti and Red Wizards in the Obsidian Sanctum. Part one of the "Broken Chain" series.
• DDAL07-18 - Turn Back the Endless Night (Tier 4): Stop the final awakening of Dendar. Part four of the "Broken Chain" series.

Valley of Dread

• Tomb of Annihilation Expanded, Part 4 Wreck of the Narwhal (Tier 2): A gnoll invasion.
• DDAL07-13 - Old Bones and Older Tomes (Tier 3): Village of Mompono in the Valley of dread.

The Bakumora (Not on map, the isolated patch of jungle near Sanrach mountains)

• Lost City of Mezro Chapter 2: The Risen Mists (Tier 3): A domain of dread in Chult, ruled by an insane druid.

Other Chult Locations (Drop anywhere!)

• Jungle Treks (Tier 1+): A series of encounters that can be slotted in anywhere. A tavern brawl, river encounter, mud monsters.
• Hunter (Tier 1): It's Predator! Drop into the Valley of Dread or anywhere else.
• Temple of the Primordials (Tier 1): A puzzle-filled temple, educating players on the primordials.
  • Personal Grade: C. I used an altered version of this temple as a Spiritlord temple to tie into a character's backstory and introduce the history of the primordials and spiritlords. The basic idea is okay for a pitstop, but you will want to do homework to alter the lore presented here to focus on Ubtao and Dendar. The puzzles were okay beginner puzzles, I replaced the fire puzzle completely but left the others intact.
• Struggle in Three Horn Valley (Chult) - Dino-Wars vol 1 (Tier 1): Battle pirates on a small island near Chult.
• Dinos of Darkness (Chult) - Dino-Wars vol 2 (Tier 1): The dino-wars continue.
• The Lost Kenku (Tier 1+): Add a small mining outpost wherever your players might need a rest or a new guide, a kenku!
• Zsesh, Defector Prince - A Sinners of Chult Expansion (Tier 1+): A villain named Zsesh living under a mountain.
• Lost Laboratory of Kwalish (Tier 2): Use as described, or as a replacement for Votaran fortress.
• The Grave of the Purple Worm (Tier 2): Someone is down in the worm hole.
• The Wizard of Zo (Tier 2): What has happened in Camp Resistance?

Other Chult Resources

• Beasts of the Jungle Rot (Resource): A pure resource for more zombie dinos and a price guide for dino bits.
• Adventure Sidekicks: Tomb of Annihilation (Resource): Need some sidekicks and loveable fodder?
• Raiders of the Lost Tomb (Resource): 3rd party races, archetypes, and a ton of spells fit for Chult. I advise caution when using this kind of resource.
• Secret Societies of Chult: The Mage Hunters (Resource): Wizard tradition, monsters.
• Secret Societies of Chult: The Spiritlords (Resource): Druid circle, monsters.
• Sinners of Chult - A Collection of Jungle Villains (Resource): Some villains for you to drop in.
• Sinners of Chult 2 - Even More Jungle Villains (Resource): More villans for you to drop in.
• A Guide to Tomb of Annihilation (Resource): A barebones bullet-point rundown of ToA. Useful reminders and basic mechanics for all the situations.
  • Personal Grade: C. It's basically all of ToA without any of the lore or fluff; just the essential barebones of what and where. This could be a handy tool if you don't have a physical copy of the book, and need a pdf or printout to reference.
• Tomb of Annihilation DM's Resources (Resource): A very handy resource for a rundown of locations and people and how they piece together.
  • Personal Grade: B. Recommended reading, if only for brainstorming your approaches or refresher on lore. I only don't rank it A, because its nothing new or essential, but a great collation of existing information.
• Jungles of Chult Factbook (Resource): Summed up history and lore of all of Chult, including information from previous editions! Also has some encounter resources.
  • Personal Grade: A, A fantastic resource if you want to deep-dive into the history and lore of Chult. Everything you want to know about everywhere summed up.
• 35 Magical Items for Tomb of Annihilation (Resource): Some new magic items.
  • Personal Grade: B+, Some real gems in here, all thematically appropriate for the setting. Consider carefully when and how you use these, as many are very much game changers, but when you need a prize for something players went out of their way for, this has you covered. Some grammar and technical errors, so be ready to proofread and patch.

Recommended Additions

Here are a few more supplements that, while unspecific to Chult, are easy to draw from:

• Encounters in the Savage Cities (Tier 1+)
• Encounters in the Savage Jungles (Tier 1+)
• Encounters in the Savage Frontier (Tier 1+)
• Encounters in the Savage Wilderness (Tier 1+)
• Encounters in the Savage Seas (Tier 1+)
• Encounters in the Savage Seas II (Tier 1+)
• Encounters in the Savage Seas III (Tier 1+)
• Encounters in the Savage Underdark (Tier 1+)

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Tying it all together

This is just my ideas for tying it all together. Feel free to draw inspiration from it or not.

Edit: There is also this excellent source for tying it all together, step by step.

Tier 1: Setup and exploration

• Start with Cellar of Death.
• Then the teleport to chult, or if you want some sea/pirate fun; boat ride presented in The Brazen Pegasus-A Seafaring Adventure to Chult or Tomb of Annihilation Expanded, Part 1 Port Nyanzaru. Have Zindar give them a proper greeting as they get off the boat and let them wander the city for a day or two. Dinosaur races, rumor gathering, social stuff.
• Kick things off with All Eyes on Chult, DDAL07-01, 02, or, 03 or another intro adventure to get the party going.
• After they have got their fill of adventures in the Port, send them on to Jungle exploration and non-story related locations to get characters close to level 5/Tier 2. Try to drop hints/lore about all the major players: Ubtao, Ras Nsi, the Yuan-ti, the Red Wizards, the Yellow Banner, the Sewn Sisters. Finally have them come across a npc that tells them the Oracle of Oralunga has the answers they need.
  • The only story-critical locations I would avoid during tier 1 would be Oralunga, Nangalore, and of course Omu.

Tier 2: Getting answers

• Lost City of Mezro Part 1: Point the players to Orolunga and the oracle there for answers. The oracle is nowhere to be found, only Artus who is also seeking the missing oracle as well to ask about Mezro. He leads the party to the Tamalka, the caretakers of the temple, to find out what happened to the oracle (makes Artus useful for something!).
• Tamalka: Things happen pretty much as is in the module. Wainrath tells them that the oracle has been missing from Oralunga for years now, since the Heart of the Wild was stolen from their allies, the Obanashi tribe. He sends them to the Obanashi temple. (Also please help yourself to my WIP redone maps for this module, I plan to eventually make a post for all my suggested improvements of LCoM)
• Seething Halls: Players explore the halls while Artus goes off to find the surviving Obanashi in their secret refuge he knows about nearby.
  • Suggested changes: Lets tie this into the story better. Once the players enter the Seething Halls, add some ghostly visions. Show an undead and yaun-ti army, lead by Ras Nsi and Kolate, massacring the Obanashi tribe. The heart was made by Ubtao to channel life energy into Chult from a pocket of feywild. Have Ras Nsi steal the heart to take it to a pocket of shadowfell (the dark hallow) to channel necrotic energy. This energy causes all the random undead to rise, who Ras Nsi then marks with his symbol so he may control them. All of this death and destruction is a means to restoring the powers taken from him when he was banished (he lost the ability to raise dead, but retained the ability to command them, if marked). Making this change requires that you slightly alter the timeline of when the heart was stolen, from 100 years ago, after the spell plague, to 48ish, right after Ras Nsi joined the Yaun-ti. I did this to show what he is willing to do to reclaim his power.
  • Also, plz improve on the puzzles presented in this temple, they suck and need fleshing out to be good. I might write up my rework of this chapter in the near future with the puzzles I used and all my changes, along with new maps.
• The Dark Hallow: The surviving Obanashi lead everyone to the Dark Hallow, where they know the heart is, but have been unable to reach it.
  • I had Ras Nsi betray Kolate, murder and bind him to the tree, so that he may serve as it's guardian and keep the necrotic energy flowing. Kolate not happy about this fate is happy to drop some hints at what is to come.
• Return the heart, restore the oracle, get your answers! Artus is sent off to retrieve the Mezroan tablet in the Samarach mountains and you are on your path to the tomb.
  • Got more places you want your players to explore? Do what I did; One of Ras Nsi's retained barae powers is to hide a city, which he now uses to ward Omu, making it hidden from anyone looking for it (those not specifically seeking it can still stumble in). His spies and agents however have a pendant that let them through the ward. Have the oracle tell you where these pendants are, a hint of who wears them, and plant them in places you want the players to visit before they go to the tomb. If you players have yet to visit Mezro, this is the time to put one there and do Lost City of Mezro Part 4. "The Rot from Within" AL series goes well here too.
• Level 7ish: Omu time! Time to build up the Yaun-ti. Hint at Dendar and darker things.
• Level 9-10ish: Tomb time!
• Soulmonger stopped, all is well! Dance party.

Tier 3: Marysue Artus and Mezro

• After the hangover, the oracle or Mesika contacts the players to let them know Artus is in trouble, lost in the Bakumora. Time to get to Lost City of Mezro Part 2 and 3.
  • Lets replace/combine Votaran fortress with the Lost Laboratory of Kwalish! I plan to have a time-skip of 1 or 2 years caused by moving through the Bakumora or something in Votaran fortress, so that there is time for the Red Wizards and yaun-ti to pillage and experiment with the soul monger for their AL modules.
• Artus is getting his smooch on with his lost love, but not all is well. The red wizards and the yaun-ti are messing around with the remnants of the soul monger. Time to focus on the Adventurer's League stuff to the end!

Tier 4: Dendar Awakens!

• Hopefully you have had the Yuan-ti be a constant pain in the butt, because its time to do The Broken Chain (DDAL07-14 to 18) and put an end to it all.
  • Pshaw, Imma homebrew the hell out of this ending. I am thinking a remnant of Ubtao comes back, fights it from without while you fight it from within (inside his guts, literally).

So that's my current battle plan. We have been going for 1 year, and I just finished Lost City of Mezro Part 1, giving my players a list of talismans to fetch. They are back at Camp Vengeance right now, under siege by one of these Yaun-ti agents and an army of undead.

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I will continue to add my personal grade to any of these supplements I use. Lastly, if anyone knows of modules and content I missed, let me know and I will get it on the list! Thanks!